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Protein

FYVE, RhoGEF and PH domain-containing protein 5

Gene

FGD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1242 – 1301FYVE-typePROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 5
Alternative name(s):
Zinc finger FYVE domain-containing protein 23
Gene namesi
Name:FGD5
Synonyms:ZFYVE23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000154783.10
HGNCiHGNC:19117 FGD5
MIMi614788 gene
neXtProtiNX_Q6ZNL6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi152273
OpenTargetsiENSG00000154783
PharmGKBiPA134874843

Polymorphism and mutation databases

BioMutaiFGD5
DMDMi296439343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809501 – 1462FYVE, RhoGEF and PH domain-containing protein 5Add BLAST1462

Proteomic databases

EPDiQ6ZNL6
PaxDbiQ6ZNL6
PeptideAtlasiQ6ZNL6
PRIDEiQ6ZNL6
ProteomicsDBi68034
68035 [Q6ZNL6-2]

PTM databases

iPTMnetiQ6ZNL6
PhosphoSitePlusiQ6ZNL6

Expressioni

Tissue specificityi

Expressed in endothelial cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000154783 Expressed in 186 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_FGD5
ExpressionAtlasiQ6ZNL6 baseline and differential
GenevisibleiQ6ZNL6 HS

Organism-specific databases

HPAiHPA014536
HPA019191

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-7962481,EBI-349968

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127439, 5 interactors
IntActiQ6ZNL6, 7 interactors
MINTiQ6ZNL6
STRINGi9606.ENSP00000285046

Structurei

Secondary structure

11462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6ZNL6
SMRiQ6ZNL6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6ZNL6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini892 – 1084DHPROSITE-ProRule annotationAdd BLAST193
Domaini1113 – 1207PH 1PROSITE-ProRule annotationAdd BLAST95
Domaini1363 – 1461PH 2PROSITE-ProRule annotationAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 323Glu-richAdd BLAST266
Compositional biasi645 – 650Poly-Lys6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1242 – 1301FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1729 Eukaryota
KOG3531 Eukaryota
ENOG410XRXV LUCA
GeneTreeiENSGT00920000148981
HOGENOMiHOG000168874
HOVERGENiHBG051609
InParanoidiQ6ZNL6
KOiK05724
OMAiEAESAYT
OrthoDBiEOG091G00IK
PhylomeDBiQ6ZNL6
TreeFamiTF343077

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZNL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRGPKPPIA PKPRLTAPNE WRASVYLNDS LNKCSNGRLP CVDRGLDEGP
60 70 80 90 100
RSIPKCSESE TDEDYIVVPR VPLREDEPKD EGSVGNKALV SPESSAEEEE
110 120 130 140 150
EREEGGEACG LEGTGAGEDS VAPAAPGAGA LSREGEEGTD LALEDEGEGC
160 170 180 190 200
ADEPGTLEQV SRSEEEEKLV QPHRECSLED SGPWAGEGVF QSDLLLPHIH
210 220 230 240 250
GEDQEPPDTP GEAEEDDEEG CASTDPAGAD EGSGPDRPTE DMGQDAEDTS
260 270 280 290 300
EEPPEKEELA GVQEAETATD CPEVLEEGCE EATGVTGGEQ VDLSEPPDHE
310 320 330 340 350
KKTNQEVAAA TLEDHAQDES AEESCQIVPF ENDCMEDFVT SLTGSPYEFF
360 370 380 390 400
PTESTSFCSE SCSPLSESAK GLESEQAPKL GLRAEENPMV GALCGQCGSL
410 420 430 440 450
QGGAAEGPAA PDVVVVLEEE ALDDALANPY VMGVGLPGQA APGEGGQAAS
460 470 480 490 500
DALGGYGSKE ELNCEAEGGL VPADRKNTST RVRPHSGKVA GYVPETVPEE
510 520 530 540 550
TGPEAGSSAP GIGGAAEEVG KTLLSLEGKP LEASRALPAK PRAFTLYPRS
560 570 580 590 600
FSVEGREIPV SVYQEPEGSG LDDHRIKRKE DNLSLSCVIG SSGSFSQRNH
610 620 630 640 650
LPSSGTSTPS SMVDIPPPFD LACITKKPIT KSSPSLLIES DSPDKYKKKK
660 670 680 690 700
SSFKRFLALT FKKKTENKLH VDVNVSSSRS SSESSYHGPS RILEVDRRSL
710 720 730 740 750
SNSPQLKSRT GKLRASESPS SLIFYRDGKR KGVPFSRTVS RVESFEDRSR
760 770 780 790 800
PPFLPLPLTK PRSISFPSAD TSDYENIPAM NSDYENIQIP PRRPARAGAF
810 820 830 840 850
TKLFEDQSRA LSTANENDGY VDMSSFNAFE SKQQSADQDA ESAYTEPYKV
860 870 880 890 900
CPISSAAPKE DLTSDEEQRS SEEEDSASRD PSVTHKVEGQ SRALVIAQEL
910 920 930 940 950
LSSEKAYVEM LQHLNLDFHG AVMRALDDMD HEGRDTLARE ELRQGLSELP
960 970 980 990 1000
AIHDLHQGIL EELEERLSNW ESQQKVADVF LAREQGFDHH ATHILQFDRY
1010 1020 1030 1040 1050
LGLLSENCLH SPRLAAAVRE FEQSVQGGSQ TAKHRLLRVV QRLFQYQVLL
1060 1070 1080 1090 1100
TDYLNNLCPD SAEYDNTQGA LSLISKVTDR ANDSMEQGEN LQKLVHIEHS
1110 1120 1130 1140 1150
VRGQGDLLQP GREFLKEGTL MKVTGKNRRP RHLFLMNDVL LYTYPQKDGK
1160 1170 1180 1190 1200
YRLKNTLAVA NMKVSRPVME KVPYALKIET SESCLMLSAS SCAERDEWYG
1210 1220 1230 1240 1250
CLSRALPEDY KAQALAAFHH SVEIRERLGV SLGERPPTLV PVTHVMMCMN
1260 1270 1280 1290 1300
CGCDFSLTLR RHHCHACGKI VCRNCSRNKY PLKYLKDRMA KVCDGCFGEL
1310 1320 1330 1340 1350
KKRGRAVPGL MRERPVSMSF PLSSPRFSGS AFSSVFQSIN PSTFKKQKKV
1360 1370 1380 1390 1400
PSALTEVAAS GEGSAISGYL SRCKRGKRHW KKLWFVIKGK VLYTYMASED
1410 1420 1430 1440 1450
KVALESMPLL GFTIAPEKEE GSSEVGPIFH LYHKKTLFYS FKAEDTNSAQ
1460
RWIEAMEDAS VL
Length:1,462
Mass (Da):159,891
Last modified:May 18, 2010 - v3
Checksum:i3012049C00F7384B
GO
Isoform 2 (identifier: Q6ZNL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.

Show »
Length:540
Mass (Da):61,238
Checksum:iA8ED7C2316625D0E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZM68B7ZM68_HUMAN
FGD5 protein
FGD5
1,178Annotation score:
H7C0G2H7C0G2_HUMAN
FYVE, RhoGEF and PH domain-containi...
FGD5
252Annotation score:
A0A1W2PRG7A0A1W2PRG7_HUMAN
FYVE, RhoGEF and PH domain-containi...
FGD5
894Annotation score:

Sequence cautioni

The sequence BAC04878 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04989 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85128 differs from that shown. Reason: Frameshift at position 79.Curated
The sequence CAD98090 differs from that shown. Reason: Erroneous termination at position 1279. Translated as Lys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124A → T in BAC85128 (PubMed:14702039).Curated1
Sequence conflicti213A → G in BAC85128 (PubMed:14702039).Curated1
Sequence conflicti354S → G in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti574H → Y in BAC04989 (PubMed:14702039).Curated1
Sequence conflicti1112R → M in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti1196D → N in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti1289M → T in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti1382K → E in BAC04989 (PubMed:14702039).Curated1
Sequence conflicti1400D → G in CAD98090 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059799403G → R. Corresponds to variant dbSNP:rs7636593Ensembl.1
Natural variantiVAR_059800828A → T. Corresponds to variant dbSNP:rs17038795Ensembl.1
Natural variantiVAR_059801941E → K. Corresponds to variant dbSNP:rs2307092Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0130881 – 922Missing in isoform 2. 2 PublicationsAdd BLAST922

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096856 mRNA Translation: BAC04878.1 Different initiation.
AK097276 mRNA Translation: BAC04989.1 Different initiation.
AK131078 mRNA Translation: BAC85128.1 Frameshift.
AK123054 mRNA Translation: BAG53865.1
AC087591 Genomic DNA No translation available.
AC090954 Genomic DNA No translation available.
BC035364 mRNA Translation: AAH35364.1
BF989107 mRNA No translation available.
BX640820 Transcribed RNA Translation: CAE45896.2
BX538312 mRNA Translation: CAD98090.1 Sequence problems.
CCDSiCCDS46767.1 [Q6ZNL6-1]
RefSeqiNP_689749.3, NM_152536.3 [Q6ZNL6-1]
UniGeneiHs.412406

Genome annotation databases

EnsembliENST00000285046; ENSP00000285046; ENSG00000154783 [Q6ZNL6-1]
GeneIDi152273
KEGGihsa:152273
UCSCiuc003bzc.4 human [Q6ZNL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096856 mRNA Translation: BAC04878.1 Different initiation.
AK097276 mRNA Translation: BAC04989.1 Different initiation.
AK131078 mRNA Translation: BAC85128.1 Frameshift.
AK123054 mRNA Translation: BAG53865.1
AC087591 Genomic DNA No translation available.
AC090954 Genomic DNA No translation available.
BC035364 mRNA Translation: AAH35364.1
BF989107 mRNA No translation available.
BX640820 Transcribed RNA Translation: CAE45896.2
BX538312 mRNA Translation: CAD98090.1 Sequence problems.
CCDSiCCDS46767.1 [Q6ZNL6-1]
RefSeqiNP_689749.3, NM_152536.3 [Q6ZNL6-1]
UniGeneiHs.412406

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MPXX-ray2.80A889-1304[»]
ProteinModelPortaliQ6ZNL6
SMRiQ6ZNL6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127439, 5 interactors
IntActiQ6ZNL6, 7 interactors
MINTiQ6ZNL6
STRINGi9606.ENSP00000285046

PTM databases

iPTMnetiQ6ZNL6
PhosphoSitePlusiQ6ZNL6

Polymorphism and mutation databases

BioMutaiFGD5
DMDMi296439343

Proteomic databases

EPDiQ6ZNL6
PaxDbiQ6ZNL6
PeptideAtlasiQ6ZNL6
PRIDEiQ6ZNL6
ProteomicsDBi68034
68035 [Q6ZNL6-2]

Protocols and materials databases

DNASUi152273
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285046; ENSP00000285046; ENSG00000154783 [Q6ZNL6-1]
GeneIDi152273
KEGGihsa:152273
UCSCiuc003bzc.4 human [Q6ZNL6-1]

Organism-specific databases

CTDi152273
DisGeNETi152273
EuPathDBiHostDB:ENSG00000154783.10
GeneCardsiFGD5
H-InvDBiHIX0003091
HIX0003092
HGNCiHGNC:19117 FGD5
HPAiHPA014536
HPA019191
MIMi614788 gene
neXtProtiNX_Q6ZNL6
OpenTargetsiENSG00000154783
PharmGKBiPA134874843
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1729 Eukaryota
KOG3531 Eukaryota
ENOG410XRXV LUCA
GeneTreeiENSGT00920000148981
HOGENOMiHOG000168874
HOVERGENiHBG051609
InParanoidiQ6ZNL6
KOiK05724
OMAiEAESAYT
OrthoDBiEOG091G00IK
PhylomeDBiQ6ZNL6
TreeFamiTF343077

Miscellaneous databases

ChiTaRSiFGD5 human
EvolutionaryTraceiQ6ZNL6
GenomeRNAii152273
PROiPR:Q6ZNL6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154783 Expressed in 186 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_FGD5
ExpressionAtlasiQ6ZNL6 baseline and differential
GenevisibleiQ6ZNL6 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGD5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNL6
Secondary accession number(s): B3KVQ3
, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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