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Entry version 147 (16 Oct 2019)
Sequence version 3 (18 May 2010)
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Protein

FYVE, RhoGEF and PH domain-containing protein 5

Gene

FGD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1242 – 1301FYVE-typePROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 5
Alternative name(s):
Zinc finger FYVE domain-containing protein 23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGD5
Synonyms:ZFYVE23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19117 FGD5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614788 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZNL6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
152273

Open Targets

More...
OpenTargetsi
ENSG00000154783

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134874843

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZNL6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FGD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439343

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809501 – 1462FYVE, RhoGEF and PH domain-containing protein 5Add BLAST1462

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZNL6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZNL6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZNL6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZNL6

PeptideAtlas

More...
PeptideAtlasi
Q6ZNL6

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZNL6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68034 [Q6ZNL6-1]
68035 [Q6ZNL6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZNL6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZNL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endothelial cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154783 Expressed in 186 organ(s), highest expression level in layer of synovial tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZNL6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZNL6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014536
HPA019191

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-7962481,EBI-349968

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127439, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZNL6, 10 interactors

Molecular INTeraction database

More...
MINTi
Q6ZNL6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000285046

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZNL6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6ZNL6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini892 – 1084DHPROSITE-ProRule annotationAdd BLAST193
Domaini1113 – 1207PH 1PROSITE-ProRule annotationAdd BLAST95
Domaini1363 – 1461PH 2PROSITE-ProRule annotationAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 323Glu-richAdd BLAST266
Compositional biasi645 – 650Poly-Lys6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1242 – 1301FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1729 Eukaryota
KOG3531 Eukaryota
ENOG410XRXV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157922

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168874

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZNL6

KEGG Orthology (KO)

More...
KOi
K05724

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDSGPWA

Database of Orthologous Groups

More...
OrthoDBi
652460at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZNL6

TreeFam database of animal gene trees

More...
TreeFami
TF343077

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZNL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRGPKPPIA PKPRLTAPNE WRASVYLNDS LNKCSNGRLP CVDRGLDEGP
60 70 80 90 100
RSIPKCSESE TDEDYIVVPR VPLREDEPKD EGSVGNKALV SPESSAEEEE
110 120 130 140 150
EREEGGEACG LEGTGAGEDS VAPAAPGAGA LSREGEEGTD LALEDEGEGC
160 170 180 190 200
ADEPGTLEQV SRSEEEEKLV QPHRECSLED SGPWAGEGVF QSDLLLPHIH
210 220 230 240 250
GEDQEPPDTP GEAEEDDEEG CASTDPAGAD EGSGPDRPTE DMGQDAEDTS
260 270 280 290 300
EEPPEKEELA GVQEAETATD CPEVLEEGCE EATGVTGGEQ VDLSEPPDHE
310 320 330 340 350
KKTNQEVAAA TLEDHAQDES AEESCQIVPF ENDCMEDFVT SLTGSPYEFF
360 370 380 390 400
PTESTSFCSE SCSPLSESAK GLESEQAPKL GLRAEENPMV GALCGQCGSL
410 420 430 440 450
QGGAAEGPAA PDVVVVLEEE ALDDALANPY VMGVGLPGQA APGEGGQAAS
460 470 480 490 500
DALGGYGSKE ELNCEAEGGL VPADRKNTST RVRPHSGKVA GYVPETVPEE
510 520 530 540 550
TGPEAGSSAP GIGGAAEEVG KTLLSLEGKP LEASRALPAK PRAFTLYPRS
560 570 580 590 600
FSVEGREIPV SVYQEPEGSG LDDHRIKRKE DNLSLSCVIG SSGSFSQRNH
610 620 630 640 650
LPSSGTSTPS SMVDIPPPFD LACITKKPIT KSSPSLLIES DSPDKYKKKK
660 670 680 690 700
SSFKRFLALT FKKKTENKLH VDVNVSSSRS SSESSYHGPS RILEVDRRSL
710 720 730 740 750
SNSPQLKSRT GKLRASESPS SLIFYRDGKR KGVPFSRTVS RVESFEDRSR
760 770 780 790 800
PPFLPLPLTK PRSISFPSAD TSDYENIPAM NSDYENIQIP PRRPARAGAF
810 820 830 840 850
TKLFEDQSRA LSTANENDGY VDMSSFNAFE SKQQSADQDA ESAYTEPYKV
860 870 880 890 900
CPISSAAPKE DLTSDEEQRS SEEEDSASRD PSVTHKVEGQ SRALVIAQEL
910 920 930 940 950
LSSEKAYVEM LQHLNLDFHG AVMRALDDMD HEGRDTLARE ELRQGLSELP
960 970 980 990 1000
AIHDLHQGIL EELEERLSNW ESQQKVADVF LAREQGFDHH ATHILQFDRY
1010 1020 1030 1040 1050
LGLLSENCLH SPRLAAAVRE FEQSVQGGSQ TAKHRLLRVV QRLFQYQVLL
1060 1070 1080 1090 1100
TDYLNNLCPD SAEYDNTQGA LSLISKVTDR ANDSMEQGEN LQKLVHIEHS
1110 1120 1130 1140 1150
VRGQGDLLQP GREFLKEGTL MKVTGKNRRP RHLFLMNDVL LYTYPQKDGK
1160 1170 1180 1190 1200
YRLKNTLAVA NMKVSRPVME KVPYALKIET SESCLMLSAS SCAERDEWYG
1210 1220 1230 1240 1250
CLSRALPEDY KAQALAAFHH SVEIRERLGV SLGERPPTLV PVTHVMMCMN
1260 1270 1280 1290 1300
CGCDFSLTLR RHHCHACGKI VCRNCSRNKY PLKYLKDRMA KVCDGCFGEL
1310 1320 1330 1340 1350
KKRGRAVPGL MRERPVSMSF PLSSPRFSGS AFSSVFQSIN PSTFKKQKKV
1360 1370 1380 1390 1400
PSALTEVAAS GEGSAISGYL SRCKRGKRHW KKLWFVIKGK VLYTYMASED
1410 1420 1430 1440 1450
KVALESMPLL GFTIAPEKEE GSSEVGPIFH LYHKKTLFYS FKAEDTNSAQ
1460
RWIEAMEDAS VL
Length:1,462
Mass (Da):159,891
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3012049C00F7384B
GO
Isoform 2 (identifier: Q6ZNL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-922: Missing.

Show »
Length:540
Mass (Da):61,238
Checksum:iA8ED7C2316625D0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZM68B7ZM68_HUMAN
FGD5 protein
FGD5
1,178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0G2H7C0G2_HUMAN
FYVE, RhoGEF and PH domain-containi...
FGD5
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRG7A0A1W2PRG7_HUMAN
FYVE, RhoGEF and PH domain-containi...
FGD5
894Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04878 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC04989 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85128 differs from that shown. Reason: Frameshift.Curated
The sequence CAD98090 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124A → T in BAC85128 (PubMed:14702039).Curated1
Sequence conflicti213A → G in BAC85128 (PubMed:14702039).Curated1
Sequence conflicti354S → G in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti574H → Y in BAC04989 (PubMed:14702039).Curated1
Sequence conflicti1112R → M in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti1196D → N in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti1289M → T in CAE45896 (PubMed:17974005).Curated1
Sequence conflicti1382K → E in BAC04989 (PubMed:14702039).Curated1
Sequence conflicti1400D → G in CAD98090 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059799403G → R. Corresponds to variant dbSNP:rs7636593Ensembl.1
Natural variantiVAR_059800828A → T. Corresponds to variant dbSNP:rs17038795Ensembl.1
Natural variantiVAR_059801941E → K. Corresponds to variant dbSNP:rs2307092Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0130881 – 922Missing in isoform 2. 2 PublicationsAdd BLAST922

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK096856 mRNA Translation: BAC04878.1 Different initiation.
AK097276 mRNA Translation: BAC04989.1 Different initiation.
AK131078 mRNA Translation: BAC85128.1 Frameshift.
AK123054 mRNA Translation: BAG53865.1
AC087591 Genomic DNA No translation available.
AC090954 Genomic DNA No translation available.
BC035364 mRNA Translation: AAH35364.1
BF989107 mRNA No translation available.
BX640820 Transcribed RNA Translation: CAE45896.2
BX538312 mRNA Translation: CAD98090.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS46767.1 [Q6ZNL6-1]

NCBI Reference Sequences

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RefSeqi
NP_689749.3, NM_152536.3 [Q6ZNL6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000285046; ENSP00000285046; ENSG00000154783 [Q6ZNL6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
152273

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:152273

UCSC genome browser

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UCSCi
uc003bzc.4 human [Q6ZNL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096856 mRNA Translation: BAC04878.1 Different initiation.
AK097276 mRNA Translation: BAC04989.1 Different initiation.
AK131078 mRNA Translation: BAC85128.1 Frameshift.
AK123054 mRNA Translation: BAG53865.1
AC087591 Genomic DNA No translation available.
AC090954 Genomic DNA No translation available.
BC035364 mRNA Translation: AAH35364.1
BF989107 mRNA No translation available.
BX640820 Transcribed RNA Translation: CAE45896.2
BX538312 mRNA Translation: CAD98090.1 Sequence problems.
CCDSiCCDS46767.1 [Q6ZNL6-1]
RefSeqiNP_689749.3, NM_152536.3 [Q6ZNL6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MPXX-ray2.80A889-1304[»]
SMRiQ6ZNL6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi127439, 5 interactors
IntActiQ6ZNL6, 10 interactors
MINTiQ6ZNL6
STRINGi9606.ENSP00000285046

PTM databases

iPTMnetiQ6ZNL6
PhosphoSitePlusiQ6ZNL6

Polymorphism and mutation databases

BioMutaiFGD5
DMDMi296439343

Proteomic databases

EPDiQ6ZNL6
jPOSTiQ6ZNL6
MassIVEiQ6ZNL6
PaxDbiQ6ZNL6
PeptideAtlasiQ6ZNL6
PRIDEiQ6ZNL6
ProteomicsDBi68034 [Q6ZNL6-1]
68035 [Q6ZNL6-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
152273

Genome annotation databases

EnsembliENST00000285046; ENSP00000285046; ENSG00000154783 [Q6ZNL6-1]
GeneIDi152273
KEGGihsa:152273
UCSCiuc003bzc.4 human [Q6ZNL6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
152273
DisGeNETi152273

GeneCards: human genes, protein and diseases

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GeneCardsi
FGD5
HGNCiHGNC:19117 FGD5
HPAiHPA014536
HPA019191
MIMi614788 gene
neXtProtiNX_Q6ZNL6
OpenTargetsiENSG00000154783
PharmGKBiPA134874843

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1729 Eukaryota
KOG3531 Eukaryota
ENOG410XRXV LUCA
GeneTreeiENSGT00940000157922
HOGENOMiHOG000168874
InParanoidiQ6ZNL6
KOiK05724
OMAiEDSGPWA
OrthoDBi652460at2759
PhylomeDBiQ6ZNL6
TreeFamiTF343077

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FGD5 human
EvolutionaryTraceiQ6ZNL6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
152273
PharosiQ6ZNL6

Protein Ontology

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PROi
PR:Q6ZNL6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154783 Expressed in 186 organ(s), highest expression level in layer of synovial tissue
ExpressionAtlasiQ6ZNL6 baseline and differential
GenevisibleiQ6ZNL6 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGD5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZNL6
Secondary accession number(s): B3KVQ3
, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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