UniProtKB - Q6ZNK6 (TIFAB_HUMAN)
Protein
TRAF-interacting protein with FHA domain-containing protein B
Gene
TIFAB
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.1 Publication
GO - Biological processi
- auditory behavior Source: CAFA
- cochlea development Source: CAFA
- cochlea morphogenesis Source: CAFA
- craniofacial suture morphogenesis Source: CAFA
- genitalia development Source: CAFA
- genitalia morphogenesis Source: CAFA
- hard palate morphogenesis Source: CAFA
- I-kappaB kinase/NF-kappaB signaling Source: InterPro
- inner ear development Source: CAFA
- inner ear morphogenesis Source: CAFA
- learned vocalization behavior Source: CAFA
- mastication Source: CAFA
- negative regulation of relaxation of muscle Source: CAFA
- negative regulation of saliva secretion Source: CAFA
- neuromuscular process controlling balance Source: CAFA
- peristalsis Source: CAFA
- regulation of muscle organ development Source: CAFA
- thorax and anterior abdomen determination Source: CAFA
- trigeminal nerve development Source: CAFA
- vestibulocochlear nerve formation Source: CAFA
Enzyme and pathway databases
PathwayCommonsi | Q6ZNK6 |
Names & Taxonomyi
Protein namesi | Recommended name: TRAF-interacting protein with FHA domain-containing protein BAlternative name(s): TIFA-like protein |
Gene namesi | Name:TIFAB1 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:34024, TIFAB |
MIMi | 612663, gene |
neXtProti | NX_Q6ZNK6 |
VEuPathDBi | HostDB:ENSG00000255833.1 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 497189 |
OpenTargetsi | ENSG00000255833 |
PharmGKBi | PA162405786 |
Miscellaneous databases
Pharosi | Q6ZNK6, Tbio |
Genetic variation databases
BioMutai | TIFAB |
DMDMi | 172046187 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000320692 | 1 – 161 | TRAF-interacting protein with FHA domain-containing protein BAdd BLAST | 161 |
Proteomic databases
MassIVEi | Q6ZNK6 |
PaxDbi | Q6ZNK6 |
PeptideAtlasi | Q6ZNK6 |
PRIDEi | Q6ZNK6 |
ProteomicsDBi | 68031 |
Expressioni
Gene expression databases
Bgeei | ENSG00000255833, Expressed in lymph node and 48 other tissues |
Genevisiblei | Q6ZNK6, HS |
Organism-specific databases
HPAi | ENSG00000255833, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with TIFA.
1 PublicationProtein-protein interaction databases
STRINGi | 9606.ENSP00000440509 |
Miscellaneous databases
RNActi | Q6ZNK6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 91 | FHASequence analysisAdd BLAST | 56 |
Phylogenomic databases
eggNOGi | ENOG502SPI3, Eukaryota |
GeneTreei | ENSGT00940000154589 |
HOGENOMi | CLU_116346_0_0_1 |
InParanoidi | Q6ZNK6 |
OMAi | KGCVWVN |
OrthoDBi | 1346020at2759 |
PhylomeDBi | Q6ZNK6 |
TreeFami | TF333218 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR008984, SMAD_FHA_dom_sf IPR033621, TIFA |
PANTHERi | PTHR31266, PTHR31266, 1 hit |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6ZNK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKPLTVLRV SLYHPTLGPS AFANVPPRLQ HDTSPLLLGR GQDAHLQLQL
60 70 80 90 100
PRLSRRHLSL EPYLEKGSAL LAFCLKALSR KGCVWVNGLT LRYLEQVPLS
110 120 130 140 150
TVNRVSFSGI QMLVRVEEGT SLEAFVCYFH VSPSPLIYRP EAEETDEWEG
160
ISQGQPPPGS G
Sequence cautioni
The sequence BAC85138 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131088 mRNA Translation: BAC85138.1 Different initiation. AB161513 mRNA Translation: BAD89018.1 |
CCDSi | CCDS43365.1 |
RefSeqi | NP_001092691.1, NM_001099221.1 |
Genome annotation databases
Ensembli | ENST00000537858; ENSP00000440509; ENSG00000255833 |
GeneIDi | 497189 |
KEGGi | hsa:497189 |
UCSCi | uc003law.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131088 mRNA Translation: BAC85138.1 Different initiation. AB161513 mRNA Translation: BAD89018.1 |
CCDSi | CCDS43365.1 |
RefSeqi | NP_001092691.1, NM_001099221.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000440509 |
Genetic variation databases
BioMutai | TIFAB |
DMDMi | 172046187 |
Proteomic databases
MassIVEi | Q6ZNK6 |
PaxDbi | Q6ZNK6 |
PeptideAtlasi | Q6ZNK6 |
PRIDEi | Q6ZNK6 |
ProteomicsDBi | 68031 |
Protocols and materials databases
Antibodypediai | 53591, 58 antibodies |
Genome annotation databases
Ensembli | ENST00000537858; ENSP00000440509; ENSG00000255833 |
GeneIDi | 497189 |
KEGGi | hsa:497189 |
UCSCi | uc003law.5, human |
Organism-specific databases
CTDi | 497189 |
DisGeNETi | 497189 |
GeneCardsi | TIFAB |
HGNCi | HGNC:34024, TIFAB |
HPAi | ENSG00000255833, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 612663, gene |
neXtProti | NX_Q6ZNK6 |
OpenTargetsi | ENSG00000255833 |
PharmGKBi | PA162405786 |
VEuPathDBi | HostDB:ENSG00000255833.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SPI3, Eukaryota |
GeneTreei | ENSGT00940000154589 |
HOGENOMi | CLU_116346_0_0_1 |
InParanoidi | Q6ZNK6 |
OMAi | KGCVWVN |
OrthoDBi | 1346020at2759 |
PhylomeDBi | Q6ZNK6 |
TreeFami | TF333218 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZNK6 |
Miscellaneous databases
BioGRID-ORCSi | 497189, 6 hits in 975 CRISPR screens |
GenomeRNAii | 497189 |
Pharosi | Q6ZNK6, Tbio |
PROi | PR:Q6ZNK6 |
RNActi | Q6ZNK6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000255833, Expressed in lymph node and 48 other tissues |
Genevisiblei | Q6ZNK6, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR008984, SMAD_FHA_dom_sf IPR033621, TIFA |
PANTHERi | PTHR31266, PTHR31266, 1 hit |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TIFAB_HUMAN | |
Accessioni | Q6ZNK6Primary (citable) accession number: Q6ZNK6 Secondary accession number(s): Q5H8A9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | April 7, 2021 | |
This is version 104 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot