TRAF-interacting protein with FHA domain-containing protein B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• auditory behavior Source: CAFA <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• cochlea development Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• cochlea morphogenesis Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• craniofacial suture morphogenesis Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• genitalia development Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• genitalia morphogenesis Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• hard palate morphogenesis Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• I-kappaB kinase/NF-kappaB signaling Source: InterPro
• inner ear development Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• inner ear morphogenesis Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• learned vocalization behavior Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• mastication Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of relaxation of muscle Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of saliva secretion Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• neuromuscular process controlling balance Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• peristalsis Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of muscle organ development Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• thorax and anterior abdomen determination Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• trigeminal nerve development Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]
• vestibulocochlear nerve formation Source: CAFAInferred from genetic interactionⁱ
  • "A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]."
    Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., Zechner U., Muller-Forell W., Keilmann A., Bartsch O.
    Behav Brain Funct 9:7-7(2013) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEKPLTVLRV SLYHPTLGPS AFANVPPRLQ HDTSPLLLGR GQDAHLQLQL 
        60         70         80         90        100
PRLSRRHLSL EPYLEKGSAL LAFCLKALSR KGCVWVNGLT LRYLEQVPLS 
       110        120        130        140        150
TVNRVSFSGI QMLVRVEEGT SLEAFVCYFH VSPSPLIYRP EAEETDEWEG 
       160 
ISQGQPPPGS G                                           

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 5
   Human chromosome 5: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot