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Protein

Zinc finger protein 497

Gene

ZNF497

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri106 – 128C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri134 – 156C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 184C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 497
Gene namesi
Name:ZNF497
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000174586.10
HGNCiHGNC:23714 ZNF497
neXtProtiNX_Q6ZNH5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174586
PharmGKBiPA134994387

Polymorphism and mutation databases

BioMutaiZNF497
DMDMi229462815

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476181 – 498Zinc finger protein 497Add BLAST498

Proteomic databases

PaxDbiQ6ZNH5
PeptideAtlasiQ6ZNH5
PRIDEiQ6ZNH5
ProteomicsDBi68026

PTM databases

iPTMnetiQ6ZNH5
PhosphoSitePlusiQ6ZNH5

Expressioni

Gene expression databases

BgeeiENSG00000174586 Expressed in 94 organ(s), highest expression level in right uterine tube
CleanExiHS_ZNF497
ExpressionAtlasiQ6ZNH5 baseline and differential
GenevisibleiQ6ZNH5 HS

Organism-specific databases

HPAiHPA047872

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi127835, 2 interactors
IntActiQ6ZNH5, 35 interactors
STRINGi9606.ENSP00000311183

Structurei

3D structure databases

ProteinModelPortaliQ6ZNH5
SMRiQ6ZNH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri106 – 128C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri134 – 156C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 184C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000151027
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6ZNH5
OMAiNFLEHRR
OrthoDBiEOG091G02KC
PhylomeDBiQ6ZNH5
TreeFamiTF337005

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6ZNH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESPRGWTLQ VAPEEGQVLC NVKTATRGLS EGAVSGGWGA WENSTEVPRE
60 70 80 90 100
AGDGQRQQAT LGAADEQGGP GRELGPADGG RDGAGPRSEP ADRALRPSPL
110 120 130 140 150
PEEPGCRCGE CGKAFSQGSY LLQHRRVHTG EKPYTCPECG KAFAWSSNLS
160 170 180 190 200
QHQRIHSGEK PYACRECGKA FRAHSQLIHH QETHSGLKPF RCPDCGKSFG
210 220 230 240 250
RSTTLVQHRR THTGEKPYEC PECGKAFSWN SNFLEHRRVH TGARPHACRD
260 270 280 290 300
CGKAFSQSSN LAEHLKIHAG ARPHACPDCG KAFVRVAGLR QHRRTHSSEK
310 320 330 340 350
PFPCAECGKA FRESSQLLQH QRTHTGERPF ECAECGQAFV MGSYLAEHRR
360 370 380 390 400
VHTGEKPHAC AQCGKAFSQR SNLLSHRRTH SGAKPFACAD CGKAFRGSSG
410 420 430 440 450
LAHHRLSHTG ERPFACAECG KAFRGSSELR QHQRLHSGER PFVCAHCSKA
460 470 480 490
FVRKSELLSH RRTHTGERPY ACGECGKPFS HRCNLNEHQK RHGGRAAP
Length:498
Mass (Da):54,721
Last modified:May 5, 2009 - v2
Checksum:iAAC4DD81A06CECFA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R159M0R159_HUMAN
Zinc finger protein 497
ZNF497
108Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212 – 214HTG → RA in AAF16412 (Ref. 4) Curated3
Sequence conflicti241T → A in AAF16412 (Ref. 4) Curated1
Sequence conflicti320H → Y in AAF16412 (Ref. 4) Curated1
Sequence conflicti367F → S in BAC86660 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055270174H → Q2 PublicationsCorresponds to variant dbSNP:rs12609654Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126727 mRNA Translation: BAC86660.1
AK131209 mRNA Translation: BAD18400.1
CH471135 Genomic DNA Translation: EAW72578.1
BC118983 mRNA Translation: AAI18984.1
BC125273 mRNA Translation: AAI25274.1
AF064790 Genomic DNA Translation: AAF16412.1
CCDSiCCDS12977.1
RefSeqiNP_001193938.1, NM_001207009.1
NP_940860.2, NM_198458.2
UniGeneiHs.447840

Genome annotation databases

EnsembliENST00000311044; ENSP00000311183; ENSG00000174586
ENST00000425453; ENSP00000402815; ENSG00000174586
GeneIDi162968
KEGGihsa:162968
UCSCiuc002qsh.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126727 mRNA Translation: BAC86660.1
AK131209 mRNA Translation: BAD18400.1
CH471135 Genomic DNA Translation: EAW72578.1
BC118983 mRNA Translation: AAI18984.1
BC125273 mRNA Translation: AAI25274.1
AF064790 Genomic DNA Translation: AAF16412.1
CCDSiCCDS12977.1
RefSeqiNP_001193938.1, NM_001207009.1
NP_940860.2, NM_198458.2
UniGeneiHs.447840

3D structure databases

ProteinModelPortaliQ6ZNH5
SMRiQ6ZNH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127835, 2 interactors
IntActiQ6ZNH5, 35 interactors
STRINGi9606.ENSP00000311183

PTM databases

iPTMnetiQ6ZNH5
PhosphoSitePlusiQ6ZNH5

Polymorphism and mutation databases

BioMutaiZNF497
DMDMi229462815

Proteomic databases

PaxDbiQ6ZNH5
PeptideAtlasiQ6ZNH5
PRIDEiQ6ZNH5
ProteomicsDBi68026

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311044; ENSP00000311183; ENSG00000174586
ENST00000425453; ENSP00000402815; ENSG00000174586
GeneIDi162968
KEGGihsa:162968
UCSCiuc002qsh.3 human

Organism-specific databases

CTDi162968
EuPathDBiHostDB:ENSG00000174586.10
GeneCardsiZNF497
HGNCiHGNC:23714 ZNF497
HPAiHPA047872
neXtProtiNX_Q6ZNH5
OpenTargetsiENSG00000174586
PharmGKBiPA134994387
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000151027
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6ZNH5
OMAiNFLEHRR
OrthoDBiEOG091G02KC
PhylomeDBiQ6ZNH5
TreeFamiTF337005

Miscellaneous databases

GenomeRNAii162968
PROiPR:Q6ZNH5

Gene expression databases

BgeeiENSG00000174586 Expressed in 94 organ(s), highest expression level in right uterine tube
CleanExiHS_ZNF497
ExpressionAtlasiQ6ZNH5 baseline and differential
GenevisibleiQ6ZNH5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN497_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNH5
Secondary accession number(s): Q05AG8
, Q0VF48, Q6ZTD2, Q9UIA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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