Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

KRAB-A domain-containing protein 2

Gene

KRBA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-46 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
KRAB-A domain-containing protein 2
Gene namesi
Name:KRBA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000184619.3
HGNCiHGNC:26989 KRBA2
neXtProtiNX_Q6ZNG9

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184619
PharmGKBiPA162393680

Polymorphism and mutation databases

BioMutaiKRBA2
DMDMi74710682

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003001131 – 492KRAB-A domain-containing protein 2Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineCombined sources1
Modified residuei117PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZNG9
PeptideAtlasiQ6ZNG9
PRIDEiQ6ZNG9
ProteomicsDBi68025

PTM databases

iPTMnetiQ6ZNG9
PhosphoSitePlusiQ6ZNG9

Expressioni

Gene expression databases

BgeeiENSG00000184619 Expressed in 95 organ(s), highest expression level in heart
CleanExiHS_KRBA2
ExpressionAtlasiQ6ZNG9 baseline and differential
GenevisibleiQ6ZNG9 HS

Organism-specific databases

HPAiHPA022849

Interactioni

Protein-protein interaction databases

BioGridi125885, 7 interactors
IntActiQ6ZNG9, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6ZNG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 117KRABAdd BLAST82
Domaini247 – 415Integrase catalyticPROSITE-ProRule annotationAdd BLAST169

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili427 – 457Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0017 Eukaryota
COG2801 LUCA
GeneTreeiENSGT00860000133692
HOGENOMiHOG000015353
HOVERGENiHBG100065
InParanoidiQ6ZNG9
OMAiYYQDHLT
OrthoDBiEOG091G09O3
PhylomeDBiQ6ZNG9
TreeFamiTF323092

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001584 Integrase_cat-core
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SUPFAMiSSF109640 SSF109640, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6ZNG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSFLVPSLV SSPVLLKLLF SPGPKTIWSL WQQPMLFQEA TAFENMTKDW
60 70 80 90 100
NYLEGSQKDC YRDTMLDSYE NTVPQGSFLQ LSMMPQRAGN DPPGVSNASE
110 120 130 140 150
MEMEISNMRE KFLMSVTKLV ESKSYNSKVF SKEKYFQTIK EVKEAKEKGK
160 170 180 190 200
KSSRDYRRAA KYDVISVQGT EKLIEATHGE RDRIRYYVHK EELFDILHDT
210 220 230 240 250
HLSIGHGGRT RMLKELQGKY GNVTKEVIVL YLTLCKQCHQ KNPVPKRGLA
260 270 280 290 300
PKPMTFKDID STCQVEILDM QSSADGEFKF ILYYQDHSTK FIILRPLRTK
310 320 330 340 350
QAHEVVSVLL DIFTILGTPS VLDSDSGVEF TNQVVHELNE LWPDLKIVSG
360 370 380 390 400
KYHPGQSQGS LEGASRDVKN MISTWMQSNH SCHWAKGLRF MQMVRNQAFD
410 420 430 440 450
VSLQQSPFEA MFGYKAKFGL YSSNLPRETV ATLQTEEELE IAEEQLENSL
460 470 480 490
WIRQEERAEI GADRSDMDDD MDPTPEASEP STSQGTSGLL CW
Length:492
Mass (Da):56,205
Last modified:July 5, 2004 - v1
Checksum:iD84C1502A38DCCAF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7G8A0A2R8Y7G8_HUMAN
KRAB-A domain-containing protein 2
KRBA2
458Annotation score:
A8MX02A8MX02_HUMAN
KRAB-A domain-containing protein 2
KRBA2
410Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051087435T → M. Corresponds to variant dbSNP:rs370752Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131219 mRNA Translation: BAD18406.1
BC033390 mRNA Translation: AAH33390.1
CCDSiCCDS11141.1
RefSeqiNP_001291876.1, NM_001304947.1
NP_998762.1, NM_213597.3
UniGeneiHs.304604

Genome annotation databases

EnsembliENST00000331336; ENSP00000328017; ENSG00000184619
ENST00000643221; ENSP00000494883; ENSG00000184619
GeneIDi124751
KEGGihsa:124751
UCSCiuc002glf.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131219 mRNA Translation: BAD18406.1
BC033390 mRNA Translation: AAH33390.1
CCDSiCCDS11141.1
RefSeqiNP_001291876.1, NM_001304947.1
NP_998762.1, NM_213597.3
UniGeneiHs.304604

3D structure databases

ProteinModelPortaliQ6ZNG9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125885, 7 interactors
IntActiQ6ZNG9, 2 interactors

PTM databases

iPTMnetiQ6ZNG9
PhosphoSitePlusiQ6ZNG9

Polymorphism and mutation databases

BioMutaiKRBA2
DMDMi74710682

Proteomic databases

PaxDbiQ6ZNG9
PeptideAtlasiQ6ZNG9
PRIDEiQ6ZNG9
ProteomicsDBi68025

Protocols and materials databases

DNASUi124751
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331336; ENSP00000328017; ENSG00000184619
ENST00000643221; ENSP00000494883; ENSG00000184619
GeneIDi124751
KEGGihsa:124751
UCSCiuc002glf.1 human

Organism-specific databases

CTDi124751
EuPathDBiHostDB:ENSG00000184619.3
GeneCardsiKRBA2
H-InvDBiHIX0039124
HGNCiHGNC:26989 KRBA2
HPAiHPA022849
neXtProtiNX_Q6ZNG9
OpenTargetsiENSG00000184619
PharmGKBiPA162393680
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0017 Eukaryota
COG2801 LUCA
GeneTreeiENSGT00860000133692
HOGENOMiHOG000015353
HOVERGENiHBG100065
InParanoidiQ6ZNG9
OMAiYYQDHLT
OrthoDBiEOG091G09O3
PhylomeDBiQ6ZNG9
TreeFamiTF323092

Miscellaneous databases

ChiTaRSiKRBA2 human
GenomeRNAii124751
PROiPR:Q6ZNG9

Gene expression databases

BgeeiENSG00000184619 Expressed in 95 organ(s), highest expression level in heart
CleanExiHS_KRBA2
ExpressionAtlasiQ6ZNG9 baseline and differential
GenevisibleiQ6ZNG9 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001584 Integrase_cat-core
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SUPFAMiSSF109640 SSF109640, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKRBA2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNG9
Secondary accession number(s): Q8IYY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again