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Protein

Homeobox protein DBX2

Gene

DBX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi186 – 245HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DBX2
Alternative name(s):
Developing brain homeobox protein 2
Gene namesi
Name:DBX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185610.6
HGNCiHGNC:33186 DBX2
neXtProtiNX_Q6ZNG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi440097
OpenTargetsiENSG00000185610
PharmGKBiPA162383249

Polymorphism and mutation databases

BioMutaiDBX2
DMDMi296434473

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028491 – 339Homeobox protein DBX2Add BLAST339

Proteomic databases

PaxDbiQ6ZNG2
PeptideAtlasiQ6ZNG2
PRIDEiQ6ZNG2
ProteomicsDBi68024

PTM databases

iPTMnetiQ6ZNG2
PhosphoSitePlusiQ6ZNG2

Expressioni

Gene expression databases

BgeeiENSG00000185610 Expressed in 34 organ(s), highest expression level in nucleus accumbens
CleanExiHS_DBX2

Organism-specific databases

HPAiHPA066053

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331470

Structurei

3D structure databases

ProteinModelPortaliQ6ZNG2
SMRiQ6ZNG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000112172
HOVERGENiHBG104467
InParanoidiQ6ZNG2
OMAiTRWAFQV
OrthoDBiEOG091G0MGV
PhylomeDBiQ6ZNG2
TreeFamiTF350735

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZNG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPSAVAAHA GAYWDVVASS ALLNLPAAPG FGNLGKSFLI ENLLRVGGAP
60 70 80 90 100
TPRLQPPAPH DPATALATAG AQLRPLPASP VPLKLCPAAE QVSPAGAPYG
110 120 130 140 150
TRWAFQVLSP SADSARLPGR APGDRDCTFQ PSAPAPSKPF LLSTPPFYSA
160 170 180 190 200
CCGGSCRRPA SSTAFPREES MLPLLTQDSN SKARRGILRR AVFSEDQRKA
210 220 230 240 250
LEKMFQKQKY ISKTDRKKLA INLGLKESQV KIWFQNRRMK WRNSKEKEVL
260 270 280 290 300
SNRCIQEVGL QEDPLSRSAL GFPSPCPSIW DVPQQHSSPR WRENSPEPSE
310 320 330
RLIQESSGAP PPEANSLQGA LYLCSEEEAG SKGVLTGAV
Length:339
Mass (Da):36,555
Last modified:May 18, 2010 - v2
Checksum:i7E9CAD61C3DAEBEB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034969171M → V1 PublicationCorresponds to variant dbSNP:rs2731038Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131230 mRNA Translation: BAD18413.1
AC008127 Genomic DNA No translation available.
AC079033 Genomic DNA No translation available.
AC089986 Genomic DNA No translation available.
CCDSiCCDS31781.1
RefSeqiNP_001004329.2, NM_001004329.2
UniGeneiHs.302764

Genome annotation databases

EnsembliENST00000332700; ENSP00000331470; ENSG00000185610
GeneIDi440097
KEGGihsa:440097
UCSCiuc001rok.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131230 mRNA Translation: BAD18413.1
AC008127 Genomic DNA No translation available.
AC079033 Genomic DNA No translation available.
AC089986 Genomic DNA No translation available.
CCDSiCCDS31781.1
RefSeqiNP_001004329.2, NM_001004329.2
UniGeneiHs.302764

3D structure databases

ProteinModelPortaliQ6ZNG2
SMRiQ6ZNG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331470

PTM databases

iPTMnetiQ6ZNG2
PhosphoSitePlusiQ6ZNG2

Polymorphism and mutation databases

BioMutaiDBX2
DMDMi296434473

Proteomic databases

PaxDbiQ6ZNG2
PeptideAtlasiQ6ZNG2
PRIDEiQ6ZNG2
ProteomicsDBi68024

Protocols and materials databases

DNASUi440097
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332700; ENSP00000331470; ENSG00000185610
GeneIDi440097
KEGGihsa:440097
UCSCiuc001rok.2 human

Organism-specific databases

CTDi440097
DisGeNETi440097
EuPathDBiHostDB:ENSG00000185610.6
GeneCardsiDBX2
HGNCiHGNC:33186 DBX2
HPAiHPA066053
neXtProtiNX_Q6ZNG2
OpenTargetsiENSG00000185610
PharmGKBiPA162383249
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000112172
HOVERGENiHBG104467
InParanoidiQ6ZNG2
OMAiTRWAFQV
OrthoDBiEOG091G0MGV
PhylomeDBiQ6ZNG2
TreeFamiTF350735

Miscellaneous databases

GeneWikiiDBX2
GenomeRNAii440097
PROiPR:Q6ZNG2

Gene expression databases

BgeeiENSG00000185610 Expressed in 34 organ(s), highest expression level in nucleus accumbens
CleanExiHS_DBX2

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDBX2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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