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Entry version 141 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Zinc finger protein 620

Gene

ZNF620

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri196 – 218C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q6ZNG0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 620
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF620
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28742, ZNF620

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZNG0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000177842.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
253639

Open Targets

More...
OpenTargetsi
ENSG00000177842

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134942360

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZNG0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF620

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762397

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476911 – 422Zinc finger protein 620Add BLAST422

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZNG0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZNG0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZNG0

PeptideAtlas

More...
PeptideAtlasi
Q6ZNG0

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZNG0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68021 [Q6ZNG0-1]
68022 [Q6ZNG0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZNG0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZNG0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177842, Expressed in adrenal tissue and 122 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZNG0, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177842, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q6ZNG0
With#Exp.IntAct
ABLIM3 - isoform 2 [O94929-2]3EBI-4395669,EBI-11961672
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-4395669,EBI-12006308
BFSP2 [Q13515]3EBI-4395669,EBI-10229433
BOLA2B [A0A087WZT3]3EBI-4395669,EBI-12006120
C1orf216 [Q8TAB5]3EBI-4395669,EBI-747505
C22orf39 [Q6P5X5]3EBI-4395669,EBI-7317823
CABP5 [Q9NP86]3EBI-4395669,EBI-10311131
CARD9 - isoform 2 [Q9H257-2]3EBI-4395669,EBI-11530605
CCDC102B [Q68D86]3EBI-4395669,EBI-10171570
CCDC6 [Q16204]3EBI-4395669,EBI-1045350
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-4395669,EBI-10175300
CCNC [P24863]3EBI-4395669,EBI-395261
CDCA7L [Q96GN5]3EBI-4395669,EBI-5278764
CDKN2D [P55273]3EBI-4395669,EBI-745859
CHAF1A [Q13111]3EBI-4395669,EBI-1020839
CIB3 [Q96Q77]3EBI-4395669,EBI-10292696
CINP [Q9BW66]3EBI-4395669,EBI-739784
CLIC3 [O95833]3EBI-4395669,EBI-10192241
CTNNA3 - isoform 2 [Q9UI47-2]3EBI-4395669,EBI-11962928
DGCR6L [Q9BY27]3EBI-4395669,EBI-742953
DTX2 [Q86UW9]3EBI-4395669,EBI-740376
EAF1 [Q96JC9]3EBI-4395669,EBI-769261
EEF2KMT [Q96G04]3EBI-4395669,EBI-747840
EIF4A2 - isoform 2 [Q14240-2]3EBI-4395669,EBI-10232522
EPM2AIP1 [Q7L775]3EBI-4395669,EBI-6255981
EXOSC5 [Q9NQT4]3EBI-4395669,EBI-371876
FHL2 [Q14192]3EBI-4395669,EBI-701903
GAS8 [O95995]3EBI-4395669,EBI-1052570
GLYCTK [Q8IVS8]3EBI-4395669,EBI-748515
GRB2 [P62993]3EBI-4395669,EBI-401755
GYS1 [P13807]3EBI-4395669,EBI-740553
IGFN1 - isoform 5 [Q86VF2-5]3EBI-4395669,EBI-11955401
IL16 - isoform 2 [Q14005-2]3EBI-4395669,EBI-17178971
JRK - isoform 2 [O75564-2]3EBI-4395669,EBI-17181882
KCTD9 [Q7L273]3EBI-4395669,EBI-4397613
LMO1 [P25800]3EBI-4395669,EBI-8639312
LMO3 - isoform 4 [Q8TAP4-4]3EBI-4395669,EBI-11742507
MAGOHB [Q96A72]3EBI-4395669,EBI-746778
MAP2K5 [Q13163]3EBI-4395669,EBI-307294
METTL21A [Q8WXB1]3EBI-4395669,EBI-8652459
MFAP1 [P55081]3EBI-4395669,EBI-1048159
MISP [Q8IVT2]3EBI-4395669,EBI-2555085
MLX - isoform Beta [Q9UH92-3]3EBI-4395669,EBI-8852072
MYOZ3 [Q8TDC0]3EBI-4395669,EBI-5662487
NDOR1 [Q9UHB4]3EBI-4395669,EBI-10249760
NME7 [Q9Y5B8]3EBI-4395669,EBI-744782
NOXA1 - isoform 2 [Q86UR1-2]3EBI-4395669,EBI-12025760
OAZ3 - isoform 2 [Q9UMX2-2]3EBI-4395669,EBI-12049527
PIBF1 [Q4G0R1]3EBI-4395669,EBI-14066006
PIK3R3 [Q92569]3EBI-4395669,EBI-79893
PLOD3 [O60568]3EBI-4395669,EBI-741582
POLE2 [P56282]3EBI-4395669,EBI-713847
RIPPLY1 [Q0D2K3]3EBI-4395669,EBI-10226430
RUSC1 [Q9BVN2]3EBI-4395669,EBI-6257312
SART3 [Q15020]3EBI-4395669,EBI-308619
SLIT1 [O75093]3EBI-4395669,EBI-947791
SNAPC3 [Q92966]3EBI-4395669,EBI-1760638
TENT5B [Q96A09]3EBI-4395669,EBI-752030
TPM2 - isoform 2 [P07951-2]3EBI-4395669,EBI-10977815
TRAF4 [Q9BUZ4]3EBI-4395669,EBI-3650647
TRIM10 - isoform Beta [Q9UDY6-2]3EBI-4395669,EBI-11981577
TRIM50 [Q86XT4]3EBI-4395669,EBI-9867283
TSEN15 [Q8WW01]3EBI-4395669,EBI-372432
TSR2 [Q969E8]3EBI-4395669,EBI-746981
USP20 [A0A024R8A9]3EBI-4395669,EBI-14096082
ZBTB16 [Q05516]3EBI-4395669,EBI-711925
ZFHX3 - isoform B [Q15911-2]3EBI-4395669,EBI-10237226
ZIC1 [Q15915]3EBI-4395669,EBI-11963196
ZNF24 [P17028]3EBI-4395669,EBI-707773
ZNF648 [Q5T619]3EBI-4395669,EBI-11985915

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128978, 75 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZNG0, 73 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000322265

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZNG0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZNG0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 82KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri196 – 218C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000163769

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_0_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6ZNG0

Identification of Orthologs from Complete Genome Data

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OMAi
YFSRMAD

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZNG0

TreeFam database of animal gene trees

More...
TreeFami
TF350844

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZNG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQTAWRQEP VTFEDVAVYF TQNEWASLDS VQRALYREVM LENYANVASL
60 70 80 90 100
AFPFTTPVLV SQLEQGELPW GLDPWEPMGR EALRGICPGD EARTEKEGLT
110 120 130 140 150
PKDHVSKETE SFRLMVGGLP GNVSQHLDFG SSLEQPQGHW IIKTKSKRRH
160 170 180 190 200
FTDTSARHHE AYEVKNGEKF EKLGKNISVS TQLTTNQTNP SGQISYECGQ
210 220 230 240 250
CGRYFIQMAD FHRHEKCHTG EKSFECKECG KYFRYNSLLI RHQIIHTGKK
260 270 280 290 300
PFKCKECGKG LSSDTALIQH QRIHTGEKPY ECKECGKAFS SSSVFLQHQR
310 320 330 340 350
FHTGEKLYEC NECWKTFSCS SSFTVHQRMH TGEKPYECKE CGKRLSSNTA
360 370 380 390 400
LTQHQRIHTG EKPFECKECG KAFNQKITLI QHQRVHTGEK PYECKVCGKT
410 420
FSWCGRFILH QKLHTQKTPV QA
Length:422
Mass (Da):48,503
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25F673810C3A1923
GO
Isoform 2 (identifier: Q6ZNG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.

Show »
Length:308
Mass (Da):35,439
Checksum:i6ED0278EE86AAFB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J967C9J967_HUMAN
Zinc finger protein 620
ZNF620
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU22A0A3B3IU22_HUMAN
Zinc finger protein 620
ZNF620
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC31F8WC31_HUMAN
Zinc finger protein 620
ZNF620
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0160401 – 114Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK093599 mRNA Translation: BAC04203.1
AK131232 mRNA Translation: BAD18415.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33740.1 [Q6ZNG0-1]
CCDS58825.1 [Q6ZNG0-2]

NCBI Reference Sequences

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RefSeqi
NP_001243096.1, NM_001256167.1 [Q6ZNG0-2]
NP_001243097.1, NM_001256168.1 [Q6ZNG0-2]
NP_787084.1, NM_175888.3 [Q6ZNG0-1]
XP_005265068.1, XM_005265011.3 [Q6ZNG0-1]
XP_005265069.1, XM_005265012.3 [Q6ZNG0-1]
XP_016861558.1, XM_017006069.1 [Q6ZNG0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000314529; ENSP00000322265; ENSG00000177842 [Q6ZNG0-1]
ENST00000418905; ENSP00000391472; ENSG00000177842 [Q6ZNG0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
253639

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:253639

UCSC genome browser

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UCSCi
uc003ckk.5, human [Q6ZNG0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093599 mRNA Translation: BAC04203.1
AK131232 mRNA Translation: BAD18415.1
CCDSiCCDS33740.1 [Q6ZNG0-1]
CCDS58825.1 [Q6ZNG0-2]
RefSeqiNP_001243096.1, NM_001256167.1 [Q6ZNG0-2]
NP_001243097.1, NM_001256168.1 [Q6ZNG0-2]
NP_787084.1, NM_175888.3 [Q6ZNG0-1]
XP_005265068.1, XM_005265011.3 [Q6ZNG0-1]
XP_005265069.1, XM_005265012.3 [Q6ZNG0-1]
XP_016861558.1, XM_017006069.1 [Q6ZNG0-2]

3D structure databases

SMRiQ6ZNG0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128978, 75 interactors
IntActiQ6ZNG0, 73 interactors
STRINGi9606.ENSP00000322265

PTM databases

iPTMnetiQ6ZNG0
PhosphoSitePlusiQ6ZNG0

Genetic variation databases

BioMutaiZNF620
DMDMi74762397

Proteomic databases

jPOSTiQ6ZNG0
MassIVEiQ6ZNG0
PaxDbiQ6ZNG0
PeptideAtlasiQ6ZNG0
PRIDEiQ6ZNG0
ProteomicsDBi68021 [Q6ZNG0-1]
68022 [Q6ZNG0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
12274, 120 antibodies

The DNASU plasmid repository

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DNASUi
253639

Genome annotation databases

EnsembliENST00000314529; ENSP00000322265; ENSG00000177842 [Q6ZNG0-1]
ENST00000418905; ENSP00000391472; ENSG00000177842 [Q6ZNG0-2]
GeneIDi253639
KEGGihsa:253639
UCSCiuc003ckk.5, human [Q6ZNG0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
253639
DisGeNETi253639

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF620
HGNCiHGNC:28742, ZNF620
HPAiENSG00000177842, Low tissue specificity
neXtProtiNX_Q6ZNG0
OpenTargetsiENSG00000177842
PharmGKBiPA134942360
VEuPathDBiHostDB:ENSG00000177842.11

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000163769
HOGENOMiCLU_002678_0_2_1
InParanoidiQ6ZNG0
OMAiYFSRMAD
OrthoDBi1318335at2759
PhylomeDBiQ6ZNG0
TreeFamiTF350844

Enzyme and pathway databases

PathwayCommonsiQ6ZNG0
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
253639, 5 hits in 1018 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
253639
PharosiQ6ZNG0, Tdark

Protein Ontology

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PROi
PR:Q6ZNG0
RNActiQ6ZNG0, protein

Gene expression databases

BgeeiENSG00000177842, Expressed in adrenal tissue and 122 other tissues
ExpressionAtlasiQ6ZNG0, baseline and differential

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 8 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN620_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZNG0
Secondary accession number(s): Q8N223
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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