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Protein

Acid phosphatase type 7

Gene

ACP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141IronBy similarity1
Metal bindingi170IronBy similarity1
Metal bindingi170ZincBy similarity1
Metal bindingi173IronBy similarity1
Metal bindingi205ZincBy similarity1
Metal bindingi286ZincBy similarity1
Metal bindingi333ZincBy similarity1
Metal bindingi335IronBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase type 7Curated (EC:3.1.3.2)
Alternative name(s):
Purple acid phosphatase long form1 Publication
Gene namesi
Name:ACP7Imported
Synonyms:PAPL1 Publication, PAPL11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000183760.10
HGNCiHGNC:33781 ACP7
MIMi610490 gene
neXtProtiNX_Q6ZNF0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183760

Polymorphism and mutation databases

BioMutaiPAPL
DMDMi269849643

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000031682427 – 438Acid phosphatase type 7Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZNF0
PeptideAtlasiQ6ZNF0
PRIDEiQ6ZNF0
ProteomicsDBi68020

PTM databases

DEPODiQ6ZNF0
iPTMnetiQ6ZNF0
PhosphoSitePlusiQ6ZNF0

Expressioni

Gene expression databases

BgeeiENSG00000183760 Expressed in 40 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ6ZNF0 baseline and differential

Organism-specific databases

HPAiHPA042005
HPA042613

Interactioni

Protein-protein interaction databases

BioGridi133739, 6 interactors
STRINGi9606.ENSP00000327557

Structurei

3D structure databases

ProteinModelPortaliQ6ZNF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1378 Eukaryota
COG1409 LUCA
GeneTreeiENSGT00390000015485
HOGENOMiHOG000187275
HOVERGENiHBG063988
InParanoidiQ6ZNF0
KOiK22390
OMAiGHVHNSQ
OrthoDBiEOG091G0DVB
PhylomeDBiQ6ZNF0

Family and domain databases

Gene3Di2.60.40.380, 1 hit
3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR039331 PPA-like
IPR008963 Purple_acid_Pase-like_N
IPR015914 Purple_acid_Pase_N
IPR025733 Purple_acid_PPase_C_dom
PANTHERiPTHR22953 PTHR22953, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF14008 Metallophos_C, 1 hit
PF16656 Pur_ac_phosph_N, 1 hit
SUPFAMiSSF49363 SSF49363, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6ZNF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPLPGYWSC YCLLLLFSLG VQGSLGAPSA APEQVHLSYP GEPGSMTVTW
60 70 80 90 100
TTWVPTRSEV QFGLQPSGPL PLRAQGTFVP FVDGGILRRK LYIHRVTLRK
110 120 130 140 150
LLPGVQYVYR CGSAQGWSRR FRFRALKNGA HWSPRLAVFG DLGADNPKAV
160 170 180 190 200
PRLRRDTQQG MYDAVLHVGD FAYNLDQDNA RVGDRFMRLI EPVAASLPYM
210 220 230 240 250
TCPGNHEERY NFSNYKARFS MPGDNEGLWY SWDLGPAHII SFSTEVYFFL
260 270 280 290 300
HYGRHLVQRQ FRWLESDLQK ANKNRAARPW IITMGHRPMY CSNADLDDCT
310 320 330 340 350
RHESKVRKGL QGKLYGLEDL FYKYGVDLQL WAHEHSYERL WPIYNYQVFN
360 370 380 390 400
GSREMPYTNP RGPVHIITGS AGCEERLTPF AVFPRPWSAV RVKEYGYTRL
410 420 430
HILNGTHIHI QQVSDDQDGK IVDDVWVVRP LFGRRMYL
Length:438
Mass (Da):50,480
Last modified:November 24, 2009 - v2
Checksum:i70C5109FAAB2DDC5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R045M0R045_HUMAN
Acid phosphatase type 7
ACP7
334Annotation score:
M0QXC1M0QXC1_HUMAN
Acid phosphatase type 7
ACP7
367Annotation score:
M0QYV2M0QYV2_HUMAN
Acid phosphatase type 7
ACP7
227Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti408I → T in BAD18425 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131245 mRNA Translation: BAD18425.1
AC011443 Genomic DNA No translation available.
BC136721 mRNA Translation: AAI36722.1
BC136722 mRNA Translation: AAI36723.1
CCDSiCCDS33018.1
RefSeqiNP_001004318.2, NM_001004318.2
XP_011525268.1, XM_011526966.2
XP_016882296.1, XM_017026807.1
UniGeneiHs.448934

Genome annotation databases

EnsembliENST00000331256; ENSP00000327557; ENSG00000183760
GeneIDi390928
KEGGihsa:390928
UCSCiuc002oki.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131245 mRNA Translation: BAD18425.1
AC011443 Genomic DNA No translation available.
BC136721 mRNA Translation: AAI36722.1
BC136722 mRNA Translation: AAI36723.1
CCDSiCCDS33018.1
RefSeqiNP_001004318.2, NM_001004318.2
XP_011525268.1, XM_011526966.2
XP_016882296.1, XM_017026807.1
UniGeneiHs.448934

3D structure databases

ProteinModelPortaliQ6ZNF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133739, 6 interactors
STRINGi9606.ENSP00000327557

PTM databases

DEPODiQ6ZNF0
iPTMnetiQ6ZNF0
PhosphoSitePlusiQ6ZNF0

Polymorphism and mutation databases

BioMutaiPAPL
DMDMi269849643

Proteomic databases

PaxDbiQ6ZNF0
PeptideAtlasiQ6ZNF0
PRIDEiQ6ZNF0
ProteomicsDBi68020

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331256; ENSP00000327557; ENSG00000183760
GeneIDi390928
KEGGihsa:390928
UCSCiuc002oki.4 human

Organism-specific databases

CTDi390928
EuPathDBiHostDB:ENSG00000183760.10
GeneCardsiACP7
H-InvDBiHIX0040034
HGNCiHGNC:33781 ACP7
HPAiHPA042005
HPA042613
MIMi610490 gene
neXtProtiNX_Q6ZNF0
OpenTargetsiENSG00000183760
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1378 Eukaryota
COG1409 LUCA
GeneTreeiENSGT00390000015485
HOGENOMiHOG000187275
HOVERGENiHBG063988
InParanoidiQ6ZNF0
KOiK22390
OMAiGHVHNSQ
OrthoDBiEOG091G0DVB
PhylomeDBiQ6ZNF0

Miscellaneous databases

GenomeRNAii390928
PROiPR:Q6ZNF0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183760 Expressed in 40 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ6ZNF0 baseline and differential

Family and domain databases

Gene3Di2.60.40.380, 1 hit
3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR039331 PPA-like
IPR008963 Purple_acid_Pase-like_N
IPR015914 Purple_acid_Pase_N
IPR025733 Purple_acid_PPase_C_dom
PANTHERiPTHR22953 PTHR22953, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF14008 Metallophos_C, 1 hit
PF16656 Pur_ac_phosph_N, 1 hit
SUPFAMiSSF49363 SSF49363, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACP7_HUMAN
AccessioniPrimary (citable) accession number: Q6ZNF0
Secondary accession number(s): B2RN68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: September 12, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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