UniProtKB - Q6ZNC8 (MBOA1_HUMAN)
Protein
Lysophospholipid acyltransferase 1
Gene
MBOAT1
Organism
Homo sapiens (Human)
Status
Functioni
Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18772128). May play a role in neurite outgrowth during neuronal differentiation (By similarity).By similarity1 Publication
Catalytic activityi
- a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA1 PublicationEC:2.3.1.n61 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA1 PublicationEC:2.3.1.231 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoABy similarityEC:2.3.1.n7By similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Partially inhibited by thimerosal.
: phospholipid metabolism Pathwayi
This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 350 | By similarity | 1 | |
Active sitei | 381 | By similarity | 1 |
GO - Molecular functioni
- 1-acylglycerophosphoethanolamine O-acyltransferase activity Source: UniProtKB
- 1-acylglycerophosphoserine O-acyltransferase activity Source: UniProtKB
- transferase activity, transferring acyl groups Source: GO_Central
GO - Biological processi
- lipid modification Source: GO_Central
- phosphatidylethanolamine acyl-chain remodeling Source: UniProtKB
- phosphatidylserine acyl-chain remodeling Source: UniProtKB
- phospholipid biosynthetic process Source: UniProtKB
- regulation of neuron projection development Source: UniProtKB
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
PathwayCommonsi | Q6ZNC8 |
Reactomei | R-HSA-1482801, Acyl chain remodelling of PS R-HSA-1482839, Acyl chain remodelling of PE |
UniPathwayi | UPA00085 |
Chemistry databases
SwissLipidsi | SLP:000000133 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophospholipid acyltransferase 1CuratedShort name: LPLAT 1 Alternative name(s): 1-acylglycerophosphocholine O-acyltransferase (EC:2.3.1.231 Publication) 1-acylglycerophosphoethanolamine O-acyltransferaseBy similarity (EC:2.3.1.n7By similarity) 1-acylglycerophosphoserine O-acyltransferase MBOAT1Curated (EC:2.3.1.n61 Publication) Lysophosphatidylserine acyltransferase Short name: LPSAT Short name: Lyso-PS acyltransferase Membrane-bound O-acyltransferase domain-containing protein 1 Short name: O-acyltransferase domain-containing protein 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172197.10 |
HGNCi | HGNC:21579, MBOAT1 |
MIMi | 611732, gene |
neXtProti | NX_Q6ZNC8 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 70 – 90 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 297 – 317 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 371 – 391 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 426 – 446 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 450 – 470 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 154141 |
OpenTargetsi | ENSG00000172197 |
PharmGKBi | PA134979205 |
Miscellaneous databases
Pharosi | Q6ZNC8, Tdark |
Polymorphism and mutation databases
BioMutai | MBOAT1 |
DMDMi | 74749574 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000273018 | 1 – 495 | Lysophospholipid acyltransferase 1Add BLAST | 495 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 488 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6ZNC8 |
jPOSTi | Q6ZNC8 |
MassIVEi | Q6ZNC8 |
MaxQBi | Q6ZNC8 |
PaxDbi | Q6ZNC8 |
PeptideAtlasi | Q6ZNC8 |
PRIDEi | Q6ZNC8 |
ProteomicsDBi | 68012 [Q6ZNC8-1] 68013 [Q6ZNC8-2] 68014 [Q6ZNC8-3] |
PTM databases
iPTMneti | Q6ZNC8 |
PhosphoSitePlusi | Q6ZNC8 |
Expressioni
Tissue specificityi
Expressed in neutrophils.1 Publication
Gene expression databases
Bgeei | ENSG00000172197, Expressed in right uterine tube and 111 other tissues |
Organism-specific databases
HPAi | ENSG00000172197, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127537, 31 interactors |
IntActi | Q6ZNC8, 31 interactors |
STRINGi | 9606.ENSP00000324944 |
Miscellaneous databases
RNActi | Q6ZNC8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the membrane-bound acyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2704, Eukaryota |
GeneTreei | ENSGT01000000214495 |
HOGENOMi | CLU_011340_3_0_1 |
InParanoidi | Q6ZNC8 |
OMAi | FVFLMGH |
OrthoDBi | 881262at2759 |
PhylomeDBi | Q6ZNC8 |
TreeFami | TF314906 |
Family and domain databases
InterProi | View protein in InterPro IPR004299, MBOAT_fam |
Pfami | View protein in Pfam PF03062, MBOAT, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6ZNC8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAEPQPSSL SYRTTGSTYL HPLSELLGIP LDQVNFVVCQ LVALFAAFWF
60 70 80 90 100
RIYLRPGTTS SDVRHAVATI FGIYFVIFCF GWYSVHLFVL VLMCYAIMVT
110 120 130 140 150
ASVSNIHRYS FFVAMGYLTI CHISRIYIFH YGILTTDFSG PLMIVTQKIT
160 170 180 190 200
TLAFQVHDGL GRRAEDLSAE QHRLAIKVKP SFLEYLSYLL NFMSVIAGPC
210 220 230 240 250
NNFKDYIAFI EGKHIHMKLL EVNWKRKGFH SLPEPSPTGA VIHKLGITLV
260 270 280 290 300
SLLLFLTLTK TFPVTCLVDD WFVHKASFPA RLCYLYVVMQ ASKPKYYFAW
310 320 330 340 350
TLADAVNNAA GFGFSGVDKN GNFCWDLLSN LNIWKIETAT SFKMYLENWN
360 370 380 390 400
IQTATWLKCV CYQRVPWYPT VLTFILSALW HGVYPGYYFT FLTGILVTLA
410 420 430 440 450
ARAVRNNYRH YFLSSRALKA VYDAGTWAVT QLAVSYTVAP FVMLAVEPTI
460 470 480 490
SLYKSMYFYL HIISLLIILF LPMKPQAHTQ RRPQTLNSIN KRKTD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 170 | E → G in BAG59421 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 181 | S → P in BAG59421 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 438 | V → I in BAC04264 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050025 | 450 | I → V. Corresponds to variant dbSNP:rs2065649Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036729 | 1 – 158 | MAAEP…FQVHD → MEFSLRIFL in isoform 2. 1 PublicationAdd BLAST | 158 | |
Alternative sequenceiVSP_036730 | 240 – 241 | AV → HL in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_036731 | 242 – 495 | Missing in isoform 3. 1 PublicationAdd BLAST | 254 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB305043 mRNA Translation: BAF93899.1 AK093994 mRNA Translation: BAC04264.1 AK131269 mRNA Translation: BAD18447.1 AK296857 mRNA Translation: BAG59421.1 AK304748 mRNA Translation: BAG65506.1 AL008627 Genomic DNA No translation available. AL158198 Genomic DNA No translation available. AL355139 Genomic DNA No translation available. BC150650 mRNA Translation: AAI50651.1 BC150652 mRNA Translation: AAI50653.1 |
CCDSi | CCDS34346.1 [Q6ZNC8-1] |
RefSeqi | NP_001073949.1, NM_001080480.2 [Q6ZNC8-1] XP_011512615.1, XM_011514313.2 [Q6ZNC8-3] |
Genome annotation databases
Ensembli | ENST00000324607; ENSP00000324944; ENSG00000172197 [Q6ZNC8-1] |
GeneIDi | 154141 |
KEGGi | hsa:154141 |
UCSCi | uc003ncx.4, human [Q6ZNC8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB305043 mRNA Translation: BAF93899.1 AK093994 mRNA Translation: BAC04264.1 AK131269 mRNA Translation: BAD18447.1 AK296857 mRNA Translation: BAG59421.1 AK304748 mRNA Translation: BAG65506.1 AL008627 Genomic DNA No translation available. AL158198 Genomic DNA No translation available. AL355139 Genomic DNA No translation available. BC150650 mRNA Translation: AAI50651.1 BC150652 mRNA Translation: AAI50653.1 |
CCDSi | CCDS34346.1 [Q6ZNC8-1] |
RefSeqi | NP_001073949.1, NM_001080480.2 [Q6ZNC8-1] XP_011512615.1, XM_011514313.2 [Q6ZNC8-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127537, 31 interactors |
IntActi | Q6ZNC8, 31 interactors |
STRINGi | 9606.ENSP00000324944 |
Chemistry databases
SwissLipidsi | SLP:000000133 |
PTM databases
iPTMneti | Q6ZNC8 |
PhosphoSitePlusi | Q6ZNC8 |
Polymorphism and mutation databases
BioMutai | MBOAT1 |
DMDMi | 74749574 |
Proteomic databases
EPDi | Q6ZNC8 |
jPOSTi | Q6ZNC8 |
MassIVEi | Q6ZNC8 |
MaxQBi | Q6ZNC8 |
PaxDbi | Q6ZNC8 |
PeptideAtlasi | Q6ZNC8 |
PRIDEi | Q6ZNC8 |
ProteomicsDBi | 68012 [Q6ZNC8-1] 68013 [Q6ZNC8-2] 68014 [Q6ZNC8-3] |
Protocols and materials databases
Antibodypediai | 25215, 30 antibodies |
DNASUi | 154141 |
Genome annotation databases
Ensembli | ENST00000324607; ENSP00000324944; ENSG00000172197 [Q6ZNC8-1] |
GeneIDi | 154141 |
KEGGi | hsa:154141 |
UCSCi | uc003ncx.4, human [Q6ZNC8-1] |
Organism-specific databases
CTDi | 154141 |
DisGeNETi | 154141 |
EuPathDBi | HostDB:ENSG00000172197.10 |
GeneCardsi | MBOAT1 |
HGNCi | HGNC:21579, MBOAT1 |
HPAi | ENSG00000172197, Low tissue specificity |
MIMi | 611732, gene |
neXtProti | NX_Q6ZNC8 |
OpenTargetsi | ENSG00000172197 |
PharmGKBi | PA134979205 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2704, Eukaryota |
GeneTreei | ENSGT01000000214495 |
HOGENOMi | CLU_011340_3_0_1 |
InParanoidi | Q6ZNC8 |
OMAi | FVFLMGH |
OrthoDBi | 881262at2759 |
PhylomeDBi | Q6ZNC8 |
TreeFami | TF314906 |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
PathwayCommonsi | Q6ZNC8 |
Reactomei | R-HSA-1482801, Acyl chain remodelling of PS R-HSA-1482839, Acyl chain remodelling of PE |
Miscellaneous databases
BioGRID-ORCSi | 154141, 7 hits in 844 CRISPR screens |
ChiTaRSi | MBOAT1, human |
GenomeRNAii | 154141 |
Pharosi | Q6ZNC8, Tdark |
PROi | PR:Q6ZNC8 |
RNActi | Q6ZNC8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172197, Expressed in right uterine tube and 111 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004299, MBOAT_fam |
Pfami | View protein in Pfam PF03062, MBOAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MBOA1_HUMAN | |
Accessioni | Q6ZNC8Primary (citable) accession number: Q6ZNC8 Secondary accession number(s): A9EDQ5 Q8N9R5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations