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UniProtKB - Q6ZNC8 (MBOA1_HUMAN)

Entry version 128 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Lysophospholipid acyltransferase 1

Gene

MBOAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18772128). May play a role in neurite outgrowth during neuronal differentiation (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Partially inhibited by thimerosal.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei350By similarity1
Active sitei381By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZNC8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1482801, Acyl chain remodelling of PS
R-HSA-1482839, Acyl chain remodelling of PE

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00085

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000133

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophospholipid acyltransferase 1Curated
Short name:
LPLAT 1
Alternative name(s):
1-acylglycerophosphocholine O-acyltransferase (EC:2.3.1.231 Publication)
1-acylglycerophosphoethanolamine O-acyltransferaseBy similarity (EC:2.3.1.n7By similarity)
1-acylglycerophosphoserine O-acyltransferase MBOAT1Curated (EC:2.3.1.n61 Publication)
Lysophosphatidylserine acyltransferase
Short name:
LPSAT
Short name:
Lyso-PS acyltransferase
Membrane-bound O-acyltransferase domain-containing protein 1
Short name:
O-acyltransferase domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MBOAT1Imported
Synonyms:OACT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000172197.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:21579, MBOAT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611732, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZNC8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		154141

Open Targets

More...OpenTargetsi		ENSG00000172197

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134979205

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZNC8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MBOAT1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74749574

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002730181 – 495Lysophospholipid acyltransferase 1Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZNC8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZNC8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZNC8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZNC8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZNC8

PeptideAtlas

More...PeptideAtlasi		Q6ZNC8

PRoteomics IDEntifications database

More...PRIDEi		Q6ZNC8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68012 [Q6ZNC8-1]
68013 [Q6ZNC8-2]
68014 [Q6ZNC8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZNC8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZNC8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neutrophils.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172197, Expressed in right uterine tube and 111 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000172197, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127537, 31 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZNC8, 31 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000324944

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZNC8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the membrane-bound acyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2704, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011340_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZNC8

Identification of Orthologs from Complete Genome Data

More...OMAi		FVFLMGH

Database of Orthologous Groups

More...OrthoDBi		881262at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZNC8

TreeFam database of animal gene trees

More...TreeFami		TF314906

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004299, MBOAT_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03062, MBOAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZNC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEPQPSSL SYRTTGSTYL HPLSELLGIP LDQVNFVVCQ LVALFAAFWF 
        60         70         80         90        100
RIYLRPGTTS SDVRHAVATI FGIYFVIFCF GWYSVHLFVL VLMCYAIMVT 
       110        120        130        140        150
ASVSNIHRYS FFVAMGYLTI CHISRIYIFH YGILTTDFSG PLMIVTQKIT 
       160        170        180        190        200
TLAFQVHDGL GRRAEDLSAE QHRLAIKVKP SFLEYLSYLL NFMSVIAGPC 
       210        220        230        240        250
NNFKDYIAFI EGKHIHMKLL EVNWKRKGFH SLPEPSPTGA VIHKLGITLV 
       260        270        280        290        300
SLLLFLTLTK TFPVTCLVDD WFVHKASFPA RLCYLYVVMQ ASKPKYYFAW 
       310        320        330        340        350
TLADAVNNAA GFGFSGVDKN GNFCWDLLSN LNIWKIETAT SFKMYLENWN 
       360        370        380        390        400
IQTATWLKCV CYQRVPWYPT VLTFILSALW HGVYPGYYFT FLTGILVTLA 
       410        420        430        440        450
ARAVRNNYRH YFLSSRALKA VYDAGTWAVT QLAVSYTVAP FVMLAVEPTI 
       460        470        480        490 
SLYKSMYFYL HIISLLIILF LPMKPQAHTQ RRPQTLNSIN KRKTD
Length:495
Mass (Da):56,557
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8666D7068D46FCD5
GO
Isoform 2 (identifier: Q6ZNC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: MAAEPQPSSL...ITTLAFQVHD → MEFSLRIFL

Show »
Length:346
Mass (Da):39,800
Checksum:i04C55E44430F5BFF
GO
Isoform 3 (identifier: Q6ZNC8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-241: AV → HL
     242-495: Missing.

Show »
Length:241
Mass (Da):27,402
Checksum:iECEC508FCB6FC275
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti170E → G in BAG59421 (PubMed:14702039).Curated1
Sequence conflicti181S → P in BAG59421 (PubMed:14702039).Curated1
Sequence conflicti438V → I in BAC04264 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050025450I → V. Corresponds to variant dbSNP:rs2065649Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0367291 – 158MAAEP…FQVHD → MEFSLRIFL in isoform 2. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_036730240 – 241AV → HL in isoform 3. 1 Publication2
Alternative sequenceiVSP_036731242 – 495Missing in isoform 3. 1 PublicationAdd BLAST254

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB305043 mRNA Translation: BAF93899.1
AK093994 mRNA Translation: BAC04264.1
AK131269 mRNA Translation: BAD18447.1
AK296857 mRNA Translation: BAG59421.1
AK304748 mRNA Translation: BAG65506.1
AL008627 Genomic DNA No translation available.
AL158198 Genomic DNA No translation available.
AL355139 Genomic DNA No translation available.
BC150650 mRNA Translation: AAI50651.1
BC150652 mRNA Translation: AAI50653.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34346.1 [Q6ZNC8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001073949.1, NM_001080480.2 [Q6ZNC8-1]
XP_011512615.1, XM_011514313.2 [Q6ZNC8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324607; ENSP00000324944; ENSG00000172197 [Q6ZNC8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		154141

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:154141

UCSC genome browser

More...UCSCi		uc003ncx.4, human [Q6ZNC8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB305043 mRNA Translation: BAF93899.1
AK093994 mRNA Translation: BAC04264.1
AK131269 mRNA Translation: BAD18447.1
AK296857 mRNA Translation: BAG59421.1
AK304748 mRNA Translation: BAG65506.1
AL008627 Genomic DNA No translation available.
AL158198 Genomic DNA No translation available.
AL355139 Genomic DNA No translation available.
BC150650 mRNA Translation: AAI50651.1
BC150652 mRNA Translation: AAI50653.1
CCDSiCCDS34346.1 [Q6ZNC8-1]
RefSeqiNP_001073949.1, NM_001080480.2 [Q6ZNC8-1]
XP_011512615.1, XM_011514313.2 [Q6ZNC8-3]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127537, 31 interactors
IntActiQ6ZNC8, 31 interactors
STRINGi9606.ENSP00000324944

Chemistry databases

SwissLipidsiSLP:000000133

PTM databases

iPTMnetiQ6ZNC8
PhosphoSitePlusiQ6ZNC8

Polymorphism and mutation databases

BioMutaiMBOAT1
DMDMi74749574

Proteomic databases

EPDiQ6ZNC8
jPOSTiQ6ZNC8
MassIVEiQ6ZNC8
MaxQBiQ6ZNC8
PaxDbiQ6ZNC8
PeptideAtlasiQ6ZNC8
PRIDEiQ6ZNC8
ProteomicsDBi68012 [Q6ZNC8-1]
68013 [Q6ZNC8-2]
68014 [Q6ZNC8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25215, 30 antibodies

The DNASU plasmid repository

More...DNASUi		154141

Genome annotation databases

EnsembliENST00000324607; ENSP00000324944; ENSG00000172197 [Q6ZNC8-1]
GeneIDi154141
KEGGihsa:154141
UCSCiuc003ncx.4, human [Q6ZNC8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		154141
DisGeNETi154141
EuPathDBiHostDB:ENSG00000172197.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		MBOAT1
HGNCiHGNC:21579, MBOAT1
HPAiENSG00000172197, Low tissue specificity
MIMi611732, gene
neXtProtiNX_Q6ZNC8
OpenTargetsiENSG00000172197
PharmGKBiPA134979205

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2704, Eukaryota
GeneTreeiENSGT01000000214495
HOGENOMiCLU_011340_3_0_1
InParanoidiQ6ZNC8
OMAiFVFLMGH
OrthoDBi881262at2759
PhylomeDBiQ6ZNC8
TreeFamiTF314906

Enzyme and pathway databases

UniPathwayiUPA00085
PathwayCommonsiQ6ZNC8
ReactomeiR-HSA-1482801, Acyl chain remodelling of PS
R-HSA-1482839, Acyl chain remodelling of PE

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		154141, 7 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MBOAT1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		154141
PharosiQ6ZNC8, Tdark

Protein Ontology

More...PROi		PR:Q6ZNC8
RNActiQ6ZNC8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000172197, Expressed in right uterine tube and 111 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR004299, MBOAT_fam
PfamiView protein in Pfam
PF03062, MBOAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBOA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZNC8
Secondary accession number(s): A9EDQ5
, B4DL59, B4E3J4, Q86XC2, Q8N9R5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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