UniProtKB - Q6ZNC4 (ZN704_HUMAN)
Protein
Zinc finger protein 704
Gene
ZNF704
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 193 – 218 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6ZNC4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 704 |
Gene namesi | Name:ZNF704 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32291, ZNF704 |
neXtProti | NX_Q6ZNC4 |
VEuPathDBi | HostDB:ENSG00000164684.13 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 619279 |
OpenTargetsi | ENSG00000164684 |
PharmGKBi | PA142670501 |
Miscellaneous databases
Pharosi | Q6ZNC4, Tdark |
Genetic variation databases
BioMutai | ZNF704 |
DMDMi | 74758726 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288824 | 1 – 412 | Zinc finger protein 704Add BLAST | 412 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 225 | PhosphoserineBy similarity | 1 | |
Modified residuei | 228 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q6ZNC4 |
MassIVEi | Q6ZNC4 |
PaxDbi | Q6ZNC4 |
PeptideAtlasi | Q6ZNC4 |
PRIDEi | Q6ZNC4 |
ProteomicsDBi | 68011 |
PTM databases
iPTMneti | Q6ZNC4 |
PhosphoSitePlusi | Q6ZNC4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164684, Expressed in forebrain and 219 other tissues |
ExpressionAtlasi | Q6ZNC4, baseline and differential |
Genevisiblei | Q6ZNC4, HS |
Organism-specific databases
HPAi | ENSG00000164684, Low tissue specificity |
Interactioni
Binary interactionsi
Q6ZNC4
With | #Exp. | IntAct |
---|---|---|
RECK [Q6P9E2] | 3 | EBI-20866837,EBI-10253121 |
Protein-protein interaction databases
BioGRIDi | 534810, 21 interactors |
IntActi | Q6ZNC4, 19 interactors |
STRINGi | 9606.ENSP00000331462 |
Miscellaneous databases
RNActi | Q6ZNC4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 318 – 412 | Sufficient for binding to RE2 sequence motifsBy similarityAdd BLAST | 95 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 383 – 387 | CR1By similarity | 5 | |
Motifi | 401 – 405 | CR2By similarity | 5 |
Domaini
The CR1 and CR2 motifs mediate sequence-specific DNA binding, and are important for binding to the MYOD1 enhancer.By similarity
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 193 – 218 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QTDT, Eukaryota |
GeneTreei | ENSGT00940000156172 |
HOGENOMi | CLU_032989_1_1_1 |
InParanoidi | Q6ZNC4 |
OMAi | MSHQHLF |
OrthoDBi | 915379at2759 |
PhylomeDBi | Q6ZNC4 |
TreeFami | TF326610 |
Family and domain databases
InterProi | View protein in InterPro IPR013087, Znf_C2H2_type |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6ZNC4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTFTFQSEDL KRDCGKKMSH QHVFSLAMEE DVKTADTKKA SRILDHEKEN
60 70 80 90 100
TRSICLLEQK RKVVSSNIDV PPARKSSEEL DMDKVTAAMV LTSLSTSPLV
110 120 130 140 150
RSPPVRPNES LSGSWKEGGC VPSSTSSSGY WSWSAPSDQS NPSTPSPPLS
160 170 180 190 200
ADSFKPFRSP AQPDDGIDEA EASNLLFDEP IPRKRKNSMK VMFKCLWKNC
210 220 230 240 250
GKVLSTAAGI QKHIRTIHLG RVGDSDYSDG EEDFYYTEIK LNTDSVADGL
260 270 280 290 300
SSLAPVSPSQ SLASPPTFPI PDSSRTETPC AKTETKLMTP LSRSAPTTLY
310 320 330 340 350
LVHTDHAYQA TPPVTIPGSA KFTPNGSSFS ISWQSPPVTF TGIPVSPTHH
360 370 380 390 400
PVGTGEQRQH AHTVLSSPPR GTVSLRKPRG EGKKCRKVYG MENRDMWCTA
410
CRWKKACQRF LD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE5RGL7 | E5RGL7_HUMAN | Zinc finger protein 704 | ZNF704 | 189 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032506 | 35 | A → S. Corresponds to variant dbSNP:rs3907424Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131274 mRNA Translation: BAD18451.1 BC136844 mRNA Translation: AAI36845.1 BC136845 mRNA Translation: AAI36846.1 |
CCDSi | CCDS34913.1 |
RefSeqi | NP_001028895.1, NM_001033723.2 |
Genome annotation databases
Ensembli | ENST00000327835; ENSP00000331462; ENSG00000164684 |
GeneIDi | 619279 |
KEGGi | hsa:619279 |
UCSCi | uc003yby.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131274 mRNA Translation: BAD18451.1 BC136844 mRNA Translation: AAI36845.1 BC136845 mRNA Translation: AAI36846.1 |
CCDSi | CCDS34913.1 |
RefSeqi | NP_001028895.1, NM_001033723.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 534810, 21 interactors |
IntActi | Q6ZNC4, 19 interactors |
STRINGi | 9606.ENSP00000331462 |
PTM databases
iPTMneti | Q6ZNC4 |
PhosphoSitePlusi | Q6ZNC4 |
Genetic variation databases
BioMutai | ZNF704 |
DMDMi | 74758726 |
Proteomic databases
jPOSTi | Q6ZNC4 |
MassIVEi | Q6ZNC4 |
PaxDbi | Q6ZNC4 |
PeptideAtlasi | Q6ZNC4 |
PRIDEi | Q6ZNC4 |
ProteomicsDBi | 68011 |
Protocols and materials databases
Antibodypediai | 12438, 52 antibodies |
Genome annotation databases
Ensembli | ENST00000327835; ENSP00000331462; ENSG00000164684 |
GeneIDi | 619279 |
KEGGi | hsa:619279 |
UCSCi | uc003yby.2, human |
Organism-specific databases
CTDi | 619279 |
DisGeNETi | 619279 |
GeneCardsi | ZNF704 |
HGNCi | HGNC:32291, ZNF704 |
HPAi | ENSG00000164684, Low tissue specificity |
neXtProti | NX_Q6ZNC4 |
OpenTargetsi | ENSG00000164684 |
PharmGKBi | PA142670501 |
VEuPathDBi | HostDB:ENSG00000164684.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTDT, Eukaryota |
GeneTreei | ENSGT00940000156172 |
HOGENOMi | CLU_032989_1_1_1 |
InParanoidi | Q6ZNC4 |
OMAi | MSHQHLF |
OrthoDBi | 915379at2759 |
PhylomeDBi | Q6ZNC4 |
TreeFami | TF326610 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZNC4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 619279, 2 hits in 878 CRISPR screens |
ChiTaRSi | ZNF704, human |
GenomeRNAii | 619279 |
Pharosi | Q6ZNC4, Tdark |
PROi | PR:Q6ZNC4 |
RNActi | Q6ZNC4, protein |
Gene expression databases
Bgeei | ENSG00000164684, Expressed in forebrain and 219 other tissues |
ExpressionAtlasi | Q6ZNC4, baseline and differential |
Genevisiblei | Q6ZNC4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013087, Znf_C2H2_type |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN704_HUMAN | |
Accessioni | Q6ZNC4Primary (citable) accession number: Q6ZNC4 Secondary accession number(s): B2RNE6, B9EGW6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - Human entries with genetic variants
List of human entries with genetic variants