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Entry version 135 (16 Oct 2019)
Sequence version 2 (06 Mar 2007)
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Protein

NF-X1-type zinc finger protein NFXL1

Gene

NFXL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri160 – 220RING-type; atypicalPROSITE-ProRule annotationAdd BLAST61
Zinc fingeri269 – 287NF-X1-type 1Add BLAST19
Zinc fingeri322 – 341NF-X1-type 2Add BLAST20
Zinc fingeri375 – 394NF-X1-type 3Add BLAST20
Zinc fingeri428 – 447NF-X1-type 4Add BLAST20
Zinc fingeri455 – 476NF-X1-type 5Add BLAST22
Zinc fingeri480 – 499NF-X1-type 6Add BLAST20
Zinc fingeri507 – 526NF-X1-type 7Add BLAST20
Zinc fingeri674 – 702NF-X1-type 8Add BLAST29
Zinc fingeri715 – 733NF-X1-type 9Add BLAST19
Zinc fingeri777 – 796NF-X1-type 10Add BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NF-X1-type zinc finger protein NFXL1
Alternative name(s):
Ovarian zinc finger protein
Short name:
hOZFP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFXL1
Synonyms:OZFP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18726 NFXL1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZNB6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei889 – 906HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
152518

Open Targets

More...
OpenTargetsi
ENSG00000170448

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
458713 NON RARE IN EUROPE: Specific language impairment

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38661

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZNB6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NFXL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134048494

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002788271 – 911NF-X1-type zinc finger protein NFXL1Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei107PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZNB6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZNB6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6ZNB6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZNB6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZNB6

PeptideAtlas

More...
PeptideAtlasi
Q6ZNB6

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZNB6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68008 [Q6ZNB6-1]
68009 [Q6ZNB6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZNB6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZNB6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6ZNB6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170448 Expressed in 188 organ(s), highest expression level in secondary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZNB6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059132

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127449, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZNB6, 8 interactors

Molecular INTeraction database

More...
MINTi
Q6ZNB6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000422037

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili822 – 873Sequence analysisAdd BLAST52

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFX1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 220RING-type; atypicalPROSITE-ProRule annotationAdd BLAST61
Zinc fingeri269 – 287NF-X1-type 1Add BLAST19
Zinc fingeri322 – 341NF-X1-type 2Add BLAST20
Zinc fingeri375 – 394NF-X1-type 3Add BLAST20
Zinc fingeri428 – 447NF-X1-type 4Add BLAST20
Zinc fingeri455 – 476NF-X1-type 5Add BLAST22
Zinc fingeri480 – 499NF-X1-type 6Add BLAST20
Zinc fingeri507 – 526NF-X1-type 7Add BLAST20
Zinc fingeri674 – 702NF-X1-type 8Add BLAST29
Zinc fingeri715 – 733NF-X1-type 9Add BLAST19
Zinc fingeri777 – 796NF-X1-type 10Add BLAST20

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1952 Eukaryota
ENOG410XR02 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157059

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000031224

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZNB6

KEGG Orthology (KO)

More...
KOi
K15683

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLVPHSC

Database of Orthologous Groups

More...
OrthoDBi
299100at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZNB6

TreeFam database of animal gene trees

More...
TreeFami
TF323611

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034078 NFX1_fam
IPR019786 Zinc_finger_PHD-type_CS
IPR000967 Znf_NFX1
IPR001841 Znf_RING

The PANTHER Classification System

More...
PANTHERi
PTHR12360 PTHR12360, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01422 zf-NF-X1, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00438 ZnF_NFX, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZNB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASWRQVAG GRGRSRGRAT AAPSGNGVHL RGAGGGREKG SVGAVPSGTS
60 70 80 90 100
PGGVATTAAA GSRHSPAGSQ ALQTTAASEL MSQKKFEEIK KANQAAARKL
110 120 130 140 150
VEEQFSSSSE EGDEDFEGKQ GKILANTFIT YTTQTDGDTR ELERTKQYVN
160 170 180 190 200
EAFQAGAMTC LICIASVKRN QAVWSCSGCF CIFHMPCIQK WAKDSQFLVS
210 220 230 240 250
SVTDDDFGKK DCPWPCPKCR FEYKRSETPS RYYCYCGKVE DPPLDPWLVP
260 270 280 290 300
HSCGQVCERE FKPPCGHKCL LLCHPGPCPP CPKMVTTTCY CKKAKPIPRR
310 320 330 340 350
CSAKEWSCQL PCGQKLLCGQ HKCENPCHAG SCQPCPRVSR QKCVCGKKVA
360 370 380 390 400
ERSCASPLWH CDQVCGKTLP CGNHTCEQVC HVGACGECPR SGKRFCPCQK
410 420 430 440 450
SKFSLPCTED VPTCGDSCDK VLECGIHRCS QRCHRGPCET CRQEVEKHCR
460 470 480 490 500
CGKHTKRMPC HKPYLCETKC VKMRDCQKHQ CRRKCCPGNC PPCDQNCGRT
510 520 530 540 550
LGCRNHKCPS VCHRGSCYPC PETVDVKCNC GNTKVTVPCG RERTTRPPKC
560 570 580 590 600
KEQCSRPPTC HHTSQEKHRC HFGSCPPCHQ PCQKVLEKCG HLCPAPCHDQ
610 620 630 640 650
ALIKQTGRHQ PTGPWEQPSE PAFIQTALPC PPCQVPIPME CLGKHEVSPL
660 670 680 690 700
PCHAVGPYSC KRVCGRILDC QNHTCMKECH KVTKTDGCTG KNKAGPECLH
710 720 730 740 750
CEEGCSKSRP LGCLHPCILR CHPGECPPCV QMLRIKCHCK ITSLYVECRK
760 770 780 790 800
ITTADVNEKN LLSCCKNQCP KELPCGHRCK EMCHPGECPF NCNQKVKLRC
810 820 830 840 850
PCKRIKKELQ CNKVRENQVS IECDTTCKEM KRKASEIKEA EAKAALEEEK
860 870 880 890 900
RRQQAELEAF ENRLKGRRKK NRKRDEVAVE LSLWQKHKYY LISVCGVVVV
910
VFAWYITHDV N
Length:911
Mass (Da):101,339
Last modified:March 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF65824C4734E6841
GO
Isoform 2 (identifier: Q6ZNB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     694-733: AGPECLHCEE...GECPPCVQML → IGKLKLCDLS...SPMCSSTHVI
     734-911: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:733
Mass (Da):80,508
Checksum:iAB084B33F0AA63A1
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18459 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti889Y → H in AAH18019 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030869246P → L. Corresponds to variant dbSNP:rs12651301Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023410694 – 733AGPEC…CVQML → IGKLKLCDLSMILQQESSKS ESTVPDLLTPSPMCSSTHVI in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_023411734 – 911Missing in isoform 2. 1 PublicationAdd BLAST178

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB181916 mRNA Translation: BAG16261.1
AK131285 mRNA Translation: BAD18459.1 Different initiation.
AK302440 mRNA Translation: BAH13710.1
AC107068 Genomic DNA Translation: AAY40918.1
BC018019 mRNA Translation: AAH18019.1
BC051193 mRNA Translation: AAH51193.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3478.2 [Q6ZNB6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001265552.1, NM_001278623.1 [Q6ZNB6-1]
NP_001265553.1, NM_001278624.1 [Q6ZNB6-1]
NP_694540.3, NM_152995.5 [Q6ZNB6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329043; ENSP00000333113; ENSG00000170448 [Q6ZNB6-1]
ENST00000381538; ENSP00000370949; ENSG00000170448 [Q6ZNB6-1]
ENST00000464756; ENSP00000425812; ENSG00000170448 [Q6ZNB6-2]
ENST00000507489; ENSP00000422037; ENSG00000170448 [Q6ZNB6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
152518

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:152518

UCSC genome browser

More...
UCSCi
uc003gxp.5 human [Q6ZNB6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB181916 mRNA Translation: BAG16261.1
AK131285 mRNA Translation: BAD18459.1 Different initiation.
AK302440 mRNA Translation: BAH13710.1
AC107068 Genomic DNA Translation: AAY40918.1
BC018019 mRNA Translation: AAH18019.1
BC051193 mRNA Translation: AAH51193.1
CCDSiCCDS3478.2 [Q6ZNB6-1]
RefSeqiNP_001265552.1, NM_001278623.1 [Q6ZNB6-1]
NP_001265553.1, NM_001278624.1 [Q6ZNB6-1]
NP_694540.3, NM_152995.5 [Q6ZNB6-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127449, 18 interactors
IntActiQ6ZNB6, 8 interactors
MINTiQ6ZNB6
STRINGi9606.ENSP00000422037

PTM databases

iPTMnetiQ6ZNB6
PhosphoSitePlusiQ6ZNB6
SwissPalmiQ6ZNB6

Polymorphism and mutation databases

BioMutaiNFXL1
DMDMi134048494

Proteomic databases

EPDiQ6ZNB6
jPOSTiQ6ZNB6
MassIVEiQ6ZNB6
MaxQBiQ6ZNB6
PaxDbiQ6ZNB6
PeptideAtlasiQ6ZNB6
PRIDEiQ6ZNB6
ProteomicsDBi68008 [Q6ZNB6-1]
68009 [Q6ZNB6-2]

Genome annotation databases

EnsembliENST00000329043; ENSP00000333113; ENSG00000170448 [Q6ZNB6-1]
ENST00000381538; ENSP00000370949; ENSG00000170448 [Q6ZNB6-1]
ENST00000464756; ENSP00000425812; ENSG00000170448 [Q6ZNB6-2]
ENST00000507489; ENSP00000422037; ENSG00000170448 [Q6ZNB6-1]
GeneIDi152518
KEGGihsa:152518
UCSCiuc003gxp.5 human [Q6ZNB6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
152518
DisGeNETi152518

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NFXL1
HGNCiHGNC:18726 NFXL1
HPAiHPA059132
neXtProtiNX_Q6ZNB6
OpenTargetsiENSG00000170448
Orphaneti458713 NON RARE IN EUROPE: Specific language impairment
PharmGKBiPA38661

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiKOG1952 Eukaryota
ENOG410XR02 LUCA
GeneTreeiENSGT00940000157059
HOGENOMiHOG000031224
InParanoidiQ6ZNB6
KOiK15683
OMAiFLVPHSC
OrthoDBi299100at2759
PhylomeDBiQ6ZNB6
TreeFamiTF323611

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NFXL1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
152518
PharosiQ6ZNB6

Protein Ontology

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PROi
PR:Q6ZNB6

Gene expression databases

BgeeiENSG00000170448 Expressed in 188 organ(s), highest expression level in secondary oocyte
GenevisibleiQ6ZNB6 HS

Family and domain databases

InterProiView protein in InterPro
IPR034078 NFX1_fam
IPR019786 Zinc_finger_PHD-type_CS
IPR000967 Znf_NFX1
IPR001841 Znf_RING
PANTHERiPTHR12360 PTHR12360, 1 hit
PfamiView protein in Pfam
PF01422 zf-NF-X1, 11 hits
SMARTiView protein in SMART
SM00438 ZnF_NFX, 11 hits
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFXL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZNB6
Secondary accession number(s): B1Q2K1, Q86VG1, Q8WVH1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: October 16, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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