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Entry version 122 (12 Aug 2020)
Sequence version 2 (15 Jan 2008)
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Protein

Ferric-chelate reductase 1

Gene

FRRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ferric-chelate reductases reduce Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm.By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi373Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi414Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi442Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi471Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZNA5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ferric-chelate reductase 1 (EC:1.-.-.-)
Alternative name(s):
Stromal cell-derived receptor 2
Short name:
SDR-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRRS1
Synonyms:SDFR2, SDR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000156869.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27622, FRRS1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611578, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZNA5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei372 – 392Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei415 – 435Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei446 – 466Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei491 – 511Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei515 – 535Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei569 – 589Helical; Name=7Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000156869

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670941

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZNA5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FRRS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166198896

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148431 – 592Ferric-chelate reductase 1Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZNA5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZNA5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZNA5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZNA5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZNA5

PeptideAtlas

More...
PeptideAtlasi
Q6ZNA5

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZNA5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68005 [Q6ZNA5-1]
68006 [Q6ZNA5-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6ZNA5, 4 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZNA5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156869, Expressed in liver and 108 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000156869, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000287474

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZNA5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 179ReelinPROSITE-ProRule annotationAdd BLAST167
Domaini216 – 331DOMONPROSITE-ProRule annotationAdd BLAST116
Domaini335 – 534Cytochrome b561PROSITE-ProRule annotationAdd BLAST200

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRRS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4293, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157704

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028305_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZNA5

Identification of Orthologs from Complete Genome Data

More...
OMAi
RKTYAMI

Database of Orthologous Groups

More...
OrthoDBi
599276at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZNA5

TreeFam database of animal gene trees

More...
TreeFami
TF316169

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08544, Reeler, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.4060, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006593, Cyt_b561/ferric_Rdtase_TM
IPR005018, DOMON_domain
IPR002861, Reeler_dom
IPR042307, Reeler_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03351, DOMON, 1 hit
PF02014, Reeler, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00665, B561, 1 hit
SM00664, DoH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit
PS50836, DOMON, 1 hit
PS51019, REELIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZNA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVSGFTLGT CILLLHISYV ANYPNGKVTQ SCHGMIPEHG HSPQSVPVHD
60 70 80 90 100
IYVSQMTFRP GDQIEVTLSG HPFKGFLLEA RNAEDLNGPP IGSFTLIDSE
110 120 130 140 150
VSQLLTCEDI QGSAVSHRSA SKKTEIKVYW NAPSSAPNHT QFLVTVVEKY
160 170 180 190 200
KIYWVKIPGP IISQPNAFPF TTPKATVVPL PTLPPVSHLT KPFSASDCGN
210 220 230 240 250
KKFCIRSPLN CDPEKEASCV FLSFTRDDQS VMVEMSGPSK GYLSFALSHD
260 270 280 290 300
QWMGDDDAYL CIHEDQTVYI QPSHLTGRSH PVMDSRDTLE DMAWRLADGV
310 320 330 340 350
MQCSFRRNIT LPGVKNRFDL NTSYYIFLAD GAANDGRIYK HSQQPLITYE
360 370 380 390 400
KYDVTDSPKN IGGSHSVLLL KVHGALMFVA WMTTVSIGVL VARFFKPVWS
410 420 430 440 450
KAFLLGEAAW FQVHRMLMFT TTVLTCIAFV MPFIYRGGWS RHAGYHPYLG
460 470 480 490 500
CIVMTLAVLQ PLLAVFRPPL HDPRRQMFNW THWSMGTAAR IIAVAAMFLG
510 520 530 540 550
MDLPGLNLPD SWKTYAMTGF VAWHVGTEVV LEVHAYRLSR KVEILDDDRI
560 570 580 590
QILQSFTAVE TEGHAFKKAV LAIYVCGNVT FLIIFLSAIN HL
Length:592
Mass (Da):66,114
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21EC19981C4AA95D
GO
Isoform 2 (identifier: Q6ZNA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-592: VHAYRLSRKV...IIFLSAINHL → LKYWMMTEFR...FSLGRLGSCL

Show »
Length:626
Mass (Da):70,465
Checksum:iA8F39D2DFA893E5B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti179P → L in BAD18470 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030400533 – 592VHAYR…AINHL → LKYWMMTEFRSFSHLLQWKQ RVMLLKRQCWQFMSVGMLLF SSYFYLQSTIYEQAKTLAFA GQVIIIIKPKKLEACPDCLE HICEFSLGRLGSCL in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK131302 mRNA Translation: BAD18470.1
AL451051 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72988.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30780.1 [Q6ZNA5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001013682.2, NM_001013660.2 [Q6ZNA5-2]
XP_005270918.1, XM_005270861.3
XP_011539753.1, XM_011541451.2 [Q6ZNA5-1]
XP_016856760.1, XM_017001271.1 [Q6ZNA5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000287474; ENSP00000287474; ENSG00000156869 [Q6ZNA5-2]
ENST00000646001; ENSP00000496583; ENSG00000156869 [Q6ZNA5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
391059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:391059

UCSC genome browser

More...
UCSCi
uc001dsh.1, human [Q6ZNA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131302 mRNA Translation: BAD18470.1
AL451051 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72988.1
CCDSiCCDS30780.1 [Q6ZNA5-2]
RefSeqiNP_001013682.2, NM_001013660.2 [Q6ZNA5-2]
XP_005270918.1, XM_005270861.3
XP_011539753.1, XM_011541451.2 [Q6ZNA5-1]
XP_016856760.1, XM_017001271.1 [Q6ZNA5-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000287474

PTM databases

GlyGeniQ6ZNA5, 4 sites, 1 O-linked glycan (1 site)
iPTMnetiQ6ZNA5

Polymorphism and mutation databases

BioMutaiFRRS1
DMDMi166198896

Proteomic databases

EPDiQ6ZNA5
jPOSTiQ6ZNA5
MassIVEiQ6ZNA5
MaxQBiQ6ZNA5
PaxDbiQ6ZNA5
PeptideAtlasiQ6ZNA5
PRIDEiQ6ZNA5
ProteomicsDBi68005 [Q6ZNA5-1]
68006 [Q6ZNA5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19970, 14 antibodies

Genome annotation databases

EnsembliENST00000287474; ENSP00000287474; ENSG00000156869 [Q6ZNA5-2]
ENST00000646001; ENSP00000496583; ENSG00000156869 [Q6ZNA5-1]
GeneIDi391059
KEGGihsa:391059
UCSCiuc001dsh.1, human [Q6ZNA5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
391059
EuPathDBiHostDB:ENSG00000156869.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FRRS1
HGNCiHGNC:27622, FRRS1
HPAiENSG00000156869, Tissue enhanced (liver)
MIMi611578, gene
neXtProtiNX_Q6ZNA5
OpenTargetsiENSG00000156869
PharmGKBiPA142670941

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4293, Eukaryota
GeneTreeiENSGT00940000157704
HOGENOMiCLU_028305_0_0_1
InParanoidiQ6ZNA5
OMAiRKTYAMI
OrthoDBi599276at2759
PhylomeDBiQ6ZNA5
TreeFamiTF316169

Enzyme and pathway databases

PathwayCommonsiQ6ZNA5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
391059, 7 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FRRS1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
391059
PharosiQ6ZNA5, Tdark

Protein Ontology

More...
PROi
PR:Q6ZNA5
RNActiQ6ZNA5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156869, Expressed in liver and 108 other tissues

Family and domain databases

CDDicd08544, Reeler, 1 hit
Gene3Di2.60.40.4060, 1 hit
InterProiView protein in InterPro
IPR006593, Cyt_b561/ferric_Rdtase_TM
IPR005018, DOMON_domain
IPR002861, Reeler_dom
IPR042307, Reeler_sf
PfamiView protein in Pfam
PF03351, DOMON, 1 hit
PF02014, Reeler, 1 hit
SMARTiView protein in SMART
SM00665, B561, 1 hit
SM00664, DoH, 1 hit
PROSITEiView protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit
PS50836, DOMON, 1 hit
PS51019, REELIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRRS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZNA5
Secondary accession number(s): A6NLN7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: August 12, 2020
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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