UniProtKB - Q6ZNA4 (RN111_HUMAN)
E3 ubiquitin-protein ligase Arkadia
RNF111
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27
Activity regulationi
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.6 PublicationsView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 942 | ZincBy similarity | 1 | |
Metal bindingi | 945 | ZincBy similarity | 1 | |
Metal bindingi | 965 | ZincBy similarity | 1 | |
Metal bindingi | 968 | ZincBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 942 – 983 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- SMAD binding Source: GO_Central
- SUMO polymer binding Source: UniProtKB
- ubiquitin protein ligase activity Source: BHF-UCL
GO - Biological processi
- global genome nucleotide-excision repair Source: Reactome
- pattern specification process Source: Ensembl
- positive regulation of protein ubiquitination Source: Ensembl
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: Reactome
- positive regulation of transforming growth factor beta receptor signaling pathway Source: GO_Central
- protein polyubiquitination Source: Ensembl
- protein ubiquitination Source: BHF-UCL
- ubiquitin-dependent protein catabolic process Source: GO_Central
- ubiquitin-dependent SMAD protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Developmental protein, Transferase |
Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 6.3.2.19, 2681 |
PathwayCommonsi | Q6ZNA4 |
Reactomei | R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-5696395, Formation of Incision Complex in GG-NER R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q6ZNA4 |
SIGNORi | Q6ZNA4 |
UniPathwayi | UPA00143 |
Protein family/group databases
MoonDBi | Q6ZNA4, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase Arkadia1 Publication (EC:2.3.2.271 Publication)Alternative name(s): RING finger protein 111Imported Short name: hRNF1111 Publication RING-type E3 ubiquitin transferase ArkadiaCurated |
Gene namesi | Name:RNF111Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17384, RNF111 |
MIMi | 605840, gene |
neXtProti | NX_Q6ZNA4 |
VEuPathDBi | HostDB:ENSG00000157450.15 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
- PML body Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 300 – 303 | VVVI → AAAA or AVAA: Abolishes binding to sumoylated proteins and ubiquitination and degradation of XPC; when associated with 326-A--A-329 and 382-A--A-385. 1 Publication | 4 | |
Mutagenesisi | 326 – 329 | VEIV → AAAA or AEAA: Abolishes binding to sumoylated proteins and ubiquitination and degradation of XPC; when associated with 300-A--A-303 and 382-A--A-385. 1 Publication | 4 | |
Mutagenesisi | 382 – 385 | VVDL → AAAA or AADA: Abolishes binding to sumoylated proteins and ubiquitination and degradation of XPC; when associated with 300-A--A-303 and 326-A--A-329. 1 Publication | 4 | |
Mutagenesisi | 382 | V → A: Abolishes SUMO binding. 1 Publication | 1 | |
Mutagenesisi | 382 | V → L: Loss of affinity to SUMO1 and SUMO2. 1 Publication | 1 | |
Mutagenesisi | 382 | V → Y: No loss of affinity toward SUMO1 and SUMO2. 1 Publication | 1 | |
Mutagenesisi | 383 | V → A: Abolishes SUMO binding. 1 Publication | 1 | |
Mutagenesisi | 383 | V → I: No loss of affinity toward SUMO1 and SUMO2. 1 Publication | 1 | |
Mutagenesisi | 384 | D → A: Abolishes SUMO binding. 1 Publication | 1 | |
Mutagenesisi | 384 | D → E: Loss of affinity to SUMO1 and SUMO2. 1 Publication | 1 | |
Mutagenesisi | 384 | D → N: Loss of affinity to SUMO1 and SUMO2. 1 Publication | 1 | |
Mutagenesisi | 385 | L → A: Abolishes SUMO binding. 1 Publication | 1 | |
Mutagenesisi | 385 | L → I: Loss of affinity to SUMO1 and SUMO2. 1 Publication | 1 | |
Mutagenesisi | 386 | T → A: Abolishes SUMO binding. 1 Publication | 1 | |
Mutagenesisi | 386 | T → S: Loss of affinity to SUMO1 and SUMO2. 1 Publication | 1 | |
Mutagenesisi | 386 | T → V: Loss of affinity to SUMO1 and SUMO2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 54778 |
OpenTargetsi | ENSG00000157450 |
PharmGKBi | PA134868772 |
Miscellaneous databases
Pharosi | Q6ZNA4, Tbio |
Genetic variation databases
BioMutai | RNF111 |
DMDMi | 308153555 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280690 | 1 – 994 | E3 ubiquitin-protein ligase ArkadiaAdd BLAST | 994 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 19 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 28 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 34 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 47 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 59 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 73 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 87 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 96 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 110 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 173 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 198 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 218 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 923 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 927 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | Q6ZNA4 |
MassIVEi | Q6ZNA4 |
MaxQBi | Q6ZNA4 |
PaxDbi | Q6ZNA4 |
PeptideAtlasi | Q6ZNA4 |
PRIDEi | Q6ZNA4 |
ProteomicsDBi | 40461 68002 [Q6ZNA4-1] 68003 [Q6ZNA4-2] 68004 [Q6ZNA4-3] |
PTM databases
iPTMneti | Q6ZNA4 |
PhosphoSitePlusi | Q6ZNA4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000157450, Expressed in secondary oocyte and 233 other tissues |
ExpressionAtlasi | Q6ZNA4, baseline and differential |
Genevisiblei | Q6ZNA4, HS |
Organism-specific databases
HPAi | ENSG00000157450, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (PubMed:26656854).
Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON (PubMed:16601693, PubMed:17591695).
Interacts with (phosphorylated) SMAD2 and SMAD3 (By similarity).
Part of a complex containing RNF111, AXIN1 and SMAD7 (PubMed:16601693).
Interacts (via SIM domains) with SUMO1 and SUMO2 (PubMed:23086935).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ6ZNA4
Isoform 2 [Q6ZNA4-2]
GO - Molecular functioni
- SMAD binding Source: GO_Central
- SUMO polymer binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120146, 87 interactors |
IntActi | Q6ZNA4, 66 interactors |
MINTi | Q6ZNA4 |
STRINGi | 9606.ENSP00000453872 |
Miscellaneous databases
RNActi | Q6ZNA4, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q6ZNA4 |
SMRi | Q6ZNA4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 241 – 404 | Interaction with AXIN11 PublicationAdd BLAST | 164 | |
Regioni | 907 – 909 | Ubiquitin bindingBy similarity | 3 | |
Regioni | 957 – 961 | Ubiquitin bindingBy similarity | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 300 – 304 | SUMO interaction motif 1 (SIM)2 Publications | 5 | |
Motifi | 325 – 331 | SUMO interaction motif 2 (SIM)2 Publications | 7 | |
Motifi | 382 – 386 | SUMO interaction motif 3 (SIM)2 Publications | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 252 – 464 | Ser-richAdd BLAST | 213 | |
Compositional biasi | 494 – 523 | His-richAdd BLAST | 30 | |
Compositional biasi | 629 – 781 | Pro-richAdd BLAST | 153 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 942 – 983 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0800, Eukaryota |
GeneTreei | ENSGT00940000157691 |
HOGENOMi | CLU_309031_0_0_1 |
InParanoidi | Q6ZNA4 |
OMAi | CFQQHSH |
OrthoDBi | 1098052at2759 |
PhylomeDBi | Q6ZNA4 |
TreeFami | TF331862 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR029306, RNF111_N IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF15303, RNF111_N, 1 hit PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQWTPEYNE LYTLKVDMKS EIPSDAPKTQ ESLKGILLHP EPIGAAKSFP
60 70 80 90 100
AGVEMINSKV GNEFSHLCDD SQKQEKEMNG NQQEQEKSLV VRKKRKSQQA
110 120 130 140 150
GPSYVQNCVK ENQGILGLRQ HLGTPSDEDN DSSFSDCLSS PSSSLHFGDS
160 170 180 190 200
DTVTSDEDKE VSVRHSQTIL NAKSRSHSAR SHKWPRTETE SVSGLLMKRP
210 220 230 240 250
CLHGSSLRRL PCRKRFVKNN SSQRTQKQKE RILMQRKKRE VLARRKYALL
260 270 280 290 300
PSSSSSSEND LSSESSSSSS TEGEEDLFVS ASENHQNNPA VPSGSIDEDV
310 320 330 340 350
VVIEASSTPQ VTANEEINVT STDSEVEIVT VGESYRSRST LGHSRSHWSQ
360 370 380 390 400
GSSSHASRPQ EPRNRSRIST VIQPLRQNAA EVVDLTVDED EPTVVPTTSA
410 420 430 440 450
RMESQATSAS INNSNPSTSE QASDTASAVT SSQPSTVSET SATLTSNSTT
460 470 480 490 500
GTSIGDDSRR TTSSAVTETG PPAMPRLPSC CPQHSPCGGS SQNHHALGHP
510 520 530 540 550
HTSCFQQHGH HFQHHHHHHH TPHPAVPVSP SFSDPACPVE RPPQVQAPCG
560 570 580 590 600
ANSSSGTSYH EQQALPVDLS NSGIRSHGSG SFHGASAFDP CCPVSSSRAA
610 620 630 640 650
IFGHQAAAAA PSQPLSSIDG YGSSMVAQPQ PQPPPQPSLS SCRHYMPPPY
660 670 680 690 700
ASLTRPLHHQ ASACPHSHGN PPPQTQPPPQ VDYVIPHPVH AFHSQISSHA
710 720 730 740 750
TSHPVAPPPP THLASTAAPI PQHLPPTHQP ISHHIPATAP PAQRLHPHEV
760 770 780 790 800
MQRMEVQRRR MMQHPTRAHE RPPPHPHRMH PNYGHGHHIH VPQTMSSHPR
810 820 830 840 850
QAPERSAWEL GIEAGVTAAT YTPGALHPHL AHYHAPPRLH HLQLGALPLM
860 870 880 890 900
VPDMAGYPHI RYISSGLDGT SFRGPFRGNF EELIHLEERL GNVNRGASQG
910 920 930 940 950
TIERCTYPHK YKKVTTDWFS QRKLHCKQDG EEGTEEDTEE KCTICLSILE
960 970 980 990
EGEDVRRLPC MHLFHQVCVD QWLITNKKCP ICRVDIEAQL PSES
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YKS2 | H0YKS2_HUMAN | E3 ubiquitin-protein ligase Arkadia | RNF111 | 131 | Annotation score: | ||
H0YKK5 | H0YKK5_HUMAN | E3 ubiquitin-protein ligase Arkadia | RNF111 | 128 | Annotation score: | ||
H0YLK9 | H0YLK9_HUMAN | E3 ubiquitin-protein ligase Arkadia | RNF111 | 190 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 165 | H → R in BX647259 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 473 | A → E in CAD98031 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 562 | Missing in AAH60862 (PubMed:16572171).Curated | 1 | |
Sequence conflicti | 562 | Missing in AAH20984 (PubMed:16572171).Curated | 1 | |
Sequence conflicti | 625 | M → T in BX647259 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 738 | T → I in BX647259 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 809 | E → G in CAD98031 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 931 | E → G in CAD98031 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 938 | T → A in BX647259 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 974 | I → V in BAD18471 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031185 | 9 | N → K3 PublicationsCorresponds to variant dbSNP:rs2899642Ensembl. | 1 | |
Natural variantiVAR_057216 | 718 | A → T. Corresponds to variant dbSNP:rs34086812Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023840 | 766 | T → TGLFVFCVSR in isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_023841 | 914 – 921 | Missing in isoform 2 and isoform 4. 2 Publications | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095327 mRNA Translation: BAC04531.1 Different initiation. AK131304 mRNA Translation: BAD18471.1 AK131488 mRNA Translation: BAD18633.1 Different initiation. AL157474 mRNA Translation: CAB75669.2 BX538130 mRNA Translation: CAD98031.1 BX647259 mRNA No translation available. AC025918 Genomic DNA No translation available. AC090515 Genomic DNA No translation available. AC092757 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77561.1 BC010369 mRNA Translation: AAH10369.1 Different initiation. BC020984 mRNA Translation: AAH20984.1 BC060862 mRNA Translation: AAH60862.1 |
CCDSi | CCDS10169.1 [Q6ZNA4-2] CCDS58365.1 [Q6ZNA4-4] CCDS58366.1 [Q6ZNA4-1] CCDS81888.1 [Q6ZNA4-3] |
PIRi | T46904 |
RefSeqi | NP_001257457.1, NM_001270528.1 [Q6ZNA4-4] NP_001257458.1, NM_001270529.1 NP_001257459.1, NM_001270530.1 [Q6ZNA4-1] NP_001317260.1, NM_001330331.1 [Q6ZNA4-3] NP_060080.6, NM_017610.7 [Q6ZNA4-2] XP_006720642.1, XM_006720579.3 [Q6ZNA4-3] XP_016877827.1, XM_017022338.1 [Q6ZNA4-1] |
Genome annotation databases
Ensembli | ENST00000348370; ENSP00000288199; ENSG00000157450 [Q6ZNA4-2] ENST00000557998; ENSP00000452732; ENSG00000157450 [Q6ZNA4-1] ENST00000559209; ENSP00000453872; ENSG00000157450 [Q6ZNA4-4] ENST00000561186; ENSP00000453015; ENSG00000157450 [Q6ZNA4-3] |
GeneIDi | 54778 |
KEGGi | hsa:54778 |
UCSCi | uc002afs.5, human [Q6ZNA4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095327 mRNA Translation: BAC04531.1 Different initiation. AK131304 mRNA Translation: BAD18471.1 AK131488 mRNA Translation: BAD18633.1 Different initiation. AL157474 mRNA Translation: CAB75669.2 BX538130 mRNA Translation: CAD98031.1 BX647259 mRNA No translation available. AC025918 Genomic DNA No translation available. AC090515 Genomic DNA No translation available. AC092757 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77561.1 BC010369 mRNA Translation: AAH10369.1 Different initiation. BC020984 mRNA Translation: AAH20984.1 BC060862 mRNA Translation: AAH60862.1 |
CCDSi | CCDS10169.1 [Q6ZNA4-2] CCDS58365.1 [Q6ZNA4-4] CCDS58366.1 [Q6ZNA4-1] CCDS81888.1 [Q6ZNA4-3] |
PIRi | T46904 |
RefSeqi | NP_001257457.1, NM_001270528.1 [Q6ZNA4-4] NP_001257458.1, NM_001270529.1 NP_001257459.1, NM_001270530.1 [Q6ZNA4-1] NP_001317260.1, NM_001330331.1 [Q6ZNA4-3] NP_060080.6, NM_017610.7 [Q6ZNA4-2] XP_006720642.1, XM_006720579.3 [Q6ZNA4-3] XP_016877827.1, XM_017022338.1 [Q6ZNA4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KIZ | NMR | - | A | 927-994 | [»] | |
5LG0 | NMR | - | A | 927-994 | [»] | |
5LG7 | NMR | - | A | 927-994 | [»] | |
BMRBi | Q6ZNA4 | |||||
SMRi | Q6ZNA4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120146, 87 interactors |
IntActi | Q6ZNA4, 66 interactors |
MINTi | Q6ZNA4 |
STRINGi | 9606.ENSP00000453872 |
Protein family/group databases
MoonDBi | Q6ZNA4, Predicted |
PTM databases
iPTMneti | Q6ZNA4 |
PhosphoSitePlusi | Q6ZNA4 |
Genetic variation databases
BioMutai | RNF111 |
DMDMi | 308153555 |
Proteomic databases
jPOSTi | Q6ZNA4 |
MassIVEi | Q6ZNA4 |
MaxQBi | Q6ZNA4 |
PaxDbi | Q6ZNA4 |
PeptideAtlasi | Q6ZNA4 |
PRIDEi | Q6ZNA4 |
ProteomicsDBi | 40461 68002 [Q6ZNA4-1] 68003 [Q6ZNA4-2] 68004 [Q6ZNA4-3] |
Protocols and materials databases
Antibodypediai | 25360, 126 antibodies |
Genome annotation databases
Ensembli | ENST00000348370; ENSP00000288199; ENSG00000157450 [Q6ZNA4-2] ENST00000557998; ENSP00000452732; ENSG00000157450 [Q6ZNA4-1] ENST00000559209; ENSP00000453872; ENSG00000157450 [Q6ZNA4-4] ENST00000561186; ENSP00000453015; ENSG00000157450 [Q6ZNA4-3] |
GeneIDi | 54778 |
KEGGi | hsa:54778 |
UCSCi | uc002afs.5, human [Q6ZNA4-1] |
Organism-specific databases
CTDi | 54778 |
DisGeNETi | 54778 |
GeneCardsi | RNF111 |
HGNCi | HGNC:17384, RNF111 |
HPAi | ENSG00000157450, Low tissue specificity |
MIMi | 605840, gene |
neXtProti | NX_Q6ZNA4 |
OpenTargetsi | ENSG00000157450 |
PharmGKBi | PA134868772 |
VEuPathDBi | HostDB:ENSG00000157450.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0800, Eukaryota |
GeneTreei | ENSGT00940000157691 |
HOGENOMi | CLU_309031_0_0_1 |
InParanoidi | Q6ZNA4 |
OMAi | CFQQHSH |
OrthoDBi | 1098052at2759 |
PhylomeDBi | Q6ZNA4 |
TreeFami | TF331862 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
BRENDAi | 6.3.2.19, 2681 |
PathwayCommonsi | Q6ZNA4 |
Reactomei | R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-5696395, Formation of Incision Complex in GG-NER R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q6ZNA4 |
SIGNORi | Q6ZNA4 |
Miscellaneous databases
BioGRID-ORCSi | 54778, 10 hits in 1002 CRISPR screens |
ChiTaRSi | RNF111, human |
GeneWikii | RNF111 |
GenomeRNAii | 54778 |
Pharosi | Q6ZNA4, Tbio |
PROi | PR:Q6ZNA4 |
RNActi | Q6ZNA4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157450, Expressed in secondary oocyte and 233 other tissues |
ExpressionAtlasi | Q6ZNA4, baseline and differential |
Genevisiblei | Q6ZNA4, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR029306, RNF111_N IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF15303, RNF111_N, 1 hit PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RN111_HUMAN | |
Accessioni | Q6ZNA4Primary (citable) accession number: Q6ZNA4 Secondary accession number(s): C9JUS4 Q9NSR1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | October 5, 2010 | |
Last modified: | April 7, 2021 | |
This is version 166 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families