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UniProtKB - Q6ZNA4 (RN111_HUMAN)

Entry version 161 (17 Jun 2020)
Sequence version 3 (05 Oct 2010)
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Protein

E3 ubiquitin-protein ligase Arkadia

Gene

RNF111

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).By similarity6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Binds free ubiquitin non-covalently via its RING-type zinc finger. Ubiquitin-binding leads to enhance the E3 ubiquitin-protein ligase activity by stabilizing the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and activating ubiquitin transfer.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.6 Publications
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi942ZincBy similarity1
Metal bindingi945ZincBy similarity1
Metal bindingi965ZincBy similarity1
Metal bindingi968ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri942 – 983RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • SMAD binding Source: GO_Central
  • SUMO polymer binding Source: UniProtKB
  • ubiquitin protein ligase activity Source: BHF-UCL
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Transferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.3.2.19 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6ZNA4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6ZNA4

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q6ZNA4 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase Arkadia1 Publication (EC:2.3.2.271 Publication)
Alternative name(s):
RING finger protein 111Imported
Short name:
hRNF1111 Publication
RING-type E3 ubiquitin transferase ArkadiaCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF111Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000157450.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:17384 RNF111

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605840 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZNA4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi300 – 303VVVI → AAAA or AVAA: Abolishes binding to sumoylated proteins and ubiquitination and degradation of XPC; when associated with 326-A--A-329 and 382-A--A-385. 1 Publication4
Mutagenesisi326 – 329VEIV → AAAA or AEAA: Abolishes binding to sumoylated proteins and ubiquitination and degradation of XPC; when associated with 300-A--A-303 and 382-A--A-385. 1 Publication4
Mutagenesisi382 – 385VVDL → AAAA or AADA: Abolishes binding to sumoylated proteins and ubiquitination and degradation of XPC; when associated with 300-A--A-303 and 326-A--A-329. 1 Publication4
Mutagenesisi382V → A: Abolishes SUMO binding. 1 Publication1
Mutagenesisi382V → L: Loss of affinity to SUMO1 and SUMO2. 1 Publication1
Mutagenesisi382V → Y: No loss of affinity toward SUMO1 and SUMO2. 1 Publication1
Mutagenesisi383V → A: Abolishes SUMO binding. 1 Publication1
Mutagenesisi383V → I: No loss of affinity toward SUMO1 and SUMO2. 1 Publication1
Mutagenesisi384D → A: Abolishes SUMO binding. 1 Publication1
Mutagenesisi384D → E: Loss of affinity to SUMO1 and SUMO2. 1 Publication1
Mutagenesisi384D → N: Loss of affinity to SUMO1 and SUMO2. 1 Publication1
Mutagenesisi385L → A: Abolishes SUMO binding. 1 Publication1
Mutagenesisi385L → I: Loss of affinity to SUMO1 and SUMO2. 1 Publication1
Mutagenesisi386T → A: Abolishes SUMO binding. 1 Publication1
Mutagenesisi386T → S: Loss of affinity to SUMO1 and SUMO2. 1 Publication1
Mutagenesisi386T → V: Loss of affinity to SUMO1 and SUMO2. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		54778

Open Targets

More...OpenTargetsi		ENSG00000157450

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134868772

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZNA4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RNF111

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153555

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002806901 – 994E3 ubiquitin-protein ligase ArkadiaAdd BLAST994

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki19Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki47Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki73Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki96Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki923Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki927Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZNA4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZNA4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZNA4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZNA4

PeptideAtlas

More...PeptideAtlasi		Q6ZNA4

PRoteomics IDEntifications database

More...PRIDEi		Q6ZNA4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		40461
68002 [Q6ZNA4-1]
68003 [Q6ZNA4-2]
68004 [Q6ZNA4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZNA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZNA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157450 Expressed in secondary oocyte and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZNA4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZNA4 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157450 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:26656854).

Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON (PubMed:16601693, PubMed:17591695).

Interacts with (phosphorylated) SMAD2 and SMAD3 (By similarity).

Part of a complex containing RNF111, AXIN1 and SMAD7 (PubMed:16601693).

Interacts (via SIM domains) with SUMO1 and SUMO2 (PubMed:23086935).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120146, 76 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZNA4, 51 interactors

Molecular INTeraction database

More...MINTi		Q6ZNA4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000453872

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZNA4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1994
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZNA4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni241 – 404Interaction with AXIN11 PublicationAdd BLAST164
Regioni907 – 909Ubiquitin bindingBy similarity3
Regioni957 – 961Ubiquitin bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi300 – 304SUMO interaction motif 1 (SIM)2 Publications5
Motifi325 – 331SUMO interaction motif 2 (SIM)2 Publications7
Motifi382 – 386SUMO interaction motif 3 (SIM)2 Publications5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi252 – 464Ser-richAdd BLAST213
Compositional biasi494 – 523His-richAdd BLAST30
Compositional biasi629 – 781Pro-richAdd BLAST153

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SUMO interaction motifs (SIMs) mediates the binding to polysumoylated substrate.2 Publications
The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin (PubMed:26656854). Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and stimulates ubiquitin transfer (By similarity).By similarity1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Arkadia family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri942 – 983RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0800 Eukaryota
ENOG41121N2 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157691

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_309031_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZNA4

KEGG Orthology (KO)

More...KOi		K10635

Identification of Orthologs from Complete Genome Data

More...OMAi		CFQQHSH

Database of Orthologous Groups

More...OrthoDBi		1098052at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZNA4

TreeFam database of animal gene trees

More...TreeFami		TF331862

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029306 RNF111_N
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15303 RNF111_N, 1 hit
PF13639 zf-RING_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184 RING, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZNA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MSQWTPEYNE LYTLKVDMKS EIPSDAPKTQ ESLKGILLHP EPIGAAKSFP 
        60         70         80         90        100
AGVEMINSKV GNEFSHLCDD SQKQEKEMNG NQQEQEKSLV VRKKRKSQQA 
       110        120        130        140        150
GPSYVQNCVK ENQGILGLRQ HLGTPSDEDN DSSFSDCLSS PSSSLHFGDS 
       160        170        180        190        200
DTVTSDEDKE VSVRHSQTIL NAKSRSHSAR SHKWPRTETE SVSGLLMKRP 
       210        220        230        240        250
CLHGSSLRRL PCRKRFVKNN SSQRTQKQKE RILMQRKKRE VLARRKYALL 
       260        270        280        290        300
PSSSSSSEND LSSESSSSSS TEGEEDLFVS ASENHQNNPA VPSGSIDEDV 
       310        320        330        340        350
VVIEASSTPQ VTANEEINVT STDSEVEIVT VGESYRSRST LGHSRSHWSQ 
       360        370        380        390        400
GSSSHASRPQ EPRNRSRIST VIQPLRQNAA EVVDLTVDED EPTVVPTTSA 
       410        420        430        440        450
RMESQATSAS INNSNPSTSE QASDTASAVT SSQPSTVSET SATLTSNSTT 
       460        470        480        490        500
GTSIGDDSRR TTSSAVTETG PPAMPRLPSC CPQHSPCGGS SQNHHALGHP 
       510        520        530        540        550
HTSCFQQHGH HFQHHHHHHH TPHPAVPVSP SFSDPACPVE RPPQVQAPCG 
       560        570        580        590        600
ANSSSGTSYH EQQALPVDLS NSGIRSHGSG SFHGASAFDP CCPVSSSRAA 
       610        620        630        640        650
IFGHQAAAAA PSQPLSSIDG YGSSMVAQPQ PQPPPQPSLS SCRHYMPPPY 
       660        670        680        690        700
ASLTRPLHHQ ASACPHSHGN PPPQTQPPPQ VDYVIPHPVH AFHSQISSHA 
       710        720        730        740        750
TSHPVAPPPP THLASTAAPI PQHLPPTHQP ISHHIPATAP PAQRLHPHEV 
       760        770        780        790        800
MQRMEVQRRR MMQHPTRAHE RPPPHPHRMH PNYGHGHHIH VPQTMSSHPR 
       810        820        830        840        850
QAPERSAWEL GIEAGVTAAT YTPGALHPHL AHYHAPPRLH HLQLGALPLM 
       860        870        880        890        900
VPDMAGYPHI RYISSGLDGT SFRGPFRGNF EELIHLEERL GNVNRGASQG 
       910        920        930        940        950
TIERCTYPHK YKKVTTDWFS QRKLHCKQDG EEGTEEDTEE KCTICLSILE 
       960        970        980        990 
EGEDVRRLPC MHLFHQVCVD QWLITNKKCP ICRVDIEAQL PSES
Length:994
Mass (Da):108,862
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E387321E5F61FAB
GO
Isoform 2 (identifier: Q6ZNA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     914-921: Missing.

Show »
Length:986
Mass (Da):107,896
Checksum:iBD07D5D2C2B6AEB4
GO
Isoform 3 (identifier: Q6ZNA4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     766-766: T → TGLFVFCVSR

Show »
Length:1,003
Mass (Da):109,871
Checksum:i9F0D0B05B5EB39A8
GO
Isoform 4 (identifier: Q6ZNA4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     766-766: T → TGLFVFCVSR
     914-921: Missing.

Show »
Length:995
Mass (Da):108,906
Checksum:iA648717F19CFB655
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKS2H0YKS2_HUMAN
E3 ubiquitin-protein ligase Arkadia
RNF111
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKK5H0YKK5_HUMAN
E3 ubiquitin-protein ligase Arkadia
RNF111
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLK9H0YLK9_HUMAN
E3 ubiquitin-protein ligase Arkadia
RNF111
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH10369 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC04531 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD18633 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti165H → R in BX647259 (PubMed:17974005).Curated1
Sequence conflicti473A → E in CAD98031 (PubMed:17974005).Curated1
Sequence conflicti562Missing in AAH60862 (PubMed:16572171).Curated1
Sequence conflicti562Missing in AAH20984 (PubMed:16572171).Curated1
Sequence conflicti625M → T in BX647259 (PubMed:17974005).Curated1
Sequence conflicti738T → I in BX647259 (PubMed:17974005).Curated1
Sequence conflicti809E → G in CAD98031 (PubMed:17974005).Curated1
Sequence conflicti931E → G in CAD98031 (PubMed:17974005).Curated1
Sequence conflicti938T → A in BX647259 (PubMed:17974005).Curated1
Sequence conflicti974I → V in BAD18471 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0311859N → K3 PublicationsCorresponds to variant dbSNP:rs2899642Ensembl.1
Natural variantiVAR_057216718A → T. Corresponds to variant dbSNP:rs34086812Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023840766T → TGLFVFCVSR in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_023841914 – 921Missing in isoform 2 and isoform 4. 2 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK095327 mRNA Translation: BAC04531.1 Different initiation.
AK131304 mRNA Translation: BAD18471.1
AK131488 mRNA Translation: BAD18633.1 Different initiation.
AL157474 mRNA Translation: CAB75669.2
BX538130 mRNA Translation: CAD98031.1
BX647259 mRNA No translation available.
AC025918 Genomic DNA No translation available.
AC090515 Genomic DNA No translation available.
AC092757 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77561.1
BC010369 mRNA Translation: AAH10369.1 Different initiation.
BC020984 mRNA Translation: AAH20984.1
BC060862 mRNA Translation: AAH60862.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10169.1 [Q6ZNA4-2]
CCDS58365.1 [Q6ZNA4-4]
CCDS58366.1 [Q6ZNA4-1]
CCDS81888.1 [Q6ZNA4-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T46904

NCBI Reference Sequences

More...RefSeqi		NP_001257457.1, NM_001270528.1 [Q6ZNA4-4]
NP_001257458.1, NM_001270529.1
NP_001257459.1, NM_001270530.1 [Q6ZNA4-1]
NP_001317260.1, NM_001330331.1 [Q6ZNA4-3]
NP_060080.6, NM_017610.7 [Q6ZNA4-2]
XP_006720642.1, XM_006720579.3 [Q6ZNA4-3]
XP_016877827.1, XM_017022338.1 [Q6ZNA4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000348370; ENSP00000288199; ENSG00000157450 [Q6ZNA4-2]
ENST00000557998; ENSP00000452732; ENSG00000157450 [Q6ZNA4-1]
ENST00000559209; ENSP00000453872; ENSG00000157450 [Q6ZNA4-4]
ENST00000561186; ENSP00000453015; ENSG00000157450 [Q6ZNA4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54778

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54778

UCSC genome browser

More...UCSCi		uc002afs.5 human [Q6ZNA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095327 mRNA Translation: BAC04531.1 Different initiation.
AK131304 mRNA Translation: BAD18471.1
AK131488 mRNA Translation: BAD18633.1 Different initiation.
AL157474 mRNA Translation: CAB75669.2
BX538130 mRNA Translation: CAD98031.1
BX647259 mRNA No translation available.
AC025918 Genomic DNA No translation available.
AC090515 Genomic DNA No translation available.
AC092757 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77561.1
BC010369 mRNA Translation: AAH10369.1 Different initiation.
BC020984 mRNA Translation: AAH20984.1
BC060862 mRNA Translation: AAH60862.1
CCDSiCCDS10169.1 [Q6ZNA4-2]
CCDS58365.1 [Q6ZNA4-4]
CCDS58366.1 [Q6ZNA4-1]
CCDS81888.1 [Q6ZNA4-3]
PIRiT46904
RefSeqiNP_001257457.1, NM_001270528.1 [Q6ZNA4-4]
NP_001257458.1, NM_001270529.1
NP_001257459.1, NM_001270530.1 [Q6ZNA4-1]
NP_001317260.1, NM_001330331.1 [Q6ZNA4-3]
NP_060080.6, NM_017610.7 [Q6ZNA4-2]
XP_006720642.1, XM_006720579.3 [Q6ZNA4-3]
XP_016877827.1, XM_017022338.1 [Q6ZNA4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KIZNMR-A927-994[»]
5LG0NMR-A927-994[»]
5LG7NMR-A927-994[»]
SMRiQ6ZNA4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120146, 76 interactors
IntActiQ6ZNA4, 51 interactors
MINTiQ6ZNA4
STRINGi9606.ENSP00000453872

Protein family/group databases

MoonDBiQ6ZNA4 Predicted

PTM databases

iPTMnetiQ6ZNA4
PhosphoSitePlusiQ6ZNA4

Polymorphism and mutation databases

BioMutaiRNF111
DMDMi308153555

Proteomic databases

jPOSTiQ6ZNA4
MassIVEiQ6ZNA4
MaxQBiQ6ZNA4
PaxDbiQ6ZNA4
PeptideAtlasiQ6ZNA4
PRIDEiQ6ZNA4
ProteomicsDBi40461
68002 [Q6ZNA4-1]
68003 [Q6ZNA4-2]
68004 [Q6ZNA4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25360 121 antibodies

Genome annotation databases

EnsembliENST00000348370; ENSP00000288199; ENSG00000157450 [Q6ZNA4-2]
ENST00000557998; ENSP00000452732; ENSG00000157450 [Q6ZNA4-1]
ENST00000559209; ENSP00000453872; ENSG00000157450 [Q6ZNA4-4]
ENST00000561186; ENSP00000453015; ENSG00000157450 [Q6ZNA4-3]
GeneIDi54778
KEGGihsa:54778
UCSCiuc002afs.5 human [Q6ZNA4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54778
DisGeNETi54778
EuPathDBiHostDB:ENSG00000157450.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		RNF111
HGNCiHGNC:17384 RNF111
HPAiENSG00000157450 Low tissue specificity
MIMi605840 gene
neXtProtiNX_Q6ZNA4
OpenTargetsiENSG00000157450
PharmGKBiPA134868772

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00940000157691
HOGENOMiCLU_309031_0_0_1
InParanoidiQ6ZNA4
KOiK10635
OMAiCFQQHSH
OrthoDBi1098052at2759
PhylomeDBiQ6ZNA4
TreeFamiTF331862

Enzyme and pathway databases

UniPathwayiUPA00143
BRENDAi6.3.2.19 2681
ReactomeiR-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ6ZNA4
SIGNORiQ6ZNA4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54778 2 hits in 791 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RNF111 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RNF111

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54778
PharosiQ6ZNA4 Tbio

Protein Ontology

More...PROi		PR:Q6ZNA4
RNActiQ6ZNA4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157450 Expressed in secondary oocyte and 223 other tissues
ExpressionAtlasiQ6ZNA4 baseline and differential
GenevisibleiQ6ZNA4 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR029306 RNF111_N
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF15303 RNF111_N, 1 hit
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRN111_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZNA4
Secondary accession number(s): C9JUS4
, H0YN55, Q6P9A4, Q6ZMU2, Q7L428, Q7Z346, Q8N1P9, Q8WUA3, Q9NSR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 5, 2010
Last modified: June 17, 2020
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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