UniProtKB - Q6ZN66 (GBP6_HUMAN)
Protein
Guanylate-binding protein 6
Gene
GBP6
Organism
Homo sapiens (Human)
Status
Functioni
Binds GTP, GDP and GMP.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 45 – 52 | GTPBy similarity | 8 | |
Nucleotide bindingi | 67 – 69 | GTPBy similarity | 3 | |
Nucleotide bindingi | 97 – 101 | GTPBy similarity | 5 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: GO_Central
GO - Biological processi
- cellular response to interferon-gamma Source: UniProtKB
- defense response to bacterium Source: UniProtKB
- defense response to Gram-positive bacterium Source: GO_Central
- defense response to protozoan Source: GO_Central
- immune response Source: UniProtKB
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6ZN66 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Guanylate-binding protein 6Alternative name(s): GTP-binding protein 6 Short name: GBP-6 Guanine nucleotide-binding protein 6 |
Gene namesi | Name:GBP6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25395, GBP6 |
MIMi | 612467, gene |
neXtProti | NX_Q6ZN66 |
VEuPathDBi | HostDB:ENSG00000183347.14 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasmic vesicle Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 163351 |
OpenTargetsi | ENSG00000183347 |
PharmGKBi | PA134964409 |
Miscellaneous databases
Pharosi | Q6ZN66, Tbio |
Genetic variation databases
BioMutai | GBP6 |
DMDMi | 74749570 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313811 | 1 – 633 | Guanylate-binding protein 6Add BLAST | 633 |
Proteomic databases
EPDi | Q6ZN66 |
jPOSTi | Q6ZN66 |
MassIVEi | Q6ZN66 |
MaxQBi | Q6ZN66 |
PaxDbi | Q6ZN66 |
PeptideAtlasi | Q6ZN66 |
PRIDEi | Q6ZN66 |
ProteomicsDBi | 67986 [Q6ZN66-1] 67987 [Q6ZN66-2] |
PTM databases
iPTMneti | Q6ZN66 |
PhosphoSitePlusi | Q6ZN66 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183347, Expressed in esophagus and 74 other tissues |
Organism-specific databases
HPAi | ENSG00000183347, Group enriched (esophagus, lymphoid tissue, tongue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127864, 8 interactors |
IntActi | Q6ZN66, 8 interactors |
STRINGi | 9606.ENSP00000359485 |
Miscellaneous databases
RNActi | Q6ZN66, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 277 | GB1/RHD3-type GPROSITE-ProRule annotationAdd BLAST | 243 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 310 | GTPase domain (Globular)By similarityAdd BLAST | 310 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 38 – 41 | Poly-Val | 4 |
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG2037, Eukaryota |
GeneTreei | ENSGT00940000154265 |
HOGENOMi | CLU_018608_2_1_1 |
InParanoidi | Q6ZN66 |
OMAi | IMMLEHT |
OrthoDBi | 1027269at2759 |
PhylomeDBi | Q6ZN66 |
TreeFami | TF331602 |
Family and domain databases
CDDi | cd16269, GBP_C, 1 hit |
InterProi | View protein in InterPro IPR030386, G_GB1_RHD3_dom IPR037684, GBP_C IPR003191, Guanylate-bd/ATL_C IPR036543, Guanylate-bd_C_sf IPR015894, Guanylate-bd_N IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF02263, GBP, 1 hit PF02841, GBP_C, 1 hit |
SUPFAMi | SSF48340, SSF48340, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51715, G_GB1_RHD3, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6ZN66-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESGPKMLAP VCLVENNNEQ LLVNQQAIQI LEKISQPVVV VAIVGLYRTG
60 70 80 90 100
KSYLMNHLAG QNHGFPLGST VQSETKGIWM WCVPHPSKPN HTLVLLDTEG
110 120 130 140 150
LGDVEKGDPK NDSWIFALAV LLCSTFVYNS MSTINHQALE QLHYVTELTE
160 170 180 190 200
LIKAKSSPRP DGVEDSTEFV SFFPDFLWTV RDFTLELKLN GHPITEDEYL
210 220 230 240 250
ENALKLIQGN NPRVQTSNFP RECIRRFFPK RKCFVFDRPT NDKDLLANIE
260 270 280 290 300
KVSEKQLDPK FQEQTNIFCS YIFTHARTKT LREGITVTGN RLGTLAVTYV
310 320 330 340 350
EAINSGAVPC LENAVITLAQ RENSAAVQRA ADYYSQQMAQ RVKLPTDTLQ
360 370 380 390 400
ELLDMHAACE REAIAIFMEH SFKDENQEFQ KKFMETTMNK KGDFLLQNEE
410 420 430 440 450
SSVQYCQAKL NELSKGLMES ISAGSFSVPG GHKLYMETKE RIEQDYWQVP
460 470 480 490 500
RKGVKAKEVF QRFLESQMVI EESILQSDKA LTDREKAVAV DRAKKEAAEK
510 520 530 540 550
EQELLKQKLQ EQQQQMEAQD KSRKENIAQL KEKLQMEREH LLREQIMMLE
560 570 580 590 600
HTQKVQNDWL HEGFKKKYEE MNAEISQFKR MIDTTKNDDT PWIARTLDNL
610 620 630
ADELTAILSA PAKLIGHGVK GVSSLFKKHK LPF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | L → Q in CAD97917 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 313 | N → D in CAD97917 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037750 | 278 | T → I. Corresponds to variant dbSNP:rs4582772Ensembl. | 1 | |
Natural variantiVAR_037751 | 331 | A → S2 PublicationsCorresponds to variant dbSNP:rs4658359Ensembl. | 1 | |
Natural variantiVAR_037752 | 344 | L → F3 PublicationsCorresponds to variant dbSNP:rs4658360Ensembl. | 1 | |
Natural variantiVAR_037753 | 355 | M → V3 PublicationsCorresponds to variant dbSNP:rs4658146Ensembl. | 1 | |
Natural variantiVAR_037754 | 520 | D → V3 PublicationsCorresponds to variant dbSNP:rs959460Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030155 | 1 – 337 | Missing in isoform 2. 1 PublicationAdd BLAST | 337 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131329 mRNA Translation: BAD18489.1 AK131356 mRNA Translation: BAD18509.1 BX537949 mRNA Translation: CAD97917.1 AL691464 Genomic DNA No translation available. BC131713 mRNA Translation: AAI31714.1 |
CCDSi | CCDS723.1 [Q6ZN66-1] |
RefSeqi | NP_940862.2, NM_198460.2 [Q6ZN66-1] XP_011539137.1, XM_011540835.2 [Q6ZN66-1] |
Genome annotation databases
Ensembli | ENST00000370456; ENSP00000359485; ENSG00000183347 [Q6ZN66-1] |
GeneIDi | 163351 |
KEGGi | hsa:163351 |
UCSCi | uc001dnf.3, human [Q6ZN66-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131329 mRNA Translation: BAD18489.1 AK131356 mRNA Translation: BAD18509.1 BX537949 mRNA Translation: CAD97917.1 AL691464 Genomic DNA No translation available. BC131713 mRNA Translation: AAI31714.1 |
CCDSi | CCDS723.1 [Q6ZN66-1] |
RefSeqi | NP_940862.2, NM_198460.2 [Q6ZN66-1] XP_011539137.1, XM_011540835.2 [Q6ZN66-1] |
3D structure databases
SMRi | Q6ZN66 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127864, 8 interactors |
IntActi | Q6ZN66, 8 interactors |
STRINGi | 9606.ENSP00000359485 |
PTM databases
iPTMneti | Q6ZN66 |
PhosphoSitePlusi | Q6ZN66 |
Genetic variation databases
BioMutai | GBP6 |
DMDMi | 74749570 |
Proteomic databases
EPDi | Q6ZN66 |
jPOSTi | Q6ZN66 |
MassIVEi | Q6ZN66 |
MaxQBi | Q6ZN66 |
PaxDbi | Q6ZN66 |
PeptideAtlasi | Q6ZN66 |
PRIDEi | Q6ZN66 |
ProteomicsDBi | 67986 [Q6ZN66-1] 67987 [Q6ZN66-2] |
Protocols and materials databases
Antibodypediai | 33619, 84 antibodies |
DNASUi | 163351 |
Genome annotation databases
Ensembli | ENST00000370456; ENSP00000359485; ENSG00000183347 [Q6ZN66-1] |
GeneIDi | 163351 |
KEGGi | hsa:163351 |
UCSCi | uc001dnf.3, human [Q6ZN66-1] |
Organism-specific databases
CTDi | 163351 |
DisGeNETi | 163351 |
GeneCardsi | GBP6 |
HGNCi | HGNC:25395, GBP6 |
HPAi | ENSG00000183347, Group enriched (esophagus, lymphoid tissue, tongue) |
MIMi | 612467, gene |
neXtProti | NX_Q6ZN66 |
OpenTargetsi | ENSG00000183347 |
PharmGKBi | PA134964409 |
VEuPathDBi | HostDB:ENSG00000183347.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2037, Eukaryota |
GeneTreei | ENSGT00940000154265 |
HOGENOMi | CLU_018608_2_1_1 |
InParanoidi | Q6ZN66 |
OMAi | IMMLEHT |
OrthoDBi | 1027269at2759 |
PhylomeDBi | Q6ZN66 |
TreeFami | TF331602 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZN66 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
Miscellaneous databases
BioGRID-ORCSi | 163351, 3 hits in 869 CRISPR screens |
GenomeRNAii | 163351 |
Pharosi | Q6ZN66, Tbio |
PROi | PR:Q6ZN66 |
RNActi | Q6ZN66, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183347, Expressed in esophagus and 74 other tissues |
Family and domain databases
CDDi | cd16269, GBP_C, 1 hit |
InterProi | View protein in InterPro IPR030386, G_GB1_RHD3_dom IPR037684, GBP_C IPR003191, Guanylate-bd/ATL_C IPR036543, Guanylate-bd_C_sf IPR015894, Guanylate-bd_N IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF02263, GBP, 1 hit PF02841, GBP_C, 1 hit |
SUPFAMi | SSF48340, SSF48340, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51715, G_GB1_RHD3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GBP6_HUMAN | |
Accessioni | Q6ZN66Primary (citable) accession number: Q6ZN66 Secondary accession number(s): A2RRM3, Q6ZN86, Q7Z3F0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families