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Entry version 122 (05 Jun 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Guanylate-binding protein 6

Gene

GBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds GTP, GDP and GMP.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi45 – 52GTPBy similarity8
Nucleotide bindingi67 – 69GTPBy similarity3
Nucleotide bindingi97 – 101GTPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-877300 Interferon gamma signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanylate-binding protein 6
Alternative name(s):
GTP-binding protein 6
Short name:
GBP-6
Guanine nucleotide-binding protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GBP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25395 GBP6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612467 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZN66

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000183347

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134964409

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GBP6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749570

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003138111 – 633Guanylate-binding protein 6Add BLAST633

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZN66

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZN66

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZN66

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZN66

PeptideAtlas

More...
PeptideAtlasi
Q6ZN66

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZN66

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67986
67987 [Q6ZN66-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZN66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZN66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183347 Expressed in 58 organ(s), highest expression level in esophagus mucosa

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027744

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127864, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZN66, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359485

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZN66

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 277GB1/RHD3-type GAdd BLAST243

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 310GTPase domain (Globular)By similarityAdd BLAST310

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 41Poly-Val4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2037 Eukaryota
ENOG410XR6Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154265

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000266974

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZN66

KEGG Orthology (KO)

More...
KOi
K20908

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNDWLHE

Database of Orthologous Groups

More...
OrthoDBi
1027269at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZN66

TreeFam database of animal gene trees

More...
TreeFami
TF331602

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16269 GBP_C, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030386 G_GB1_RHD3_dom
IPR037684 GBP_C
IPR003191 Guanylate-bd/ATL_C
IPR036543 Guanylate-bd_C_sf
IPR015894 Guanylate-bd_N
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02263 GBP, 1 hit
PF02841 GBP_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48340 SSF48340, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51715 G_GB1_RHD3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZN66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESGPKMLAP VCLVENNNEQ LLVNQQAIQI LEKISQPVVV VAIVGLYRTG
60 70 80 90 100
KSYLMNHLAG QNHGFPLGST VQSETKGIWM WCVPHPSKPN HTLVLLDTEG
110 120 130 140 150
LGDVEKGDPK NDSWIFALAV LLCSTFVYNS MSTINHQALE QLHYVTELTE
160 170 180 190 200
LIKAKSSPRP DGVEDSTEFV SFFPDFLWTV RDFTLELKLN GHPITEDEYL
210 220 230 240 250
ENALKLIQGN NPRVQTSNFP RECIRRFFPK RKCFVFDRPT NDKDLLANIE
260 270 280 290 300
KVSEKQLDPK FQEQTNIFCS YIFTHARTKT LREGITVTGN RLGTLAVTYV
310 320 330 340 350
EAINSGAVPC LENAVITLAQ RENSAAVQRA ADYYSQQMAQ RVKLPTDTLQ
360 370 380 390 400
ELLDMHAACE REAIAIFMEH SFKDENQEFQ KKFMETTMNK KGDFLLQNEE
410 420 430 440 450
SSVQYCQAKL NELSKGLMES ISAGSFSVPG GHKLYMETKE RIEQDYWQVP
460 470 480 490 500
RKGVKAKEVF QRFLESQMVI EESILQSDKA LTDREKAVAV DRAKKEAAEK
510 520 530 540 550
EQELLKQKLQ EQQQQMEAQD KSRKENIAQL KEKLQMEREH LLREQIMMLE
560 570 580 590 600
HTQKVQNDWL HEGFKKKYEE MNAEISQFKR MIDTTKNDDT PWIARTLDNL
610 620 630
ADELTAILSA PAKLIGHGVK GVSSLFKKHK LPF
Length:633
Mass (Da):72,427
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3487659300D5678
GO
Isoform 2 (identifier: Q6ZN66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-337: Missing.

Show »
Length:296
Mass (Da):34,494
Checksum:i3A1A17E856C484B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13L → Q in CAD97917 (PubMed:17974005).Curated1
Sequence conflicti313N → D in CAD97917 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037750278T → I. Corresponds to variant dbSNP:rs4582772Ensembl.1
Natural variantiVAR_037751331A → S2 PublicationsCorresponds to variant dbSNP:rs4658359Ensembl.1
Natural variantiVAR_037752344L → F3 PublicationsCorresponds to variant dbSNP:rs4658360Ensembl.1
Natural variantiVAR_037753355M → V3 PublicationsCorresponds to variant dbSNP:rs4658146Ensembl.1
Natural variantiVAR_037754520D → V3 PublicationsCorresponds to variant dbSNP:rs959460Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0301551 – 337Missing in isoform 2. 1 PublicationAdd BLAST337

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK131329 mRNA Translation: BAD18489.1
AK131356 mRNA Translation: BAD18509.1
BX537949 mRNA Translation: CAD97917.1
AL691464 Genomic DNA No translation available.
BC131713 mRNA Translation: AAI31714.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS723.1 [Q6ZN66-1]

NCBI Reference Sequences

More...
RefSeqi
NP_940862.2, NM_198460.2 [Q6ZN66-1]
XP_011539137.1, XM_011540835.2 [Q6ZN66-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370456; ENSP00000359485; ENSG00000183347 [Q6ZN66-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
163351

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:163351

UCSC genome browser

More...
UCSCi
uc001dnf.3 human [Q6ZN66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131329 mRNA Translation: BAD18489.1
AK131356 mRNA Translation: BAD18509.1
BX537949 mRNA Translation: CAD97917.1
AL691464 Genomic DNA No translation available.
BC131713 mRNA Translation: AAI31714.1
CCDSiCCDS723.1 [Q6ZN66-1]
RefSeqiNP_940862.2, NM_198460.2 [Q6ZN66-1]
XP_011539137.1, XM_011540835.2 [Q6ZN66-1]

3D structure databases

SMRiQ6ZN66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127864, 3 interactors
IntActiQ6ZN66, 5 interactors
STRINGi9606.ENSP00000359485

PTM databases

iPTMnetiQ6ZN66
PhosphoSitePlusiQ6ZN66

Polymorphism and mutation databases

BioMutaiGBP6
DMDMi74749570

Proteomic databases

EPDiQ6ZN66
jPOSTiQ6ZN66
MaxQBiQ6ZN66
PaxDbiQ6ZN66
PeptideAtlasiQ6ZN66
PRIDEiQ6ZN66
ProteomicsDBi67986
67987 [Q6ZN66-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
163351
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370456; ENSP00000359485; ENSG00000183347 [Q6ZN66-1]
GeneIDi163351
KEGGihsa:163351
UCSCiuc001dnf.3 human [Q6ZN66-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
163351

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GBP6

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0000767
HGNCiHGNC:25395 GBP6
HPAiHPA027744
MIMi612467 gene
neXtProtiNX_Q6ZN66
OpenTargetsiENSG00000183347
PharmGKBiPA134964409

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2037 Eukaryota
ENOG410XR6Z LUCA
GeneTreeiENSGT00940000154265
HOGENOMiHOG000266974
InParanoidiQ6ZN66
KOiK20908
OMAiQNDWLHE
OrthoDBi1027269at2759
PhylomeDBiQ6ZN66
TreeFamiTF331602

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
163351

Protein Ontology

More...
PROi
PR:Q6ZN66

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183347 Expressed in 58 organ(s), highest expression level in esophagus mucosa

Family and domain databases

CDDicd16269 GBP_C, 1 hit
InterProiView protein in InterPro
IPR030386 G_GB1_RHD3_dom
IPR037684 GBP_C
IPR003191 Guanylate-bd/ATL_C
IPR036543 Guanylate-bd_C_sf
IPR015894 Guanylate-bd_N
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02263 GBP, 1 hit
PF02841 GBP_C, 1 hit
SUPFAMiSSF48340 SSF48340, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51715 G_GB1_RHD3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBP6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZN66
Secondary accession number(s): A2RRM3, Q6ZN86, Q7Z3F0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: June 5, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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