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UniProtKB - Q6ZN66 (GBP6_HUMAN)

Entry version 131 (10 Feb 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Guanylate-binding protein 6

Gene

GBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds GTP, GDP and GMP.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi45 – 52GTPBy similarity8
Nucleotide bindingi67 – 69GTPBy similarity3
Nucleotide bindingi97 – 101GTPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZN66

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-877300, Interferon gamma signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanylate-binding protein 6
Alternative name(s):
GTP-binding protein 6
Short name:
GBP-6
Guanine nucleotide-binding protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GBP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25395, GBP6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612467, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZN66

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000183347.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		163351

Open Targets

More...OpenTargetsi		ENSG00000183347

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134964409

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZN66, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GBP6

Domain mapping of disease mutations (DMDM)

More...DMDMi		74749570

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003138111 – 633Guanylate-binding protein 6Add BLAST633

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZN66

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZN66

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZN66

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZN66

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZN66

PeptideAtlas

More...PeptideAtlasi		Q6ZN66

PRoteomics IDEntifications database

More...PRIDEi		Q6ZN66

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67986 [Q6ZN66-1]
67987 [Q6ZN66-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZN66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZN66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183347, Expressed in esophagus and 74 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183347, Group enriched (esophagus, lymphoid tissue, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127864, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZN66, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359485

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZN66, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZN66

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 277GB1/RHD3-type GPROSITE-ProRule annotationAdd BLAST243

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 310GTPase domain (Globular)By similarityAdd BLAST310

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 41Poly-Val4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2037, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154265

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018608_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZN66

Identification of Orthologs from Complete Genome Data

More...OMAi		IMMLEHT

Database of Orthologous Groups

More...OrthoDBi		1027269at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZN66

TreeFam database of animal gene trees

More...TreeFami		TF331602

Family and domain databases

Conserved Domains Database

More...CDDi		cd16269, GBP_C, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030386, G_GB1_RHD3_dom
IPR037684, GBP_C
IPR003191, Guanylate-bd/ATL_C
IPR036543, Guanylate-bd_C_sf
IPR015894, Guanylate-bd_N
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02263, GBP, 1 hit
PF02841, GBP_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48340, SSF48340, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51715, G_GB1_RHD3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZN66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESGPKMLAP VCLVENNNEQ LLVNQQAIQI LEKISQPVVV VAIVGLYRTG 
        60         70         80         90        100
KSYLMNHLAG QNHGFPLGST VQSETKGIWM WCVPHPSKPN HTLVLLDTEG 
       110        120        130        140        150
LGDVEKGDPK NDSWIFALAV LLCSTFVYNS MSTINHQALE QLHYVTELTE 
       160        170        180        190        200
LIKAKSSPRP DGVEDSTEFV SFFPDFLWTV RDFTLELKLN GHPITEDEYL 
       210        220        230        240        250
ENALKLIQGN NPRVQTSNFP RECIRRFFPK RKCFVFDRPT NDKDLLANIE 
       260        270        280        290        300
KVSEKQLDPK FQEQTNIFCS YIFTHARTKT LREGITVTGN RLGTLAVTYV 
       310        320        330        340        350
EAINSGAVPC LENAVITLAQ RENSAAVQRA ADYYSQQMAQ RVKLPTDTLQ 
       360        370        380        390        400
ELLDMHAACE REAIAIFMEH SFKDENQEFQ KKFMETTMNK KGDFLLQNEE 
       410        420        430        440        450
SSVQYCQAKL NELSKGLMES ISAGSFSVPG GHKLYMETKE RIEQDYWQVP 
       460        470        480        490        500
RKGVKAKEVF QRFLESQMVI EESILQSDKA LTDREKAVAV DRAKKEAAEK 
       510        520        530        540        550
EQELLKQKLQ EQQQQMEAQD KSRKENIAQL KEKLQMEREH LLREQIMMLE 
       560        570        580        590        600
HTQKVQNDWL HEGFKKKYEE MNAEISQFKR MIDTTKNDDT PWIARTLDNL 
       610        620        630 
ADELTAILSA PAKLIGHGVK GVSSLFKKHK LPF
Length:633
Mass (Da):72,427
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3487659300D5678
GO
Isoform 2 (identifier: Q6ZN66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-337: Missing.

Show »
Length:296
Mass (Da):34,494
Checksum:i3A1A17E856C484B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13L → Q in CAD97917 (PubMed:17974005).Curated1
Sequence conflicti313N → D in CAD97917 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037750278T → I. Corresponds to variant dbSNP:rs4582772Ensembl.1
Natural variantiVAR_037751331A → S2 PublicationsCorresponds to variant dbSNP:rs4658359Ensembl.1
Natural variantiVAR_037752344L → F3 PublicationsCorresponds to variant dbSNP:rs4658360Ensembl.1
Natural variantiVAR_037753355M → V3 PublicationsCorresponds to variant dbSNP:rs4658146Ensembl.1
Natural variantiVAR_037754520D → V3 PublicationsCorresponds to variant dbSNP:rs959460Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0301551 – 337Missing in isoform 2. 1 PublicationAdd BLAST337

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK131329 mRNA Translation: BAD18489.1
AK131356 mRNA Translation: BAD18509.1
BX537949 mRNA Translation: CAD97917.1
AL691464 Genomic DNA No translation available.
BC131713 mRNA Translation: AAI31714.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS723.1 [Q6ZN66-1]

NCBI Reference Sequences

More...RefSeqi		NP_940862.2, NM_198460.2 [Q6ZN66-1]
XP_011539137.1, XM_011540835.2 [Q6ZN66-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370456; ENSP00000359485; ENSG00000183347 [Q6ZN66-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		163351

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:163351

UCSC genome browser

More...UCSCi		uc001dnf.3, human [Q6ZN66-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131329 mRNA Translation: BAD18489.1
AK131356 mRNA Translation: BAD18509.1
BX537949 mRNA Translation: CAD97917.1
AL691464 Genomic DNA No translation available.
BC131713 mRNA Translation: AAI31714.1
CCDSiCCDS723.1 [Q6ZN66-1]
RefSeqiNP_940862.2, NM_198460.2 [Q6ZN66-1]
XP_011539137.1, XM_011540835.2 [Q6ZN66-1]

3D structure databases

SMRiQ6ZN66
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127864, 8 interactors
IntActiQ6ZN66, 8 interactors
STRINGi9606.ENSP00000359485

PTM databases

iPTMnetiQ6ZN66
PhosphoSitePlusiQ6ZN66

Genetic variation databases

BioMutaiGBP6
DMDMi74749570

Proteomic databases

EPDiQ6ZN66
jPOSTiQ6ZN66
MassIVEiQ6ZN66
MaxQBiQ6ZN66
PaxDbiQ6ZN66
PeptideAtlasiQ6ZN66
PRIDEiQ6ZN66
ProteomicsDBi67986 [Q6ZN66-1]
67987 [Q6ZN66-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33619, 84 antibodies

The DNASU plasmid repository

More...DNASUi		163351

Genome annotation databases

EnsembliENST00000370456; ENSP00000359485; ENSG00000183347 [Q6ZN66-1]
GeneIDi163351
KEGGihsa:163351
UCSCiuc001dnf.3, human [Q6ZN66-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		163351
DisGeNETi163351

GeneCards: human genes, protein and diseases

More...GeneCardsi		GBP6
HGNCiHGNC:25395, GBP6
HPAiENSG00000183347, Group enriched (esophagus, lymphoid tissue, tongue)
MIMi612467, gene
neXtProtiNX_Q6ZN66
OpenTargetsiENSG00000183347
PharmGKBiPA134964409
VEuPathDBiHostDB:ENSG00000183347.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2037, Eukaryota
GeneTreeiENSGT00940000154265
HOGENOMiCLU_018608_2_1_1
InParanoidiQ6ZN66
OMAiIMMLEHT
OrthoDBi1027269at2759
PhylomeDBiQ6ZN66
TreeFamiTF331602

Enzyme and pathway databases

PathwayCommonsiQ6ZN66
ReactomeiR-HSA-877300, Interferon gamma signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		163351, 3 hits in 869 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		163351
PharosiQ6ZN66, Tbio

Protein Ontology

More...PROi		PR:Q6ZN66
RNActiQ6ZN66, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183347, Expressed in esophagus and 74 other tissues

Family and domain databases

CDDicd16269, GBP_C, 1 hit
InterProiView protein in InterPro
IPR030386, G_GB1_RHD3_dom
IPR037684, GBP_C
IPR003191, Guanylate-bd/ATL_C
IPR036543, Guanylate-bd_C_sf
IPR015894, Guanylate-bd_N
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF02263, GBP, 1 hit
PF02841, GBP_C, 1 hit
SUPFAMiSSF48340, SSF48340, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51715, G_GB1_RHD3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZN66
Secondary accession number(s): A2RRM3, Q6ZN86, Q7Z3F0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: February 10, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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