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UniProtKB - Q6ZN30 (BNC2_HUMAN)

Entry version 148 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Zinc finger protein basonuclin-2

Gene

BNC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri441 – 464C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri833 – 856C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1035 – 1058C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1063 – 1090C2H2-type 4PROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZN30

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein basonuclin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BNC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30988, BNC2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608669, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZN30

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173068.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lower urinary tract obstruction, congenital (LUTO)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by urinary bladder outflow obstruction, which can represent an anatomical blockage or a functional obstruction. The most common anatomical causes are posterior urethral valves at the level of the prostatic urethra, a lesion unique to males. Less common are anterior urethral valves, also called urethral atresia, that can occur in either sex. LUTO is an autosomal dominant disease with variable expression.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083492158T → I in LUTO; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs144242525Ensembl.1
Natural variantiVAR_083493346E → Q in LUTO; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs945575406Ensembl.1
Natural variantiVAR_083494853 – 1099Missing in LUTO. 1 PublicationCorresponds to variant dbSNP:rs1350162888Add BLAST247
Natural variantiVAR_083495888H → R in LUTO. 1 PublicationCorresponds to variant dbSNP:rs1563774686EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		54796

MalaCards human disease database

More...MalaCardsi		BNC2
MIMi618612, phenotype

Open Targets

More...OpenTargetsi		ENSG00000173068

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		93110, Posterior urethral valve

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134953132

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZN30, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BNC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000469341 – 1099Zinc finger protein basonuclin-2Add BLAST1099

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki396Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki416Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei561PhosphoserineCombined sources1
Cross-linki641Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki894Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki919Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZN30

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZN30

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZN30

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZN30

PeptideAtlas

More...PeptideAtlasi		Q6ZN30

PRoteomics IDEntifications database

More...PRIDEi		Q6ZN30

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67969 [Q6ZN30-1]
67970 [Q6ZN30-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZN30

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZN30

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis, uterus and small intestine, and weakly expressed in colon and prostate. Also expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa and HEK293 cells. Not detected in blood, thymus, spleen or Hep-G2 cells.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In a 7-week embryo, expressed in the urogenital sinus, the precursor of the bladder, and its outflow tract. The most prominent expression is in the primitive urothelium, and there is weaker expression in the surrounding mesenchyme. Expression also detected in the urothelium of the adult male urethra.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173068, Expressed in sural nerve and 209 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZN30, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZN30, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173068, Tissue enhanced (endometrium, ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120155, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZN30, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370047

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZN30, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi534 – 614Pro-richSequence analysisAdd BLAST81

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri441 – 464C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri833 – 856C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1035 – 1058C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1063 – 1090C2H2-type 4PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QR8N, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005844

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZN30

Identification of Orthologs from Complete Genome Data

More...OMAi		GTHFINP

Database of Orthologous Groups

More...OrthoDBi		96985at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZN30

TreeFam database of animal gene trees

More...TreeFami		TF350399

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040436, Disconnected-like
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR15021, PTHR15021, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q6ZN30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHLGPTPPP HSLNYKSEDR LSEQDWPAYF KVPCCGVDTS QIESEEAEVD 
        60         70         80         90        100
VRERETQRDR EPKRARDLTL RDSCTDNSMQ FGTRTTTAEP GFMGTWQNAD 
       110        120        130        140        150
TNLLFRMSQQ AIRCTLVNCT CECFQPGKIN LRTCDQCKHG WVAHALDKLS 
       160        170        180        190        200
TQHLYHPTQV EIVQSNVVFD ISSLMLYGTQ AVPVRLKILL DRLFSVLKQE 
       210        220        230        240        250
EVLHILHGLG WTLRDYVRGY ILQDAAGKVL DRWAIMSREE EIITLQQFLR 
       260        270        280        290        300
FGETKSIVEL MAIQEKEGQA VAVPSSKTDS DIRTFIESNN RTRSPSLLAH 
       310        320        330        340        350
LENSNPSSIH HFENIPNSLA FLLPFQYINP VSAPLLGLPP NGLLLEQPGL 
       360        370        380        390        400
RLREPSLSTQ NEYNESSESE VSPTPYKNDQ TPNRNALTSI TNVEPKTEPA 
       410        420        430        440        450
CVSPIQNSAP VSDLTKTEHP KSSFRIHRMR RMGSASRKGR VFCNACGKTF 
       460        470        480        490        500
YDKGTLKIHY NAVHLKIKHR CTIEGCNMVF SSLRSRNRHS ANPNPRLHMP 
       510        520        530        540        550
MLRNNRDKDL IRATSGAATP VIASTKSNLA LTSPGRPPMG FTTPPLDPVL 
       560        570        580        590        600
QNPLPSQLVF SGLKTVQPVP PFYRSLLTPG EMVSPPTSLP TSPIIPTSGT 
       610        620        630        640        650
IEQHPPPPSE PVVPAVMMAT HEPSADLAPK KKPRKSSMPV KIEKEIIDTA 
       660        670        680        690        700
DEFDDEDDDP NDGGAVVNDM SHDNHCHSQE EMSPGMSVKD FSKHNRTRCI 
       710        720        730        740        750
SRTEIRRADS MTSEDQEPER DYENESESSE PKLGEESMEG DEHIHSEVSE 
       760        770        780        790        800
KVLMNSERPD ENHSEPSHQD VIKVKEEFTD PTYDMFYMSQ YGLYNGGGAS 
       810        820        830        840        850
MAALHESFTS SLNYGSPQKF SPEGDLCSSP DPKICYVCKK SFKSSYSVKL 
       860        870        880        890        900
HYRNVHLKEM HVCTVAGCNA AFPSRRSRDR HSANINLHRK LLTKELDDMG 
       910        920        930        940        950
LDSSQPSLSK DLRDEFLVKI YGAQHPMGLD VREDASSPAG TEDSHLNGYG 
       960        970        980        990       1000
RGMAEDYMVL DLSTTSSLQS SSSIHSSRES DAGSDEGILL DDIDGASDSG 
      1010       1020       1030       1040       1050
ESAHKAEAPA LPGSLGAEVS GSLMFSSLSG SNGGIMCNIC HKMYSNKGTL 
      1060       1070       1080       1090 
RVHYKTVHLR EMHKCKVPGC NMMFSSVRSR NRHSQNPNLH KNIPFTSVD
Length:1,099
Mass (Da):122,330
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1601EACD158D3D3
GO
Isoform 2Curated (identifier: Q6ZN30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     881-903: HSANINLHRKLLTKELDDMGLDS → YWEKSNEQNGLLVSWGETLSSLK
     904-1099: Missing.

Show »
Length:903
Mass (Da):101,333
Checksum:iCDE800F776B4644F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1APH0B1APH0_HUMAN
Zinc finger protein basonuclin-2
BNC2
1,032Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H586F5H586_HUMAN
Zinc finger protein basonuclin-2
BNC2
729Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6W5H0Y6W5_HUMAN
Zinc finger protein basonuclin-2
BNC2
860Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3K9S4R3K9_HUMAN
Zinc finger protein basonuclin-2
BNC2
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4J1H0Y4J1_HUMAN
Zinc finger protein basonuclin-2
BNC2
327Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3X5S4R3X5_HUMAN
Zinc finger protein basonuclin-2
BNC2
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3R8S4R3R8_HUMAN
Zinc finger protein basonuclin-2
BNC2
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q06HB9Q06HB9_HUMAN
Basonuclin 2
BNC2
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R351S4R351_HUMAN
Zinc finger protein basonuclin-2
BNC2
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q06HC7Q06HC7_HUMAN
Basonuclin 2
BNC2
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAR99389 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA90908 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15269 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC03837 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti560F → L in BAC03837 (PubMed:14702039).Curated1
Sequence conflicti630K → T in BAC03837 (PubMed:14702039).Curated1
Sequence conflicti797G → E in BAB15269 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083492158T → I in LUTO; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs144242525Ensembl.1
Natural variantiVAR_083493346E → Q in LUTO; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs945575406Ensembl.1
Natural variantiVAR_052707550L → V. Corresponds to variant dbSNP:rs4961490EnsemblClinVar.1
Natural variantiVAR_033543782T → A. Corresponds to variant dbSNP:rs3739714Ensembl.1
Natural variantiVAR_083494853 – 1099Missing in LUTO. 1 PublicationCorresponds to variant dbSNP:rs1350162888Add BLAST247
Natural variantiVAR_083495888H → R in LUTO. 1 PublicationCorresponds to variant dbSNP:rs1563774686EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051873881 – 903HSANI…MGLDS → YWEKSNEQNGLLVSWGETLS SLK in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_051874904 – 1099Missing in isoform 2. 1 PublicationAdd BLAST196

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000050 mRNA Translation: BAA90908.1 Different initiation.
AK025882 mRNA Translation: BAB15269.1 Different initiation.
AK092247 mRNA Translation: BAC03837.1 Different initiation.
AK131398 mRNA Translation: BAD18545.1
AL449983 Genomic DNA No translation available.
AL450003 Genomic DNA No translation available.
AL450105 Genomic DNA No translation available.
AY438376 mRNA Translation: AAR99389.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6482.2 [Q6ZN30-1]

NCBI Reference Sequences

More...RefSeqi		NP_060107.3, NM_017637.5 [Q6ZN30-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000380672; ENSP00000370047; ENSG00000173068 [Q6ZN30-1]
ENST00000484726; ENSP00000431516; ENSG00000173068 [Q6ZN30-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54796

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54796

UCSC genome browser

More...UCSCi		uc003zml.4, human [Q6ZN30-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000050 mRNA Translation: BAA90908.1 Different initiation.
AK025882 mRNA Translation: BAB15269.1 Different initiation.
AK092247 mRNA Translation: BAC03837.1 Different initiation.
AK131398 mRNA Translation: BAD18545.1
AL449983 Genomic DNA No translation available.
AL450003 Genomic DNA No translation available.
AL450105 Genomic DNA No translation available.
AY438376 mRNA Translation: AAR99389.1 Different initiation.
CCDSiCCDS6482.2 [Q6ZN30-1]
RefSeqiNP_060107.3, NM_017637.5 [Q6ZN30-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120155, 7 interactors
IntActiQ6ZN30, 4 interactors
STRINGi9606.ENSP00000370047

PTM databases

iPTMnetiQ6ZN30
PhosphoSitePlusiQ6ZN30

Genetic variation databases

BioMutaiBNC2
DMDMi74762393

Proteomic databases

EPDiQ6ZN30
MassIVEiQ6ZN30
MaxQBiQ6ZN30
PaxDbiQ6ZN30
PeptideAtlasiQ6ZN30
PRIDEiQ6ZN30
ProteomicsDBi67969 [Q6ZN30-1]
67970 [Q6ZN30-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10169, 79 antibodies

The DNASU plasmid repository

More...DNASUi		54796

Genome annotation databases

EnsembliENST00000380672; ENSP00000370047; ENSG00000173068 [Q6ZN30-1]
ENST00000484726; ENSP00000431516; ENSG00000173068 [Q6ZN30-2]
GeneIDi54796
KEGGihsa:54796
UCSCiuc003zml.4, human [Q6ZN30-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54796
DisGeNETi54796

GeneCards: human genes, protein and diseases

More...GeneCardsi		BNC2
HGNCiHGNC:30988, BNC2
HPAiENSG00000173068, Tissue enhanced (endometrium, ovary)
MalaCardsiBNC2
MIMi608669, gene
618612, phenotype
neXtProtiNX_Q6ZN30
OpenTargetsiENSG00000173068
Orphaneti93110, Posterior urethral valve
PharmGKBiPA134953132
VEuPathDBiHostDB:ENSG00000173068.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QR8N, Eukaryota
GeneTreeiENSGT00390000005844
InParanoidiQ6ZN30
OMAiGTHFINP
OrthoDBi96985at2759
PhylomeDBiQ6ZN30
TreeFamiTF350399

Enzyme and pathway databases

PathwayCommonsiQ6ZN30

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54796, 13 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BNC2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BNC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54796
PharosiQ6ZN30, Tbio

Protein Ontology

More...PROi		PR:Q6ZN30
RNActiQ6ZN30, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173068, Expressed in sural nerve and 209 other tissues
ExpressionAtlasiQ6ZN30, baseline and differential
GenevisibleiQ6ZN30, HS

Family and domain databases

InterProiView protein in InterPro
IPR040436, Disconnected-like
IPR013087, Znf_C2H2_type
PANTHERiPTHR15021, PTHR15021, 1 hit
PfamiView protein in Pfam
PF00096, zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 6 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBNC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZN30
Secondary accession number(s): B1APG9
, Q6T3A3, Q8NAR2, Q9H6J0, Q9NXV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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