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Entry version 113 (08 May 2019)
Sequence version 2 (08 Apr 2008)
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Protein

Metastasis-associated in colon cancer protein 1

Gene

MACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Growth factor, Mitogen
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metastasis-associated in colon cancer protein 1
Alternative name(s):
SH3 domain-containing protein 7a5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30215 MACC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612646 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZN28

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
346389

Open Targets

More...
OpenTargetsi
ENSG00000183742

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164722150

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MACC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
182627616

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003290321 – 852Metastasis-associated in colon cancer protein 1Add BLAST852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZN28

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZN28

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZN28

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZN28

PeptideAtlas

More...
PeptideAtlasi
Q6ZN28

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZN28

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67968

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZN28

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZN28

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in metastasizing tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183742 Expressed in 99 organ(s), highest expression level in intestine

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZN28 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB068194
HPA020081
HPA020103
HPA029476

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FASLG.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131381, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZN28, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383185

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZN28

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini212 – 349ZU5PROSITE-ProRule annotationAdd BLAST138
Domaini549 – 619SH3PROSITE-ProRule annotationAdd BLAST71

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHUQ Eukaryota
ENOG410YRKQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013151

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015297

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZN28

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAWLSHR

Database of Orthologous Groups

More...
OrthoDBi
140316at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZN28

TreeFam database of animal gene trees

More...
TreeFami
TF105572

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001452 SH3_domain
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00791 ZU5, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit
PS51145 ZU5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ZN28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLITERKHFR SGRIAQSMSE ANLIDMEAGK LSKSCNITEC QDPDLLHNWP
60 70 80 90 100
DAFTLRGNNA SKVANPFWNQ LSASNPFLDD ITQLRNNRKR NNISILKEDP
110 120 130 140 150
FLFCREIENG NSFDSSGDEL DVHQLLRQTS SRNSGRSKSV SELLDILDDT
160 170 180 190 200
AHAHQSIHNS DQILLHDLEW LKNDREAYKM AWLSQRQLAR SCLDLNTISQ
210 220 230 240 250
SPGWAQTQLA EVTIACKVNH QGGSVQLPES DITVHVPQGH VAVGEFQEVS
260 270 280 290 300
LRAFLDPPHM LNHDLSCTVS PLLEIMLGNL NTMEALLLEM KIGAEVRKDP
310 320 330 340 350
FSQVMTEMVC LHSLGKEGPF KVLSNCYIYK DTIQVKLIDL SQVMYLVVAA
360 370 380 390 400
QAKALPSPAA TIWDYIHKTT SIGIYGPKYI HPSFTVVLTV CGHNYMPGQL
410 420 430 440 450
TISDIKKGGK NISPVVFQLW GKQSFLLDKP QDLSISIFSC DPDFEVKTEG
460 470 480 490 500
ERKEIKQKQL EAGEVVHQQF LFSLVEHREM HLFDFCVQVE PPNGEPVAQF
510 520 530 540 550
SITTPDPTPN LKRLSNLPGY LQKKEEIKSA PLSPKILVKY PTFQDKTLNF
560 570 580 590 600
SNYGVTLKAV LRQSKIDYFL EYFKGDTIAL LGEGKVKAIG QSKVKEWYVG
610 620 630 640 650
VLRGKIGLVH CKNVKVISKE QVMFMSDSVF TTRNLLEQIV LPLKKLTYIY
660 670 680 690 700
SVVLTLVSEK VYDWKVLADV LGYSHLSLED FDQIQADKES EKVSYVIKKL
710 720 730 740 750
KEDCHTERNT RKFLYELIVA LLKMDCQELV ARLIQEAAVL TSAVKLGKGW
760 770 780 790 800
RELAEKLVRL TKQQMEAYEI PHRGNTGDVA VEMMWKPAYD FLYTWSAHYG
810 820 830 840 850
NNYRDVLQDL QSALDRMKNP VTKHWRELTG VLILVNSLEV LRVTAFSTSE

EV
Length:852
Mass (Da):96,639
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9272110E1F91489A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC87646 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW93719 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171L → P in BAD18547 (PubMed:14702039).Curated1
Sequence conflicti264D → N in BAD18547 (PubMed:14702039).Curated1
Sequence conflicti383S → N in BAD18547 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04262031L → V1 PublicationCorresponds to variant dbSNP:rs4721888Ensembl.1
Natural variantiVAR_04262150P → L. Corresponds to variant dbSNP:rs17142503Ensembl.1
Natural variantiVAR_042622515S → L1 PublicationCorresponds to variant dbSNP:rs975263Ensembl.1
Natural variantiVAR_042623728E → A. Corresponds to variant dbSNP:rs12671170Ensembl.1
Natural variantiVAR_042624804R → T1 PublicationCorresponds to variant dbSNP:rs3735615Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ313524 mRNA Translation: CAC86408.1
AK128850 mRNA Translation: BAC87646.1 Different initiation.
AK131400 mRNA Translation: BAD18547.1
CH236948 Genomic DNA Translation: EAL24276.1
AC007001 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93719.1 Sequence problems.
BC137090 mRNA Translation: AAI37091.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5369.1

NCBI Reference Sequences

More...
RefSeqi
NP_877439.3, NM_182762.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332878; ENSP00000328410; ENSG00000183742
ENST00000400331; ENSP00000383185; ENSG00000183742
ENST00000589011; ENSP00000466864; ENSG00000183742

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
346389

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:346389

UCSC genome browser

More...
UCSCi
uc003sus.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313524 mRNA Translation: CAC86408.1
AK128850 mRNA Translation: BAC87646.1 Different initiation.
AK131400 mRNA Translation: BAD18547.1
CH236948 Genomic DNA Translation: EAL24276.1
AC007001 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93719.1 Sequence problems.
BC137090 mRNA Translation: AAI37091.1
CCDSiCCDS5369.1
RefSeqiNP_877439.3, NM_182762.3

3D structure databases

SMRiQ6ZN28
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131381, 8 interactors
IntActiQ6ZN28, 2 interactors
STRINGi9606.ENSP00000383185

PTM databases

iPTMnetiQ6ZN28
PhosphoSitePlusiQ6ZN28

Polymorphism and mutation databases

BioMutaiMACC1
DMDMi182627616

Proteomic databases

EPDiQ6ZN28
jPOSTiQ6ZN28
MaxQBiQ6ZN28
PaxDbiQ6ZN28
PeptideAtlasiQ6ZN28
PRIDEiQ6ZN28
ProteomicsDBi67968

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332878; ENSP00000328410; ENSG00000183742
ENST00000400331; ENSP00000383185; ENSG00000183742
ENST00000589011; ENSP00000466864; ENSG00000183742
GeneIDi346389
KEGGihsa:346389
UCSCiuc003sus.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
346389
DisGeNETi346389

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MACC1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0025430
HGNCiHGNC:30215 MACC1
HPAiCAB068194
HPA020081
HPA020103
HPA029476
MIMi612646 gene
neXtProtiNX_Q6ZN28
OpenTargetsiENSG00000183742
PharmGKBiPA164722150

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHUQ Eukaryota
ENOG410YRKQ LUCA
GeneTreeiENSGT00390000013151
HOGENOMiHOG000015297
InParanoidiQ6ZN28
OMAiMAWLSHR
OrthoDBi140316at2759
PhylomeDBiQ6ZN28
TreeFamiTF105572

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
346389

Protein Ontology

More...
PROi
PR:Q6ZN28

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183742 Expressed in 99 organ(s), highest expression level in intestine
GenevisibleiQ6ZN28 HS

Family and domain databases

InterProiView protein in InterPro
IPR001452 SH3_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00791 ZU5, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
PS51145 ZU5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMACC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZN28
Secondary accession number(s): A8MUS5
, B2RNR9, Q6ZQN8, Q7Z5A5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 8, 2019
This is version 113 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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