UniProtKB - Q6ZN28 (MACC1_HUMAN)
Protein
Metastasis-associated in colon cancer protein 1
Gene
MACC1
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.1 Publication
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Keywordsi
Molecular function | Activator, Growth factor, Mitogen |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6ZN28 |
Names & Taxonomyi
Protein namesi | Recommended name: Metastasis-associated in colon cancer protein 1Alternative name(s): SH3 domain-containing protein 7a5 |
Gene namesi | Name:MACC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30215, MACC1 |
MIMi | 612646, gene |
neXtProti | NX_Q6ZN28 |
VEuPathDBi | HostDB:ENSG00000183742.12 |
Subcellular locationi
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 346389 |
OpenTargetsi | ENSG00000183742 |
PharmGKBi | PA164722150 |
Miscellaneous databases
Pharosi | Q6ZN28, Tbio |
Genetic variation databases
BioMutai | MACC1 |
DMDMi | 182627616 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000329032 | 1 – 852 | Metastasis-associated in colon cancer protein 1Add BLAST | 852 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6ZN28 |
jPOSTi | Q6ZN28 |
MassIVEi | Q6ZN28 |
MaxQBi | Q6ZN28 |
PaxDbi | Q6ZN28 |
PeptideAtlasi | Q6ZN28 |
PRIDEi | Q6ZN28 |
ProteomicsDBi | 67968 |
PTM databases
iPTMneti | Q6ZN28 |
PhosphoSitePlusi | Q6ZN28 |
Expressioni
Tissue specificityi
Preferentially expressed in metastasizing tumors.1 Publication
Gene expression databases
Bgeei | ENSG00000183742, Expressed in intestine and 112 other tissues |
Genevisiblei | Q6ZN28, HS |
Organism-specific databases
HPAi | ENSG00000183742, Tissue enhanced (intestine, kidney) |
Interactioni
Subunit structurei
Interacts with FASLG.
1 PublicationGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 131381, 9 interactors |
IntActi | Q6ZN28, 3 interactors |
STRINGi | 9606.ENSP00000383185 |
Miscellaneous databases
RNActi | Q6ZN28, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 212 – 349 | ZU5PROSITE-ProRule annotationAdd BLAST | 138 | |
Domaini | 549 – 619 | SH3PROSITE-ProRule annotationAdd BLAST | 71 |
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | ENOG502QZDM, Eukaryota |
GeneTreei | ENSGT00390000013151 |
HOGENOMi | CLU_013080_1_0_1 |
InParanoidi | Q6ZN28 |
OMAi | ILVNCME |
OrthoDBi | 140316at2759 |
PhylomeDBi | Q6ZN28 |
TreeFami | TF105572 |
Family and domain databases
InterProi | View protein in InterPro IPR001452, SH3_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00791, ZU5, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS51145, ZU5, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6ZN28-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLITERKHFR SGRIAQSMSE ANLIDMEAGK LSKSCNITEC QDPDLLHNWP
60 70 80 90 100
DAFTLRGNNA SKVANPFWNQ LSASNPFLDD ITQLRNNRKR NNISILKEDP
110 120 130 140 150
FLFCREIENG NSFDSSGDEL DVHQLLRQTS SRNSGRSKSV SELLDILDDT
160 170 180 190 200
AHAHQSIHNS DQILLHDLEW LKNDREAYKM AWLSQRQLAR SCLDLNTISQ
210 220 230 240 250
SPGWAQTQLA EVTIACKVNH QGGSVQLPES DITVHVPQGH VAVGEFQEVS
260 270 280 290 300
LRAFLDPPHM LNHDLSCTVS PLLEIMLGNL NTMEALLLEM KIGAEVRKDP
310 320 330 340 350
FSQVMTEMVC LHSLGKEGPF KVLSNCYIYK DTIQVKLIDL SQVMYLVVAA
360 370 380 390 400
QAKALPSPAA TIWDYIHKTT SIGIYGPKYI HPSFTVVLTV CGHNYMPGQL
410 420 430 440 450
TISDIKKGGK NISPVVFQLW GKQSFLLDKP QDLSISIFSC DPDFEVKTEG
460 470 480 490 500
ERKEIKQKQL EAGEVVHQQF LFSLVEHREM HLFDFCVQVE PPNGEPVAQF
510 520 530 540 550
SITTPDPTPN LKRLSNLPGY LQKKEEIKSA PLSPKILVKY PTFQDKTLNF
560 570 580 590 600
SNYGVTLKAV LRQSKIDYFL EYFKGDTIAL LGEGKVKAIG QSKVKEWYVG
610 620 630 640 650
VLRGKIGLVH CKNVKVISKE QVMFMSDSVF TTRNLLEQIV LPLKKLTYIY
660 670 680 690 700
SVVLTLVSEK VYDWKVLADV LGYSHLSLED FDQIQADKES EKVSYVIKKL
710 720 730 740 750
KEDCHTERNT RKFLYELIVA LLKMDCQELV ARLIQEAAVL TSAVKLGKGW
760 770 780 790 800
RELAEKLVRL TKQQMEAYEI PHRGNTGDVA VEMMWKPAYD FLYTWSAHYG
810 820 830 840 850
NNYRDVLQDL QSALDRMKNP VTKHWRELTG VLILVNSLEV LRVTAFSTSE
EV
Sequence cautioni
The sequence BAC87646 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW93719 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 171 | L → P in BAD18547 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 264 | D → N in BAD18547 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 383 | S → N in BAD18547 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042620 | 31 | L → V1 PublicationCorresponds to variant dbSNP:rs4721888Ensembl. | 1 | |
Natural variantiVAR_042621 | 50 | P → L. Corresponds to variant dbSNP:rs17142503Ensembl. | 1 | |
Natural variantiVAR_042622 | 515 | S → L1 PublicationCorresponds to variant dbSNP:rs975263Ensembl. | 1 | |
Natural variantiVAR_042623 | 728 | E → A. Corresponds to variant dbSNP:rs12671170Ensembl. | 1 | |
Natural variantiVAR_042624 | 804 | R → T1 PublicationCorresponds to variant dbSNP:rs3735615Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ313524 mRNA Translation: CAC86408.1 AK128850 mRNA Translation: BAC87646.1 Different initiation. AK131400 mRNA Translation: BAD18547.1 CH236948 Genomic DNA Translation: EAL24276.1 AC007001 Genomic DNA No translation available. CH471073 Genomic DNA Translation: EAW93719.1 Sequence problems. BC137090 mRNA Translation: AAI37091.1 |
CCDSi | CCDS5369.1 |
RefSeqi | NP_877439.3, NM_182762.3 |
Genome annotation databases
Ensembli | ENST00000332878; ENSP00000328410; ENSG00000183742 ENST00000400331; ENSP00000383185; ENSG00000183742 ENST00000589011; ENSP00000466864; ENSG00000183742 |
GeneIDi | 346389 |
KEGGi | hsa:346389 |
UCSCi | uc003sus.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ313524 mRNA Translation: CAC86408.1 AK128850 mRNA Translation: BAC87646.1 Different initiation. AK131400 mRNA Translation: BAD18547.1 CH236948 Genomic DNA Translation: EAL24276.1 AC007001 Genomic DNA No translation available. CH471073 Genomic DNA Translation: EAW93719.1 Sequence problems. BC137090 mRNA Translation: AAI37091.1 |
CCDSi | CCDS5369.1 |
RefSeqi | NP_877439.3, NM_182762.3 |
3D structure databases
SMRi | Q6ZN28 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131381, 9 interactors |
IntActi | Q6ZN28, 3 interactors |
STRINGi | 9606.ENSP00000383185 |
PTM databases
iPTMneti | Q6ZN28 |
PhosphoSitePlusi | Q6ZN28 |
Genetic variation databases
BioMutai | MACC1 |
DMDMi | 182627616 |
Proteomic databases
EPDi | Q6ZN28 |
jPOSTi | Q6ZN28 |
MassIVEi | Q6ZN28 |
MaxQBi | Q6ZN28 |
PaxDbi | Q6ZN28 |
PeptideAtlasi | Q6ZN28 |
PRIDEi | Q6ZN28 |
ProteomicsDBi | 67968 |
Protocols and materials databases
Antibodypediai | 11924, 166 antibodies |
Genome annotation databases
Ensembli | ENST00000332878; ENSP00000328410; ENSG00000183742 ENST00000400331; ENSP00000383185; ENSG00000183742 ENST00000589011; ENSP00000466864; ENSG00000183742 |
GeneIDi | 346389 |
KEGGi | hsa:346389 |
UCSCi | uc003sus.5, human |
Organism-specific databases
CTDi | 346389 |
DisGeNETi | 346389 |
GeneCardsi | MACC1 |
HGNCi | HGNC:30215, MACC1 |
HPAi | ENSG00000183742, Tissue enhanced (intestine, kidney) |
MIMi | 612646, gene |
neXtProti | NX_Q6ZN28 |
OpenTargetsi | ENSG00000183742 |
PharmGKBi | PA164722150 |
VEuPathDBi | HostDB:ENSG00000183742.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QZDM, Eukaryota |
GeneTreei | ENSGT00390000013151 |
HOGENOMi | CLU_013080_1_0_1 |
InParanoidi | Q6ZN28 |
OMAi | ILVNCME |
OrthoDBi | 140316at2759 |
PhylomeDBi | Q6ZN28 |
TreeFami | TF105572 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZN28 |
Miscellaneous databases
BioGRID-ORCSi | 346389, 5 hits in 999 CRISPR screens |
ChiTaRSi | MACC1, human |
GenomeRNAii | 346389 |
Pharosi | Q6ZN28, Tbio |
PROi | PR:Q6ZN28 |
RNActi | Q6ZN28, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183742, Expressed in intestine and 112 other tissues |
Genevisiblei | Q6ZN28, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001452, SH3_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00791, ZU5, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS51145, ZU5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MACC1_HUMAN | |
Accessioni | Q6ZN28Primary (citable) accession number: Q6ZN28 Secondary accession number(s): A8MUS5 Q7Z5A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | April 7, 2021 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot