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Entry version 152 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Zinc finger protein 841

Gene

ZNF841

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 16; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 727C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri733 – 755C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri761 – 783C2H2-type 23PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZN19

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 841
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF841
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27611, ZNF841

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZN19

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000197608.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
284371

Open Targets

More...
OpenTargetsi
ENSG00000197608

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162410839

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZN19, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF841

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758703

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003346771 – 808Zinc finger protein 841Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki137Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki791Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6ZN19

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6ZN19

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZN19

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6ZN19

PeptideAtlas

More...
PeptideAtlasi
Q6ZN19

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZN19

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67964 [Q6ZN19-1]
67965 [Q6ZN19-2]
67966 [Q6ZN19-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZN19

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZN19

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197608, Expressed in ectocervix and 112 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZN19, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197608, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
129850, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6ZN19, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000470746

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZN19, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZN19

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 16; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 727C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri733 – 755C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri761 – 783C2H2-type 23PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164553

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_17_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZN19

Identification of Orthologs from Complete Genome Data

More...
OMAi
SRKYGND

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZN19

TreeFam database of animal gene trees

More...
TreeFami
TF343410

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 19 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 22 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 20 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZN19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLEGHESYDT ENFYFREIRK NLQEVDFQWK DGEINYKEGP MTHKNNLTGQ
60 70 80 90 100
RVRHSQGDVE NKHMENQLIL RFQSGLGELQ KFQTAEKIYG CNQIERTVNN
110 120 130 140 150
CFLASPLQRI FPGVQTNISR KYGNDFLQLS LPTQDEKTHI REKPYIGNEC
160 170 180 190 200
GKAFRVSSSL INHQMIHTTE KPYRCNESGK AFHRGSLLTV HQIVHTRGKP
210 220 230 240 250
YQCDVCGRIF RQNSDLVNHR RSHTGDKPYI CNECGKSFSK SSHLAVHQRI
260 270 280 290 300
HTGEKPYKCN RCGKCFSQSS SLATHQTVHT GDKPYKCNEC GKTFKRNSSL
310 320 330 340 350
TAHHIIHAGK KPYTCDVCGK VFYQNSQLVR HQIIHTGETP YKCNECGKVF
360 370 380 390 400
FQRSRLAGHR RIHTGEKPYK CNECGKVFSQ HSHLAVHQRV HTGEKPYKCN
410 420 430 440 450
ECGKAFNWGS LLTVHQRIHT GEKPYKCNVC GKVFNYGGYL SVHMRCHTGE
460 470 480 490 500
KPLHCNKCGM VFTYYSCLAR HQRMHTGEKP YKCNVCGKVF IDSGNLSIHR
510 520 530 540 550
RSHTGEKPFQ CNECGKVFSY YSCLARHRKI HTGEKPYKCN DCGKAYTQRS
560 570 580 590 600
SLTKHLVIHT GENPYHCNEF GEAFIQSSKL ARYHRNPTGE KPHKCSECGR
610 620 630 640 650
TFSHKTSLVY HQRRHTGEMP YKCIECGKVF NSTTTLARHR RIHTGEKPYK
660 670 680 690 700
CNECGKVFRY RSGLARHWSI HTGEKPYKCN ECGKAFRVRS ILLNHQMMHT
710 720 730 740 750
GEKPYKCNEC GKAFIERSNL VYHQRNHTGE KPYKCMECGK AFGRRSCLTK
760 770 780 790 800
HQRIHSSEKP YKCNECGKSY ISRSGLTKHQ IKHAGENLTT KLNVERPLDV

VLTSGIPK
Length:808
Mass (Da):93,148
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD06B2DEE9F14BCE
GO
Isoform 2 (identifier: Q6ZN19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-647: Missing.

Show »
Length:500
Mass (Da):57,630
Checksum:i94C29F61F23F51C6
GO
Isoform 3 (identifier: Q6ZN19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MALPQGSLTF...NTGEKFQAVM

Show »
Length:924
Mass (Da):106,101
Checksum:i1BC02AE07FE5FE16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYV6M0QYV6_HUMAN
Zinc finger protein 841
ZNF841
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0F3M0R0F3_HUMAN
Zinc finger protein 841
ZNF841
512Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04190 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD18493 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti748L → P in BAC04190 (PubMed:14702039).Curated1
Sequence conflicti778K → N in BAC85253 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0407521M → MALPQGSLTFRDVAVEFSQE EWKCLDPVQKALYRDVMLEN YRNLGFLGLCLPDLNIISML EQGKEPWTVVSQVKIARNPN CGECMKGVITGISPKCVIKE LPPIQNSNTGEKFQAVM in isoform 3. 1 Publication1
Alternative sequenceiVSP_033755340 – 647Missing in isoform 2. 1 PublicationAdd BLAST308

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093512 mRNA Translation: BAC04190.1 Different initiation.
AK129938 mRNA Translation: BAC85253.1
AK131334 mRNA Translation: BAD18493.1 Different initiation.
AK131409 mRNA Translation: BAD18556.1
AC011468 Genomic DNA No translation available.
BC136254 mRNA Translation: AAI36255.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46161.1 [Q6ZN19-3]
CCDS82388.1 [Q6ZN19-1]

NCBI Reference Sequences

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RefSeqi
NP_001129971.1, NM_001136499.1 [Q6ZN19-3]
NP_001308278.1, NM_001321349.1 [Q6ZN19-1]
XP_016882145.1, XM_017026656.1
XP_016882146.1, XM_017026657.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389534; ENSP00000374185; ENSG00000197608 [Q6ZN19-3]
ENST00000426391; ENSP00000415453; ENSG00000197608 [Q6ZN19-1]
ENST00000594295; ENSP00000470746; ENSG00000197608 [Q6ZN19-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
284371

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:284371

UCSC genome browser

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UCSCi
uc002pyl.1, human [Q6ZN19-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093512 mRNA Translation: BAC04190.1 Different initiation.
AK129938 mRNA Translation: BAC85253.1
AK131334 mRNA Translation: BAD18493.1 Different initiation.
AK131409 mRNA Translation: BAD18556.1
AC011468 Genomic DNA No translation available.
BC136254 mRNA Translation: AAI36255.1
CCDSiCCDS46161.1 [Q6ZN19-3]
CCDS82388.1 [Q6ZN19-1]
RefSeqiNP_001129971.1, NM_001136499.1 [Q6ZN19-3]
NP_001308278.1, NM_001321349.1 [Q6ZN19-1]
XP_016882145.1, XM_017026656.1
XP_016882146.1, XM_017026657.1

3D structure databases

SMRiQ6ZN19
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129850, 1 interactor
IntActiQ6ZN19, 1 interactor
STRINGi9606.ENSP00000470746

PTM databases

iPTMnetiQ6ZN19
PhosphoSitePlusiQ6ZN19

Genetic variation databases

BioMutaiZNF841
DMDMi74758703

Proteomic databases

jPOSTiQ6ZN19
MassIVEiQ6ZN19
MaxQBiQ6ZN19
PaxDbiQ6ZN19
PeptideAtlasiQ6ZN19
PRIDEiQ6ZN19
ProteomicsDBi67964 [Q6ZN19-1]
67965 [Q6ZN19-2]
67966 [Q6ZN19-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
66958, 58 antibodies

The DNASU plasmid repository

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DNASUi
284371

Genome annotation databases

EnsembliENST00000389534; ENSP00000374185; ENSG00000197608 [Q6ZN19-3]
ENST00000426391; ENSP00000415453; ENSG00000197608 [Q6ZN19-1]
ENST00000594295; ENSP00000470746; ENSG00000197608 [Q6ZN19-3]
GeneIDi284371
KEGGihsa:284371
UCSCiuc002pyl.1, human [Q6ZN19-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
284371
DisGeNETi284371

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF841
HGNCiHGNC:27611, ZNF841
HPAiENSG00000197608, Low tissue specificity
neXtProtiNX_Q6ZN19
OpenTargetsiENSG00000197608
PharmGKBiPA162410839
VEuPathDBiHostDB:ENSG00000197608.11

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000164553
HOGENOMiCLU_002678_17_0_1
InParanoidiQ6ZN19
OMAiSRKYGND
PhylomeDBiQ6ZN19
TreeFamiTF343410

Enzyme and pathway databases

PathwayCommonsiQ6ZN19

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
284371, 5 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF841, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
284371
PharosiQ6ZN19, Tdark

Protein Ontology

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PROi
PR:Q6ZN19
RNActiQ6ZN19, protein

Gene expression databases

BgeeiENSG00000197608, Expressed in ectocervix and 112 other tissues
ExpressionAtlasiQ6ZN19, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 19 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 22 hits
SUPFAMiSSF57667, SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 20 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN841_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZN19
Secondary accession number(s): B9EG58
, Q6ZN82, Q6ZP71, Q8N9U7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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