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Protein

Zinc finger protein AEBP2

Gene

AEBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri261 – 286C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri300 – 322C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-3214841 PKMTs methylate histone lysines

SIGNOR Signaling Network Open Resource

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SIGNORi
Q6ZN18

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein AEBP2
Alternative name(s):
Adipocyte enhancer-binding protein 2
Short name:
AE-binding protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AEBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000139154.14

Human Gene Nomenclature Database

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HGNCi
HGNC:24051 AEBP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617934 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q6ZN18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000139154

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134875401

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3137287

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AEBP2

Domain mapping of disease mutations (DMDM)

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DMDMi
190358163

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003415902 – 517Zinc finger protein AEBP2Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6ZN18

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6ZN18

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6ZN18

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6ZN18

PeptideAtlas

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PeptideAtlasi
Q6ZN18

PRoteomics IDEntifications database

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PRIDEi
Q6ZN18

ProteomicsDB human proteome resource

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ProteomicsDBi
67961
67962 [Q6ZN18-2]
67963 [Q6ZN18-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6ZN18

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6ZN18

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000139154 Expressed in 202 organ(s), highest expression level in epithelial cell of pancreas

CleanEx database of gene expression profiles

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CleanExi
HS_AEBP2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6ZN18 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6ZN18 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA020893
HPA022282

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates. Interacts with EED, EZH2, RBBP4 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2 (By similarity). May also interact with RBBP7.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HMBOX1Q6NT765EBI-10255023,EBI-2549423

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125736, 30 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q6ZN18

Database of interacting proteins

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DIPi
DIP-58581N

Protein interaction database and analysis system

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IntActi
Q6ZN18, 24 interactors

Molecular INTeraction database

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MINTi
Q6ZN18

STRING: functional protein association networks

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STRINGi
9606.ENSP00000381840

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q6ZN18

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1517
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WAIX-ray2.90C/G407-503[»]
5Y0UNMR-A258-357[»]
5Y1UX-ray2.14C/D379-390[»]
6C23electron microscopy3.90P209-503[»]
6C24electron microscopy3.50P209-503[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6ZN18

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6ZN18

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni209 – 294Interaction with RBBP4Add BLAST86
Regioni353 – 517Interaction with SUZ12Add BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 123Glu-richAdd BLAST90
Compositional biasi61 – 205Gly-richAdd BLAST145
Compositional biasi110 – 256Ser-richAdd BLAST147

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 286C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri300 – 322C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000048519

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000033826

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6ZN18

KEGG Orthology (KO)

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KOi
K17452

Identification of Orthologs from Complete Genome Data

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OMAi
RSTPVMM

Database of Orthologous Groups

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OrthoDBi
959457at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6ZN18

TreeFam database of animal gene trees

More...
TreeFami
TF328864

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZN18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAITDMAD LEELSRLSPL PPGSPGSAAR GRAEPPEEEE EEEEEEEEAE
60 70 80 90 100
AEAVAALLLN GGSGGGGGGG GGGVGGGEAE TMSEPSPESA SQAGEDEDEE
110 120 130 140 150
EDDEEEEDES SSSGGGEEES SAESLVGSSG GSSSDETRSL SPGAASSSSG
160 170 180 190 200
DGDGKEGLEE PKGPRGSQGG GGGGSSSSSV VSSGGDEGYG TGGGGSSATS
210 220 230 240 250
GGRRGSLEMS SDGEPLSRMD SEDSISSTIM DVDSTISSGR STPAMMNGQG
260 270 280 290 300
STTSSSKNIA YNCCWDQCQA CFNSSPDLAD HIRSIHVDGQ RGGVFVCLWK
310 320 330 340 350
GCKVYNTPST SQSWLQRHML THSGDKPFKC VVGGCNASFA SQGGLARHVP
360 370 380 390 400
THFSQQNSSK VSSQPKAKEE SPSKAGMNKR RKLKNKRRRS LPRPHDFFDA
410 420 430 440 450
QTLDAIRHRA ICFNLSAHIE SLGKGHSVVF HSTVIAKRKE DSGKIKLLLH
460 470 480 490 500
WMPEDILPDV WVNESERHQL KTKVVHLSKL PKDTALLLDP NIYRTMPQKR
510
LKRTLIRKVF NLYLSKQ
Length:517
Mass (Da):54,467
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C59888ACEE4F9AF
GO
Isoform 2 (identifier: Q6ZN18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-517: Missing.

Show »
Length:503
Mass (Da):52,761
Checksum:i032090A790243D07
GO
Isoform 3 (identifier: Q6ZN18-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.
     217-223: SRMDSED → MYTRRYS

Show »
Length:301
Mass (Da):33,981
Checksum:iDD766CAAB61DADB3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EA50G5EA50_HUMAN
AE binding protein 2, isoform CRA_a
AEBP2 hCG_1811073
274Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZR7F5GZR7_HUMAN
Zinc finger protein AEBP2
AEBP2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYT4H7BYT4_HUMAN
Zinc finger protein AEBP2
AEBP2
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH08H0YH08_HUMAN
Zinc finger protein AEBP2
AEBP2
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15624 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH22220 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD18513 differs from that shown. Reason: Erroneous termination at position 269. Translated as Gln.Curated
The sequence EAW96400 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0343571 – 216Missing in isoform 3. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_034358217 – 223SRMDSED → MYTRRYS in isoform 3. 1 Publication7
Alternative sequenceiVSP_034359504 – 517Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK131361 mRNA Translation: BAD18513.1 Sequence problems.
AK131410 mRNA Translation: BAD18557.1
CH471094 Genomic DNA Translation: EAW96400.1 Different initiation.
BC015624 mRNA Translation: AAH15624.1 Different initiation.
BC022220 mRNA Translation: AAH22220.1 Different initiation.
AB209384 mRNA Translation: BAD92621.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44841.1 [Q6ZN18-1]
CCDS44842.1 [Q6ZN18-2]
CCDS58215.1 [Q6ZN18-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001107648.1, NM_001114176.1 [Q6ZN18-1]
NP_001253972.1, NM_001267043.1 [Q6ZN18-3]
NP_694939.2, NM_153207.4 [Q6ZN18-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.126497

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266508; ENSP00000266508; ENSG00000139154 [Q6ZN18-2]
ENST00000360995; ENSP00000354267; ENSG00000139154 [Q6ZN18-3]
ENST00000398864; ENSP00000381840; ENSG00000139154 [Q6ZN18-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
121536

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:121536

UCSC genome browser

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UCSCi
uc001ree.3 human [Q6ZN18-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131361 mRNA Translation: BAD18513.1 Sequence problems.
AK131410 mRNA Translation: BAD18557.1
CH471094 Genomic DNA Translation: EAW96400.1 Different initiation.
BC015624 mRNA Translation: AAH15624.1 Different initiation.
BC022220 mRNA Translation: AAH22220.1 Different initiation.
AB209384 mRNA Translation: BAD92621.1
CCDSiCCDS44841.1 [Q6ZN18-1]
CCDS44842.1 [Q6ZN18-2]
CCDS58215.1 [Q6ZN18-3]
RefSeqiNP_001107648.1, NM_001114176.1 [Q6ZN18-1]
NP_001253972.1, NM_001267043.1 [Q6ZN18-3]
NP_694939.2, NM_153207.4 [Q6ZN18-2]
UniGeneiHs.126497

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WAIX-ray2.90C/G407-503[»]
5Y0UNMR-A258-357[»]
5Y1UX-ray2.14C/D379-390[»]
6C23electron microscopy3.90P209-503[»]
6C24electron microscopy3.50P209-503[»]
ProteinModelPortaliQ6ZN18
SMRiQ6ZN18
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125736, 30 interactors
CORUMiQ6ZN18
DIPiDIP-58581N
IntActiQ6ZN18, 24 interactors
MINTiQ6ZN18
STRINGi9606.ENSP00000381840

Chemistry databases

BindingDBiQ6ZN18
ChEMBLiCHEMBL3137287

PTM databases

iPTMnetiQ6ZN18
PhosphoSitePlusiQ6ZN18

Polymorphism and mutation databases

BioMutaiAEBP2
DMDMi190358163

Proteomic databases

EPDiQ6ZN18
jPOSTiQ6ZN18
MaxQBiQ6ZN18
PaxDbiQ6ZN18
PeptideAtlasiQ6ZN18
PRIDEiQ6ZN18
ProteomicsDBi67961
67962 [Q6ZN18-2]
67963 [Q6ZN18-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
121536
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266508; ENSP00000266508; ENSG00000139154 [Q6ZN18-2]
ENST00000360995; ENSP00000354267; ENSG00000139154 [Q6ZN18-3]
ENST00000398864; ENSP00000381840; ENSG00000139154 [Q6ZN18-1]
GeneIDi121536
KEGGihsa:121536
UCSCiuc001ree.3 human [Q6ZN18-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
121536
EuPathDBiHostDB:ENSG00000139154.14

GeneCards: human genes, protein and diseases

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GeneCardsi
AEBP2
HGNCiHGNC:24051 AEBP2
HPAiHPA020893
HPA022282
MIMi617934 gene
neXtProtiNX_Q6ZN18
OpenTargetsiENSG00000139154
PharmGKBiPA134875401

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00510000048519
HOGENOMiHOG000033826
InParanoidiQ6ZN18
KOiK17452
OMAiRSTPVMM
OrthoDBi959457at2759
PhylomeDBiQ6ZN18
TreeFamiTF328864

Enzyme and pathway databases

ReactomeiR-HSA-212300 PRC2 methylates histones and DNA
R-HSA-3214841 PKMTs methylate histone lysines
SIGNORiQ6ZN18

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AEBP2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
121536

Protein Ontology

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PROi
PR:Q6ZN18

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139154 Expressed in 202 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_AEBP2
ExpressionAtlasiQ6ZN18 baseline and differential
GenevisibleiQ6ZN18 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAEBP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZN18
Secondary accession number(s): Q59FS5, Q6ZN62, Q96BG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: January 16, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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