MAP3K15

Functionⁱ

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.1 Publication

Catalytic activityⁱ

ATP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-seryl-[protein]
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Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-seryl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells."
  Kaji T., Yoshida S., Kawai K., Fuchigami Y., Watanabe W., Kubodera H., Kishimoto T.
  Biochem. Biophys. Res. Commun. 395:213-218(2010) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
EC:
2.7.11.25
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells."
  Kaji T., Yoshida S., Kawai K., Fuchigami Y., Watanabe W., Kubodera H., Kishimoto T.
  Biochem. Biophys. Res. Commun. 395:213-218(2010) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-seryl-[protein]
L-serine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-seryl-[protein]
O-phospho-L-serine residue
zoom
ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells."
  Kaji T., Yoshida S., Kawai K., Fuchigami Y., Watanabe W., Kubodera H., Kishimoto T.
  Biochem. Biophys. Res. Commun. 395:213-218(2010) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
EC:
2.7.11.25
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells."
  Kaji T., Yoshida S., Kawai K., Fuchigami Y., Watanabe W., Kubodera H., Kishimoto T.
  Biochem. Biophys. Res. Commun. 395:213-218(2010) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-threonyl-[protein]
L-threonine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-threonyl-[protein]
O-phospho-L-threonine residue
zoom

Cofactorⁱ

Mg²⁺By similarity

Activity regulationⁱ

Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-812, inhibited by phosphorylation at Ser-924 and Ser-994 (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	681	ATPPROSITE-ProRule annotation		1
Active siteⁱ	773	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	658 – 666	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPKK activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q6ZN16

SignaLinkⁱ

Q6ZN16

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitogen-activated protein kinase kinase kinase 15 (EC:2.7.11.25) Alternative name(s): Apoptosis signal-regulating kinase 3 MAPK/ERK kinase kinase 15 Short name: MEK kinase 15 Short name: MEKK 15
Gene namesⁱ	Name:MAP3K15 Synonyms:ASK3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180815.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31689 MAP3K15
MIMⁱ	300820 gene
neXtProtⁱ	NX_Q6ZN16

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	389840
Open Targets More...OpenTargetsⁱ	ENSG00000180815
PharmGKBⁱ	PA134935369

Miscellaneous databases

Pharosⁱ	Q6ZN16 Tchem

Pharosⁱ

Q6ZN16 Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL1163127
Drug and drug target database More...DrugBankⁱ	DB12010 Fostamatinib
DrugCentral More...DrugCentralⁱ	Q6ZN16

Polymorphism and mutation databases

BioMutaⁱ	MAP3K15
DMDMⁱ	116248533

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000253481	1 – 1313	Mitogen-activated protein kinase kinase kinase 15Add BLAST		1313

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	994	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-841 CPTAC-842
jPOSTⁱ	Q6ZN16
MassIVEⁱ	Q6ZN16
PaxDbⁱ	Q6ZN16
PeptideAtlas More...PeptideAtlasⁱ	Q6ZN16
PRIDEⁱ	Q6ZN16
ProteomicsDBⁱ	67956 [Q6ZN16-1] 67957 [Q6ZN16-2] 67958 [Q6ZN16-3]

PTM databases

iPTMnetⁱ	Q6ZN16
PhosphoSitePlusⁱ	Q6ZN16

Expressionⁱ

Tissue specificityⁱ

Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000180815 Expressed in 63 organ(s), highest expression level in adrenal tissue
ExpressionAtlasⁱ	Q6ZN16 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA004006

HPAⁱ

HPA004006

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	133293, 5 interactors
IntActⁱ	Q6ZN16, 7 interactors
STRINGⁱ	9606.ENSP00000345629

Chemistry databases

BindingDBⁱ

Q6ZN16

Miscellaneous databases

RNActⁱ	Q6ZN16 protein

RNActⁱ

Q6ZN16 protein

Structureⁱ

3D structure databases

SMRⁱ	Q6ZN16
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	652 – 908	Protein kinasePROSITE-ProRule annotationAdd BLAST		257

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1179 – 1225	Sequence analysisAdd BLAST		47

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4279 Eukaryota ENOG410XQGS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159562
HOGENOMⁱ	HOG000293286
InParanoidⁱ	Q6ZN16
KEGG Orthology (KO) More...KOⁱ	K13986
OMAⁱ	RIWNAIL
Database of Orthologous Groups More...OrthoDBⁱ	226722at2759
PhylomeDBⁱ	Q6ZN16
TreeFamⁱ	TF105115

Family and domain databases

InterProⁱ	View protein in InterPro IPR025136 DUF4071 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR013761 SAM/pointed_sf IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13281 DUF4071, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q6ZN16-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGGGNAPA GALGAASESP QCPPPPGVEG AAGPAEPDGA AEGAAGGSGE 
        60         70         80         90        100
GESGGGPRRA LRAVYVRSES SQGGAAGGPE AGARQCLLRA CEAEGAHLTS 
       110        120        130        140        150
VPFGELDFGE TAVLDAFYDA DVAVVDMSDV SRQPSLFYHL GVRESFDMAN 
       160        170        180        190        200
NVILYHDTDA DTALSLKDMV TQKNTASSGN YYFIPYIVTP CADYFCCESD 
       210        220        230        240        250
AQRRASEYMQ PNWDNILGPL CMPLVDRFIS LLKDIHVTSC VYYKETLLND 
       260        270        280        290        300
IRKAREKYQG EELAKELARI KLRMDNTEVL TSDIIINLLL SYRDIQDYDA 
       310        320        330        340        350
MVKLVETLEM LPTCDLADQH NIKFHYAFAL NRRNSTGDRE KALQIMLQVL 
       360        370        380        390        400
QSCDHPGPDM FCLCGRIYKD IFLDSDCKDD TSRDSAIEWY RKGFELQSSL 
       410        420        430        440        450
YSGINLAVLL IVAGQQFETS LELRKIGVRL NSLLGRKGSL EKMNNYWDVG 
       460        470        480        490        500
QFFSVSMLAH DVGKAVQAAE RLFKLKPPVW YLRSLVQNLL LIRRFKKTII 
       510        520        530        540        550
EHSPRQERLN FWLDIIFEAT NEVTNGLRFP VLVIEPTKVY QPSYVSINNE 
       560        570        580        590        600
AEERTVSLWH VSPTEMKQMH EWNFTASSIK GISLSKFDER CCFLYVHDNS 
       610        620        630        640        650
DDFQIYFSTE EQCSRFFSLV KEMITNTAGS TVELEGETDG DTLEYEYDHD 
       660        670        680        690        700
ANGERVVLGK GTYGIVYAGR DLSNQVRIAI KEIPERDSRY SQPLHEEIAL 
       710        720        730        740        750
HKYLKHRNIV QYLGSVSENG YIKIFMEQVP GGSLSALLRS KWGPMKEPTI 
       760        770        780        790        800
KFYTKQILEG LKYLHENQIV HRDIKGDNVL VNTYSGVVKI SDFGTSKRLA 
       810        820        830        840        850
GVNPCTETFT GTLQYMAPEI IDQGPRGYGA PADIWSLGCT IIEMATSKPP 
       860        870        880        890        900
FHELGEPQAA MFKVGMFKIH PEIPEALSAE ARAFILSCFE PDPHKRATTA 
       910        920        930        940        950
ELLREGFLRQ VNKGKKNRIA FKPSEGPRGV VLALPTQGEP MATSSSEHGS 
       960        970        980        990       1000
VSPDSDAQPD ALFERTRAPR HHLGHLLSVP DESSALEDRG LASSPEDRDQ 
      1010       1020       1030       1040       1050
GLFLLRKDSE RRAILYKILW EEQNQVASNL QECVAQSSEE LHLSVGHIKQ 
      1060       1070       1080       1090       1100
IIGILRDFIR SPEHRVMATT ISKLKVDLDF DSSSISQIHL VLFGFQDAVN 
      1110       1120       1130       1140       1150
KILRNHLIRP HWMFAMDNII RRAVQAAVTI LIPELRAHFE PTCETEGVDK 
      1160       1170       1180       1190       1200
DMDEAEEGYP PATGPGQEAQ PHQQHLSLQL GELRQETNRL LEHLVEKERE 
      1210       1220       1230       1240       1250
YQNLLRQTLE QKTQELYHLQ LKLKSNCITE NPAGPYGQRT DKELIDWLRL 
      1260       1270       1280       1290       1300
QGADAKTIEK IVEEGYTLSD ILNEITKEDL RYLRLRGGLL CRLWSAVSQY 
      1310 
RRAQEASETK DKA

Length:1,313

Mass (Da):147,437

Last modified:October 17, 2006 - v2

Checksum:ⁱ60751706D6AEE3E9

GO

Isoform 2 (identifier: Q6ZN16-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-565: Missing.

« Hide

        10         20         30         40         50
MKQMHEWNFT ASSIKGISLS KFDERCCFLY VHDNSDDFQI YFSTEEQCSR 
        60         70         80         90        100
FFSLVKEMIT NTAGSTVELE GETDGDTLEY EYDHDANGER VVLGKGTYGI 
       110        120        130        140        150
VYAGRDLSNQ VRIAIKEIPE RDSRYSQPLH EEIALHKYLK HRNIVQYLGS 
       160        170        180        190        200
VSENGYIKIF MEQVPGGSLS ALLRSKWGPM KEPTIKFYTK QILEGLKYLH 
       210        220        230        240        250
ENQIVHRDIK GDNVLVNTYS GVVKISDFGT SKRLAGVNPC TETFTGTLQY 
       260        270        280        290        300
MAPEIIDQGP RGYGAPADIW SLGCTIIEMA TSKPPFHELG EPQAAMFKVG 
       310        320        330        340        350
MFKIHPEIPE ALSAEARAFI LSCFEPDPHK RATTAELLRE GFLRQVNKGK 
       360        370        380        390        400
KNRIAFKPSE GPRGVVLALP TQGEPMATSS SEHGSVSPDS DAQPDALFER 
       410        420        430        440        450
TRAPRHHLGH LLSVPDESSA LEDRGLASSP EDRDQGLFLL RKDSERRAIL 
       460        470        480        490        500
YKILWEEQNQ VASNLQECVA QSSEELHLSV GHIKQIIGIL RDFIRSPEHR 
       510        520        530        540        550
VMATTISKLK VDLDFDSSSI SQIHLVLFGF QDAVNKILRN HLIRPHWMFA 
       560        570        580        590        600
MDNIIRRAVQ AAVTILIPEL RAHFEPTCET EGVDKDMDEA EEGYPPATGP 
       610        620        630        640        650
GQEAQPHQQH LSLQLGELRQ ETNRLLEHLV EKEREYQNLL RQTLEQKTQE 
       660        670        680        690        700
LYHLQLKLKS NCITENPAGP YGQRTDKELI DWLRLQGADA KTIEKIVEEG 
       710        720        730        740 
YTLSDILNEI TKEDLRYLRL RGGLLCRLWS AVSQYRRAQE ASETKDKA

Show »

Length:748

Mass (Da):84,729

Checksum:ⁱB062EF833B28DB1C

GO

Isoform 3 (identifier: Q6ZN16-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-525: Missing.
526-582: GLRFPVLVIE...NFTASSIKGI → MACLTHRNET...CLSLQSSWDY

« Hide

        10         20         30         40         50
MACLTHRNET DARMEFYSLF HKGNKAGVQW HDLGSLQPLP PRFKRFSCLS 
        60         70         80         90        100
LQSSWDYSLS KFDERCCFLY VHDNSDDFQI YFSTEEQCSR FFSLVKEMIT 
       110        120        130        140        150
NTAGSTVELE GETDGDTLEY EYDHDANGER VVLGKGTYGI VYAGRDLSNQ 
       160        170        180        190        200
VRIAIKEIPE RDSRYSQPLH EEIALHKYLK HRNIVQYLGS VSENGYIKIF 
       210        220        230        240        250
MEQVPGGSLS ALLRSKWGPM KEPTIKFYTK QILEGLKYLH ENQIVHRDIK 
       260        270        280        290        300
GDNVLVNTYS GVVKISDFGT SKRLAGVNPC TETFTGTLQY MAPEIIDQGP 
       310        320        330        340        350
RGYGAPADIW SLGCTIIEMA TSKPPFHELG EPQAAMFKVG MFKIHPEIPE 
       360        370        380        390        400
ALSAEARAFI LSCFEPDPHK RATTAELLRE GFLRQVNKGK KNRIAFKPSE 
       410        420        430        440        450
GPRGVVLALP TQGEPMATSS SEHGSVSPDS DAQPDALFER TRAPRHHLGH 
       460        470        480        490        500
LLSVPDESSA LEDRGLASSP EDRDQGLFLL RKDSERRAIL YKILWEEQNQ 
       510        520        530        540        550
VASNLQECVA QSSEELHLSV GHIKQIIGIL RDFIRSPEHR VMATTISKLK 
       560        570        580        590        600
VDLDFDSSSI SQIHLVLFGF QDAVNKILRN HLIRPHWMFA MDNIIRRAVQ 
       610        620        630        640        650
AAVTILIPEL RAHFEPTCET EGVDKDMDEA EEGYPPATGP GQEAQPHQQH 
       660        670        680        690        700
LSLQLGELRQ ETNRLLEHLV EKEREYQNLL RQTLEQKTQE LYHLQLKLKS 
       710        720        730        740        750
NCITENPAGP YGQRTDKELI DWLRLQGADA KTIEKIVEEG YTLSDILNEI 
       760        770        780 
TKEDLRYLRL RGGLLCRLWS AVSQYRRAQE ASETKDKA

Show »

Length:788

Mass (Da):89,423

Checksum:ⁱ5C9C9774E3F069F3

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A140T8W5	A0A140T8W5_HUMAN		Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase 15	MAP3K15	283	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	793	F → L in BAD18622 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040716	192	A → T1 PublicationCorresponds to variant dbSNP:rs5909299Ensembl.	1
Natural variantⁱVAR_040717	199	S → N1 PublicationCorresponds to variant dbSNP:rs55916006Ensembl.	1
Natural variantⁱVAR_040718	226	D → H1 PublicationCorresponds to variant dbSNP:rs56338727Ensembl.	1
Natural variantⁱVAR_040719	255	R → S in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040720	456	S → G1 PublicationCorresponds to variant dbSNP:rs56212339Ensembl.	1
Natural variantⁱVAR_040721	494	R → C1 PublicationCorresponds to variant dbSNP:rs41305349Ensembl.	1
Natural variantⁱVAR_040722	562	S → L in a lung adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040723	677	R → Q in a metastatic melanoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040724	838	G → S1 PublicationCorresponds to variant dbSNP:rs56381411Ensembl.	1
Natural variantⁱVAR_040725	993	S → L1 PublicationCorresponds to variant dbSNP:rs56233219Ensembl.	1
Natural variantⁱVAR_040726	1029	N → H1 PublicationCorresponds to variant dbSNP:rs55787622Ensembl.	1
Natural variantⁱVAR_040727	1247	W → R in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040728	1251	Q → E1 PublicationCorresponds to variant dbSNP:rs15943Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_021038	1 – 565	Missing in isoform 2. 1 PublicationAdd BLAST	565
Alternative sequenceⁱVSP_021039	1 – 525	Missing in isoform 3. 1 PublicationAdd BLAST	525
Alternative sequenceⁱVSP_021040	526 – 582	GLRFP…SIKGI → MACLTHRNETDARMEFYSLF HKGNKAGVQWHDLGSLQPLP PRFKRFSCLSLQSSWDY in isoform 3. 1 PublicationAdd BLAST	57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK131412 mRNA Translation: BAD18559.1 AK131477 mRNA Translation: BAD18622.1 AL732326 Genomic DNA No translation available. AL732423 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35212.2 [Q6ZN16-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001001671.3, NM_001001671.3 [Q6ZN16-1] XP_011543813.1, XM_011545511.2 [Q6ZN16-2]

Genome annotation databases

Ensemblⁱ	ENST00000338883; ENSP00000345629; ENSG00000180815 [Q6ZN16-1]
GeneIDⁱ	389840
KEGGⁱ	hsa:389840
UCSC genome browser More...UCSCⁱ	uc004czj.3 human [Q6ZN16-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q6ZN16	Isoform 2 of Mitogen-activated protein kinase kinase kinase 15		HUMAN		748	UniRef100_Q6ZN16
UPI0005D02A8B		HUMAN		871

Protein	Similar proteins		Species	Score	Length	Source
Q6ZN16	Isoform 2 of Mitogen-activated protein kinase kinase kinase 15		HUMAN		748	UniRef90_Q6ZN16
Mitogen-activated protein kinase kinase kinase 15		GORGO		1313
Mitogen-activated protein kinase kinase kinase 15		PANPA		1199
Mitogen-activated protein kinase kinase kinase 15		MANLE		1192
MAP3K15 isoform 4 (Fragment)		PANTR		1138
+10
Q6ZN16-3	Protein kinase domain-containing protein		MACMU		784	UniRef90_Q6ZN16-3
Protein kinase domain-containing protein		MACFA		784

Protein	Similar proteins		Species	Score	Length	Source
Q6ZN16	Mitogen-activated protein kinase kinase kinase 15		MOUSE		1331	UniRef50_Q6ZN16
Isoform 2 of Mitogen-activated protein kinase kinase kinase 15		HUMAN		748
Mitogen-activated protein kinase kinase kinase 15		GORGO		1313
Mitogen-activated protein kinase kinase kinase 15		PANPA		1199
Mitogen-activated protein kinase kinase kinase 15		MANLE		1192
+435
Q6ZN16-3	Protein kinase domain-containing protein		MACMU		784	UniRef50_Q6ZN16-3
Protein kinase domain-containing protein		MACFA		784
Mitogen-activated protein kinase kinase kinase 15 (Fragment)		NOTKU		957
Mitogen-activated protein kinase kinase kinase 15 (Fragment)		yellow-throated sandgrouse		751
Mitogen-activated protein kinase kinase kinase 15 (Fragment)		PHALP		736
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK131412 mRNA Translation: BAD18559.1 AK131477 mRNA Translation: BAD18622.1 AL732326 Genomic DNA No translation available. AL732423 Genomic DNA No translation available.
CCDSⁱ	CCDS35212.2 [Q6ZN16-1]
RefSeqⁱ	NP_001001671.3, NM_001001671.3 [Q6ZN16-1] XP_011543813.1, XM_011545511.2 [Q6ZN16-2]

3D structure databases

SMRⁱ	Q6ZN16
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	133293, 5 interactors
IntActⁱ	Q6ZN16, 7 interactors
STRINGⁱ	9606.ENSP00000345629

Chemistry databases

BindingDBⁱ	Q6ZN16
ChEMBLⁱ	CHEMBL1163127
DrugBankⁱ	DB12010 Fostamatinib
DrugCentralⁱ	Q6ZN16

PTM databases

iPTMnetⁱ	Q6ZN16
PhosphoSitePlusⁱ	Q6ZN16

Polymorphism and mutation databases

BioMutaⁱ	MAP3K15
DMDMⁱ	116248533

Proteomic databases

CPTACⁱ	CPTAC-841 CPTAC-842
jPOSTⁱ	Q6ZN16
MassIVEⁱ	Q6ZN16
PaxDbⁱ	Q6ZN16
PeptideAtlasⁱ	Q6ZN16
PRIDEⁱ	Q6ZN16
ProteomicsDBⁱ	67956 [Q6ZN16-1] 67957 [Q6ZN16-2] 67958 [Q6ZN16-3]

Genome annotation databases

Ensemblⁱ	ENST00000338883; ENSP00000345629; ENSG00000180815 [Q6ZN16-1]
GeneIDⁱ	389840
KEGGⁱ	hsa:389840
UCSCⁱ	uc004czj.3 human [Q6ZN16-1]

Organism-specific databases

CTDⁱ	389840
DisGeNETⁱ	389840
EuPathDBⁱ	HostDB:ENSG00000180815.14
GeneCardsⁱ	MAP3K15
HGNCⁱ	HGNC:31689 MAP3K15
HPAⁱ	HPA004006
MIMⁱ	300820 gene
neXtProtⁱ	NX_Q6ZN16
OpenTargetsⁱ	ENSG00000180815
PharmGKBⁱ	PA134935369
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4279 Eukaryota ENOG410XQGS LUCA
GeneTreeⁱ	ENSGT00940000159562
HOGENOMⁱ	HOG000293286
InParanoidⁱ	Q6ZN16
KOⁱ	K13986
OMAⁱ	RIWNAIL
OrthoDBⁱ	226722at2759
PhylomeDBⁱ	Q6ZN16
TreeFamⁱ	TF105115

Enzyme and pathway databases

SignaLinkⁱ	Q6ZN16

SignaLinkⁱ

Q6ZN16

Miscellaneous databases

ChiTaRSⁱ	MAP3K15 human
GenomeRNAiⁱ	389840
Pharosⁱ	Q6ZN16 Tchem
Protein Ontology More...PROⁱ	PR:Q6ZN16
RNActⁱ	Q6ZN16 protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180815 Expressed in 63 organ(s), highest expression level in adrenal tissue
ExpressionAtlasⁱ	Q6ZN16 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR025136 DUF4071 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR013761 SAM/pointed_sf IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF13281 DUF4071, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M3K15_HUMAN
Accessionⁱ	Q6ZN16Primary (citable) accession number: Q6ZN16 Secondary accession number(s): A2AI49 , A2AI50, A6NJ61, Q5JPR4, Q6ZMV3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	October 17, 2006
	Last modified:	December 11, 2019
	This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q6ZN16 (M3K15_HUMAN)

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Mitogen-activated protein kinase kinase kinase 15

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

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Experimental Info

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ