UniProtKB - Q6ZN11 (ZN793_HUMAN)
Protein
Zinc finger protein 793
Gene
ZNF793
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 227 – 249 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 277 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 283 – 305 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 311 – 333 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 339 – 361 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6ZN11 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 793 |
Gene namesi | Name:ZNF793 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33115, ZNF793 |
neXtProti | NX_Q6ZN11 |
VEuPathDBi | HostDB:ENSG00000188227.12 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 390927 |
OpenTargetsi | ENSG00000188227 |
PharmGKBi | PA162410548 |
Miscellaneous databases
Pharosi | Q6ZN11, Tdark |
Genetic variation databases
BioMutai | ZNF793 |
DMDMi | 527504072 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000293699 | 1 – 406 | Zinc finger protein 793Add BLAST | 406 |
Proteomic databases
MassIVEi | Q6ZN11 |
MaxQBi | Q6ZN11 |
PaxDbi | Q6ZN11 |
PeptideAtlasi | Q6ZN11 |
PRIDEi | Q6ZN11 |
ProteomicsDBi | 20354 67954 [Q6ZN11-1] 67955 [Q6ZN11-2] |
PTM databases
iPTMneti | Q6ZN11 |
PhosphoSitePlusi | Q6ZN11 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188227, Expressed in cerebellum and 225 other tissues |
ExpressionAtlasi | Q6ZN11, baseline and differential |
Genevisiblei | Q6ZN11, HS |
Organism-specific databases
HPAi | ENSG00000188227, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 133738, 2 interactors |
IntActi | Q6ZN11, 2 interactors |
MINTi | Q6ZN11 |
STRINGi | 9606.ENSP00000396402 |
Miscellaneous databases
RNActi | Q6ZN11, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 79 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 227 – 249 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 277 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 283 – 305 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 311 – 333 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 339 – 361 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163141 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | Q6ZN11 |
OMAi | PALMYKP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6ZN11 |
TreeFami | TF340838 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZN11-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIEYQIPVSF KDVVVGFTQE EWHRLSPAQR ALYRDVMLET YSNLVSVGYE
60 70 80 90 100
GTKPDVILRL EQEEAPWIGE AACPGCHCWE DIWRVNIQRK RRQDMLLRPG
110 120 130 140 150
AAISKKTLPK EKSCEYNKFG KISLLSTDLF SSIQSPSNWN PCGKNLNHNL
160 170 180 190 200
DLIGFKRNCA KKQDECYAYG KLLQRINHGR RPNGEKPRGC SHCEKAFTQN
210 220 230 240 250
PALMYKPAVS DSLLYKRKRV PPTEKPHVCS ECGKAFCYKS EFIRHQRSHT
260 270 280 290 300
GEKPYGCTDC GKAFSHKSTL IKHQRIHTGV RPFECFFCGK AFTQKSHRTE
310 320 330 340 350
HQRTHTGERP FVCSECGKSF GEKSYLNVHR KMHTGERPYR CRECGKSFSQ
360 370 380 390 400
KSCLNKHWRT HTGEKPYGCN ECGKAFYQKP NLSRHQKIHA RKNAYRNENL
IIVGNT
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EL37 | K7EL37_HUMAN | Zinc finger protein 793 | ZNF793 | 83 | Annotation score: | ||
K7EMU0 | K7EMU0_HUMAN | Zinc finger protein 793 | ZNF793 | 131 | Annotation score: | ||
K7EN11 | K7EN11_HUMAN | Zinc finger protein 793 | ZNF793 | 138 | Annotation score: | ||
K7EQP3 | K7EQP3_HUMAN | Zinc finger protein 793 | ZNF793 | 93 | Annotation score: | ||
K7ERJ7 | K7ERJ7_HUMAN | Zinc finger protein 793 | ZNF793 | 53 | Annotation score: | ||
A0A0A0MTM4 | A0A0A0MTM4_HUMAN | Zinc finger protein 793 | ZNF793 | 305 | Annotation score: | ||
K7EMH8 | K7EMH8_HUMAN | Zinc finger protein 793 | ZNF793 | 59 | Annotation score: |
Sequence cautioni
The sequence CAD97772 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 45 | V → A in BAD18564 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033107 | 68 | I → M. Corresponds to variant dbSNP:rs12977460Ensembl. | 1 | |
Natural variantiVAR_061967 | 133 | I → V. Corresponds to variant dbSNP:rs45593644Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026564 | 1 – 94 | Missing in isoform 3. 1 PublicationAdd BLAST | 94 | |
Alternative sequenceiVSP_026565 | 362 – 406 | TGEKP…IVGNT → FGESSLRSKSSNT in isoform 2. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131417 mRNA Translation: BAD18564.1 AC022148 Genomic DNA No translation available. BX537524 mRNA Translation: CAD97772.1 Frameshift. |
CCDSi | CCDS46062.1 [Q6ZN11-1] |
RefSeqi | NP_001013681.2, NM_001013659.2 [Q6ZN11-1] XP_005258984.1, XM_005258927.3 [Q6ZN11-1] XP_006723276.1, XM_006723213.3 [Q6ZN11-1] |
Genome annotation databases
Ensembli | ENST00000445217; ENSP00000396402; ENSG00000188227 [Q6ZN11-1] ENST00000587143; ENSP00000468605; ENSG00000188227 [Q6ZN11-1] ENST00000627814; ENSP00000487183; ENSG00000188227 [Q6ZN11-1] |
GeneIDi | 390927 |
KEGGi | hsa:390927 |
UCSCi | uc010xts.3, human [Q6ZN11-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131417 mRNA Translation: BAD18564.1 AC022148 Genomic DNA No translation available. BX537524 mRNA Translation: CAD97772.1 Frameshift. |
CCDSi | CCDS46062.1 [Q6ZN11-1] |
RefSeqi | NP_001013681.2, NM_001013659.2 [Q6ZN11-1] XP_005258984.1, XM_005258927.3 [Q6ZN11-1] XP_006723276.1, XM_006723213.3 [Q6ZN11-1] |
3D structure databases
SMRi | Q6ZN11 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 133738, 2 interactors |
IntActi | Q6ZN11, 2 interactors |
MINTi | Q6ZN11 |
STRINGi | 9606.ENSP00000396402 |
PTM databases
iPTMneti | Q6ZN11 |
PhosphoSitePlusi | Q6ZN11 |
Genetic variation databases
BioMutai | ZNF793 |
DMDMi | 527504072 |
Proteomic databases
MassIVEi | Q6ZN11 |
MaxQBi | Q6ZN11 |
PaxDbi | Q6ZN11 |
PeptideAtlasi | Q6ZN11 |
PRIDEi | Q6ZN11 |
ProteomicsDBi | 20354 67954 [Q6ZN11-1] 67955 [Q6ZN11-2] |
Protocols and materials databases
Antibodypediai | 29906, 40 antibodies |
Genome annotation databases
Ensembli | ENST00000445217; ENSP00000396402; ENSG00000188227 [Q6ZN11-1] ENST00000587143; ENSP00000468605; ENSG00000188227 [Q6ZN11-1] ENST00000627814; ENSP00000487183; ENSG00000188227 [Q6ZN11-1] |
GeneIDi | 390927 |
KEGGi | hsa:390927 |
UCSCi | uc010xts.3, human [Q6ZN11-1] |
Organism-specific databases
CTDi | 390927 |
DisGeNETi | 390927 |
GeneCardsi | ZNF793 |
HGNCi | HGNC:33115, ZNF793 |
HPAi | ENSG00000188227, Low tissue specificity |
neXtProti | NX_Q6ZN11 |
OpenTargetsi | ENSG00000188227 |
PharmGKBi | PA162410548 |
VEuPathDBi | HostDB:ENSG00000188227.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163141 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | Q6ZN11 |
OMAi | PALMYKP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6ZN11 |
TreeFami | TF340838 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZN11 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 390927, 6 hits in 1019 CRISPR screens |
ChiTaRSi | ZNF793, human |
GenomeRNAii | 390927 |
Pharosi | Q6ZN11, Tdark |
PROi | PR:Q6ZN11 |
RNActi | Q6ZN11, protein |
Gene expression databases
Bgeei | ENSG00000188227, Expressed in cerebellum and 225 other tissues |
ExpressionAtlasi | Q6ZN11, baseline and differential |
Genevisiblei | Q6ZN11, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN793_HUMAN | |
Accessioni | Q6ZN11Primary (citable) accession number: Q6ZN11 Secondary accession number(s): E9PGN4, Q7Z3Q9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | July 24, 2013 | |
Last modified: | April 7, 2021 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families