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Protein

RNA-binding protein MEX3B

Gene

MEX3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 558RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein MEX3B
Alternative name(s):
RING finger and KH domain-containing protein 3
RING finger protein 195
Gene namesi
Name:MEX3B
Synonyms:KIAA2009, RKHD3, RNF195
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000183496.5
HGNCiHGNC:25297 MEX3B
MIMi611008 gene
neXtProtiNX_Q6ZN04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi177G → D: Prevents RNA binding. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000183496
PharmGKBiPA162395820

Polymorphism and mutation databases

DMDMi74762391

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002787841 – 569RNA-binding protein MEX3BAdd BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei462Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZN04
MaxQBiQ6ZN04
PaxDbiQ6ZN04
PeptideAtlasiQ6ZN04
PRIDEiQ6ZN04
ProteomicsDBi67950
67951 [Q6ZN04-3]

PTM databases

iPTMnetiQ6ZN04
PhosphoSitePlusiQ6ZN04

Expressioni

Tissue specificityi

Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.1 Publication

Gene expression databases

BgeeiENSG00000183496 Expressed in 106 organ(s), highest expression level in sperm
CleanExiHS_MEX3B
GenevisibleiQ6ZN04 HS

Organism-specific databases

HPAiHPA041093

Interactioni

Protein-protein interaction databases

BioGridi123945, 16 interactors
IntActiQ6ZN04, 5 interactors
MINTiQ6ZN04
STRINGi9606.ENSP00000329918

Structurei

3D structure databases

ProteinModelPortaliQ6ZN04
SMRiQ6ZN04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 127KH 1PROSITE-ProRule annotationAdd BLAST62
Domaini160 – 221KH 2PROSITE-ProRule annotationAdd BLAST62

Domaini

Binds RNA through its KH domains.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 558RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2113 Eukaryota
ENOG410YCYR LUCA
GeneTreeiENSGT00390000018714
HOGENOMiHOG000236282
HOVERGENiHBG071698
InParanoidiQ6ZN04
KOiK15686
OMAiLHPGASC
OrthoDBiEOG091G06LE
PhylomeDBiQ6ZN04
TreeFamiTF315107

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SM00184 RING, 1 hit
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 2 hits
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZN04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSSLFADLE RNGSGGGGGG SSGGGETLDD QRALQLALDQ LSLLGLDSDE
60 70 80 90 100
GASLYDSEPR KKSVNMTECV PVPSSEHVAE IVGRQGCKIK ALRAKTNTYI
110 120 130 140 150
KTPVRGEEPV FVVTGRKEDV AMARREIISA AEHFSMIRAS RNKNTALNGA
160 170 180 190 200
VPGPPNLPGQ TTIQVRVPYR VVGLVVGPKG ATIKRIQQQT HTYIVTPSRD
210 220 230 240 250
KEPVFEVTGM PENVDRAREE IEAHIALRTG GIIELTDEND FHANGTDVGF
260 270 280 290 300
DLHHGSGGSG PGSLWSKPTP SITPTPGRKP FSSYRNDSSS SLGSASTDSY
310 320 330 340 350
FGGGTSSSAA ATQRLADYSP PSPALSFAHN GNNNNNGNGY TYTAGGEASV
360 370 380 390 400
PSPDGCPELQ PTFDPAPAPP PGAPLIWAQF ERSPGGGPAA PVSSSCSSSA
410 420 430 440 450
SSSASSSSVV FPGGGASAPS NANLGLLVHR RLHPGTSCPR LSPPLHMAPG
460 470 480 490 500
AGEHHLARRV RSDPGGGGLA YAAYANGLGA QLPGLQPSDT SGSSSSSSSS
510 520 530 540 550
SSSSSSSSGL RRKGSRDCSV CFESEVIAAL VPCGHNLFCM ECANRICEKS
560
EPECPVCHTA VTQAIRIFS
Length:569
Mass (Da):58,832
Last modified:July 5, 2004 - v1
Checksum:iDA5D014C4D8E1BB8
GO
Isoform 2 (identifier: Q6ZN04-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-158: CKIKALRAKT...GAVPGPPNLP → RSRRDGEVGG...AALAGCTFFC
     159-569: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):16,780
Checksum:i53C7C1A592FF24F2
GO

Sequence cautioni

The sequence BAC23105 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti414G → S in AAH36211 (PubMed:15489334).Curated1
Sequence conflicti536N → S in AAH36211 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04189187 – 158CKIKA…PPNLP → RSRRDGEVGGGGVGSQATAS RGRRVQYRDPRRGVPWGERK SRAMGRRPRQRKCRQAVSRS RAAALAGCTFFC in isoform 2. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_041892159 – 569Missing in isoform 2. 1 PublicationAdd BLAST411

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY950678 mRNA Translation: AAY34146.1
AK131424 mRNA Translation: BAD18571.1
AB095929 mRNA Translation: BAC23105.1 Sequence problems.
BC036211 mRNA Translation: AAH36211.1
BC111545 mRNA Translation: AAI11546.1
AL136778 mRNA Translation: CAB66712.2
CCDSiCCDS10319.1 [Q6ZN04-1]
RefSeqiNP_115622.2, NM_032246.4 [Q6ZN04-1]
UniGeneiHs.104744
Hs.745180

Genome annotation databases

EnsembliENST00000329713; ENSP00000329918; ENSG00000183496 [Q6ZN04-1]
ENST00000558133; ENSP00000456938; ENSG00000183496 [Q6ZN04-3]
GeneIDi84206
KEGGihsa:84206
UCSCiuc002bgq.3 human [Q6ZN04-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY950678 mRNA Translation: AAY34146.1
AK131424 mRNA Translation: BAD18571.1
AB095929 mRNA Translation: BAC23105.1 Sequence problems.
BC036211 mRNA Translation: AAH36211.1
BC111545 mRNA Translation: AAI11546.1
AL136778 mRNA Translation: CAB66712.2
CCDSiCCDS10319.1 [Q6ZN04-1]
RefSeqiNP_115622.2, NM_032246.4 [Q6ZN04-1]
UniGeneiHs.104744
Hs.745180

3D structure databases

ProteinModelPortaliQ6ZN04
SMRiQ6ZN04
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123945, 16 interactors
IntActiQ6ZN04, 5 interactors
MINTiQ6ZN04
STRINGi9606.ENSP00000329918

PTM databases

iPTMnetiQ6ZN04
PhosphoSitePlusiQ6ZN04

Polymorphism and mutation databases

DMDMi74762391

Proteomic databases

EPDiQ6ZN04
MaxQBiQ6ZN04
PaxDbiQ6ZN04
PeptideAtlasiQ6ZN04
PRIDEiQ6ZN04
ProteomicsDBi67950
67951 [Q6ZN04-3]

Protocols and materials databases

DNASUi84206
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329713; ENSP00000329918; ENSG00000183496 [Q6ZN04-1]
ENST00000558133; ENSP00000456938; ENSG00000183496 [Q6ZN04-3]
GeneIDi84206
KEGGihsa:84206
UCSCiuc002bgq.3 human [Q6ZN04-1]

Organism-specific databases

CTDi84206
EuPathDBiHostDB:ENSG00000183496.5
GeneCardsiMEX3B
HGNCiHGNC:25297 MEX3B
HPAiHPA041093
MIMi611008 gene
neXtProtiNX_Q6ZN04
OpenTargetsiENSG00000183496
PharmGKBiPA162395820
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2113 Eukaryota
ENOG410YCYR LUCA
GeneTreeiENSGT00390000018714
HOGENOMiHOG000236282
HOVERGENiHBG071698
InParanoidiQ6ZN04
KOiK15686
OMAiLHPGASC
OrthoDBiEOG091G06LE
PhylomeDBiQ6ZN04
TreeFamiTF315107

Miscellaneous databases

GeneWikiiMEX3B
GenomeRNAii84206
PROiPR:Q6ZN04
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183496 Expressed in 106 organ(s), highest expression level in sperm
CleanExiHS_MEX3B
GenevisibleiQ6ZN04 HS

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SM00184 RING, 1 hit
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 2 hits
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEX3B_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN04
Secondary accession number(s): Q4G0W1, Q8IVG2, Q9H0J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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