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UniProtKB - Q6ZMZ0 (RN19B_HUMAN)

Entry version 157 (07 Apr 2021)
Sequence version 2 (23 Oct 2007)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase RNF19B

Gene

RNF19B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.By similarity EC:2.3.2.31

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi119Zinc 1PROSITE-ProRule annotation1
Metal bindingi122Zinc 1PROSITE-ProRule annotation1
Metal bindingi142Zinc 1PROSITE-ProRule annotation1
Metal bindingi145Zinc 1PROSITE-ProRule annotation1
Metal bindingi206Zinc 2PROSITE-ProRule annotation1
Metal bindingi211Zinc 2PROSITE-ProRule annotation1
Metal bindingi228Zinc 2PROSITE-ProRule annotation1
Metal bindingi233Zinc 2PROSITE-ProRule annotation1
Metal bindingi238Zinc 3PROSITE-ProRule annotation1
Metal bindingi241Zinc 3PROSITE-ProRule annotation1
Metal bindingi246Zinc 3; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi251Zinc 3PROSITE-ProRule annotation1
Metal bindingi287Zinc 4PROSITE-ProRule annotation1
Metal bindingi290Zinc 4PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei302PROSITE-ProRule annotation1
Metal bindingi307Zinc 4PROSITE-ProRule annotation1
Metal bindingi310Zinc 4PROSITE-ProRule annotation1
Metal bindingi315Zinc 5PROSITE-ProRule annotation1
Metal bindingi318Zinc 5PROSITE-ProRule annotation1
Metal bindingi326Zinc 5; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi333Zinc 5PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri119 – 168RING-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri186 – 251IBR-typePROSITE-ProRule annotationAdd BLAST66
Zinc fingeri287 – 318RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processAdaptive immunity, Immunity, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZMZ0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF19B (EC:2.3.2.31By similarity)
Alternative name(s):
IBR domain-containing protein 3
Natural killer lytic-associated molecule
RING finger protein 19B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF19B
Synonyms:IBRDC3, NKLAM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26886, RNF19B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610872, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZMZ0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116514.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		127544

Open Targets

More...OpenTargetsi		ENSG00000116514

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162401626

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZMZ0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RNF19B

Domain mapping of disease mutations (DMDM)

More...DMDMi		160370005

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000841291 – 732E3 ubiquitin-protein ligase RNF19BAdd BLAST732

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZMZ0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6ZMZ0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZMZ0

PeptideAtlas

More...PeptideAtlasi		Q6ZMZ0

PRoteomics IDEntifications database

More...PRIDEi		Q6ZMZ0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19093
33676
67939 [Q6ZMZ0-1]
67940 [Q6ZMZ0-2]
67941 [Q6ZMZ0-3]
67942 [Q6ZMZ0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZMZ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZMZ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells (PubMed:10438909). Present in natural killer cells (at protein level) (PubMed:10912506). Ubiquitously expressed with high expression in testis (PubMed:27485036).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In natural killer cells, by IFNB1/IFN-beta and IL2/interleukin-2 (at protein level) (PubMed:10438909). Up-regulated by endoplasmic reticulum (ER) stress triggered by thapsigargin or tunicamycin (PubMed:27485036).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116514, Expressed in testis and 228 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZMZ0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116514, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBE2L3, UBE2L6 and UCKL1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126065, 83 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZMZ0, 68 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362555

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZMZ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZMZ0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 318Required for ubiquitin ligase activity and for protection against staurosporin-induced cell death1 PublicationAdd BLAST318
Regioni115 – 337TRIAD supradomainPROSITE-ProRule annotationAdd BLAST223

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 32Poly-Arg4
Compositional biasi41 – 97Ala-richAdd BLAST57
Compositional biasi52 – 84Pro-richAdd BLAST33
Compositional biasi625 – 630Poly-Gly6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1.
Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RBR family. RNF19 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri119 – 168RING-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri186 – 251IBR-typePROSITE-ProRule annotationAdd BLAST66
Zinc fingeri287 – 318RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1815, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158451

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016793_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZMZ0

Identification of Orthologs from Complete Genome Data

More...OMAi		LTSDECG

Database of Orthologous Groups

More...OrthoDBi		257621at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZMZ0

TreeFam database of animal gene trees

More...TreeFami		TF324777

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031127, E3_UB_ligase_RBR
IPR002867, IBR_dom
IPR044066, TRIAD_supradom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR11685, PTHR11685, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01485, IBR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00647, IBR, 2 hits
SM00184, RING, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51873, TRIAD, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZMZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSEKDSESP RSTSLHAAAP DPKCRSGGRR RRLTLHSVFS ASARGRRARA 
        60         70         80         90        100
KPQAEPPPPA AQPPPAPAPA AAQGPPPEAL PAEPAAEAEA EAAAAAAEPG 
       110        120        130        140        150
FDDEEAAEGG GPGAEEVECP LCLVRLPPER APRLLSCPHR SCRDCLRHYL 
       160        170        180        190        200
RLEISESRVP ISCPECSERL NPHDIRLLLA DPPLMHKYEE FMLRRYLASD 
       210        220        230        240        250
PDCRWCPAPD CGYAVIAYGC ASCPKLTCER EGCQTEFCYH CKQIWHPNQT 
       260        270        280        290        300
CDMARQQRAQ TLRVRTKHTS GLSYGQESGP ADDIKPCPRC SAYIIKMNDG 
       310        320        330        340        350
SCNHMTCAVC GCEFCWLCMK EISDLHYLSP SGCTFWGKKP WSRKKKILWQ 
       360        370        380        390        400
LGTLIGAPVG ISLIAGIAIP AMVIGIPVYV GRKIHSRYEG RKTSKHKRNL 
       410        420        430        440        450
AITGGVTLSV IASPVIAAVS VGIGVPIMLA YVYGVVPISL CRGGGCGVST 
       460        470        480        490        500
ANGKGVKIEF DEDDGPITVA DAWRALKNPS IGESSIEGLT SVLSTSGSPT 
       510        520        530        540        550
DGLSVMQGPY SETASFAALS GGTLSGGILS SGKGKYSRLE VQADVQKEIF 
       560        570        580        590        600
PKDTASLGAI SDNASTRAMA GSIISSYNPQ DRECNNMEIQ VDIEAKPSHY 
       610        620        630        640        650
QLVSGSSTED SLHVHAQMAE NEEEGSGGGG SEEDPPCRHQ SCEQKDCLAS 
       660        670        680        690        700
KPWDISLAQP ESIRSDLESS DAQSDDVPDI TSDECGSPRS HTAACPSTPR 
       710        720        730 
AQGAPSPSAH MNLSALAEGQ TVLKPEGGEA RV
Length:732
Mass (Da):77,925
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB30FBB46393C30B
GO
Isoform 2 (identifier: Q6ZMZ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-281: Missing.
     583-588: ECNNME → FSMIHA
     589-732: Missing.

Show »
Length:587
Mass (Da):62,717
Checksum:i1BB83ED988E1DCDF
GO
Isoform 3 (identifier: Q6ZMZ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-133: Missing.
     281-281: Missing.
     583-588: ECNNME → FSMIHA
     589-732: Missing.

Show »
Length:486
Mass (Da):52,668
Checksum:iF9FFA09A39464082
GO
Isoform 4 (identifier: Q6ZMZ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-281: Missing.

Show »
Length:731
Mass (Da):77,854
Checksum:iAB43F675B795E72B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI13561 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI43688 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAX07490 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti284I → V in BAC11017 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02863233 – 133Missing in isoform 3. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_028635281Missing in isoform 2, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_028633583 – 588ECNNME → FSMIHA in isoform 2 and isoform 3. 3 Publications6
Alternative sequenceiVSP_028634589 – 732Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST144

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK074486 mRNA Translation: BAC11017.1
AK131439 mRNA Translation: BAD18585.1
AL031602 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07490.1 Different initiation.
CH471059 Genomic DNA Translation: EAX07491.1
BC020595 mRNA Translation: AAH20595.2
BC062374 mRNA Translation: AAH62374.1
BC113560 mRNA Translation: AAI13561.1 Different initiation.
BC143687 mRNA Translation: AAI43688.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS372.2 [Q6ZMZ0-1]
CCDS44107.1 [Q6ZMZ0-2]
CCDS72754.1 [Q6ZMZ0-4]

NCBI Reference Sequences

More...RefSeqi		NP_001120833.1, NM_001127361.2 [Q6ZMZ0-2]
NP_001287755.1, NM_001300826.1 [Q6ZMZ0-4]
NP_699172.2, NM_153341.3 [Q6ZMZ0-1]
XP_006710419.1, XM_006710356.2 [Q6ZMZ0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000235150; ENSP00000235150; ENSG00000116514 [Q6ZMZ0-4]
ENST00000356990; ENSP00000349482; ENSG00000116514 [Q6ZMZ0-2]
ENST00000373456; ENSP00000362555; ENSG00000116514 [Q6ZMZ0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		127544

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:127544

UCSC genome browser

More...UCSCi		uc001bwm.5, human [Q6ZMZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074486 mRNA Translation: BAC11017.1
AK131439 mRNA Translation: BAD18585.1
AL031602 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07490.1 Different initiation.
CH471059 Genomic DNA Translation: EAX07491.1
BC020595 mRNA Translation: AAH20595.2
BC062374 mRNA Translation: AAH62374.1
BC113560 mRNA Translation: AAI13561.1 Different initiation.
BC143687 mRNA Translation: AAI43688.1 Different initiation.
CCDSiCCDS372.2 [Q6ZMZ0-1]
CCDS44107.1 [Q6ZMZ0-2]
CCDS72754.1 [Q6ZMZ0-4]
RefSeqiNP_001120833.1, NM_001127361.2 [Q6ZMZ0-2]
NP_001287755.1, NM_001300826.1 [Q6ZMZ0-4]
NP_699172.2, NM_153341.3 [Q6ZMZ0-1]
XP_006710419.1, XM_006710356.2 [Q6ZMZ0-1]

3D structure databases

SMRiQ6ZMZ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126065, 83 interactors
IntActiQ6ZMZ0, 68 interactors
STRINGi9606.ENSP00000362555

PTM databases

iPTMnetiQ6ZMZ0
PhosphoSitePlusiQ6ZMZ0

Genetic variation databases

BioMutaiRNF19B
DMDMi160370005

Proteomic databases

MassIVEiQ6ZMZ0
MaxQBiQ6ZMZ0
PaxDbiQ6ZMZ0
PeptideAtlasiQ6ZMZ0
PRIDEiQ6ZMZ0
ProteomicsDBi19093
33676
67939 [Q6ZMZ0-1]
67940 [Q6ZMZ0-2]
67941 [Q6ZMZ0-3]
67942 [Q6ZMZ0-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		57831, 114 antibodies

The DNASU plasmid repository

More...DNASUi		127544

Genome annotation databases

EnsembliENST00000235150; ENSP00000235150; ENSG00000116514 [Q6ZMZ0-4]
ENST00000356990; ENSP00000349482; ENSG00000116514 [Q6ZMZ0-2]
ENST00000373456; ENSP00000362555; ENSG00000116514 [Q6ZMZ0-1]
GeneIDi127544
KEGGihsa:127544
UCSCiuc001bwm.5, human [Q6ZMZ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		127544
DisGeNETi127544

GeneCards: human genes, protein and diseases

More...GeneCardsi		RNF19B
HGNCiHGNC:26886, RNF19B
HPAiENSG00000116514, Tissue enhanced (testis)
MIMi610872, gene
neXtProtiNX_Q6ZMZ0
OpenTargetsiENSG00000116514
PharmGKBiPA162401626
VEuPathDBiHostDB:ENSG00000116514.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1815, Eukaryota
GeneTreeiENSGT00940000158451
HOGENOMiCLU_016793_3_0_1
InParanoidiQ6ZMZ0
OMAiLTSDECG
OrthoDBi257621at2759
PhylomeDBiQ6ZMZ0
TreeFamiTF324777

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ6ZMZ0
ReactomeiR-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		127544, 7 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RNF19B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		127544
PharosiQ6ZMZ0, Tbio

Protein Ontology

More...PROi		PR:Q6ZMZ0
RNActiQ6ZMZ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116514, Expressed in testis and 228 other tissues
GenevisibleiQ6ZMZ0, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR031127, E3_UB_ligase_RBR
IPR002867, IBR_dom
IPR044066, TRIAD_supradom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR11685, PTHR11685, 1 hit
PfamiView protein in Pfam
PF01485, IBR, 2 hits
SMARTiView protein in SMART
SM00647, IBR, 2 hits
SM00184, RING, 1 hit
PROSITEiView protein in PROSITE
PS51873, TRIAD, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRN19B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMZ0
Secondary accession number(s): B7ZLB2
, E9PAW6, G3XA82, Q0VG77, Q5TH44, Q5TH45, Q6P6A4, Q8N2S8, Q8WUF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 23, 2007
Last modified: April 7, 2021
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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