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Entry version 128 (12 Aug 2020)
Sequence version 2 (10 Jun 2008)
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Protein

Echinoderm microtubule-associated protein-like 6

Gene

EML6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: GO_Central

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZMW3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6ZMW3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 6
Short name:
EMAP-6
Alternative name(s):
Echinoderm microtubule-associated protein-like 5-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EML6
Synonyms:EML5L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000214595.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:35412, EML6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZMW3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
400954

Open Targets

More...
OpenTargetsi
ENSG00000214595

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164719036

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZMW3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EML6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190358904

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003259761 – 1958Echinoderm microtubule-associated protein-like 6Add BLAST1958

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZMW3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZMW3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZMW3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZMW3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZMW3

PeptideAtlas

More...
PeptideAtlasi
Q6ZMW3

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZMW3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67929 [Q6ZMW3-1]
67930 [Q6ZMW3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZMW3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZMW3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214595, Expressed in middle temporal gyrus and 180 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZMW3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000214595, Tissue enhanced (brain, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
134838, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZMW3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348842

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZMW3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZMW3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati59 – 100WD 1Add BLAST42
Repeati104 – 145WD 2Add BLAST42
Repeati148 – 187WD 3Add BLAST40
Repeati195 – 233WD 4Add BLAST39
Repeati235 – 273WD 5Add BLAST39
Repeati280 – 321WD 6Add BLAST42
Repeati323 – 362WD 7Add BLAST40
Repeati364 – 403WD 8Add BLAST40
Repeati406 – 445WD 9Add BLAST40
Repeati561 – 601WD 10Add BLAST41
Repeati725 – 766WD 11Add BLAST42
Repeati770 – 811WD 12Add BLAST42
Repeati814 – 853WD 13Add BLAST40
Repeati861 – 900WD 14Add BLAST40
Repeati901 – 940WD 15Add BLAST40
Repeati996 – 1035WD 16Add BLAST40
Repeati1038 – 1077WD 17Add BLAST40
Repeati1080 – 1120WD 18Add BLAST41
Repeati1191 – 1230WD 19Add BLAST40
Repeati1236 – 1276WD 20Add BLAST41
Repeati1412 – 1456WD 21Add BLAST45
Repeati1460 – 1501WD 22Add BLAST42
Repeati1504 – 1543WD 23Add BLAST40
Repeati1553 – 1591WD 24Add BLAST39
Repeati1593 – 1638WD 25Add BLAST46
Repeati1685 – 1724WD 26Add BLAST40
Repeati1726 – 1767WD 27Add BLAST42
Repeati1768 – 1807WD 28Add BLAST40
Repeati1880 – 1919WD 29Add BLAST40
Repeati1925 – 1958WD 30Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1355 – 1358Poly-Lys4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2106, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155564

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001930_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZMW3

KEGG Orthology (KO)

More...
KOi
K18598

Identification of Orthologs from Complete Genome Data

More...
OMAi
YIWRDTT

Database of Orthologous Groups

More...
OrthoDBi
97584at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZMW3

TreeFam database of animal gene trees

More...
TreeFami
TF317832

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977, Apc4_WD40_dom
IPR011048, Haem_d1_sf
IPR005108, HELP
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894, ANAPC4_WD40, 1 hit
PF03451, HELP, 3 hits
PF00400, WD40, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 2 hits
SSF50998, SSF50998, 2 hits
SSF51004, SSF51004, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 6 hits
PS50294, WD_REPEATS_REGION, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZMW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADRTAPRCQ LRLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR
60 70 80 90 100
EHSQKFFLGH NDDIISLALH PDKTLVATGQ VGKEPYICIW DSYNVQTVSL
110 120 130 140 150
LKDVHTHGVA CLAFDSDGQR LASVGLDAKN TVCIWDWRKG KLLASATGHS
160 170 180 190 200
DRIFDISWDP YQPNRVVSCG VKHIKFWTLC GNALTAKRGI FGKTGDLQTI
210 220 230 240 250
LCLACAKEDI TYSGALNGDI YVWKGLNLVR TIQGAHSAGI FSMYACEEGF
260 270 280 290 300
ATGGRDGCIR LWDTDFKPIT KIDLRETEQG YKGLSIRSVC WKADRLLAGT
310 320 330 340 350
QDSEIFEVIV RERDKPMLIL QGHCEGELWA LALHPKKPLA VTGSDDRSVR
360 370 380 390 400
LWSLADHALI ARCNMEEAVR SVAFSPDGSQ LALGMKDGSF IVLRVRDMTE
410 420 430 440 450
VVHIKDRKEV IHEMKFSPDG SYLAVGSNDG PVDVYAVAQR YKKIGECSKS
460 470 480 490 500
LSFITHIDWS LDSKYLQTND GAGERLFYRM PSGKPLTSKE EIKGIPWASW
510 520 530 540 550
TCVKGPEVSG IWPKYTEVTD INSVDANYNS SVLVSGDDFG LVKLFKFPCL
560 570 580 590 600
KRGAKFRKYV GHSAHVTNVR WSHDFQWVLS TGGADHSVFQ WRFIPEGVSN
610 620 630 640 650
GMLETAPQEG GADSYSEESD SDLSDVPELD SDIEQEAQIN YDRQVYKEDL
660 670 680 690 700
PQLKQQSKEK NHAVPFLKRE KAPEDSLKLQ FIHGYRGYDC RNNLFYTQAG
710 720 730 740 750
EVVYHIAAVA VVYNRQQHSQ RLYLGHDDDI LSLTIHPVKD YVATGQVGRD
760 770 780 790 800
AAIHVWDTQT LKCLSLLKGQ HQRGVCALDF SADGKCLVSV GLDDFHSIVF
810 820 830 840 850
WDWKKGEKIA TTRGHKDKIF VVKCNPHHVD KLVTVGIKHI KFWQQAGGGF
860 870 880 890 900
TSKRGTFGSV GKLETMMCVS YGRMEDLVFS GAATGDIFIW KDILLLKTVK
910 920 930 940 950
AHDGPVFAMY ALDKGFVTGG KDGIVELWDD MFERCLKTYA IKRSALSTSS
960 970 980 990 1000
KGLLLEDNPS IRAITLGHGH ILVGTKNGEI LEIDKSGPMT LLVQGHMEGE
1010 1020 1030 1040 1050
VWGLAAHPLL PICATVSDDK TLRIWELSAQ HRMLAVRKLK KGGRCCAFSP
1060 1070 1080 1090 1100
DGKALAVGLN DGSFLVVNAD TVEDMVSFHH RKEMISDIKF SKDTGKYLAV
1110 1120 1130 1140 1150
ASHDNFVDIY NVLTSKRVGI CKGASSYITH IDWDSRGKLL QVNSGAREQL
1160 1170 1180 1190 1200
FFEAPRGKRH IIRPSEIEKI EWDTWTCVLG PTCEGIWPAH SDITDVNAAS
1210 1220 1230 1240 1250
LTKDCSLLAT GDDFGFVKLF SYPVKGQHAR FKKYVGHSAH VTNVRWLHND
1260 1270 1280 1290 1300
SVLLTVGGAD TALMIWTREF VGTQESKLVD SEESDTDVEE DGGYDSDVAR
1310 1320 1330 1340 1350
EKAIDYTTKI YAVSIREMEG TKPHQQLKEV SVEERPPVSR AAPQPEKLQK
1360 1370 1380 1390 1400
NNITKKKKLV EELALDHVFG YRGFDCRNNL HYLNDGADII FHTAAAGIVQ
1410 1420 1430 1440 1450
NLSTGSQSFY LEHTDDILCL TVNQHPKYRN VVATSQIGTT PSIHIWDAMT
1460 1470 1480 1490 1500
KHTLSMLRCF HSKGVNYINF SATGKLLVSV GVDPEHTITV WRWQEGAKVA
1510 1520 1530 1540 1550
SRGGHLERIF VVEFRPDSDT QFVSVGVKHM KFWTLAGSAL LYKKGVIGSL
1560 1570 1580 1590 1600
GAAKMQTMLS VAFGANNLTF TGAINGDVYV WKDHFLIRLV AKAHTGPVFT
1610 1620 1630 1640 1650
MYTTLRDGLI VTGGKERPTK EGGAVKLWDQ EMKRCRAFQL ETGQLVECVR
1660 1670 1680 1690 1700
SVCRGKGKIL VGTKDGEIIE VGEKNAASNI LIDGHMEGEI WGLATHPSKD
1710 1720 1730 1740 1750
LFISASNDGT ARIWDLADKK LLNKVSLGHA ARCAAYSPDG EMVAIGMKNG
1760 1770 1780 1790 1800
EFVILLVNSL KVWGKKRDRK SAIQDIRISP DNRFLAVGSS EHTVDFYDLT
1810 1820 1830 1840 1850
QGTNLNRIGY CKDIPSFVIQ MDFSADGKYI QVSTGAYKRQ VHEVPLGKQV
1860 1870 1880 1890 1900
TEAVVIEKIT WASWTSVLGD EVIGIWPRNA DKADVNCACV THAGLNIVTG
1910 1920 1930 1940 1950
DDFGLVKLFD FPCTEKFAKH KRYFGHSAHV TNIRFSYDDK YVVSTGGDDC

SVFVWRCL
Length:1,958
Mass (Da):217,899
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A634ACFE1CDF891
GO
Isoform 2 (identifier: Q6ZMW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1832-1958: VSTGAYKRQV...DCSVFVWRCL → MQLTLLVGNH...WPAVVVMGWP

Show »
Length:1,874
Mass (Da):208,805
Checksum:iCDE15BA84F799B10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A669KBD4A0A669KBD4_HUMAN
Echinoderm microtubule-associated p...
EML6
1,340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KBG7A0A669KBG7_HUMAN
Echinoderm microtubule-associated p...
EML6
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KB65A0A669KB65_HUMAN
Echinoderm microtubule-associated p...
EML6
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KBH1A0A669KBH1_HUMAN
Echinoderm microtubule-associated p...
EML6
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KAL3A0A669KAL3_HUMAN
Echinoderm microtubule-associated p...
EML6
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KB40A0A669KB40_HUMAN
Echinoderm microtubule-associated p...
EML6
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1828K → Y in BAD18612 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0342211832 – 1958VSTGA…VWRCL → MQLTLLVGNHTQRTAILGLW KIARKWMRRKMGKWPAVVVM GWP in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC013414 Genomic DNA No translation available.
AC093110 Genomic DNA No translation available.
AC104781 Genomic DNA No translation available.
AK131467 mRNA Translation: BAD18612.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS46286.1 [Q6ZMW3-1]

NCBI Reference Sequences

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RefSeqi
NP_001034842.2, NM_001039753.2 [Q6ZMW3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000356458; ENSP00000348842; ENSG00000214595 [Q6ZMW3-1]
ENST00000673695; ENSP00000501148; ENSG00000214595 [Q6ZMW3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
400954

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:400954

UCSC genome browser

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UCSCi
uc002ryb.5, human [Q6ZMW3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013414 Genomic DNA No translation available.
AC093110 Genomic DNA No translation available.
AC104781 Genomic DNA No translation available.
AK131467 mRNA Translation: BAD18612.1
CCDSiCCDS46286.1 [Q6ZMW3-1]
RefSeqiNP_001034842.2, NM_001039753.2 [Q6ZMW3-1]

3D structure databases

SMRiQ6ZMW3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi134838, 4 interactors
IntActiQ6ZMW3, 2 interactors
STRINGi9606.ENSP00000348842

PTM databases

iPTMnetiQ6ZMW3
PhosphoSitePlusiQ6ZMW3

Polymorphism and mutation databases

BioMutaiEML6
DMDMi190358904

Proteomic databases

EPDiQ6ZMW3
jPOSTiQ6ZMW3
MassIVEiQ6ZMW3
MaxQBiQ6ZMW3
PaxDbiQ6ZMW3
PeptideAtlasiQ6ZMW3
PRIDEiQ6ZMW3
ProteomicsDBi67929 [Q6ZMW3-1]
67930 [Q6ZMW3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
74753, 8 antibodies

Genome annotation databases

EnsembliENST00000356458; ENSP00000348842; ENSG00000214595 [Q6ZMW3-1]
ENST00000673695; ENSP00000501148; ENSG00000214595 [Q6ZMW3-1]
GeneIDi400954
KEGGihsa:400954
UCSCiuc002ryb.5, human [Q6ZMW3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
400954
DisGeNETi400954
EuPathDBiHostDB:ENSG00000214595.11

GeneCards: human genes, protein and diseases

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GeneCardsi
EML6
HGNCiHGNC:35412, EML6
HPAiENSG00000214595, Tissue enhanced (brain, lymphoid tissue)
neXtProtiNX_Q6ZMW3
OpenTargetsiENSG00000214595
PharmGKBiPA164719036

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2106, Eukaryota
GeneTreeiENSGT00940000155564
HOGENOMiCLU_001930_0_0_1
InParanoidiQ6ZMW3
KOiK18598
OMAiYIWRDTT
OrthoDBi97584at2759
PhylomeDBiQ6ZMW3
TreeFamiTF317832

Enzyme and pathway databases

PathwayCommonsiQ6ZMW3
SignaLinkiQ6ZMW3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
400954, 5 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EML6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
400954
PharosiQ6ZMW3, Tdark

Protein Ontology

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PROi
PR:Q6ZMW3
RNActiQ6ZMW3, protein

Gene expression databases

BgeeiENSG00000214595, Expressed in middle temporal gyrus and 180 other tissues
GenevisibleiQ6ZMW3, HS

Family and domain databases

Gene3Di2.130.10.10, 6 hits
InterProiView protein in InterPro
IPR024977, Apc4_WD40_dom
IPR011048, Haem_d1_sf
IPR005108, HELP
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894, ANAPC4_WD40, 1 hit
PF03451, HELP, 3 hits
PF00400, WD40, 9 hits
SMARTiView protein in SMART
SM00320, WD40, 30 hits
SUPFAMiSSF50978, SSF50978, 2 hits
SSF50998, SSF50998, 2 hits
SSF51004, SSF51004, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 6 hits
PS50294, WD_REPEATS_REGION, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMAL6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMW3
Secondary accession number(s): A8MUB5, B6ZDG7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 10, 2008
Last modified: August 12, 2020
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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