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Entry version 137 (22 Apr 2020)
Sequence version 3 (01 May 2007)
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Protein

Kinesin-like protein KIF6

Gene

KIF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF6
Synonyms:C6orf102
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:21202 KIF6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613919 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZMV9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
221458

Open Targets

More...
OpenTargetsi
ENSG00000164627

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134920075

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZMV9 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3308907

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KIF6

Domain mapping of disease mutations (DMDM)

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DMDMi
146345445

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254411 – 814Kinesin-like protein KIF6Add BLAST814

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6ZMV9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZMV9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZMV9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZMV9

PeptideAtlas

More...
PeptideAtlasi
Q6ZMV9

PRoteomics IDEntifications database

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PRIDEi
Q6ZMV9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67924 [Q6ZMV9-1]
67925 [Q6ZMV9-2]
67926 [Q6ZMV9-3]
67927 [Q6ZMV9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZMV9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6ZMV9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164627 Expressed in corpus callosum and 131 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6ZMV9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6ZMV9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164627 Group enriched (brain, fallopian tube, pituitary gland, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128728, 6 interactors

Protein interaction database and analysis system

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IntActi
Q6ZMV9, 8 interactors

Molecular INTeraction database

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MINTi
Q6ZMV9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000287152

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZMV9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6ZMV9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 345Kinesin motorPROSITE-ProRule annotationAdd BLAST341

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili356 – 385Sequence analysisAdd BLAST30
Coiled coili456 – 494Sequence analysisAdd BLAST39
Coiled coili588 – 683Sequence analysisAdd BLAST96

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4280 Eukaryota
COG5059 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157697

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001485_16_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6ZMV9

KEGG Orthology (KO)

More...
KOi
K10397

Identification of Orthologs from Complete Genome Data

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OMAi
KEIQHIQ

Database of Orthologous Groups

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OrthoDBi
424630at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6ZMV9

TreeFam database of animal gene trees

More...
TreeFami
TF329752

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24115 PTHR24115, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00225 Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZMV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKQTIQIFA RVKPPVRKHQ QGIYSIDEDE KLIPSLEIIL PRDLADGFVN
60 70 80 90 100
NKRESYKFKF QRIFDQDANQ ETVFENIAKP VAGSVLAGYN GTIFAYGQTG
110 120 130 140 150
SGKTFTITGG AERYSDRGII PRTLSYIFEQ LQKDSSKIYT THISYLEIYN
160 170 180 190 200
ECGYDLLDPR HEASSLEDLP KVTILEDPDQ NIHLKNLTLH QATTEEEALN
210 220 230 240 250
LLFLGDTNRM IAETPMNQAS TRSHCIFTIH LSSKEPGSAT VRHAKLHLVD
260 270 280 290 300
LAGSERVAKT GVGGHLLTEA KYINLSLHYL EQVIIALSEK HRSHIPYRNS
310 320 330 340 350
MMTSVLRDSL GGNCMTTMIA TLSLEKRNLD ESISTCRFAQ RVALIKNEAV
360 370 380 390 400
LNEEINPRLV IKRLQKEIQE LKDELAMVTG EQRTEALTEA ELLQLEKLIT
410 420 430 440 450
SFLEDQDSDS RLEVGADMRK VHHCFHHLKK LLNDKKILEN NTVSSESKDQ
460 470 480 490 500
DCQEPLKEEE YRKLRDILKQ RDNEINILVN MLKKEKKKAQ EALHLAGMDR
510 520 530 540 550
REFRQSQSPP FRLGNPEEGQ RMRLSSAPSQ AQDFSILGKR SSLLHKKIGM
560 570 580 590 600
REEMSLGCQE AFEIFKRDHA DSVTIDDNKQ ILKQRFSEAK ALGESINEAR
610 620 630 640 650
SKIGHLKEEI TQRHIQQVAL GISENMAVPL MPDQQEEKLR SQLEEEKRRY
660 670 680 690 700
KTMFTRLKAL KVEIEHLQLL MDKAKVKLQK EFEVWWAEEA TNLQVNSPAV
710 720 730 740 750
NSLDHTKPFL QTSDSQHEWS QLLSNKSSGG WEVQDQGTGR FDVCDVNARK
760 770 780 790 800
ILPSPCPSPH SQKQSSTSTP LEDSIPKRPV SSIPLTGDSQ TDSDIIAFIK
810
ARQSILQKQC LGSN
Length:814
Mass (Da):92,569
Last modified:May 1, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0BB982845286F31
GO
Isoform 2 (identifier: Q6ZMV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.

Show »
Length:265
Mass (Da):30,082
Checksum:iCDE6BB34F2EDEACA
GO
Isoform 3 (identifier: Q6ZMV9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     728-744: Missing.

Show »
Length:797
Mass (Da):90,746
Checksum:iB693765C871D24D9
GO
Isoform 4 (identifier: Q6ZMV9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.
     708-720: PFLQTSDSQHEWS → SKIKALADSMSVM
     721-814: Missing.

Show »
Length:171
Mass (Da):19,809
Checksum:i7053D9CB3640985B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y718H0Y718_HUMAN
Kinesin-like protein
KIF6
689Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JRK0Q5JRK0_HUMAN
Kinesin-like protein KIF6
KIF6
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q2MDE8Q2MDE8_HUMAN
Kinesin-like protein KIF6
KIF6
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VGH2F6VGH2_HUMAN
Kinesin-like protein KIF6
KIF6
293Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti551R → K in BAD18616 (PubMed:14702039).Curated1
Sequence conflicti558 – 584CQEAF…QILKQ → NATILSSLTGPGLQHFGEKI QFAPQEN in CAD89950 (PubMed:17974005).CuratedAdd BLAST27
Sequence conflicti715S → F in BAD18616 (PubMed:14702039).Curated1
Sequence conflicti772E → G in BAD18616 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036217386A → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049698512R → H. Corresponds to variant dbSNP:rs2273063Ensembl.1
Natural variantiVAR_022810719W → R1 PublicationCorresponds to variant dbSNP:rs20455EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0144681 – 549Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST549
Alternative sequenceiVSP_014469708 – 720PFLQT…QHEWS → SKIKALADSMSVM in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_014470721 – 814Missing in isoform 4. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_014471728 – 744Missing in isoform 3. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK123217 mRNA Translation: BAC85560.1
AK131471 mRNA Translation: BAD18616.1
AL035464 Genomic DNA No translation available.
AL136087 Genomic DNA No translation available.
AL160161 Genomic DNA No translation available.
AL161439 Genomic DNA No translation available.
AL590387 Genomic DNA No translation available.
BC022074 mRNA Translation: AAH22074.1
BX649045 mRNA No translation available.
AL832634 mRNA Translation: CAD89950.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4844.1 [Q6ZMV9-1]
CCDS75449.1 [Q6ZMV9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001275953.1, NM_001289024.1 [Q6ZMV9-2]
NP_659464.3, NM_145027.4 [Q6ZMV9-1]
XP_011512661.1, XM_011514359.2 [Q6ZMV9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229913; ENSP00000229913; ENSG00000164627 [Q6ZMV9-2]
ENST00000287152; ENSP00000287152; ENSG00000164627 [Q6ZMV9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
221458

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:221458

UCSC genome browser

More...
UCSCi
uc003oos.3 human [Q6ZMV9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123217 mRNA Translation: BAC85560.1
AK131471 mRNA Translation: BAD18616.1
AL035464 Genomic DNA No translation available.
AL136087 Genomic DNA No translation available.
AL160161 Genomic DNA No translation available.
AL161439 Genomic DNA No translation available.
AL590387 Genomic DNA No translation available.
BC022074 mRNA Translation: AAH22074.1
BX649045 mRNA No translation available.
AL832634 mRNA Translation: CAD89950.1
CCDSiCCDS4844.1 [Q6ZMV9-1]
CCDS75449.1 [Q6ZMV9-2]
RefSeqiNP_001275953.1, NM_001289024.1 [Q6ZMV9-2]
NP_659464.3, NM_145027.4 [Q6ZMV9-1]
XP_011512661.1, XM_011514359.2 [Q6ZMV9-3]

3D structure databases

SMRiQ6ZMV9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128728, 6 interactors
IntActiQ6ZMV9, 8 interactors
MINTiQ6ZMV9
STRINGi9606.ENSP00000287152

Chemistry databases

ChEMBLiCHEMBL3308907

PTM databases

iPTMnetiQ6ZMV9
PhosphoSitePlusiQ6ZMV9

Polymorphism and mutation databases

BioMutaiKIF6
DMDMi146345445

Proteomic databases

jPOSTiQ6ZMV9
MassIVEiQ6ZMV9
MaxQBiQ6ZMV9
PaxDbiQ6ZMV9
PeptideAtlasiQ6ZMV9
PRIDEiQ6ZMV9
ProteomicsDBi67924 [Q6ZMV9-1]
67925 [Q6ZMV9-2]
67926 [Q6ZMV9-3]
67927 [Q6ZMV9-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29939 202 antibodies

Genome annotation databases

EnsembliENST00000229913; ENSP00000229913; ENSG00000164627 [Q6ZMV9-2]
ENST00000287152; ENSP00000287152; ENSG00000164627 [Q6ZMV9-1]
GeneIDi221458
KEGGihsa:221458
UCSCiuc003oos.3 human [Q6ZMV9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221458
DisGeNETi221458

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIF6
HGNCiHGNC:21202 KIF6
HPAiENSG00000164627 Group enriched (brain, fallopian tube, pituitary gland, testis)
MIMi613919 gene
neXtProtiNX_Q6ZMV9
OpenTargetsiENSG00000164627
PharmGKBiPA134920075

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000157697
HOGENOMiCLU_001485_16_1_1
InParanoidiQ6ZMV9
KOiK10397
OMAiKEIQHIQ
OrthoDBi424630at2759
PhylomeDBiQ6ZMV9
TreeFamiTF329752

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIF6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
221458
PharosiQ6ZMV9 Tbio

Protein Ontology

More...
PROi
PR:Q6ZMV9
RNActiQ6ZMV9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164627 Expressed in corpus callosum and 131 other tissues
ExpressionAtlasiQ6ZMV9 baseline and differential
GenevisibleiQ6ZMV9 HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMV9
Secondary accession number(s): Q2MDE3
, Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 2007
Last modified: April 22, 2020
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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