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Protein

Kinesin-like protein KIF6

Gene

KIF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF6
Gene namesi
Name:KIF6
Synonyms:C6orf102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164627.17
HGNCiHGNC:21202 KIF6
MIMi613919 gene
neXtProtiNX_Q6ZMV9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi221458
OpenTargetsiENSG00000164627
PharmGKBiPA134920075

Chemistry databases

ChEMBLiCHEMBL3308907

Polymorphism and mutation databases

BioMutaiKIF6
DMDMi146345445

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254411 – 814Kinesin-like protein KIF6Add BLAST814

Proteomic databases

EPDiQ6ZMV9
MaxQBiQ6ZMV9
PaxDbiQ6ZMV9
PeptideAtlasiQ6ZMV9
PRIDEiQ6ZMV9
ProteomicsDBi67924
67925 [Q6ZMV9-2]
67926 [Q6ZMV9-3]
67927 [Q6ZMV9-4]

PTM databases

iPTMnetiQ6ZMV9
PhosphoSitePlusiQ6ZMV9

Expressioni

Gene expression databases

BgeeiENSG00000164627 Expressed in 132 organ(s), highest expression level in corpus callosum
CleanExiHS_KIF6
ExpressionAtlasiQ6ZMV9 baseline and differential
GenevisibleiQ6ZMV9 HS

Organism-specific databases

HPAiHPA038811
HPA058624

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-751100,EBI-743771

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128728, 6 interactors
IntActiQ6ZMV9, 3 interactors
MINTiQ6ZMV9
STRINGi9606.ENSP00000287152

Structurei

3D structure databases

ProteinModelPortaliQ6ZMV9
SMRiQ6ZMV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 345Kinesin motorPROSITE-ProRule annotationAdd BLAST341

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili356 – 385Sequence analysisAdd BLAST30
Coiled coili456 – 494Sequence analysisAdd BLAST39
Coiled coili588 – 683Sequence analysisAdd BLAST96

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150825
HOVERGENiHBG081854
InParanoidiQ6ZMV9
KOiK10397
OMAiWWAEEAS
OrthoDBiEOG091G02ZJ
PhylomeDBiQ6ZMV9
TreeFamiTF329752

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZMV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKQTIQIFA RVKPPVRKHQ QGIYSIDEDE KLIPSLEIIL PRDLADGFVN
60 70 80 90 100
NKRESYKFKF QRIFDQDANQ ETVFENIAKP VAGSVLAGYN GTIFAYGQTG
110 120 130 140 150
SGKTFTITGG AERYSDRGII PRTLSYIFEQ LQKDSSKIYT THISYLEIYN
160 170 180 190 200
ECGYDLLDPR HEASSLEDLP KVTILEDPDQ NIHLKNLTLH QATTEEEALN
210 220 230 240 250
LLFLGDTNRM IAETPMNQAS TRSHCIFTIH LSSKEPGSAT VRHAKLHLVD
260 270 280 290 300
LAGSERVAKT GVGGHLLTEA KYINLSLHYL EQVIIALSEK HRSHIPYRNS
310 320 330 340 350
MMTSVLRDSL GGNCMTTMIA TLSLEKRNLD ESISTCRFAQ RVALIKNEAV
360 370 380 390 400
LNEEINPRLV IKRLQKEIQE LKDELAMVTG EQRTEALTEA ELLQLEKLIT
410 420 430 440 450
SFLEDQDSDS RLEVGADMRK VHHCFHHLKK LLNDKKILEN NTVSSESKDQ
460 470 480 490 500
DCQEPLKEEE YRKLRDILKQ RDNEINILVN MLKKEKKKAQ EALHLAGMDR
510 520 530 540 550
REFRQSQSPP FRLGNPEEGQ RMRLSSAPSQ AQDFSILGKR SSLLHKKIGM
560 570 580 590 600
REEMSLGCQE AFEIFKRDHA DSVTIDDNKQ ILKQRFSEAK ALGESINEAR
610 620 630 640 650
SKIGHLKEEI TQRHIQQVAL GISENMAVPL MPDQQEEKLR SQLEEEKRRY
660 670 680 690 700
KTMFTRLKAL KVEIEHLQLL MDKAKVKLQK EFEVWWAEEA TNLQVNSPAV
710 720 730 740 750
NSLDHTKPFL QTSDSQHEWS QLLSNKSSGG WEVQDQGTGR FDVCDVNARK
760 770 780 790 800
ILPSPCPSPH SQKQSSTSTP LEDSIPKRPV SSIPLTGDSQ TDSDIIAFIK
810
ARQSILQKQC LGSN
Length:814
Mass (Da):92,569
Last modified:May 1, 2007 - v3
Checksum:iD0BB982845286F31
GO
Isoform 2 (identifier: Q6ZMV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.

Show »
Length:265
Mass (Da):30,082
Checksum:iCDE6BB34F2EDEACA
GO
Isoform 3 (identifier: Q6ZMV9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     728-744: Missing.

Note: No experimental confirmation available.
Show »
Length:797
Mass (Da):90,746
Checksum:iB693765C871D24D9
GO
Isoform 4 (identifier: Q6ZMV9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.
     708-720: PFLQTSDSQHEWS → SKIKALADSMSVM
     721-814: Missing.

Note: No experimental confirmation available.
Show »
Length:171
Mass (Da):19,809
Checksum:i7053D9CB3640985B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y718H0Y718_HUMAN
Kinesin-like protein
KIF6
689Annotation score:
Q5JRK0Q5JRK0_HUMAN
Kinesin-like protein KIF6
KIF6
161Annotation score:
Q2MDE8Q2MDE8_HUMAN
Kinesin-like protein KIF6
KIF6
248Annotation score:
F6VGH2F6VGH2_HUMAN
Kinesin-like protein KIF6
KIF6
293Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti551R → K in BAD18616 (PubMed:14702039).Curated1
Sequence conflicti558 – 584CQEAF…QILKQ → NATILSSLTGPGLQHFGEKI QFAPQEN in CAD89950 (PubMed:17974005).CuratedAdd BLAST27
Sequence conflicti715S → F in BAD18616 (PubMed:14702039).Curated1
Sequence conflicti772E → G in BAD18616 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036217386A → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049698512R → H. Corresponds to variant dbSNP:rs2273063Ensembl.1
Natural variantiVAR_022810719W → R1 PublicationCorresponds to variant dbSNP:rs20455EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0144681 – 549Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST549
Alternative sequenceiVSP_014469708 – 720PFLQT…QHEWS → SKIKALADSMSVM in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_014470721 – 814Missing in isoform 4. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_014471728 – 744Missing in isoform 3. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123217 mRNA Translation: BAC85560.1
AK131471 mRNA Translation: BAD18616.1
AL035464 Genomic DNA No translation available.
AL136087 Genomic DNA No translation available.
AL160161 Genomic DNA No translation available.
AL161439 Genomic DNA No translation available.
AL590387 Genomic DNA No translation available.
BC022074 mRNA Translation: AAH22074.1
BX649045 mRNA No translation available.
AL832634 mRNA Translation: CAD89950.1
CCDSiCCDS4844.1 [Q6ZMV9-1]
CCDS75449.1 [Q6ZMV9-2]
RefSeqiNP_001275953.1, NM_001289024.1 [Q6ZMV9-2]
NP_659464.3, NM_145027.4 [Q6ZMV9-1]
XP_011512661.1, XM_011514359.2 [Q6ZMV9-3]
UniGeneiHs.588202
Hs.703192

Genome annotation databases

EnsembliENST00000229913; ENSP00000229913; ENSG00000164627 [Q6ZMV9-2]
ENST00000287152; ENSP00000287152; ENSG00000164627 [Q6ZMV9-1]
GeneIDi221458
KEGGihsa:221458
UCSCiuc003oos.3 human [Q6ZMV9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123217 mRNA Translation: BAC85560.1
AK131471 mRNA Translation: BAD18616.1
AL035464 Genomic DNA No translation available.
AL136087 Genomic DNA No translation available.
AL160161 Genomic DNA No translation available.
AL161439 Genomic DNA No translation available.
AL590387 Genomic DNA No translation available.
BC022074 mRNA Translation: AAH22074.1
BX649045 mRNA No translation available.
AL832634 mRNA Translation: CAD89950.1
CCDSiCCDS4844.1 [Q6ZMV9-1]
CCDS75449.1 [Q6ZMV9-2]
RefSeqiNP_001275953.1, NM_001289024.1 [Q6ZMV9-2]
NP_659464.3, NM_145027.4 [Q6ZMV9-1]
XP_011512661.1, XM_011514359.2 [Q6ZMV9-3]
UniGeneiHs.588202
Hs.703192

3D structure databases

ProteinModelPortaliQ6ZMV9
SMRiQ6ZMV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128728, 6 interactors
IntActiQ6ZMV9, 3 interactors
MINTiQ6ZMV9
STRINGi9606.ENSP00000287152

Chemistry databases

ChEMBLiCHEMBL3308907

PTM databases

iPTMnetiQ6ZMV9
PhosphoSitePlusiQ6ZMV9

Polymorphism and mutation databases

BioMutaiKIF6
DMDMi146345445

Proteomic databases

EPDiQ6ZMV9
MaxQBiQ6ZMV9
PaxDbiQ6ZMV9
PeptideAtlasiQ6ZMV9
PRIDEiQ6ZMV9
ProteomicsDBi67924
67925 [Q6ZMV9-2]
67926 [Q6ZMV9-3]
67927 [Q6ZMV9-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229913; ENSP00000229913; ENSG00000164627 [Q6ZMV9-2]
ENST00000287152; ENSP00000287152; ENSG00000164627 [Q6ZMV9-1]
GeneIDi221458
KEGGihsa:221458
UCSCiuc003oos.3 human [Q6ZMV9-1]

Organism-specific databases

CTDi221458
DisGeNETi221458
EuPathDBiHostDB:ENSG00000164627.17
GeneCardsiKIF6
H-InvDBiHIX0005853
HGNCiHGNC:21202 KIF6
HPAiHPA038811
HPA058624
MIMi613919 gene
neXtProtiNX_Q6ZMV9
OpenTargetsiENSG00000164627
PharmGKBiPA134920075
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150825
HOVERGENiHBG081854
InParanoidiQ6ZMV9
KOiK10397
OMAiWWAEEAS
OrthoDBiEOG091G02ZJ
PhylomeDBiQ6ZMV9
TreeFamiTF329752

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

ChiTaRSiKIF6 human
GenomeRNAii221458
PROiPR:Q6ZMV9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164627 Expressed in 132 organ(s), highest expression level in corpus callosum
CleanExiHS_KIF6
ExpressionAtlasiQ6ZMV9 baseline and differential
GenevisibleiQ6ZMV9 HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF6_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMV9
Secondary accession number(s): Q2MDE3
, Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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