PPP4R3C

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein PPP4R3CCurated Alternative name(s): SMEK homolog 3 Serine/threonine-protein phosphatase 4 regulatory subunit 3CImported
Gene namesⁱ	Name:PPP4R3CImported Synonyms:PPP4R3CP, SMEK3P
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33146 PPP4R3C
neXtProtⁱ	NX_Q6ZMV5

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000224960

OpenTargetsⁱ

ENSG00000224960

Polymorphism and mutation databases

DMDMⁱ	206558317

DMDMⁱ

206558317

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000344447	1 – 832	Protein PPP4R3CAdd BLAST		832

Proteomic databases

EPDⁱ	Q6ZMV5
PeptideAtlas More...PeptideAtlasⁱ	Q6ZMV5
PRIDEⁱ	Q6ZMV5
ProteomicsDBⁱ	67920 67921 [Q6ZMV5-2]

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6ZMV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SMEK family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018199
HOVERGENⁱ	HBG056624
InParanoidⁱ	Q6ZMV5
OMAⁱ	RFMRRMI
PhylomeDBⁱ	Q6ZMV5

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR006887 DUF625 IPR011993 PH-like_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04802 SMK-1, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 2 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q6ZMV5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLRYSVKV YVLNEDEEWN NLGTGQVSST YDEQFQGMSL LVRSDSDGSV 
        60         70         80         90        100
ILRSQIPPDR PYGKYQETLI VWYEAENQGL VLKFQDPAGC QDIWKEICQA 
       110        120        130        140        150
QGKDPSIQTT VNISDEPEED FNEMSVISNM VVLPDCELNT LDQIADIVTS 
       160        170        180        190        200
VFSSPVTDRE RLAEILKNEA YIPKLLQLFH TCENLENTEG LHHLYEIIKG 
       210        220        230        240        250
ILFLNEACLF EIMFSDECIM DVVGCLEYDP ALDQPKRHRD FLTNDAKFKE 
       260        270        280        290        300
VIPITNSELR QKIHQTYRLQ YIYDILLPVP SIFEDNFLST LTTFIFSNKA 
       310        320        330        340        350
EIVSMLQKDH KFLYEVFAQL KDETTHDDRR CELLFFFKEL CSFSQALQPQ 
       360        370        380        390        400
SKDALFETLI QLGVLPALKI VMIRDDLQVR SAAAVICAYL VEYSPSRIRE 
       410        420        430        440        450
FIISEAHVCK DSDLFINVII KQMICDTDPE LGGAVHLMVV LHTLLDPRNM 
       460        470        480        490        500
LTTPEKSERS EFLHFFYKHC MHKFTAPLLA ATSEHNCEED DIAGYDKSKN 
       510        520        530        540        550
CPNDNQTAQL LALILELLTF CIQHHTFYIR SYILNKDLLR KALILMNSKH 
       560        570        580        590        600
THLILCVLRF MRRMICLNDE AYNNYIIKGN LFEPVVNALL DNGTRYNMLN 
       610        620        630        640        650
SAILELFEYI RVENIKPLVS HIVEKFYNTL ESIEYVQTFK GLKIKYEKER 
       660        670        680        690        700
DRQSQIQKNL HSVLQNIVVF RGTIEEIGLE EEICFMEDAG EVVMPPLEDD 
       710        720        730        740        750
DEFMETKRTQ EGEAVMPPLE DDDKFTETKR THQEGEAVMP PLEDDDEFME 
       760        770        780        790        800
TKRNQEHEGK VDSPKRTSSG DFKFSSSYSA CAAIGTGSPS GSSVVRLVDH 
       810        820        830 
PDDEEEKEED EEEKEEDKED ETSPKKKPHL SS

Length:832

Mass (Da):95,804

Last modified:December 20, 2017 - v3

Checksum:ⁱF9318B12F14DDB09

GO

Isoform 2 (identifier: Q6ZMV5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
734-809: Missing.

« Hide

        10         20         30         40         50
MAGLRYSVKV YVLNEDEEWN NLGTGQVSST YDEQFQGMSL LVRSDSDGSV 
        60         70         80         90        100
ILRSQIPPDR PYGKYQETLI VWYEAENQGL VLKFQDPAGC QDIWKEICQA 
       110        120        130        140        150
QGKDPSIQTT VNISDEPEED FNEMSVISNM VVLPDCELNT LDQIADIVTS 
       160        170        180        190        200
VFSSPVTDRE RLAEILKNEA YIPKLLQLFH TCENLENTEG LHHLYEIIKG 
       210        220        230        240        250
ILFLNEACLF EIMFSDECIM DVVGCLEYDP ALDQPKRHRD FLTNDAKFKE 
       260        270        280        290        300
VIPITNSELR QKIHQTYRLQ YIYDILLPVP SIFEDNFLST LTTFIFSNKA 
       310        320        330        340        350
EIVSMLQKDH KFLYEVFAQL KDETTHDDRR CELLFFFKEL CSFSQALQPQ 
       360        370        380        390        400
SKDALFETLI QLGVLPALKI VMIRDDLQVR SAAAVICAYL VEYSPSRIRE 
       410        420        430        440        450
FIISEAHVCK DSDLFINVII KQMICDTDPE LGGAVHLMVV LHTLLDPRNM 
       460        470        480        490        500
LTTPEKSERS EFLHFFYKHC MHKFTAPLLA ATSEHNCEED DIAGYDKSKN 
       510        520        530        540        550
CPNDNQTAQL LALILELLTF CIQHHTFYIR SYILNKDLLR KALILMNSKH 
       560        570        580        590        600
THLILCVLRF MRRMICLNDE AYNNYIIKGN LFEPVVNALL DNGTRYNMLN 
       610        620        630        640        650
SAILELFEYI RVENIKPLVS HIVEKFYNTL ESIEYVQTFK GLKIKYEKER 
       660        670        680        690        700
DRQSQIQKNL HSVLQNIVVF RGTIEEIGLE EEICFMEDAG EVVMPPLEDD 
       710        720        730        740        750
DEFMETKRTQ EGEAVMPPLE DDDKFTETKR THQDEEEKEE DKEDETSPKK 

KPHLSS

Note: No experimental confirmation available.

Show »

Length:756

Mass (Da):87,529

Checksum:ⁱF3FA37E8C8E7F413

GO

Sequence cautionⁱ

The sequence BAB71482 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	412 – 413	SD → IY in BAD18620 (PubMed:14702039).Curated	2
Sequence conflictⁱ	692	V → A in BAD18620 (PubMed:14702039).Curated	1
Sequence conflictⁱ	692	V → A in BAB71482 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034762	734 – 809	Missing in isoform 2. 1 PublicationAdd BLAST		76

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057429 mRNA Translation: BAB71482.1 Different initiation. AK131475 mRNA Translation: BAD18620.1 AC006210 Genomic DNA No translation available.
UniGeneⁱ	Hs.350673 Hs.641864

Genome annotation databases

Ensemblⁱ	ENST00000412172; ENSP00000489770; ENSG00000224960 [Q6ZMV5-1]

Ensemblⁱ

ENST00000412172; ENSP00000489770; ENSG00000224960 [Q6ZMV5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length
Q6ZMV5	PPP4R3CP isoform 1		PANTR		832
Protein phosphatase 4 regulatory subunit 3C		PANPA		832
PPP4R3CP isoform 1		PONAB		825
UPI0005F3C1E3		COLAP		823
Protein phosphatase 4 regulatory subunit 3C		GORGO		822
+5

Protein	Similar proteins		Species	Score	Length
Q6ZMV5	PPP4R3CP isoform 1		PANTR		832
Protein phosphatase 4 regulatory subunit 3C		PANPA		832
Protein phosphatase 4 regulatory subunit 3C		PONAB		825
UPI0005F3C1E3		COLAP		823
Protein phosphatase 4 regulatory subunit 3C		GORGO		822
+5

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057429 mRNA Translation: BAB71482.1 Different initiation. AK131475 mRNA Translation: BAD18620.1 AC006210 Genomic DNA No translation available.
UniGeneⁱ	Hs.350673 Hs.641864

3D structure databases

ProteinModelPortalⁱ	Q6ZMV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Polymorphism and mutation databases

DMDMⁱ	206558317

DMDMⁱ

206558317

Proteomic databases

EPDⁱ	Q6ZMV5
PeptideAtlas More...PeptideAtlasⁱ	Q6ZMV5
PRIDEⁱ	Q6ZMV5
ProteomicsDBⁱ	67920 67921 [Q6ZMV5-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000412172; ENSP00000489770; ENSG00000224960 [Q6ZMV5-1]

Ensemblⁱ

ENST00000412172; ENSP00000489770; ENSG00000224960 [Q6ZMV5-1]

Organism-specific databases

GeneCardsⁱ	PPP4R3C
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33146 PPP4R3C
neXtProtⁱ	NX_Q6ZMV5
Open Targets More...OpenTargetsⁱ	ENSG00000224960
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018199
HOVERGENⁱ	HBG056624
InParanoidⁱ	Q6ZMV5
OMAⁱ	RFMRRMI
PhylomeDBⁱ	Q6ZMV5

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6ZMV5

PROⁱ

PR:Q6ZMV5

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR006887 DUF625 IPR011993 PH-like_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04802 SMK-1, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	P4R3C_HUMAN
Accessionⁱ	Q6ZMV5Primary (citable) accession number: Q6ZMV5 Secondary accession number(s): A0A1B0GTN1, Q96M31
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
	Last sequence update:	December 20, 2017
	Last modified:	June 20, 2018
	This is version 83 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6ZMV5 (P4R3C_HUMAN)

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Protein PPP4R3C

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ