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Protein

Protein PPP4R3C

Gene

PPP4R3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PPP4R3CCurated
Alternative name(s):
SMEK homolog 3
Serine/threonine-protein phosphatase 4 regulatory subunit 3CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP4R3CImported
Synonyms:PPP4R3CP, SMEK3P
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33146 PPP4R3C

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZMV5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000224960

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
206558317

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003444471 – 832Protein PPP4R3CAdd BLAST832

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6ZMV5

PeptideAtlas

More...
PeptideAtlasi
Q6ZMV5

PRoteomics IDEntifications database

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PRIDEi
Q6ZMV5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67920
67921 [Q6ZMV5-2]

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6ZMV5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMEK family.Curated

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00390000018199

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056624

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZMV5

Identification of Orthologs from Complete Genome Data

More...
OMAi
VICAYLV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZMV5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR006887 DUF625
IPR011993 PH-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04802 SMK-1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZMV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLRYSVKV YVLNEDEEWN NLGTGQVSST YDEQFQGMSL LVRSDSDGSV
60 70 80 90 100
ILRSQIPPDR PYGKYQETLI VWYEAENQGL VLKFQDPAGC QDIWKEICQA
110 120 130 140 150
QGKDPSIQTT VNISDEPEED FNEMSVISNM VVLPDCELNT LDQIADIVTS
160 170 180 190 200
VFSSPVTDRE RLAEILKNEA YIPKLLQLFH TCENLENTEG LHHLYEIIKG
210 220 230 240 250
ILFLNEACLF EIMFSDECIM DVVGCLEYDP ALDQPKRHRD FLTNDAKFKE
260 270 280 290 300
VIPITNSELR QKIHQTYRLQ YIYDILLPVP SIFEDNFLST LTTFIFSNKA
310 320 330 340 350
EIVSMLQKDH KFLYEVFAQL KDETTHDDRR CELLFFFKEL CSFSQALQPQ
360 370 380 390 400
SKDALFETLI QLGVLPALKI VMIRDDLQVR SAAAVICAYL VEYSPSRIRE
410 420 430 440 450
FIISEAHVCK DSDLFINVII KQMICDTDPE LGGAVHLMVV LHTLLDPRNM
460 470 480 490 500
LTTPEKSERS EFLHFFYKHC MHKFTAPLLA ATSEHNCEED DIAGYDKSKN
510 520 530 540 550
CPNDNQTAQL LALILELLTF CIQHHTFYIR SYILNKDLLR KALILMNSKH
560 570 580 590 600
THLILCVLRF MRRMICLNDE AYNNYIIKGN LFEPVVNALL DNGTRYNMLN
610 620 630 640 650
SAILELFEYI RVENIKPLVS HIVEKFYNTL ESIEYVQTFK GLKIKYEKER
660 670 680 690 700
DRQSQIQKNL HSVLQNIVVF RGTIEEIGLE EEICFMEDAG EVVMPPLEDD
710 720 730 740 750
DEFMETKRTQ EGEAVMPPLE DDDKFTETKR THQEGEAVMP PLEDDDEFME
760 770 780 790 800
TKRNQEHEGK VDSPKRTSSG DFKFSSSYSA CAAIGTGSPS GSSVVRLVDH
810 820 830
PDDEEEKEED EEEKEEDKED ETSPKKKPHL SS
Length:832
Mass (Da):95,804
Last modified:December 20, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9318B12F14DDB09
GO
Isoform 2 (identifier: Q6ZMV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     734-809: Missing.

Note: No experimental confirmation available.
Show »
Length:756
Mass (Da):87,529
Checksum:iF3FA37E8C8E7F413
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB71482 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti412 – 413SD → IY in BAD18620 (PubMed:14702039).Curated2
Sequence conflicti692V → A in BAD18620 (PubMed:14702039).Curated1
Sequence conflicti692V → A in BAB71482 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034762734 – 809Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK057429 mRNA Translation: BAB71482.1 Different initiation.
AK131475 mRNA Translation: BAD18620.1
AC006210 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS87732.1 [Q6ZMV5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.350673
Hs.641864

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000412172; ENSP00000489770; ENSG00000224960 [Q6ZMV5-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057429 mRNA Translation: BAB71482.1 Different initiation.
AK131475 mRNA Translation: BAD18620.1
AC006210 Genomic DNA No translation available.
CCDSiCCDS87732.1 [Q6ZMV5-1]
UniGeneiHs.350673
Hs.641864

3D structure databases

ProteinModelPortaliQ6ZMV5
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi206558317

Proteomic databases

EPDiQ6ZMV5
PeptideAtlasiQ6ZMV5
PRIDEiQ6ZMV5
ProteomicsDBi67920
67921 [Q6ZMV5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412172; ENSP00000489770; ENSG00000224960 [Q6ZMV5-1]

Organism-specific databases

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP4R3C
HGNCiHGNC:33146 PPP4R3C
neXtProtiNX_Q6ZMV5
OpenTargetsiENSG00000224960

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000018199
HOVERGENiHBG056624
InParanoidiQ6ZMV5
OMAiVICAYLV
PhylomeDBiQ6ZMV5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6ZMV5

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR006887 DUF625
IPR011993 PH-like_dom_sf
PfamiView protein in Pfam
PF04802 SMK-1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP4R3C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMV5
Secondary accession number(s): A0A1B0GTN1, Q96M31
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 20, 2017
Last modified: November 7, 2018
This is version 85 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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