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UniProtKB - Q6ZMV5 (P4R3C_HUMAN)

Entry version 97 (25 May 2022)
Sequence version 3 (20 Dec 2017)
Previous versions | rss
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Protein

Protein PPP4R3C

Gene

PPP4R3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZMV5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PPP4R3CCurated
Alternative name(s):
SMEK homolog 3
Serine/threonine-protein phosphatase 4 regulatory subunit 3CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP4R3CImported
Synonyms:PPP4R3CP, SMEK3P
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:33146, PPP4R3C

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZMV5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000224960

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000224960

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZMV5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPP4R3C

Domain mapping of disease mutations (DMDM)

More...DMDMi		206558317

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003444471 – 832Protein PPP4R3CAdd BLAST832

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZMV5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZMV5

PeptideAtlas

More...PeptideAtlasi		Q6ZMV5

PRoteomics IDEntifications database

More...PRIDEi		Q6ZMV5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67920 [Q6ZMV5-1]
67921 [Q6ZMV5-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000224960, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZMV5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6ZMV5

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni708 – 832DisorderedSequence analysisAdd BLAST125

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi708 – 767Basic and acidic residuesSequence analysisAdd BLAST60
Compositional biasi768 – 793Polar residuesSequence analysisAdd BLAST26
Compositional biasi803 – 818Acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMEK family.Curated

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018199

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZMV5

Identification of Orthologs from Complete Genome Data

More...OMAi		EFLHFFY

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZMV5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR006887, DUF625
IPR011993, PH-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04802, SMK-1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZMV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLRYSVKV YVLNEDEEWN NLGTGQVSST YDEQFQGMSL LVRSDSDGSV 
        60         70         80         90        100
ILRSQIPPDR PYGKYQETLI VWYEAENQGL VLKFQDPAGC QDIWKEICQA 
       110        120        130        140        150
QGKDPSIQTT VNISDEPEED FNEMSVISNM VVLPDCELNT LDQIADIVTS 
       160        170        180        190        200
VFSSPVTDRE RLAEILKNEA YIPKLLQLFH TCENLENTEG LHHLYEIIKG 
       210        220        230        240        250
ILFLNEACLF EIMFSDECIM DVVGCLEYDP ALDQPKRHRD FLTNDAKFKE 
       260        270        280        290        300
VIPITNSELR QKIHQTYRLQ YIYDILLPVP SIFEDNFLST LTTFIFSNKA 
       310        320        330        340        350
EIVSMLQKDH KFLYEVFAQL KDETTHDDRR CELLFFFKEL CSFSQALQPQ 
       360        370        380        390        400
SKDALFETLI QLGVLPALKI VMIRDDLQVR SAAAVICAYL VEYSPSRIRE 
       410        420        430        440        450
FIISEAHVCK DSDLFINVII KQMICDTDPE LGGAVHLMVV LHTLLDPRNM 
       460        470        480        490        500
LTTPEKSERS EFLHFFYKHC MHKFTAPLLA ATSEHNCEED DIAGYDKSKN 
       510        520        530        540        550
CPNDNQTAQL LALILELLTF CIQHHTFYIR SYILNKDLLR KALILMNSKH 
       560        570        580        590        600
THLILCVLRF MRRMICLNDE AYNNYIIKGN LFEPVVNALL DNGTRYNMLN 
       610        620        630        640        650
SAILELFEYI RVENIKPLVS HIVEKFYNTL ESIEYVQTFK GLKIKYEKER 
       660        670        680        690        700
DRQSQIQKNL HSVLQNIVVF RGTIEEIGLE EEICFMEDAG EVVMPPLEDD 
       710        720        730        740        750
DEFMETKRTQ EGEAVMPPLE DDDKFTETKR THQEGEAVMP PLEDDDEFME 
       760        770        780        790        800
TKRNQEHEGK VDSPKRTSSG DFKFSSSYSA CAAIGTGSPS GSSVVRLVDH 
       810        820        830 
PDDEEEKEED EEEKEEDKED ETSPKKKPHL SS
Length:832
Mass (Da):95,804
Last modified:December 20, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9318B12F14DDB09
GO
Isoform 2 (identifier: Q6ZMV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     734-809: Missing.

Show »
Length:756
Mass (Da):87,529
Checksum:iF3FA37E8C8E7F413
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB71482 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti412 – 413SD → IY in BAD18620 (PubMed:14702039).Curated2
Sequence conflicti692V → A in BAD18620 (PubMed:14702039).Curated1
Sequence conflicti692V → A in BAB71482 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034762734 – 809Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK057429 mRNA Translation: BAB71482.1 Different initiation.
AK131475 mRNA Translation: BAD18620.1
AC006210 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS87732.1 [Q6ZMV5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000412172.4; ENSP00000489770.1; ENSG00000224960.5

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000412172.4; ENSP00000489770.1; NM_207319.4; NP_997202.3

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057429 mRNA Translation: BAB71482.1 Different initiation.
AK131475 mRNA Translation: BAD18620.1
AC006210 Genomic DNA No translation available.
CCDSiCCDS87732.1 [Q6ZMV5-1]

3D structure databases

AlphaFoldDBiQ6ZMV5
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Genetic variation databases

BioMutaiPPP4R3C
DMDMi206558317

Proteomic databases

EPDiQ6ZMV5
MassIVEiQ6ZMV5
PeptideAtlasiQ6ZMV5
PRIDEiQ6ZMV5
ProteomicsDBi67920 [Q6ZMV5-1]
67921 [Q6ZMV5-2]

Genome annotation databases

EnsembliENST00000412172.4; ENSP00000489770.1; ENSG00000224960.5
MANE-SelectiENST00000412172.4; ENSP00000489770.1; NM_207319.4; NP_997202.3

Organism-specific databases

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPP4R3C
HGNCiHGNC:33146, PPP4R3C
HPAiENSG00000224960, Tissue enriched (testis)
neXtProtiNX_Q6ZMV5
OpenTargetsiENSG00000224960
VEuPathDBiHostDB:ENSG00000224960

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00390000018199
InParanoidiQ6ZMV5
OMAiEFLHFFY
PhylomeDBiQ6ZMV5

Enzyme and pathway databases

PathwayCommonsiQ6ZMV5

Miscellaneous databases

PharosiQ6ZMV5, Tdark

Protein Ontology

More...PROi		PR:Q6ZMV5
RNActiQ6ZMV5, protein

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR006887, DUF625
IPR011993, PH-like_dom_sf
PfamiView protein in Pfam
PF04802, SMK-1, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP4R3C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMV5
Secondary accession number(s): A0A1B0GTN1, Q96M31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 20, 2017
Last modified: May 25, 2022
This is version 97 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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