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UniProtKB - Q6ZMV5 (P4R3C_HUMAN)
Protein
Protein PPP4R3C
Gene
PPP4R3C
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- protein phosphatase activator activity Source: GO_Central
GO - Biological processi
- cellular response to DNA damage stimulus Source: GO_Central
- protein dephosphorylation Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q6ZMV5 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein PPP4R3CCuratedAlternative name(s): SMEK homolog 3 Serine/threonine-protein phosphatase 4 regulatory subunit 3CImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33146, PPP4R3C |
neXtProti | NX_Q6ZMV5 |
VEuPathDBi | HostDB:ENSG00000224960 |
Subcellular locationi
Nucleus
- nucleoplasm Source: GO_Central
Other locations
- protein phosphatase 4 complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000224960 |
Miscellaneous databases
Pharosi | Q6ZMV5, Tdark |
Genetic variation databases
BioMutai | PPP4R3C |
DMDMi | 206558317 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000344447 | 1 – 832 | Protein PPP4R3CAdd BLAST | 832 |
Proteomic databases
EPDi | Q6ZMV5 |
MassIVEi | Q6ZMV5 |
PeptideAtlasi | Q6ZMV5 |
PRIDEi | Q6ZMV5 |
ProteomicsDBi | 67920 [Q6ZMV5-1] 67921 [Q6ZMV5-2] |
Structurei
3D structure databases
AlphaFoldDBi | Q6ZMV5 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 708 – 832 | DisorderedSequence analysisAdd BLAST | 125 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 708 – 767 | Basic and acidic residuesSequence analysisAdd BLAST | 60 | |
Compositional biasi | 768 – 793 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 803 – 818 | Acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the SMEK family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000018199 |
InParanoidi | Q6ZMV5 |
OMAi | EFLHFFY |
PhylomeDBi | Q6ZMV5 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR006887, DUF625 IPR011993, PH-like_dom_sf |
Pfami | View protein in Pfam PF04802, SMK-1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6ZMV5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGLRYSVKV YVLNEDEEWN NLGTGQVSST YDEQFQGMSL LVRSDSDGSV
60 70 80 90 100
ILRSQIPPDR PYGKYQETLI VWYEAENQGL VLKFQDPAGC QDIWKEICQA
110 120 130 140 150
QGKDPSIQTT VNISDEPEED FNEMSVISNM VVLPDCELNT LDQIADIVTS
160 170 180 190 200
VFSSPVTDRE RLAEILKNEA YIPKLLQLFH TCENLENTEG LHHLYEIIKG
210 220 230 240 250
ILFLNEACLF EIMFSDECIM DVVGCLEYDP ALDQPKRHRD FLTNDAKFKE
260 270 280 290 300
VIPITNSELR QKIHQTYRLQ YIYDILLPVP SIFEDNFLST LTTFIFSNKA
310 320 330 340 350
EIVSMLQKDH KFLYEVFAQL KDETTHDDRR CELLFFFKEL CSFSQALQPQ
360 370 380 390 400
SKDALFETLI QLGVLPALKI VMIRDDLQVR SAAAVICAYL VEYSPSRIRE
410 420 430 440 450
FIISEAHVCK DSDLFINVII KQMICDTDPE LGGAVHLMVV LHTLLDPRNM
460 470 480 490 500
LTTPEKSERS EFLHFFYKHC MHKFTAPLLA ATSEHNCEED DIAGYDKSKN
510 520 530 540 550
CPNDNQTAQL LALILELLTF CIQHHTFYIR SYILNKDLLR KALILMNSKH
560 570 580 590 600
THLILCVLRF MRRMICLNDE AYNNYIIKGN LFEPVVNALL DNGTRYNMLN
610 620 630 640 650
SAILELFEYI RVENIKPLVS HIVEKFYNTL ESIEYVQTFK GLKIKYEKER
660 670 680 690 700
DRQSQIQKNL HSVLQNIVVF RGTIEEIGLE EEICFMEDAG EVVMPPLEDD
710 720 730 740 750
DEFMETKRTQ EGEAVMPPLE DDDKFTETKR THQEGEAVMP PLEDDDEFME
760 770 780 790 800
TKRNQEHEGK VDSPKRTSSG DFKFSSSYSA CAAIGTGSPS GSSVVRLVDH
810 820 830
PDDEEEKEED EEEKEEDKED ETSPKKKPHL SS
Sequence cautioni
The sequence BAB71482 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 412 – 413 | SD → IY in BAD18620 (PubMed:14702039).Curated | 2 | |
Sequence conflicti | 692 | V → A in BAD18620 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 692 | V → A in BAB71482 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034762 | 734 – 809 | Missing in isoform 2. 1 PublicationAdd BLAST | 76 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057429 mRNA Translation: BAB71482.1 Different initiation. AK131475 mRNA Translation: BAD18620.1 AC006210 Genomic DNA No translation available. |
CCDSi | CCDS87732.1 [Q6ZMV5-1] |
Genome annotation databases
Ensembli | ENST00000412172.4; ENSP00000489770.1; ENSG00000224960.5 |
MANE-Selecti | ENST00000412172.4; ENSP00000489770.1; NM_207319.4; NP_997202.3 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057429 mRNA Translation: BAB71482.1 Different initiation. AK131475 mRNA Translation: BAD18620.1 AC006210 Genomic DNA No translation available. |
CCDSi | CCDS87732.1 [Q6ZMV5-1] |
3D structure databases
AlphaFoldDBi | Q6ZMV5 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genetic variation databases
BioMutai | PPP4R3C |
DMDMi | 206558317 |
Proteomic databases
EPDi | Q6ZMV5 |
MassIVEi | Q6ZMV5 |
PeptideAtlasi | Q6ZMV5 |
PRIDEi | Q6ZMV5 |
ProteomicsDBi | 67920 [Q6ZMV5-1] 67921 [Q6ZMV5-2] |
Genome annotation databases
Ensembli | ENST00000412172.4; ENSP00000489770.1; ENSG00000224960.5 |
MANE-Selecti | ENST00000412172.4; ENSP00000489770.1; NM_207319.4; NP_997202.3 |
Organism-specific databases
GeneCardsi | PPP4R3C |
HGNCi | HGNC:33146, PPP4R3C |
HPAi | ENSG00000224960, Tissue enriched (testis) |
neXtProti | NX_Q6ZMV5 |
OpenTargetsi | ENSG00000224960 |
VEuPathDBi | HostDB:ENSG00000224960 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000018199 |
InParanoidi | Q6ZMV5 |
OMAi | EFLHFFY |
PhylomeDBi | Q6ZMV5 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZMV5 |
Miscellaneous databases
Pharosi | Q6ZMV5, Tdark |
PROi | PR:Q6ZMV5 |
RNActi | Q6ZMV5, protein |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR006887, DUF625 IPR011993, PH-like_dom_sf |
Pfami | View protein in Pfam PF04802, SMK-1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P4R3C_HUMAN | |
Accessioni | Q6ZMV5Primary (citable) accession number: Q6ZMV5 Secondary accession number(s): A0A1B0GTN1, Q96M31 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | December 20, 2017 | |
Last modified: | May 25, 2022 | |
This is version 97 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families