UniProtKB - Q6ZMT9 (DTHD1_HUMAN)
Protein
Death domain-containing protein 1
Gene
DTHD1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- signal transduction Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q6ZMT9 |
Names & Taxonomyi
Protein namesi | Recommended name: Death domain-containing protein 1 |
Gene namesi | Name:DTHD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:37261, DTHD1 |
MIMi | 616979, gene |
neXtProti | NX_Q6ZMT9 |
VEuPathDBi | HostDB:ENSG00000197057.8 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 401124 |
OpenTargetsi | ENSG00000197057 |
PharmGKBi | PA165663634 |
Miscellaneous databases
Pharosi | Q6ZMT9, Tdark |
Genetic variation databases
BioMutai | DTHD1 |
DMDMi | 300669694 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349274 | 1 – 781 | Death domain-containing protein 1Add BLAST | 781 |
Proteomic databases
jPOSTi | Q6ZMT9 |
PaxDbi | Q6ZMT9 |
PeptideAtlasi | Q6ZMT9 |
PRIDEi | Q6ZMT9 |
ProteomicsDBi | 67915 [Q6ZMT9-1] 67916 [Q6ZMT9-2] |
PTM databases
iPTMneti | Q6ZMT9 |
PhosphoSitePlusi | Q6ZMT9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197057, Expressed in right uterine tube and 91 other tissues |
ExpressionAtlasi | Q6ZMT9, baseline and differential |
Genevisiblei | Q6ZMT9, HS |
Organism-specific databases
HPAi | ENSG00000197057, Tissue enhanced (brain, fallopian tube, lung) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000401597 |
Miscellaneous databases
RNActi | Q6ZMT9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 167 – 301 | ZU5 1PROSITE-ProRule annotationAdd BLAST | 135 | |
Domaini | 302 – 483 | ZU5 2PROSITE-ProRule annotationAdd BLAST | 182 | |
Domaini | 679 – 764 | DeathPROSITE-ProRule annotationAdd BLAST | 86 |
Phylogenomic databases
eggNOGi | ENOG502QTTM, Eukaryota |
GeneTreei | ENSGT00940000153404 |
HOGENOMi | CLU_013631_0_0_1 |
InParanoidi | Q6ZMT9 |
OrthoDBi | 1115198at2759 |
PhylomeDBi | Q6ZMT9 |
TreeFami | TF351910 |
Family and domain databases
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00531, Death, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZMT9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHDECTPQQT MSSIQDTKAA DIAARGELNV IETATVSPTN GEESHYTNQV
60 70 80 90 100
QLEKNKTHMS SALVEKENNT SLNGRVLGQE ESQNKMFPDN AENEDDKQIE
110 120 130 140 150
HMTVENINGN REETHGIIQT TETEIQETSE SPREEMTTSS IICDISKKYI
160 170 180 190 200
NSTLPNDSEN IKHKNNIMEK EYLDVLSDVT GPQVSCYITA PSYVLQQLEC
210 220 230 240 250
RIINHMSSLI VGDNEELVSN VITIECSDKE KRVPFPIGIA IPFTARYRGN
260 270 280 290 300
YRDIMVKVCD INLQSSYLNP NSLEGMKGGY KGTCASVKVY KLGIFSVVSC
310 320 330 340 350
LKKESFTVTK KGLALKSSMD SRISLNYPPG VFTSPVLVQL KIQPVDPALV
360 370 380 390 400
AHLKAQQDTF YSVQSTSPLI HIQHPSTYPF QKPVTLFLPC SPYLDKNNLG
410 420 430 440 450
SEIDHKRRAS ATINRITPSY FNRTKIASIR KPRKNASECL KLLGFRSQDS
460 470 480 490 500
GWCGLDDVVK TIQSGLVSVE LYEHLERFIV LHLSSTMDNS HLVTFVKSLE
510 520 530 540 550
EAMLSTTACI VLSHQKDNPH RIAVLVVPSK DLSQVLKDLH LEGFGGPPEP
560 570 580 590 600
SRHFQVREGE QLLLRFTGNI FASSNGKDYG KDYTLIFHLQ RKPRLELQIK
610 620 630 640 650
EVDEFGNYSC PHYKGTIVVY KVPKGKIVPN LNQSLVINEN HSQLPICKLP
660 670 680 690 700
LKLPKHKKLI NRPQSTKRVS KDPVEALWDN LLHWLAEELS EENAESLSST
710 720 730 740 750
LPLRRSTIQL IKLKNPDDLT EQIHEFLCFW KKSLPTFTDK LRLLARHLRK
760 770 780
IGRSDLAEEL KFKWENKVFT EPQQCFDVAP E
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RB49 | D6RB49_HUMAN | Death domain-containing protein 1 | DTHD1 | 821 | Annotation score: | ||
A0A1W2PR94 | A0A1W2PR94_HUMAN | Death domain-containing protein 1 | DTHD1 | 906 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 749 | R → S in BAG65199 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 749 | R → S in BAH14894 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046339 | 26 | G → R. Corresponds to variant dbSNP:rs16992035Ensembl. | 1 | |
Natural variantiVAR_046340 | 179 | V → D2 PublicationsCorresponds to variant dbSNP:rs1995319Ensembl. | 1 | |
Natural variantiVAR_046341 | 552 | R → C1 PublicationCorresponds to variant dbSNP:rs12507599Ensembl. | 1 | |
Natural variantiVAR_046342 | 662 | R → H1 PublicationCorresponds to variant dbSNP:rs9654132Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035302 | 1 – 165 | Missing in isoform 2. 1 PublicationAdd BLAST | 165 | |
Alternative sequenceiVSP_035303 | 166 – 171 | NIMEKE → MCLEKR in isoform 2. 1 Publication | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131492 mRNA Translation: BAD18636.1 AK304357 mRNA Translation: BAG65199.1 AK316523 mRNA Translation: BAH14894.1 AC104078 Genomic DNA No translation available. BC157885 mRNA Translation: AAI57886.1 |
RefSeqi | NP_001130008.2, NM_001136536.4 [Q6ZMT9-2] NP_001164171.1, NM_001170700.2 |
Genome annotation databases
Ensembli | ENST00000357504; ENSP00000350103; ENSG00000197057 [Q6ZMT9-2] ENST00000456874; ENSP00000401597; ENSG00000197057 [Q6ZMT9-1] |
GeneIDi | 401124 |
KEGGi | hsa:401124 |
UCSCi | uc011bxy.4, human [Q6ZMT9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131492 mRNA Translation: BAD18636.1 AK304357 mRNA Translation: BAG65199.1 AK316523 mRNA Translation: BAH14894.1 AC104078 Genomic DNA No translation available. BC157885 mRNA Translation: AAI57886.1 |
RefSeqi | NP_001130008.2, NM_001136536.4 [Q6ZMT9-2] NP_001164171.1, NM_001170700.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000401597 |
PTM databases
iPTMneti | Q6ZMT9 |
PhosphoSitePlusi | Q6ZMT9 |
Genetic variation databases
BioMutai | DTHD1 |
DMDMi | 300669694 |
Proteomic databases
jPOSTi | Q6ZMT9 |
PaxDbi | Q6ZMT9 |
PeptideAtlasi | Q6ZMT9 |
PRIDEi | Q6ZMT9 |
ProteomicsDBi | 67915 [Q6ZMT9-1] 67916 [Q6ZMT9-2] |
Protocols and materials databases
Antibodypediai | 52334, 6 antibodies |
Genome annotation databases
Ensembli | ENST00000357504; ENSP00000350103; ENSG00000197057 [Q6ZMT9-2] ENST00000456874; ENSP00000401597; ENSG00000197057 [Q6ZMT9-1] |
GeneIDi | 401124 |
KEGGi | hsa:401124 |
UCSCi | uc011bxy.4, human [Q6ZMT9-1] |
Organism-specific databases
CTDi | 401124 |
DisGeNETi | 401124 |
GeneCardsi | DTHD1 |
HGNCi | HGNC:37261, DTHD1 |
HPAi | ENSG00000197057, Tissue enhanced (brain, fallopian tube, lung) |
MIMi | 616979, gene |
neXtProti | NX_Q6ZMT9 |
OpenTargetsi | ENSG00000197057 |
PharmGKBi | PA165663634 |
VEuPathDBi | HostDB:ENSG00000197057.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTTM, Eukaryota |
GeneTreei | ENSGT00940000153404 |
HOGENOMi | CLU_013631_0_0_1 |
InParanoidi | Q6ZMT9 |
OrthoDBi | 1115198at2759 |
PhylomeDBi | Q6ZMT9 |
TreeFami | TF351910 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZMT9 |
Miscellaneous databases
BioGRID-ORCSi | 401124, 7 hits in 945 CRISPR screens |
ChiTaRSi | DTHD1, human |
GenomeRNAii | 401124 |
Pharosi | Q6ZMT9, Tdark |
PROi | PR:Q6ZMT9 |
RNActi | Q6ZMT9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197057, Expressed in right uterine tube and 91 other tissues |
ExpressionAtlasi | Q6ZMT9, baseline and differential |
Genevisiblei | Q6ZMT9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00531, Death, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DTHD1_HUMAN | |
Accessioni | Q6ZMT9Primary (citable) accession number: Q6ZMT9 Secondary accession number(s): B2RXK4, B4E2N7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | July 13, 2010 | |
Last modified: | April 7, 2021 | |
This is version 118 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot