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Entry version 118 (07 Apr 2021)
Sequence version 3 (13 Jul 2010)
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Protein

Death domain-containing protein 1

Gene

DTHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZMT9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Death domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DTHD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:37261, DTHD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616979, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZMT9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000197057.8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
401124

Open Targets

More...
OpenTargetsi
ENSG00000197057

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165663634

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZMT9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DTHD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
300669694

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003492741 – 781Death domain-containing protein 1Add BLAST781

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZMT9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZMT9

PeptideAtlas

More...
PeptideAtlasi
Q6ZMT9

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZMT9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67915 [Q6ZMT9-1]
67916 [Q6ZMT9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZMT9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZMT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197057, Expressed in right uterine tube and 91 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZMT9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZMT9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197057, Tissue enhanced (brain, fallopian tube, lung)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000401597

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZMT9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 301ZU5 1PROSITE-ProRule annotationAdd BLAST135
Domaini302 – 483ZU5 2PROSITE-ProRule annotationAdd BLAST182
Domaini679 – 764DeathPROSITE-ProRule annotationAdd BLAST86

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTTM, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153404

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013631_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZMT9

Database of Orthologous Groups

More...
OrthoDBi
1115198at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZMT9

TreeFam database of animal gene trees

More...
TreeFami
TF351910

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00531, Death, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZMT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHDECTPQQT MSSIQDTKAA DIAARGELNV IETATVSPTN GEESHYTNQV
60 70 80 90 100
QLEKNKTHMS SALVEKENNT SLNGRVLGQE ESQNKMFPDN AENEDDKQIE
110 120 130 140 150
HMTVENINGN REETHGIIQT TETEIQETSE SPREEMTTSS IICDISKKYI
160 170 180 190 200
NSTLPNDSEN IKHKNNIMEK EYLDVLSDVT GPQVSCYITA PSYVLQQLEC
210 220 230 240 250
RIINHMSSLI VGDNEELVSN VITIECSDKE KRVPFPIGIA IPFTARYRGN
260 270 280 290 300
YRDIMVKVCD INLQSSYLNP NSLEGMKGGY KGTCASVKVY KLGIFSVVSC
310 320 330 340 350
LKKESFTVTK KGLALKSSMD SRISLNYPPG VFTSPVLVQL KIQPVDPALV
360 370 380 390 400
AHLKAQQDTF YSVQSTSPLI HIQHPSTYPF QKPVTLFLPC SPYLDKNNLG
410 420 430 440 450
SEIDHKRRAS ATINRITPSY FNRTKIASIR KPRKNASECL KLLGFRSQDS
460 470 480 490 500
GWCGLDDVVK TIQSGLVSVE LYEHLERFIV LHLSSTMDNS HLVTFVKSLE
510 520 530 540 550
EAMLSTTACI VLSHQKDNPH RIAVLVVPSK DLSQVLKDLH LEGFGGPPEP
560 570 580 590 600
SRHFQVREGE QLLLRFTGNI FASSNGKDYG KDYTLIFHLQ RKPRLELQIK
610 620 630 640 650
EVDEFGNYSC PHYKGTIVVY KVPKGKIVPN LNQSLVINEN HSQLPICKLP
660 670 680 690 700
LKLPKHKKLI NRPQSTKRVS KDPVEALWDN LLHWLAEELS EENAESLSST
710 720 730 740 750
LPLRRSTIQL IKLKNPDDLT EQIHEFLCFW KKSLPTFTDK LRLLARHLRK
760 770 780
IGRSDLAEEL KFKWENKVFT EPQQCFDVAP E
Length:781
Mass (Da):88,329
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D92ADC3A73E613F
GO
Isoform 2 (identifier: Q6ZMT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.
     166-171: NIMEKE → MCLEKR

Show »
Length:616
Mass (Da):69,841
Checksum:iECA47121F34919DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RB49D6RB49_HUMAN
Death domain-containing protein 1
DTHD1
821Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PR94A0A1W2PR94_HUMAN
Death domain-containing protein 1
DTHD1
906Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti749R → S in BAG65199 (PubMed:14702039).Curated1
Sequence conflicti749R → S in BAH14894 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04633926G → R. Corresponds to variant dbSNP:rs16992035Ensembl.1
Natural variantiVAR_046340179V → D2 PublicationsCorresponds to variant dbSNP:rs1995319Ensembl.1
Natural variantiVAR_046341552R → C1 PublicationCorresponds to variant dbSNP:rs12507599Ensembl.1
Natural variantiVAR_046342662R → H1 PublicationCorresponds to variant dbSNP:rs9654132Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0353021 – 165Missing in isoform 2. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_035303166 – 171NIMEKE → MCLEKR in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK131492 mRNA Translation: BAD18636.1
AK304357 mRNA Translation: BAG65199.1
AK316523 mRNA Translation: BAH14894.1
AC104078 Genomic DNA No translation available.
BC157885 mRNA Translation: AAI57886.1

NCBI Reference Sequences

More...
RefSeqi
NP_001130008.2, NM_001136536.4 [Q6ZMT9-2]
NP_001164171.1, NM_001170700.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357504; ENSP00000350103; ENSG00000197057 [Q6ZMT9-2]
ENST00000456874; ENSP00000401597; ENSG00000197057 [Q6ZMT9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
401124

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:401124

UCSC genome browser

More...
UCSCi
uc011bxy.4, human [Q6ZMT9-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131492 mRNA Translation: BAD18636.1
AK304357 mRNA Translation: BAG65199.1
AK316523 mRNA Translation: BAH14894.1
AC104078 Genomic DNA No translation available.
BC157885 mRNA Translation: AAI57886.1
RefSeqiNP_001130008.2, NM_001136536.4 [Q6ZMT9-2]
NP_001164171.1, NM_001170700.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000401597

PTM databases

iPTMnetiQ6ZMT9
PhosphoSitePlusiQ6ZMT9

Genetic variation databases

BioMutaiDTHD1
DMDMi300669694

Proteomic databases

jPOSTiQ6ZMT9
PaxDbiQ6ZMT9
PeptideAtlasiQ6ZMT9
PRIDEiQ6ZMT9
ProteomicsDBi67915 [Q6ZMT9-1]
67916 [Q6ZMT9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52334, 6 antibodies

Genome annotation databases

EnsembliENST00000357504; ENSP00000350103; ENSG00000197057 [Q6ZMT9-2]
ENST00000456874; ENSP00000401597; ENSG00000197057 [Q6ZMT9-1]
GeneIDi401124
KEGGihsa:401124
UCSCiuc011bxy.4, human [Q6ZMT9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
401124
DisGeNETi401124

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DTHD1
HGNCiHGNC:37261, DTHD1
HPAiENSG00000197057, Tissue enhanced (brain, fallopian tube, lung)
MIMi616979, gene
neXtProtiNX_Q6ZMT9
OpenTargetsiENSG00000197057
PharmGKBiPA165663634
VEuPathDBiHostDB:ENSG00000197057.8

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QTTM, Eukaryota
GeneTreeiENSGT00940000153404
HOGENOMiCLU_013631_0_0_1
InParanoidiQ6ZMT9
OrthoDBi1115198at2759
PhylomeDBiQ6ZMT9
TreeFamiTF351910

Enzyme and pathway databases

PathwayCommonsiQ6ZMT9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
401124, 7 hits in 945 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DTHD1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
401124
PharosiQ6ZMT9, Tdark

Protein Ontology

More...
PROi
PR:Q6ZMT9
RNActiQ6ZMT9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197057, Expressed in right uterine tube and 91 other tissues
ExpressionAtlasiQ6ZMT9, baseline and differential
GenevisibleiQ6ZMT9, HS

Family and domain databases

InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00531, Death, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTHD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMT9
Secondary accession number(s): B2RXK4, B4E2N7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 13, 2010
Last modified: April 7, 2021
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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