UniProtKB - Q6ZMT1 (STAC2_HUMAN)
Protein
SH3 and cysteine-rich domain-containing protein 2
Gene
STAC2
Organism
Homo sapiens (Human)
Status
Functioni
Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 110 – 161 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 52 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- intracellular signal transduction Source: InterPro
- positive regulation of protein localization to plasma membrane Source: UniProtKB
- positive regulation of voltage-gated calcium channel activity Source: UniProtKB
- skeletal muscle contraction Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6ZMT1 |
Names & Taxonomyi
Protein namesi | Recommended name: SH3 and cysteine-rich domain-containing protein 2Alternative name(s): 24b2/STAC21 Publication Src homology 3 and cysteine-rich domain-containing protein 2 |
Gene namesi | Name:STAC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141750.6 |
HGNCi | HGNC:23990, STAC2 |
neXtProti | NX_Q6ZMT1 |
Subcellular locationi
Cytosol
- cytosol By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
- sarcolemma By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Colocalizes with CACNA1C at the plasma membrane of transfected cells.By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- sarcolemma Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 306 | Q → L: Mildly decreased affinity for CACNA1S. 1 Publication | 1 | |
Mutagenesisi | 329 | W → S: Loss of interaction with CACNA1S. 1 Publication | 1 | |
Mutagenesisi | 347 | Q → I: No effect on the structure of the two SH3 domains. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 342667 |
OpenTargetsi | ENSG00000141750 |
PharmGKBi | PA134939947 |
Miscellaneous databases
Pharosi | Q6ZMT1, Tdark |
Polymorphism and mutation databases
BioMutai | STAC2 |
DMDMi | 74749556 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274413 | 1 – 411 | SH3 and cysteine-rich domain-containing protein 2Add BLAST | 411 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 48 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q6ZMT1 |
PaxDbi | Q6ZMT1 |
PeptideAtlasi | Q6ZMT1 |
PRIDEi | Q6ZMT1 |
ProteomicsDBi | 67911 [Q6ZMT1-1] 67912 [Q6ZMT1-2] |
PTM databases
iPTMneti | Q6ZMT1 |
PhosphoSitePlusi | Q6ZMT1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141750, Expressed in popliteal artery and 133 other tissues |
ExpressionAtlasi | Q6ZMT1, baseline and differential |
Genevisiblei | Q6ZMT1, HS |
Organism-specific databases
HPAi | ENSG00000141750, Tissue enhanced (ductus deferens, seminal vesicle) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 131192, 16 interactors |
IntActi | Q6ZMT1, 3 interactors |
STRINGi | 9606.ENSP00000327509 |
Miscellaneous databases
RNActi | Q6ZMT1, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q6ZMT1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 292 – 351 | SH3 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 354 – 411 | SH3 2PROSITE-ProRule annotationAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 70 – 101 | Pro-richAdd BLAST | 32 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 110 – 161 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 52 |
Keywords - Domaini
Repeat, SH3 domain, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QW9G, Eukaryota |
GeneTreei | ENSGT00950000183092 |
HOGENOMi | CLU_048120_0_0_1 |
InParanoidi | Q6ZMT1 |
OMAi | AAHLWCS |
OrthoDBi | 584382at2759 |
PhylomeDBi | Q6ZMT1 |
TreeFami | TF332878 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd11985, SH3_Stac2_C, 1 hit |
InterProi | View protein in InterPro IPR002219, PE/DAG-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR039688, STAC1/2/3 IPR035509, Stac2_SH3 |
PANTHERi | PTHR15135, PTHR15135, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZMT1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTEMSEKENE PDDAATHSPP GTVSALQETK LQRFKRSLSL KTILRSKSLE
60 70 80 90 100
NFFLRSGSEL KCPTEVLLTP PTPLPPPSPP PTASDRGLAT PSPSPCPVPR
110 120 130 140 150
PLAALKPVRL HSFQEHVFKR ASPCELCHQL IVGNSKQGLR CKMCKVSVHL
160 170 180 190 200
WCSEEISHQQ CPGKTSTSFR RNFSSPLLVH EPPPVCATSK ESPPTGDSGK
210 220 230 240 250
VDPVYETLRY GTSLALMNRS SFSSTSESPT RSLSERDELT EDGEGSIRSS
260 270 280 290 300
EEGPGDSASP VFTAPAESEG PGPEEKSPGQ QLPKATLRKD VGPMYSYVAL
310 320 330 340 350
YKFLPQENND LALQPGDRIM LVDDSNEDWW KGKIGDRVGF FPANFVQRVR
360 370 380 390 400
PGENVWRCCQ PFSGNKEQGY MSLKENQICV GVGRSKDADG FIRVSSGKKR
410
GLVPVDALTE I
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3QKZ0 | J3QKZ0_HUMAN | SH3 and cysteine-rich domain-contai... | STAC2 | 148 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022742 | 1 – 142 | Missing in isoform 2. 1 PublicationAdd BLAST | 142 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ608762 mRNA Translation: CAE75539.1 AK131500 mRNA Translation: BAD18644.1 BC109231 mRNA Translation: AAI09232.1 |
CCDSi | CCDS11335.1 [Q6ZMT1-1] |
RefSeqi | NP_945344.1, NM_198993.3 [Q6ZMT1-1] |
Genome annotation databases
Ensembli | ENST00000333461; ENSP00000327509; ENSG00000141750 [Q6ZMT1-1] |
GeneIDi | 342667 |
KEGGi | hsa:342667 |
UCSCi | uc002hrs.4, human [Q6ZMT1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ608762 mRNA Translation: CAE75539.1 AK131500 mRNA Translation: BAD18644.1 BC109231 mRNA Translation: AAI09232.1 |
CCDSi | CCDS11335.1 [Q6ZMT1-1] |
RefSeqi | NP_945344.1, NM_198993.3 [Q6ZMT1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6B26 | X-ray | 1.20 | A | 296-411 | [»] | |
6B27 | X-ray | 1.73 | A/B/C/D/E/F | 296-411 | [»] | |
6B28 | X-ray | 2.55 | A | 296-411 | [»] | |
SMRi | Q6ZMT1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 131192, 16 interactors |
IntActi | Q6ZMT1, 3 interactors |
STRINGi | 9606.ENSP00000327509 |
PTM databases
iPTMneti | Q6ZMT1 |
PhosphoSitePlusi | Q6ZMT1 |
Polymorphism and mutation databases
BioMutai | STAC2 |
DMDMi | 74749556 |
Proteomic databases
MassIVEi | Q6ZMT1 |
PaxDbi | Q6ZMT1 |
PeptideAtlasi | Q6ZMT1 |
PRIDEi | Q6ZMT1 |
ProteomicsDBi | 67911 [Q6ZMT1-1] 67912 [Q6ZMT1-2] |
Protocols and materials databases
Antibodypediai | 2798, 154 antibodies |
Genome annotation databases
Ensembli | ENST00000333461; ENSP00000327509; ENSG00000141750 [Q6ZMT1-1] |
GeneIDi | 342667 |
KEGGi | hsa:342667 |
UCSCi | uc002hrs.4, human [Q6ZMT1-1] |
Organism-specific databases
CTDi | 342667 |
DisGeNETi | 342667 |
EuPathDBi | HostDB:ENSG00000141750.6 |
GeneCardsi | STAC2 |
HGNCi | HGNC:23990, STAC2 |
HPAi | ENSG00000141750, Tissue enhanced (ductus deferens, seminal vesicle) |
neXtProti | NX_Q6ZMT1 |
OpenTargetsi | ENSG00000141750 |
PharmGKBi | PA134939947 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QW9G, Eukaryota |
GeneTreei | ENSGT00950000183092 |
HOGENOMi | CLU_048120_0_0_1 |
InParanoidi | Q6ZMT1 |
OMAi | AAHLWCS |
OrthoDBi | 584382at2759 |
PhylomeDBi | Q6ZMT1 |
TreeFami | TF332878 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZMT1 |
Miscellaneous databases
BioGRID-ORCSi | 342667, 5 hits in 838 CRISPR screens |
ChiTaRSi | STAC2, human |
GenomeRNAii | 342667 |
Pharosi | Q6ZMT1, Tdark |
PROi | PR:Q6ZMT1 |
RNActi | Q6ZMT1, protein |
Gene expression databases
Bgeei | ENSG00000141750, Expressed in popliteal artery and 133 other tissues |
ExpressionAtlasi | Q6ZMT1, baseline and differential |
Genevisiblei | Q6ZMT1, HS |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd11985, SH3_Stac2_C, 1 hit |
InterProi | View protein in InterPro IPR002219, PE/DAG-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR039688, STAC1/2/3 IPR035509, Stac2_SH3 |
PANTHERi | PTHR15135, PTHR15135, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAC2_HUMAN | |
Accessioni | Q6ZMT1Primary (citable) accession number: Q6ZMT1 Secondary accession number(s): Q32MA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM