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UniProtKB - Q6ZMT1 (STAC2_HUMAN)

Entry version 140 (23 Feb 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

SH3 and cysteine-rich domain-containing protein 2

Gene

STAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri110 – 161Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST52

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZMT1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6ZMT1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein 2
Alternative name(s):
24b2/STAC21 Publication
Src homology 3 and cysteine-rich domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23990, STAC2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZMT1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000141750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi306Q → L: Mildly decreased affinity for CACNA1S. 1 Publication1
Mutagenesisi329W → S: Loss of interaction with CACNA1S. 1 Publication1
Mutagenesisi347Q → I: No effect on the structure of the two SH3 domains. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		342667

Open Targets

More...OpenTargetsi		ENSG00000141750

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134939947

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZMT1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STAC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74749556

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002744131 – 411SH3 and cysteine-rich domain-containing protein 2Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZMT1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZMT1

PeptideAtlas

More...PeptideAtlasi		Q6ZMT1

PRoteomics IDEntifications database

More...PRIDEi		Q6ZMT1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67911 [Q6ZMT1-1]
67912 [Q6ZMT1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZMT1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZMT1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000141750, Expressed in popliteal artery and 134 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZMT1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZMT1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000141750, Tissue enhanced (brain, breast, retina, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SH3 domains) with CACNA1S (PubMed:29078335).

Interacts (via SH3 domains) with CACNA1C (PubMed:29078335). Has much lower affinity for CACNA1C than for CACNA1S (PubMed:29078335).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131192, 18 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZMT1, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000327509

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZMT1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZMT1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini292 – 351SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini354 – 411SH3 2PROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni64 – 95DisorderedSequence analysisAdd BLAST32
Regioni174 – 203DisorderedSequence analysisAdd BLAST30
Regioni219 – 288DisorderedSequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi68 – 95Pro residuesSequence analysisAdd BLAST28
Compositional biasi231 – 249Basic and acidic residuesSequence analysisAdd BLAST19

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 161Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QW9G, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183092

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048120_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZMT1

Identification of Orthologs from Complete Genome Data

More...OMAi		CAMSRES

Database of Orthologous Groups

More...OrthoDBi		584382at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZMT1

TreeFam database of animal gene trees

More...TreeFami		TF332878

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029, C1, 1 hit
cd11985, SH3_Stac2_C, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002219, PE/DAG-bd
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR039688, STAC1/2/3
IPR035509, Stac2_SH3

The PANTHER Classification System

More...PANTHERi		PTHR15135, PTHR15135, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00130, C1_1, 1 hit
PF14604, SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109, C1, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50002, SH3, 2 hits
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZMT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEMSEKENE PDDAATHSPP GTVSALQETK LQRFKRSLSL KTILRSKSLE 
        60         70         80         90        100
NFFLRSGSEL KCPTEVLLTP PTPLPPPSPP PTASDRGLAT PSPSPCPVPR 
       110        120        130        140        150
PLAALKPVRL HSFQEHVFKR ASPCELCHQL IVGNSKQGLR CKMCKVSVHL 
       160        170        180        190        200
WCSEEISHQQ CPGKTSTSFR RNFSSPLLVH EPPPVCATSK ESPPTGDSGK 
       210        220        230        240        250
VDPVYETLRY GTSLALMNRS SFSSTSESPT RSLSERDELT EDGEGSIRSS 
       260        270        280        290        300
EEGPGDSASP VFTAPAESEG PGPEEKSPGQ QLPKATLRKD VGPMYSYVAL 
       310        320        330        340        350
YKFLPQENND LALQPGDRIM LVDDSNEDWW KGKIGDRVGF FPANFVQRVR 
       360        370        380        390        400
PGENVWRCCQ PFSGNKEQGY MSLKENQICV GVGRSKDADG FIRVSSGKKR 
       410 
GLVPVDALTE I
Length:411
Mass (Da):45,009
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i878DD19AFC305D0E
GO
Isoform 2 (identifier: Q6ZMT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Show »
Length:269
Mass (Da):29,484
Checksum:iA3EE27693F29E892
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QKZ0J3QKZ0_HUMAN
SH3 and cysteine-rich domain-contai...
STAC2
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0227421 – 142Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ608762 mRNA Translation: CAE75539.1
AK131500 mRNA Translation: BAD18644.1
BC109231 mRNA Translation: AAI09232.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11335.1 [Q6ZMT1-1]

NCBI Reference Sequences

More...RefSeqi		NP_945344.1, NM_198993.3 [Q6ZMT1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000333461; ENSP00000327509; ENSG00000141750

Database of genes from NCBI RefSeq genomes

More...GeneIDi		342667

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:342667

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000333461.6; ENSP00000327509.5; NM_198993.5; NP_945344.1

UCSC genome browser

More...UCSCi		uc002hrs.4, human [Q6ZMT1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ608762 mRNA Translation: CAE75539.1
AK131500 mRNA Translation: BAD18644.1
BC109231 mRNA Translation: AAI09232.1
CCDSiCCDS11335.1 [Q6ZMT1-1]
RefSeqiNP_945344.1, NM_198993.3 [Q6ZMT1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6B26X-ray1.20A296-411[»]
6B27X-ray1.73A/B/C/D/E/F296-411[»]
6B28X-ray2.55A296-411[»]
SMRiQ6ZMT1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi131192, 18 interactors
IntActiQ6ZMT1, 3 interactors
STRINGi9606.ENSP00000327509

PTM databases

iPTMnetiQ6ZMT1
PhosphoSitePlusiQ6ZMT1

Genetic variation databases

BioMutaiSTAC2
DMDMi74749556

Proteomic databases

MassIVEiQ6ZMT1
PaxDbiQ6ZMT1
PeptideAtlasiQ6ZMT1
PRIDEiQ6ZMT1
ProteomicsDBi67911 [Q6ZMT1-1]
67912 [Q6ZMT1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2798, 160 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		342667

Genome annotation databases

EnsembliENST00000333461; ENSP00000327509; ENSG00000141750
GeneIDi342667
KEGGihsa:342667
MANE-SelectiENST00000333461.6; ENSP00000327509.5; NM_198993.5; NP_945344.1
UCSCiuc002hrs.4, human [Q6ZMT1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		342667
DisGeNETi342667

GeneCards: human genes, protein and diseases

More...GeneCardsi		STAC2
HGNCiHGNC:23990, STAC2
HPAiENSG00000141750, Tissue enhanced (brain, breast, retina, skin)
neXtProtiNX_Q6ZMT1
OpenTargetsiENSG00000141750
PharmGKBiPA134939947
VEuPathDBiHostDB:ENSG00000141750

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QW9G, Eukaryota
GeneTreeiENSGT00950000183092
HOGENOMiCLU_048120_0_0_1
InParanoidiQ6ZMT1
OMAiCAMSRES
OrthoDBi584382at2759
PhylomeDBiQ6ZMT1
TreeFamiTF332878

Enzyme and pathway databases

PathwayCommonsiQ6ZMT1
SignaLinkiQ6ZMT1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		342667, 5 hits in 1029 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STAC2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		342667
PharosiQ6ZMT1, Tbio

Protein Ontology

More...PROi		PR:Q6ZMT1
RNActiQ6ZMT1, protein

Gene expression databases

BgeeiENSG00000141750, Expressed in popliteal artery and 134 other tissues
ExpressionAtlasiQ6ZMT1, baseline and differential
GenevisibleiQ6ZMT1, HS

Family and domain databases

CDDicd00029, C1, 1 hit
cd11985, SH3_Stac2_C, 1 hit
InterProiView protein in InterPro
IPR002219, PE/DAG-bd
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR039688, STAC1/2/3
IPR035509, Stac2_SH3
PANTHERiPTHR15135, PTHR15135, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF14604, SH3_9, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002, SH3, 2 hits
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMT1
Secondary accession number(s): Q32MA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: February 23, 2022
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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