UniProtKB - Q6ZMS7 (ZN783_HUMAN)
Protein
Protein ZNF783
Gene
ZNF783
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Caution
Despite its name, it does not contain a canonical C2H2-type zinc-finger.Curated
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- identical protein binding Source: IntAct
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6ZMS7 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein ZNF783 |
Gene namesi | Name:ZNF783 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27222, ZNF783 |
neXtProti | NX_Q6ZMS7 |
VEuPathDBi | HostDB:ENSG00000204946.9 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 100289678 |
OpenTargetsi | ENSG00000204946 |
PharmGKBi | PA162410441 |
Miscellaneous databases
Pharosi | Q6ZMS7, Tdark |
Genetic variation databases
BioMutai | ZNF783 |
DMDMi | 74722910 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000270995 | 2 – 281 | Protein ZNF783Add BLAST | 280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q6ZMS7 |
MassIVEi | Q6ZMS7 |
PaxDbi | Q6ZMS7 |
PeptideAtlasi | Q6ZMS7 |
PRIDEi | Q6ZMS7 |
ProteomicsDBi | 67910 [Q6ZMS7-1] 9196 |
PTM databases
iPTMneti | Q6ZMS7 |
PhosphoSitePlusi | Q6ZMS7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204946, Expressed in sural nerve and 196 other tissues |
Genevisiblei | Q6ZMS7, HS |
Organism-specific databases
HPAi | ENSG00000204946, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ6ZMS7
With | #Exp. | IntAct |
---|---|---|
PLAAT5 - isoform 3 [Q96KN8-3] | 3 | EBI-10254978,EBI-10290304 |
ZNF212 [Q9UDV6] | 5 | EBI-10254978,EBI-1640204 |
ZNF398 [Q8TD17] | 4 | EBI-10254978,EBI-8643207 |
ZNF783 - isoform 2 [Q6ZMS7-2]
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 941329, 7 interactors |
IntActi | Q6ZMS7, 5 interactors |
STRINGi | 9606.ENSP00000410890 |
Miscellaneous databases
RNActi | Q6ZMS7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 143 – 214 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 48 – 124 | Sequence analysisAdd BLAST | 77 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162942 |
HOGENOMi | CLU_002678_76_3_1 |
InParanoidi | Q6ZMS7 |
OMAi | RGQTECR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6ZMS7 |
TreeFami | TF337777 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR022137, Znf_prot_DUF3669 |
Pfami | View protein in Pfam PF12417, DUF3669, 1 hit PF01352, KRAB, 1 hit |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit |
SUPFAMi | SSF109640, SSF109640, 1 hit |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6ZMS7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEAAPARDP ETDKHTEDQS PSTPLPQPAA EKNSYLYSTE ITLWTVVAAI
60 70 80 90 100
QALEKKVDSC LTRLLTLEGR TGTAEKKLAD CEKTAVEFGN QLEGKWAVLG
110 120 130 140 150
TLLQEYGLLQ RRLENVENLL RNRNFWILRL PPGSKGEAPK VPVTFDDVAV
160 170 180 190 200
YFSELEWGKL EDWQKELYKH VMRGNYETLV SLDYAISKPD ILTRIERGEE
210 220 230 240 250
PCLDRWGQEK GNEVEVGRPR MMGTGLPPYP EHLTSPLSPA QEELKEGQAP
260 270 280
KQQQDSEARV APAGPEAGLA LRTDLQGEAQ I
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069466 | 63 | R → C1 PublicationCorresponds to variant dbSNP:rs764239191Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055627 | 269 – 281 | LALRT…GEAQI → GGVAIKTEAQSEDEMTPERL FLGVSRGQTECRIPRGPRNR PGGPSRHQAQGMPRVRAGEP RPPGASGETPRVLSRRRQRA FPCPDCGQSFRLKINLTIHQ RTHVEEGRQEAPGRSPTSCG DSQAMLEPGEVVVPGPVIRW LPEEPEGRRSVAGGRALVGR RPAASKMYHCSECLRFFQQR KSLLLHQRLHTGNGQGWPAC PYCGKAFRRPSDLFRHQRIH TGERPYQCPQCGRTFNRNHH LAVHMQTHARGQVGPHFPAA PARHGSLPLPWPSRKEEG in isoform 2. CuratedAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131504 mRNA Translation: BAD18648.1 AC004890 Genomic DNA No translation available. |
CCDSi | CCDS56519.1 [Q6ZMS7-2] |
RefSeqi | NP_001182149.1, NM_001195220.1 [Q6ZMS7-2] |
Genome annotation databases
Ensembli | ENST00000378052; ENSP00000367291; ENSG00000204946 [Q6ZMS7-1] ENST00000434415; ENSP00000410890; ENSG00000204946 [Q6ZMS7-2] ENST00000476295; ENSP00000418666; ENSG00000204946 [Q6ZMS7-1] |
GeneIDi | 100289678 |
KEGGi | hsa:100289678 |
UCSCi | uc011kuo.3, human [Q6ZMS7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131504 mRNA Translation: BAD18648.1 AC004890 Genomic DNA No translation available. |
CCDSi | CCDS56519.1 [Q6ZMS7-2] |
RefSeqi | NP_001182149.1, NM_001195220.1 [Q6ZMS7-2] |
3D structure databases
SMRi | Q6ZMS7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 941329, 7 interactors |
IntActi | Q6ZMS7, 5 interactors |
STRINGi | 9606.ENSP00000410890 |
PTM databases
iPTMneti | Q6ZMS7 |
PhosphoSitePlusi | Q6ZMS7 |
Genetic variation databases
BioMutai | ZNF783 |
DMDMi | 74722910 |
Proteomic databases
EPDi | Q6ZMS7 |
MassIVEi | Q6ZMS7 |
PaxDbi | Q6ZMS7 |
PeptideAtlasi | Q6ZMS7 |
PRIDEi | Q6ZMS7 |
ProteomicsDBi | 67910 [Q6ZMS7-1] 9196 |
Protocols and materials databases
Antibodypediai | 10415, 72 antibodies |
Genome annotation databases
Ensembli | ENST00000378052; ENSP00000367291; ENSG00000204946 [Q6ZMS7-1] ENST00000434415; ENSP00000410890; ENSG00000204946 [Q6ZMS7-2] ENST00000476295; ENSP00000418666; ENSG00000204946 [Q6ZMS7-1] |
GeneIDi | 100289678 |
KEGGi | hsa:100289678 |
UCSCi | uc011kuo.3, human [Q6ZMS7-1] |
Organism-specific databases
CTDi | 100289678 |
DisGeNETi | 100289678 |
GeneCardsi | ZNF783 |
HGNCi | HGNC:27222, ZNF783 |
HPAi | ENSG00000204946, Low tissue specificity |
neXtProti | NX_Q6ZMS7 |
OpenTargetsi | ENSG00000204946 |
PharmGKBi | PA162410441 |
VEuPathDBi | HostDB:ENSG00000204946.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162942 |
HOGENOMi | CLU_002678_76_3_1 |
InParanoidi | Q6ZMS7 |
OMAi | RGQTECR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6ZMS7 |
TreeFami | TF337777 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZMS7 |
Miscellaneous databases
BioGRID-ORCSi | 100289678, 8 hits in 895 CRISPR screens |
ChiTaRSi | ZNF783, human |
GenomeRNAii | 100289678 |
Pharosi | Q6ZMS7, Tdark |
PROi | PR:Q6ZMS7 |
RNActi | Q6ZMS7, protein |
Gene expression databases
Bgeei | ENSG00000204946, Expressed in sural nerve and 196 other tissues |
Genevisiblei | Q6ZMS7, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR022137, Znf_prot_DUF3669 |
Pfami | View protein in Pfam PF12417, DUF3669, 1 hit PF01352, KRAB, 1 hit |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit |
SUPFAMi | SSF109640, SSF109640, 1 hit |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN783_HUMAN | |
Accessioni | Q6ZMS7Primary (citable) accession number: Q6ZMS7 Secondary accession number(s): C9J9J2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants