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Protein

Transmembrane protease serine 11A

Gene

TMPRSS11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei230Charge relay systemBy similarity1
Active sitei275Charge relay systemBy similarity1
Active sitei371Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processCell cycle

Protein family/group databases

MEROPSiS01.292

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11A (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 1
Epidermal type-II transmembrane serine protease
Esophageal cancer-susceptibility gene 1 protein
Gene namesi
Name:TMPRSS11A
Synonyms:ECRG1, HATL1, HESP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000187054.14
HGNCiHGNC:27954 TMPRSS11A
MIMi611704 gene
neXtProtiNX_Q6ZMR5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini40 – 421ExtracellularSequence analysisAdd BLAST382

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi339967
PharmGKBiPA142670726

Polymorphism and mutation databases

BioMutaiTMPRSS11A
DMDMi74758674

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_50000959741 – 421Transmembrane protease serine 11AAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi215 ↔ 231PROSITE-ProRule annotation
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi340 ↔ 356PROSITE-ProRule annotation
Disulfide bondi367 ↔ 396PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZMR5
PeptideAtlasiQ6ZMR5
PRIDEiQ6ZMR5
ProteomicsDBi67906
67907 [Q6ZMR5-2]
TopDownProteomicsiQ6ZMR5-2 [Q6ZMR5-2]

PTM databases

iPTMnetiQ6ZMR5
PhosphoSitePlusiQ6ZMR5

Expressioni

Tissue specificityi

Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.1 Publication

Gene expression databases

BgeeiENSG00000187054 Expressed in 31 organ(s), highest expression level in ectocervix
CleanExiHS_TMPRSS11A
ExpressionAtlasiQ6ZMR5 baseline and differential

Interactioni

Subunit structurei

May interact with ZBTB17.

Protein-protein interaction databases

BioGridi130971, 8 interactors
IntActiQ6ZMR5, 1 interactor
STRINGi9606.ENSP00000334611

Structurei

3D structure databases

ProteinModelPortaliQ6ZMR5
SMRiQ6ZMR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 167SEAPROSITE-ProRule annotationAdd BLAST121
Domaini190 – 420Peptidase S1PROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251823
HOVERGENiHBG013304
InParanoidiQ6ZMR5
KOiK09750
PhylomeDBiQ6ZMR5
TreeFamiTF351684

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q6ZMR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY
60 70 80 90 100
YHGSFKILDP QINNNFGQSN TYQLKDLRET TENLVSQVDE IFIDSAWKKN
110 120 130 140 150
YIKNQVVRLT PEEDGVKVDV IMVFQFPSTE QRAVREKKIQ SILNQKIRNL
160 170 180 190 200
RALPINASSV QVNAMSSSTG ELTVQASCGK RVVPLNVNRI ASGVIAPKAA
210 220 230 240 250
WPWQASLQYD NIHQCGATLI SNTWLVTAAH CFQKYKNPHQ WTVSFGTKIN
260 270 280 290 300
PPLMKRNVRR FIIHEKYRSA AREYDIAVVQ VSSRVTFSDD IRRICLPEAS
310 320 330 340 350
ASFQPNLTVH ITGFGALYYG GESQNDLREA RVKIISDDVC KQPQVYGNDI
360 370 380 390 400
KPGMFCAGYM EGIYDACRGD SGGPLVTRDL KDTWYLIGIV SWGDNCGQKD
410 420
KPGVYTQVTY YRNWIASKTG I
Length:421
Mass (Da):47,569
Last modified:July 5, 2004 - v1
Checksum:iC695A10DF76EF87C
GO
Isoform 2 (identifier: Q6ZMR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-87: Missing.

Show »
Length:418
Mass (Da):47,254
Checksum:i96674ECABCA9B301
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR82A0A0A0MR82_HUMAN
Transmembrane protease serine
TMPRSS11A
421Annotation score:
H0YAL9H0YAL9_HUMAN
Transmembrane protease serine 11A
TMPRSS11A
385Annotation score:

Sequence cautioni

The sequence AAD41463 differs from that shown. Reason: Frameshift at position 371.Curated
The sequence CAD67985 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50Y → F in AAD41463 (PubMed:10920976).Curated1
Sequence conflicti52H → P in AAD41463 (PubMed:10920976).Curated1
Sequence conflicti173T → I in AAD41463 (PubMed:10920976).Curated1
Sequence conflicti267Y → C in AAD41463 (PubMed:10920976).Curated1
Sequence conflicti271A → P in AAD41463 (PubMed:10920976).Curated1
Sequence conflicti273E → K in AAD41463 (PubMed:10920976).Curated1
Sequence conflicti288S → P in AAD41463 (PubMed:10920976).Curated1
Sequence conflicti330A → V in AAD41463 (PubMed:10920976).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034797293R → Q Common polymorphism; may be a susceptibility factor for developing esophageal cancer especially in smoking population. 2 PublicationsCorresponds to variant dbSNP:rs353163Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02761085 – 87Missing in isoform 2. 3 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071882 mRNA Translation: AAD41463.1 Frameshift.
AY498712 mRNA Translation: AAS78642.1
AK131518 mRNA Translation: BAD18660.1
AC096653 Genomic DNA No translation available.
AC096727 Genomic DNA No translation available.
BC111796 mRNA Translation: AAI11797.1
BN000133 mRNA Translation: CAD67985.1 Sequence problems.
CCDSiCCDS3519.1 [Q6ZMR5-1]
CCDS47065.1 [Q6ZMR5-2]
RefSeqiNP_001107859.1, NM_001114387.1
NP_872412.3, NM_182606.3
UniGeneiHs.450110

Genome annotation databases

EnsembliENST00000508048; ENSP00000426911; ENSG00000187054
GeneIDi339967
KEGGihsa:339967
UCSCiuc003hds.2 human [Q6ZMR5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM11A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMR5
Secondary accession number(s): J3KNQ8
, Q2NKI9, Q6JE90, Q7RTY4, Q86TK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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