UniProtKB - Q6ZMP0 (THSD4_HUMAN)
Protein
Thrombospondin type-1 domain-containing protein 4
Gene
THSD4
Organism
Homo sapiens (Human)
Status
Functioni
Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity).By similarity
GO - Molecular functioni
- metalloendopeptidase activity Source: GO_Central
GO - Biological processi
- elastic fiber assembly Source: Ensembl
- extracellular matrix organization Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | Q6ZMP0 |
Reactomei | R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Thrombospondin type-1 domain-containing protein 4Alternative name(s): A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6 Short name: ADAMTS-like protein 6 Short name: ADAMTSL-6 |
Gene namesi | Name:THSD4 ORF Names:UNQ9334/PRO34005 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000187720.14 |
HGNCi | HGNC:25835, THSD4 |
MIMi | 614476, gene |
neXtProti | NX_Q6ZMP0 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular matrix Source: GO_Central
- microfibril Source: Ensembl
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 79875 |
OpenTargetsi | ENSG00000187720 |
PharmGKBi | PA143485631 |
Miscellaneous databases
Pharosi | Q6ZMP0, Tdark |
Polymorphism and mutation databases
BioMutai | THSD4 |
DMDMi | 166229088 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000313583 | 26 – 1018 | Thrombospondin type-1 domain-containing protein 4Add BLAST | 993 |
Proteomic databases
EPDi | Q6ZMP0 |
jPOSTi | Q6ZMP0 |
MassIVEi | Q6ZMP0 |
PaxDbi | Q6ZMP0 |
PeptideAtlasi | Q6ZMP0 |
PRIDEi | Q6ZMP0 |
ProteomicsDBi | 4917 67896 [Q6ZMP0-1] 67897 [Q6ZMP0-2] 67898 [Q6ZMP0-3] |
PTM databases
GlyConnecti | 1807, 6 N-Linked glycans (3 sites) |
GlyGeni | Q6ZMP0, 6 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q6ZMP0 |
PhosphoSitePlusi | Q6ZMP0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187720, Expressed in oviduct epithelium and 199 other tissues |
ExpressionAtlasi | Q6ZMP0, baseline and differential |
Genevisiblei | Q6ZMP0, HS |
Organism-specific databases
HPAi | ENSG00000187720, Tissue enhanced (enhanced) |
Interactioni
Subunit structurei
Interacts with FBN1. May interact with TGFB1.
By similarityProtein-protein interaction databases
BioGRIDi | 122963, 24 interactors |
IntActi | Q6ZMP0, 20 interactors |
STRINGi | 9606.ENSP00000347484 |
Miscellaneous databases
RNActi | Q6ZMP0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 307 | TSP type-1 1PROSITE-ProRule annotationAdd BLAST | 255 | |
Domaini | 676 – 737 | TSP type-1 2PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 739 – 792 | TSP type-1 3PROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 793 – 851 | TSP type-1 4PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 852 – 911 | TSP type-1 5PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 912 – 968 | TSP type-1 6PROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 971 – 1008 | PLACPROSITE-ProRule annotationAdd BLAST | 38 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG3538, Eukaryota KOG4597, Eukaryota |
GeneTreei | ENSGT00940000156594 |
HOGENOMi | CLU_000660_6_0_1 |
InParanoidi | Q6ZMP0 |
OMAi | NRCSAEC |
OrthoDBi | 414258at2759 |
PhylomeDBi | Q6ZMP0 |
TreeFami | TF316874 |
Family and domain databases
Gene3Di | 2.20.100.10, 7 hits |
InterProi | View protein in InterPro IPR010294, ADAM_spacer1 IPR010909, PLAC IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF05986, ADAM_spacer1, 1 hit PF08686, PLAC, 1 hit PF00090, TSP_1, 1 hit |
SMARTi | View protein in SMART SM00209, TSP1, 7 hits |
SUPFAMi | SSF82895, SSF82895, 7 hits |
PROSITEi | View protein in PROSITE PS50900, PLAC, 1 hit PS50092, TSP1, 6 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZMP0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG
60 70 80 90 100
GAPGVWGAWG PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF
110 120 130 140 150
ADHVVSAVRT SVPLHRSRDE TPALAGTDAS RQGPTVLRGS RHPQPQGLEV
160 170 180 190 200
TGDRRSRTRG TIGPGKYGYG KAPYILPLQT DTAHTPQRLR RQKLSSRHSR
210 220 230 240 250
SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA PIYQLPLTHD
260 270 280 290 300
QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL
310 320 330 340 350
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ
360 370 380 390 400
AMGYRFYVRQ AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK
410 420 430 440 450
CGVCGGDNTG CQVVSGVFKH ALTSLGYHRV VEIPEGATKI NITEMYKSNN
460 470 480 490 500
YLALRSRSGR SIINGNWAID RPGKYEGGGT MFTYKRPNEI SSTAGESFLA
510 520 530 540 550
EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH RRPGEPFNGQ
560 570 580 590 600
MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH
610 620 630 640 650
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH
660 670 680 690 700
EEAPESYCDS SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ
710 720 730 740 750
VLCRQVYANR SLTVQPYRCQ HLEKPETTST CQLKICSEWQ IRTDWTSCSV
760 770 780 790 800
PCGVGQRTRD VKCVSNIGDV VDDEECNMKL RPNDIENCDM GPCAKSWFLT
810 820 830 840 850
EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA EATPCDNGPC
860 870 880 890 900
TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK
910 920 930 940 950
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC
960 970 980 990 1000
DPQLKPEERE SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC
1010
CASCTRVANR QTGFLGSR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X1T0 | A0A087X1T0_HUMAN | Thrombospondin type-1 domain-contai... | THSD4 | 101 | Annotation score: |
Sequence cautioni
The sequence BAB14673 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 104 | V → A in BAD18685 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 434 | P → S in BAD18685 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 806 | C → S in BAB14673 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030036 | 1 – 360 | Missing in isoform 3. 1 PublicationAdd BLAST | 360 | |
Alternative sequenceiVSP_054877 | 1 – 24 | MVSHF…FQFVC → MFVSYLILTLLHVQTAVLAR PGGE in isoform 4. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_054878 | 25 – 384 | Missing in isoform 4. 1 PublicationAdd BLAST | 360 | |
Alternative sequenceiVSP_030037 | 361 – 384 | AEKVI…SGQCK → MFVSYLILTLLHVQTAVLAR PGGE in isoform 3. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_030038 | 450 – 579 | NYLAL…GEAPE → KKKSHLKPATRGSQFSSVKV CSVPAACKLLGTPGRARQPV PAPRELEHDKNSPHCAYLSL YLTSLAQSSWRVFSLFSYVL IYLFSKYLAFNTLFALKRMA LQRDRKEKTRAWCIFIKLCG REIQILPGPV in isoform 3. 1 PublicationAdd BLAST | 130 | |
Alternative sequenceiVSP_030039 | 512 – 523 | MIHQQ…PGVHY → VSLDVSGLFFGF in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_030040 | 524 – 1018 | Missing in isoform 2. 1 PublicationAdd BLAST | 495 | |
Alternative sequenceiVSP_030041 | 580 – 1018 | Missing in isoform 3. 1 PublicationAdd BLAST | 439 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358143 mRNA Translation: AAQ88510.1 AK023772 mRNA Translation: BAB14673.1 Different initiation. AK131551 mRNA Translation: BAD18685.1 AK299056 mRNA Translation: BAG61125.1 AC015711 Genomic DNA No translation available. AC026636 Genomic DNA No translation available. AC064799 Genomic DNA No translation available. AC068181 Genomic DNA No translation available. AC108861 Genomic DNA No translation available. AC104938 Genomic DNA No translation available. AC104943 Genomic DNA No translation available. AC105132 Genomic DNA No translation available. BC140868 mRNA Translation: AAI40869.1 BX641106 mRNA Translation: CAE46049.1 |
CCDSi | CCDS10238.2 [Q6ZMP0-1] CCDS66817.1 [Q6ZMP0-4] |
RefSeqi | NP_001273358.1, NM_001286429.1 [Q6ZMP0-4] NP_079093.2, NM_024817.2 [Q6ZMP0-1] XP_006720755.1, XM_006720692.3 [Q6ZMP0-1] |
Genome annotation databases
Ensembli | ENST00000261862; ENSP00000261862; ENSG00000187720 [Q6ZMP0-3] ENST00000355327; ENSP00000347484; ENSG00000187720 [Q6ZMP0-1] ENST00000357769; ENSP00000350413; ENSG00000187720 [Q6ZMP0-4] |
GeneIDi | 79875 |
KEGGi | hsa:79875 |
UCSCi | uc002atb.2, human [Q6ZMP0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358143 mRNA Translation: AAQ88510.1 AK023772 mRNA Translation: BAB14673.1 Different initiation. AK131551 mRNA Translation: BAD18685.1 AK299056 mRNA Translation: BAG61125.1 AC015711 Genomic DNA No translation available. AC026636 Genomic DNA No translation available. AC064799 Genomic DNA No translation available. AC068181 Genomic DNA No translation available. AC108861 Genomic DNA No translation available. AC104938 Genomic DNA No translation available. AC104943 Genomic DNA No translation available. AC105132 Genomic DNA No translation available. BC140868 mRNA Translation: AAI40869.1 BX641106 mRNA Translation: CAE46049.1 |
CCDSi | CCDS10238.2 [Q6ZMP0-1] CCDS66817.1 [Q6ZMP0-4] |
RefSeqi | NP_001273358.1, NM_001286429.1 [Q6ZMP0-4] NP_079093.2, NM_024817.2 [Q6ZMP0-1] XP_006720755.1, XM_006720692.3 [Q6ZMP0-1] |
3D structure databases
SMRi | Q6ZMP0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122963, 24 interactors |
IntActi | Q6ZMP0, 20 interactors |
STRINGi | 9606.ENSP00000347484 |
PTM databases
GlyConnecti | 1807, 6 N-Linked glycans (3 sites) |
GlyGeni | Q6ZMP0, 6 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q6ZMP0 |
PhosphoSitePlusi | Q6ZMP0 |
Polymorphism and mutation databases
BioMutai | THSD4 |
DMDMi | 166229088 |
Proteomic databases
EPDi | Q6ZMP0 |
jPOSTi | Q6ZMP0 |
MassIVEi | Q6ZMP0 |
PaxDbi | Q6ZMP0 |
PeptideAtlasi | Q6ZMP0 |
PRIDEi | Q6ZMP0 |
ProteomicsDBi | 4917 67896 [Q6ZMP0-1] 67897 [Q6ZMP0-2] 67898 [Q6ZMP0-3] |
Protocols and materials databases
Antibodypediai | 26512, 7 antibodies |
Genome annotation databases
Ensembli | ENST00000261862; ENSP00000261862; ENSG00000187720 [Q6ZMP0-3] ENST00000355327; ENSP00000347484; ENSG00000187720 [Q6ZMP0-1] ENST00000357769; ENSP00000350413; ENSG00000187720 [Q6ZMP0-4] |
GeneIDi | 79875 |
KEGGi | hsa:79875 |
UCSCi | uc002atb.2, human [Q6ZMP0-1] |
Organism-specific databases
CTDi | 79875 |
DisGeNETi | 79875 |
EuPathDBi | HostDB:ENSG00000187720.14 |
GeneCardsi | THSD4 |
HGNCi | HGNC:25835, THSD4 |
HPAi | ENSG00000187720, Tissue enhanced (enhanced) |
MIMi | 614476, gene |
neXtProti | NX_Q6ZMP0 |
OpenTargetsi | ENSG00000187720 |
PharmGKBi | PA143485631 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3538, Eukaryota KOG4597, Eukaryota |
GeneTreei | ENSGT00940000156594 |
HOGENOMi | CLU_000660_6_0_1 |
InParanoidi | Q6ZMP0 |
OMAi | NRCSAEC |
OrthoDBi | 414258at2759 |
PhylomeDBi | Q6ZMP0 |
TreeFami | TF316874 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZMP0 |
Reactomei | R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
Miscellaneous databases
BioGRID-ORCSi | 79875, 2 hits in 839 CRISPR screens |
ChiTaRSi | THSD4, human |
GenomeRNAii | 79875 |
Pharosi | Q6ZMP0, Tdark |
PROi | PR:Q6ZMP0 |
RNActi | Q6ZMP0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187720, Expressed in oviduct epithelium and 199 other tissues |
ExpressionAtlasi | Q6ZMP0, baseline and differential |
Genevisiblei | Q6ZMP0, HS |
Family and domain databases
Gene3Di | 2.20.100.10, 7 hits |
InterProi | View protein in InterPro IPR010294, ADAM_spacer1 IPR010909, PLAC IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF05986, ADAM_spacer1, 1 hit PF08686, PLAC, 1 hit PF00090, TSP_1, 1 hit |
SMARTi | View protein in SMART SM00209, TSP1, 7 hits |
SUPFAMi | SSF82895, SSF82895, 7 hits |
PROSITEi | View protein in PROSITE PS50900, PLAC, 1 hit PS50092, TSP1, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THSD4_HUMAN | |
Accessioni | Q6ZMP0Primary (citable) accession number: Q6ZMP0 Secondary accession number(s): B2RTY3 Q9H8E4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM