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UniProtKB - Q6ZMP0 (THSD4_HUMAN)

Entry version 142 (02 Jun 2021)
Sequence version 2 (15 Jan 2008)
Previous versions | rss
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Protein

Thrombospondin type-1 domain-containing protein 4

Gene

THSD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6ZMP0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thrombospondin type-1 domain-containing protein 4
Alternative name(s):
A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6
Short name:
ADAMTS-like protein 6
Short name:
ADAMTSL-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THSD4
ORF Names:UNQ9334/PRO34005
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25835, THSD4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614476, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6ZMP0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000187720.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79875

Open Targets

More...OpenTargetsi		ENSG00000187720

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485631

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6ZMP0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		THSD4

Domain mapping of disease mutations (DMDM)

More...DMDMi		166229088

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031358326 – 1018Thrombospondin type-1 domain-containing protein 4Add BLAST993

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6ZMP0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6ZMP0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6ZMP0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6ZMP0

PeptideAtlas

More...PeptideAtlasi		Q6ZMP0

PRoteomics IDEntifications database

More...PRIDEi		Q6ZMP0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4917
67896 [Q6ZMP0-1]
67897 [Q6ZMP0-2]
67898 [Q6ZMP0-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1807, 6 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6ZMP0, 6 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6ZMP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6ZMP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187720, Expressed in oviduct epithelium and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6ZMP0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6ZMP0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187720, Tissue enhanced (enhanced)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBN1. May interact with TGFB1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122963, 25 interactors

Protein interaction database and analysis system

More...IntActi		Q6ZMP0, 20 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347484

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6ZMP0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6ZMP0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 307TSP type-1 1PROSITE-ProRule annotationAdd BLAST255
Domaini676 – 737TSP type-1 2PROSITE-ProRule annotationAdd BLAST62
Domaini739 – 792TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini793 – 851TSP type-1 4PROSITE-ProRule annotationAdd BLAST59
Domaini852 – 911TSP type-1 5PROSITE-ProRule annotationAdd BLAST60
Domaini912 – 968TSP type-1 6PROSITE-ProRule annotationAdd BLAST57
Domaini971 – 1008PLACPROSITE-ProRule annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 235DisorderedSequence analysisAdd BLAST125
Regioni254 – 279DisorderedSequence analysisAdd BLAST26
Regioni534 – 623DisorderedSequence analysisAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 233Polar residuesSequence analysisAdd BLAST36
Compositional biasi258 – 279Polar residuesSequence analysisAdd BLAST22
Compositional biasi557 – 578Basic and acidic residuesSequence analysisAdd BLAST22

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3538, Eukaryota
KOG4597, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156594

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000660_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6ZMP0

Identification of Orthologs from Complete Genome Data

More...OMAi		NRCSAEC

Database of Orthologous Groups

More...OrthoDBi		414258at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6ZMP0

TreeFam database of animal gene trees

More...TreeFami		TF316874

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010294, ADAM_spacer1
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05986, ADAM_spacer1, 1 hit
PF08686, PLAC, 1 hit
PF00090, TSP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00209, TSP1, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82895, SSF82895, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50900, PLAC, 1 hit
PS50092, TSP1, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZMP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG 
        60         70         80         90        100
GAPGVWGAWG PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF 
       110        120        130        140        150
ADHVVSAVRT SVPLHRSRDE TPALAGTDAS RQGPTVLRGS RHPQPQGLEV 
       160        170        180        190        200
TGDRRSRTRG TIGPGKYGYG KAPYILPLQT DTAHTPQRLR RQKLSSRHSR 
       210        220        230        240        250
SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA PIYQLPLTHD 
       260        270        280        290        300
QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL 
       310        320        330        340        350
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ 
       360        370        380        390        400
AMGYRFYVRQ AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK 
       410        420        430        440        450
CGVCGGDNTG CQVVSGVFKH ALTSLGYHRV VEIPEGATKI NITEMYKSNN 
       460        470        480        490        500
YLALRSRSGR SIINGNWAID RPGKYEGGGT MFTYKRPNEI SSTAGESFLA 
       510        520        530        540        550
EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH RRPGEPFNGQ 
       560        570        580        590        600
MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH 
       610        620        630        640        650
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH 
       660        670        680        690        700
EEAPESYCDS SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ 
       710        720        730        740        750
VLCRQVYANR SLTVQPYRCQ HLEKPETTST CQLKICSEWQ IRTDWTSCSV 
       760        770        780        790        800
PCGVGQRTRD VKCVSNIGDV VDDEECNMKL RPNDIENCDM GPCAKSWFLT 
       810        820        830        840        850
EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA EATPCDNGPC 
       860        870        880        890        900
TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK 
       910        920        930        940        950
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC 
       960        970        980        990       1000
DPQLKPEERE SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC 
      1010 
CASCTRVANR QTGFLGSR
Length:1,018
Mass (Da):112,450
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67D710FBA3ABAFBC
GO
Isoform 2 (identifier: Q6ZMP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-523: MIHQQPNPGVHY → VSLDVSGLFFGF
     524-1018: Missing.

Show »
Length:523
Mass (Da):56,628
Checksum:i4AD13F0A4E4594EF
GO
Isoform 3 (identifier: Q6ZMP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.
     361-384: AEKVIDGTPCDQNGTAICVSGQCK → MFVSYLILTLLHVQTAVLARPGGE
     450-579: NYLALRSRSG...KEDLRGEAPE → KKKSHLKPAT...REIQILPGPV
     580-1018: Missing.

Show »
Length:219
Mass (Da):24,246
Checksum:i2EB28120469F0E15
GO
Isoform 4 (identifier: Q6ZMP0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MVSHFMGSLSVLCFLLLLGFQFVC → MFVSYLILTLLHVQTAVLARPGGE
     25-384: Missing.

Show »
Length:658
Mass (Da):73,408
Checksum:i470AE1076A3093F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1T0A0A087X1T0_HUMAN
Thrombospondin type-1 domain-contai...
THSD4
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14673 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104V → A in BAD18685 (PubMed:14702039).Curated1
Sequence conflicti434P → S in BAD18685 (PubMed:14702039).Curated1
Sequence conflicti806C → S in BAB14673 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0300361 – 360Missing in isoform 3. 1 PublicationAdd BLAST360
Alternative sequenceiVSP_0548771 – 24MVSHF…FQFVC → MFVSYLILTLLHVQTAVLAR PGGE in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_05487825 – 384Missing in isoform 4. 1 PublicationAdd BLAST360
Alternative sequenceiVSP_030037361 – 384AEKVI…SGQCK → MFVSYLILTLLHVQTAVLAR PGGE in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_030038450 – 579NYLAL…GEAPE → KKKSHLKPATRGSQFSSVKV CSVPAACKLLGTPGRARQPV PAPRELEHDKNSPHCAYLSL YLTSLAQSSWRVFSLFSYVL IYLFSKYLAFNTLFALKRMA LQRDRKEKTRAWCIFIKLCG REIQILPGPV in isoform 3. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_030039512 – 523MIHQQ…PGVHY → VSLDVSGLFFGF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_030040524 – 1018Missing in isoform 2. 1 PublicationAdd BLAST495
Alternative sequenceiVSP_030041580 – 1018Missing in isoform 3. 1 PublicationAdd BLAST439

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY358143 mRNA Translation: AAQ88510.1
AK023772 mRNA Translation: BAB14673.1 Different initiation.
AK131551 mRNA Translation: BAD18685.1
AK299056 mRNA Translation: BAG61125.1
AC015711 Genomic DNA No translation available.
AC026636 Genomic DNA No translation available.
AC064799 Genomic DNA No translation available.
AC068181 Genomic DNA No translation available.
AC108861 Genomic DNA No translation available.
AC104938 Genomic DNA No translation available.
AC104943 Genomic DNA No translation available.
AC105132 Genomic DNA No translation available.
BC140868 mRNA Translation: AAI40869.1
BX641106 mRNA Translation: CAE46049.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10238.2 [Q6ZMP0-1]
CCDS66817.1 [Q6ZMP0-4]

NCBI Reference Sequences

More...RefSeqi		NP_001273358.1, NM_001286429.1 [Q6ZMP0-4]
NP_079093.2, NM_024817.2 [Q6ZMP0-1]
XP_006720755.1, XM_006720692.3 [Q6ZMP0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261862; ENSP00000261862; ENSG00000187720 [Q6ZMP0-3]
ENST00000355327; ENSP00000347484; ENSG00000187720 [Q6ZMP0-1]
ENST00000357769; ENSP00000350413; ENSG00000187720 [Q6ZMP0-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79875

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79875

UCSC genome browser

More...UCSCi		uc002atb.2, human [Q6ZMP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358143 mRNA Translation: AAQ88510.1
AK023772 mRNA Translation: BAB14673.1 Different initiation.
AK131551 mRNA Translation: BAD18685.1
AK299056 mRNA Translation: BAG61125.1
AC015711 Genomic DNA No translation available.
AC026636 Genomic DNA No translation available.
AC064799 Genomic DNA No translation available.
AC068181 Genomic DNA No translation available.
AC108861 Genomic DNA No translation available.
AC104938 Genomic DNA No translation available.
AC104943 Genomic DNA No translation available.
AC105132 Genomic DNA No translation available.
BC140868 mRNA Translation: AAI40869.1
BX641106 mRNA Translation: CAE46049.1
CCDSiCCDS10238.2 [Q6ZMP0-1]
CCDS66817.1 [Q6ZMP0-4]
RefSeqiNP_001273358.1, NM_001286429.1 [Q6ZMP0-4]
NP_079093.2, NM_024817.2 [Q6ZMP0-1]
XP_006720755.1, XM_006720692.3 [Q6ZMP0-1]

3D structure databases

SMRiQ6ZMP0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122963, 25 interactors
IntActiQ6ZMP0, 20 interactors
STRINGi9606.ENSP00000347484

PTM databases

GlyConnecti1807, 6 N-Linked glycans (3 sites)
GlyGeniQ6ZMP0, 6 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ6ZMP0
PhosphoSitePlusiQ6ZMP0

Genetic variation databases

BioMutaiTHSD4
DMDMi166229088

Proteomic databases

EPDiQ6ZMP0
jPOSTiQ6ZMP0
MassIVEiQ6ZMP0
PaxDbiQ6ZMP0
PeptideAtlasiQ6ZMP0
PRIDEiQ6ZMP0
ProteomicsDBi4917
67896 [Q6ZMP0-1]
67897 [Q6ZMP0-2]
67898 [Q6ZMP0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26512, 8 antibodies

The DNASU plasmid repository

More...DNASUi		79875

Genome annotation databases

EnsembliENST00000261862; ENSP00000261862; ENSG00000187720 [Q6ZMP0-3]
ENST00000355327; ENSP00000347484; ENSG00000187720 [Q6ZMP0-1]
ENST00000357769; ENSP00000350413; ENSG00000187720 [Q6ZMP0-4]
GeneIDi79875
KEGGihsa:79875
UCSCiuc002atb.2, human [Q6ZMP0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79875
DisGeNETi79875

GeneCards: human genes, protein and diseases

More...GeneCardsi		THSD4
HGNCiHGNC:25835, THSD4
HPAiENSG00000187720, Tissue enhanced (enhanced)
MIMi614476, gene
neXtProtiNX_Q6ZMP0
OpenTargetsiENSG00000187720
PharmGKBiPA143485631
VEuPathDBiHostDB:ENSG00000187720.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
KOG4597, Eukaryota
GeneTreeiENSGT00940000156594
HOGENOMiCLU_000660_6_0_1
InParanoidiQ6ZMP0
OMAiNRCSAEC
OrthoDBi414258at2759
PhylomeDBiQ6ZMP0
TreeFamiTF316874

Enzyme and pathway databases

PathwayCommonsiQ6ZMP0
ReactomeiR-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79875, 3 hits in 980 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		THSD4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79875
PharosiQ6ZMP0, Tdark

Protein Ontology

More...PROi		PR:Q6ZMP0
RNActiQ6ZMP0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187720, Expressed in oviduct epithelium and 199 other tissues
ExpressionAtlasiQ6ZMP0, baseline and differential
GenevisibleiQ6ZMP0, HS

Family and domain databases

Gene3Di2.20.100.10, 7 hits
InterProiView protein in InterPro
IPR010294, ADAM_spacer1
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF05986, ADAM_spacer1, 1 hit
PF08686, PLAC, 1 hit
PF00090, TSP_1, 1 hit
SMARTiView protein in SMART
SM00209, TSP1, 7 hits
SUPFAMiSSF82895, SSF82895, 7 hits
PROSITEiView protein in PROSITE
PS50900, PLAC, 1 hit
PS50092, TSP1, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHSD4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMP0
Secondary accession number(s): B2RTY3
, B4DR13, Q6MZI3, Q6UXZ8, Q9H8E4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 2, 2021
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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