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UniProtKB - Q6ZMP0 (THSD4_HUMAN)

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Protein

Thrombospondin type-1 domain-containing protein 4

Gene

THSD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin type-1 domain-containing protein 4
Alternative name(s):
A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6
Short name:
ADAMTS-like protein 6
Short name:
ADAMTSL-6
Gene namesi
Name:THSD4
ORF Names:UNQ9334/PRO34005
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000187720.14
HGNCiHGNC:25835 THSD4
MIMi614476 gene
neXtProtiNX_Q6ZMP0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79875
OpenTargetsiENSG00000187720
PharmGKBiPA143485631

Polymorphism and mutation databases

BioMutaiTHSD4
DMDMi166229088

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000031358326 – 1018Thrombospondin type-1 domain-containing protein 4Add BLAST993

Proteomic databases

EPDiQ6ZMP0
PaxDbiQ6ZMP0
PeptideAtlasiQ6ZMP0
PRIDEiQ6ZMP0
ProteomicsDBi67896
67897 [Q6ZMP0-2]
67898 [Q6ZMP0-3]

PTM databases

iPTMnetiQ6ZMP0
PhosphoSitePlusiQ6ZMP0

Expressioni

Gene expression databases

BgeeiENSG00000187720
CleanExiHS_THSD4
ExpressionAtlasiQ6ZMP0 baseline and differential
GenevisibleiQ6ZMP0 HS

Organism-specific databases

HPAiHPA026845

Interactioni

Subunit structurei

Interacts with FBN1. May interact with TGFB1.By similarity

Protein-protein interaction databases

BioGridi122963, 22 interactors
IntActiQ6ZMP0, 1 interactor
STRINGi9606.ENSP00000261862

Structurei

3D structure databases

ProteinModelPortaliQ6ZMP0
SMRiQ6ZMP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 307TSP type-1 1PROSITE-ProRule annotationAdd BLAST255
Domaini676 – 737TSP type-1 2PROSITE-ProRule annotationAdd BLAST62
Domaini739 – 792TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini793 – 851TSP type-1 4PROSITE-ProRule annotationAdd BLAST59
Domaini852 – 911TSP type-1 5PROSITE-ProRule annotationAdd BLAST60
Domaini912 – 968TSP type-1 6PROSITE-ProRule annotationAdd BLAST57
Domaini971 – 1008PLACPROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
KOG4597 Eukaryota
ENOG41102GD LUCA
GeneTreeiENSGT00900000140774
HOGENOMiHOG000034174
HOVERGENiHBG080879
InParanoidiQ6ZMP0
OMAiYSQRRCM
OrthoDBiEOG091G14M8
PhylomeDBiQ6ZMP0
TreeFamiTF316874

Family and domain databases

Gene3Di2.20.100.10, 7 hits
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF08686 PLAC, 1 hit
PF00090 TSP_1, 6 hits
SMARTiView protein in SMART
SM00209 TSP1, 7 hits
SUPFAMiSSF82895 SSF82895, 7 hits
PROSITEiView protein in PROSITE
PS50900 PLAC, 1 hit
PS50092 TSP1, 6 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG 
        60         70         80         90        100
GAPGVWGAWG PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF 
       110        120        130        140        150
ADHVVSAVRT SVPLHRSRDE TPALAGTDAS RQGPTVLRGS RHPQPQGLEV 
       160        170        180        190        200
TGDRRSRTRG TIGPGKYGYG KAPYILPLQT DTAHTPQRLR RQKLSSRHSR 
       210        220        230        240        250
SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA PIYQLPLTHD 
       260        270        280        290        300
QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL 
       310        320        330        340        350
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ 
       360        370        380        390        400
AMGYRFYVRQ AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK 
       410        420        430        440        450
CGVCGGDNTG CQVVSGVFKH ALTSLGYHRV VEIPEGATKI NITEMYKSNN 
       460        470        480        490        500
YLALRSRSGR SIINGNWAID RPGKYEGGGT MFTYKRPNEI SSTAGESFLA 
       510        520        530        540        550
EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH RRPGEPFNGQ 
       560        570        580        590        600
MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH 
       610        620        630        640        650
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH 
       660        670        680        690        700
EEAPESYCDS SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ 
       710        720        730        740        750
VLCRQVYANR SLTVQPYRCQ HLEKPETTST CQLKICSEWQ IRTDWTSCSV 
       760        770        780        790        800
PCGVGQRTRD VKCVSNIGDV VDDEECNMKL RPNDIENCDM GPCAKSWFLT 
       810        820        830        840        850
EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA EATPCDNGPC 
       860        870        880        890        900
TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK 
       910        920        930        940        950
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC 
       960        970        980        990       1000
DPQLKPEERE SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC 
      1010 
CASCTRVANR QTGFLGSR
Length:1,018
Mass (Da):112,450
Last modified:January 15, 2008 - v2
Checksum:i67D710FBA3ABAFBC
GO
Isoform 2 (identifier: Q6ZMP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-523: MIHQQPNPGVHY → VSLDVSGLFFGF
     524-1018: Missing.

Show »
Length:523
Mass (Da):56,628
Checksum:i4AD13F0A4E4594EF
GO
Isoform 3 (identifier: Q6ZMP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.
     361-384: AEKVIDGTPCDQNGTAICVSGQCK → MFVSYLILTLLHVQTAVLARPGGE
     450-579: NYLALRSRSG...KEDLRGEAPE → KKKSHLKPAT...REIQILPGPV
     580-1018: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,246
Checksum:i2EB28120469F0E15
GO
Isoform 4 (identifier: Q6ZMP0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MVSHFMGSLSVLCFLLLLGFQFVC → MFVSYLILTLLHVQTAVLARPGGE
     25-384: Missing.

Note: No experimental confirmation available.
Show »
Length:658
Mass (Da):73,408
Checksum:i470AE1076A3093F1
GO

Sequence cautioni

The sequence BAB14673 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104V → A in BAD18685 (PubMed:14702039).Curated1
Sequence conflicti434P → S in BAD18685 (PubMed:14702039).Curated1
Sequence conflicti806C → S in BAB14673 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0300361 – 360Missing in isoform 3. 1 PublicationAdd BLAST360
Alternative sequenceiVSP_0548771 – 24MVSHF…FQFVC → MFVSYLILTLLHVQTAVLAR PGGE in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_05487825 – 384Missing in isoform 4. 1 PublicationAdd BLAST360
Alternative sequenceiVSP_030037361 – 384AEKVI…SGQCK → MFVSYLILTLLHVQTAVLAR PGGE in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_030038450 – 579NYLAL…GEAPE → KKKSHLKPATRGSQFSSVKV CSVPAACKLLGTPGRARQPV PAPRELEHDKNSPHCAYLSL YLTSLAQSSWRVFSLFSYVL IYLFSKYLAFNTLFALKRMA LQRDRKEKTRAWCIFIKLCG REIQILPGPV in isoform 3. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_030039512 – 523MIHQQ…PGVHY → VSLDVSGLFFGF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_030040524 – 1018Missing in isoform 2. 1 PublicationAdd BLAST495
Alternative sequenceiVSP_030041580 – 1018Missing in isoform 3. 1 PublicationAdd BLAST439

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358143 mRNA Translation: AAQ88510.1
AK023772 mRNA Translation: BAB14673.1 Different initiation.
AK131551 mRNA Translation: BAD18685.1
AK299056 mRNA Translation: BAG61125.1
AC015711 Genomic DNA No translation available.
AC026636 Genomic DNA No translation available.
AC064799 Genomic DNA No translation available.
AC068181 Genomic DNA No translation available.
AC108861 Genomic DNA No translation available.
AC104938 Genomic DNA No translation available.
AC104943 Genomic DNA No translation available.
AC105132 Genomic DNA No translation available.
BC140868 mRNA Translation: AAI40869.1
BX641106 mRNA Translation: CAE46049.1
CCDSiCCDS10238.2 [Q6ZMP0-1]
CCDS66817.1 [Q6ZMP0-4]
RefSeqiNP_001273358.1, NM_001286429.1 [Q6ZMP0-4]
NP_079093.2, NM_024817.2 [Q6ZMP0-1]
XP_006720755.1, XM_006720692.3 [Q6ZMP0-1]
UniGeneiHs.387057

Genome annotation databases

EnsembliENST00000261862; ENSP00000261862; ENSG00000187720 [Q6ZMP0-3]
ENST00000355327; ENSP00000347484; ENSG00000187720 [Q6ZMP0-1]
ENST00000357769; ENSP00000350413; ENSG00000187720 [Q6ZMP0-4]
GeneIDi79875
KEGGihsa:79875
UCSCiuc002atb.2 human [Q6ZMP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTHSD4_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMP0
Secondary accession number(s): B2RTY3
, B4DR13, Q6MZI3, Q6UXZ8, Q9H8E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 18, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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