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Protein

Cyclin-I2

Gene

CCNI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Keywordsi

Molecular functionCyclin

Enzyme and pathway databases

SignaLinkiQ6ZMN8

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-I2
Gene namesi
Name:CCNI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000205089.7
HGNCiHGNC:33869 CCNI2
neXtProtiNX_Q6ZMN8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205089
PharmGKBiPA162381968

Polymorphism and mutation databases

DMDMi74749548

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003358211 – 369Cyclin-I2Add BLAST369

Proteomic databases

PaxDbiQ6ZMN8
PeptideAtlasiQ6ZMN8
PRIDEiQ6ZMN8
ProteomicsDBi67895

PTM databases

iPTMnetiQ6ZMN8
PhosphoSitePlusiQ6ZMN8

Expressioni

Gene expression databases

BgeeiENSG00000205089 Expressed in 88 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_CCNI2

Organism-specific databases

HPAiHPA056288

Interactioni

Protein-protein interaction databases

BioGridi570168, 6 interactors
STRINGi9606.ENSP00000368005

Structurei

3D structure databases

ProteinModelPortaliQ6ZMN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00530000062971
HOGENOMiHOG000111450
HOVERGENiHBG050841
InParanoidiQ6ZMN8
OMAiDLYTATP
OrthoDBiEOG091G0HQN
PhylomeDBiQ6ZMN8
TreeFamiTF101007

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR028861 CCNI2
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF57 PTHR10177:SF57, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZMN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGAQLPPQ PSSSEVSAVQ SPGGRPGAGL EETALGVPLP PSPGEAPLPR
60 70 80 90 100
SNRSRCPGTR QPGAASLHAA SAAVPVRPRR GTAPAGKTAD AVPAAAPEQA
110 120 130 140 150
PRPAPQSRKP RNLEGDLDER RLLCHLQLAQ DREARLWRGG KPQDEICDAF
160 170 180 190 200
EEVVLWLLRL QNTFYFSQST FNLALTIFGR LLISVKVKEK YLHCATITSL
210 220 230 240 250
RLAAKVNEEE EFIPQVKDFT KHYGSDYSPN ELLRMELAIL DRLHWDLYIG
260 270 280 290 300
TPLDFLTIFH ALVVLSWPHV LELLPQRNPS LHVASLTRQL QHCMAGHQLL
310 320 330 340 350
QFKGSTLALV IITLELERLM PGWCAPISDL LKKAQVGDMQ YSCCKELVMQ
360
QLRSLQSSSC TDNFVSPAN
Length:369
Mass (Da):40,622
Last modified:July 5, 2004 - v1
Checksum:i68B887A9C0044708
GO
Isoform 2 (identifier: Q6ZMN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: I → IEKYGVFCSNIKNHGLQ

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):42,441
Checksum:i3263E903B4AF7236
GO
Isoform 3 (identifier: Q6ZMN8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-143: Q → QQ

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):40,750
Checksum:i4F73E6EB1B3805C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04347191A → P. Corresponds to variant dbSNP:rs803056Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057179143Q → QQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_057180258I → IEKYGVFCSNIKNHGLQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131553 mRNA Translation: BAD18687.1
BC132837 mRNA Translation: AAI32838.1
BC136836 mRNA Translation: AAI36837.1
BC144416 mRNA Translation: AAI44417.1
BC144417 mRNA Translation: AAI44418.1
CCDSiCCDS34236.1 [Q6ZMN8-1]
CCDS75297.1 [Q6ZMN8-2]
RefSeqiNP_001034869.1, NM_001039780.3 [Q6ZMN8-1]
NP_001274181.1, NM_001287252.1 [Q6ZMN8-2]
NP_001274182.1, NM_001287253.1 [Q6ZMN8-3]
UniGeneiHs.522057
Hs.714496

Genome annotation databases

EnsembliENST00000378731; ENSP00000368005; ENSG00000205089 [Q6ZMN8-1]
ENST00000614847; ENSP00000478257; ENSG00000205089 [Q6ZMN8-2]
GeneIDi645121
KEGGihsa:645121
UCSCiuc003kxq.3 human [Q6ZMN8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131553 mRNA Translation: BAD18687.1
BC132837 mRNA Translation: AAI32838.1
BC136836 mRNA Translation: AAI36837.1
BC144416 mRNA Translation: AAI44417.1
BC144417 mRNA Translation: AAI44418.1
CCDSiCCDS34236.1 [Q6ZMN8-1]
CCDS75297.1 [Q6ZMN8-2]
RefSeqiNP_001034869.1, NM_001039780.3 [Q6ZMN8-1]
NP_001274181.1, NM_001287252.1 [Q6ZMN8-2]
NP_001274182.1, NM_001287253.1 [Q6ZMN8-3]
UniGeneiHs.522057
Hs.714496

3D structure databases

ProteinModelPortaliQ6ZMN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi570168, 6 interactors
STRINGi9606.ENSP00000368005

PTM databases

iPTMnetiQ6ZMN8
PhosphoSitePlusiQ6ZMN8

Polymorphism and mutation databases

DMDMi74749548

Proteomic databases

PaxDbiQ6ZMN8
PeptideAtlasiQ6ZMN8
PRIDEiQ6ZMN8
ProteomicsDBi67895

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378731; ENSP00000368005; ENSG00000205089 [Q6ZMN8-1]
ENST00000614847; ENSP00000478257; ENSG00000205089 [Q6ZMN8-2]
GeneIDi645121
KEGGihsa:645121
UCSCiuc003kxq.3 human [Q6ZMN8-1]

Organism-specific databases

CTDi645121
EuPathDBiHostDB:ENSG00000205089.7
GeneCardsiCCNI2
HGNCiHGNC:33869 CCNI2
HPAiHPA056288
neXtProtiNX_Q6ZMN8
OpenTargetsiENSG00000205089
PharmGKBiPA162381968
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00530000062971
HOGENOMiHOG000111450
HOVERGENiHBG050841
InParanoidiQ6ZMN8
OMAiDLYTATP
OrthoDBiEOG091G0HQN
PhylomeDBiQ6ZMN8
TreeFamiTF101007

Enzyme and pathway databases

SignaLinkiQ6ZMN8

Miscellaneous databases

GenomeRNAii645121
PROiPR:Q6ZMN8

Gene expression databases

BgeeiENSG00000205089 Expressed in 88 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_CCNI2

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR028861 CCNI2
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF57 PTHR10177:SF57, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCNI2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMN8
Secondary accession number(s): B2RNE2, B7ZMB7, B7ZMB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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