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Entry version 151 (12 Aug 2020)
Sequence version 3 (17 Oct 2006)
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Protein

PDZ domain-containing RING finger protein 4

Gene

PDZRN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZMN7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PDZ domain-containing RING finger protein 4
Alternative name(s):
Ligand of Numb protein X 4
SEMACAP3-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDZRN4
Synonyms:LNX4, SEMCAP3L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165966.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30552, PDZRN4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609730, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZMN7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29951

Open Targets

More...
OpenTargetsi
ENSG00000165966

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134974780

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZMN7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDZRN4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242741

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559201 – 1036PDZ domain-containing RING finger protein 4Add BLAST1036

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZMN7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZMN7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZMN7

PeptideAtlas

More...
PeptideAtlasi
Q6ZMN7

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZMN7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67892 [Q6ZMN7-1]
67893 [Q6ZMN7-2]
67894 [Q6ZMN7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZMN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZMN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165966, Expressed in cauda epididymis and 175 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZMN7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZMN7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165966, Tissue enhanced (epididymis, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118988, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZMN7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384197

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZMN7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini224 – 314PDZ 1PROSITE-ProRule annotationAdd BLAST91
Domaini402 – 486PDZ 2PROSITE-ProRule annotationAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili655 – 689Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi116 – 161Gly-richAdd BLAST46
Compositional biasi533 – 536Poly-Glu4
Compositional biasi957 – 960Poly-Arg4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0297, Eukaryota
KOG0312, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011096_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZMN7

KEGG Orthology (KO)

More...
KOi
K15682

Identification of Orthologs from Complete Genome Data

More...
OMAi
QSSNYMT

Database of Orthologous Groups

More...
OrthoDBi
631580at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZMN7

TreeFam database of animal gene trees

More...
TreeFami
TF315909

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 2 hits
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR008974, TRAF-like
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 2 hits
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49599, SSF49599, 1 hit
SSF50156, SSF50156, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 2 hits
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZMN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFALERFAE AVDPALECKL CGQVLEEPLC TPCGHVFCAS CLLPWAVRRR
60 70 80 90 100
RCPLQCQPLA PGELYRVLPL RSLIQKLRVQ CDYRARGCGH SVRLHELEAH
110 120 130 140 150
VEHCDFGPAR RLRSRGGCAS GLGGGEVPAR GGCGPTPRAG RGGGARGGPP
160 170 180 190 200
GGRWGRGRGP GPRVLAWRRR EKALLAQLWA LQGEVQLTAR RYQEKFTQYM
210 220 230 240 250
AHVRNFVGDL GGGHRRDGEH KPFTIVLERE NDTLGFNIIG GRPNQNNQEG
260 270 280 290 300
TSTEGIYVSK ILENGPADRA DGLEIHDKIM EVNGKDLSKA THEEAVEAFR
310 320 330 340 350
NAKEPIVVQV LRRTPLSRPA YGMASEVQLM NASTQTDITF EHIMALAKLR
360 370 380 390 400
PPTPPVPDIC PFLLSDSCHS LHPMEHEFYE DNEYISSLPA DADRTEDFEY
410 420 430 440 450
EEVELCRVSS QEKLGLTVCY RTDDEEDTGI YVSEVDPNSI AAKDGRIREG
460 470 480 490 500
DRILQINGED VQNREEAVAL LSNDECKRIV LLVARPEIQL DEGWLEDERN
510 520 530 540 550
EFLEELNLEM LEEEHNEAMQ PTANEVEQPK KQEEEEGTTD TATSSSNNHE
560 570 580 590 600
KDSGVGRTDE SLRNDESSEQ ENAAEDPNST SLKSKRDLGQ SQDTLGSVEL
610 620 630 640 650
QYNESLVSGE YIDSDCIGNP DEDCERFRQL LELKCKIRNH GEYDLYYSSS
660 670 680 690 700
TIECNQGEQE GVEHELQLLN EELRNIELEC QNIMQAHRLQ KVTDQYGDIW
710 720 730 740 750
TLHDGGFRNY NTSIDMQRGK LDDIMEHPEK SDKDSSSAYN TAESCRSTPL
760 770 780 790 800
TVDRSPDSSL PRVINLTNKK NLRSTMAATQ SSSGQSSKES TSTKAKTTEQ
810 820 830 840 850
GCSAESKEKV LEGSKLPDQE KAVSEHIPYL SPYHSSSYRY ANIPAHARHY
860 870 880 890 900
QSYMQLIQQK SAVEYAQSQL SLVSMCKESQ KCSEPKMEWK VKIRSDGTRY
910 920 930 940 950
ITKRPVRDRI LKERALKIKE ERSGMTTDDD TMSEMKMGRY WSKEERKQHL
960 970 980 990 1000
VRAKEQRRRR EFMMRSRLEC LKESPQSGSE GKKEINIIEL SHKKMMKKRN
1010 1020 1030
KKILDNWMTI QELMTHGAKS PDGTRVHNAF LSVTTV
Length:1,036
Mass (Da):117,103
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26A43A0789CEA6B2
GO
Isoform 2 (identifier: Q6ZMN7-2) [UniParc]FASTAAdd to basket
Also known as: PDZRN4S

The sequence of this isoform differs from the canonical sequence as follows:
     1-258: Missing.
     259-281: SKILENGPADRADGLEIHDKIME → MGCNLCTFQKREEHYKLLYEVSQ

Show »
Length:778
Mass (Da):89,067
Checksum:iD7EDD0E1CBE6ABF2
GO
Isoform 4 (identifier: Q6ZMN7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     261-281: ILENGPADRADGLEIHDKIME → MSGKRQFFLKPLALLTCWPST

Show »
Length:776
Mass (Da):88,672
Checksum:i726F2C05EB8B6700
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ISS2A0A3B3ISS2_HUMAN
PDZ domain-containing RING finger p...
PDZRN4
714Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti650S → G (PubMed:16541075).Curated1
Sequence conflicti650S → G in BAD18688 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020966429G → S. Corresponds to variant dbSNP:rs285584Ensembl.1
Natural variantiVAR_035951784G → R in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0126141 – 260Missing in isoform 4. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_0126111 – 258Missing in isoform 2. 1 PublicationAdd BLAST258
Alternative sequenceiVSP_012612259 – 281SKILE…DKIME → MGCNLCTFQKREEHYKLLYE VSQ in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_012615261 – 281ILENG…DKIME → MSGKRQFFLKPLALLTCWPS T in isoform 4. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC090531 Genomic DNA No translation available.
AC021651 Genomic DNA No translation available.
AK131554 mRNA Translation: BAD18688.1
BC040922 mRNA Translation: AAH40922.1
BC093744 mRNA Translation: AAH93744.1
BC093746 mRNA Translation: AAH93746.2
BX640695 mRNA Translation: CAE45818.2
AL133067 mRNA Translation: CAB61390.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53777.1 [Q6ZMN7-1]
CCDS8739.1 [Q6ZMN7-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42667

NCBI Reference Sequences

More...
RefSeqi
NP_001158067.1, NM_001164595.1 [Q6ZMN7-1]
NP_037509.3, NM_013377.3 [Q6ZMN7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298919; ENSP00000298919; ENSG00000165966 [Q6ZMN7-4]
ENST00000402685; ENSP00000384197; ENSG00000165966 [Q6ZMN7-1]
ENST00000539469; ENSP00000439990; ENSG00000165966 [Q6ZMN7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29951

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29951

UCSC genome browser

More...
UCSCi
uc001rmq.5, human [Q6ZMN7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090531 Genomic DNA No translation available.
AC021651 Genomic DNA No translation available.
AK131554 mRNA Translation: BAD18688.1
BC040922 mRNA Translation: AAH40922.1
BC093744 mRNA Translation: AAH93744.1
BC093746 mRNA Translation: AAH93746.2
BX640695 mRNA Translation: CAE45818.2
AL133067 mRNA Translation: CAB61390.3
CCDSiCCDS53777.1 [Q6ZMN7-1]
CCDS8739.1 [Q6ZMN7-2]
PIRiT42667
RefSeqiNP_001158067.1, NM_001164595.1 [Q6ZMN7-1]
NP_037509.3, NM_013377.3 [Q6ZMN7-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi118988, 5 interactors
IntActiQ6ZMN7, 1 interactor
STRINGi9606.ENSP00000384197

PTM databases

iPTMnetiQ6ZMN7
PhosphoSitePlusiQ6ZMN7

Polymorphism and mutation databases

BioMutaiPDZRN4
DMDMi116242741

Proteomic databases

jPOSTiQ6ZMN7
MassIVEiQ6ZMN7
PaxDbiQ6ZMN7
PeptideAtlasiQ6ZMN7
PRIDEiQ6ZMN7
ProteomicsDBi67892 [Q6ZMN7-1]
67893 [Q6ZMN7-2]
67894 [Q6ZMN7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25032, 50 antibodies

Genome annotation databases

EnsembliENST00000298919; ENSP00000298919; ENSG00000165966 [Q6ZMN7-4]
ENST00000402685; ENSP00000384197; ENSG00000165966 [Q6ZMN7-1]
ENST00000539469; ENSP00000439990; ENSG00000165966 [Q6ZMN7-2]
GeneIDi29951
KEGGihsa:29951
UCSCiuc001rmq.5, human [Q6ZMN7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29951
DisGeNETi29951
EuPathDBiHostDB:ENSG00000165966.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PDZRN4
HGNCiHGNC:30552, PDZRN4
HPAiENSG00000165966, Tissue enhanced (epididymis, seminal vesicle)
MIMi609730, gene
neXtProtiNX_Q6ZMN7
OpenTargetsiENSG00000165966
PharmGKBiPA134974780

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0297, Eukaryota
KOG0312, Eukaryota
GeneTreeiENSGT00950000183062
HOGENOMiCLU_011096_0_0_1
InParanoidiQ6ZMN7
KOiK15682
OMAiQSSNYMT
OrthoDBi631580at2759
PhylomeDBiQ6ZMN7
TreeFamiTF315909

Enzyme and pathway databases

PathwayCommonsiQ6ZMN7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
29951, 1 hit in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PDZRN4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29951
PharosiQ6ZMN7, Tdark

Protein Ontology

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PROi
PR:Q6ZMN7
RNActiQ6ZMN7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165966, Expressed in cauda epididymis and 175 other tissues
ExpressionAtlasiQ6ZMN7, baseline and differential
GenevisibleiQ6ZMN7, HS

Family and domain databases

Gene3Di2.30.42.10, 2 hits
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR008974, TRAF-like
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF00595, PDZ, 2 hits
SMARTiView protein in SMART
SM00228, PDZ, 2 hits
SM00184, RING, 1 hit
SUPFAMiSSF49599, SSF49599, 1 hit
SSF50156, SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 2 hits
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPZRN4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMN7
Secondary accession number(s): Q52LY3
, Q52LY4, Q6N052, Q8IUU1, Q9NTP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 17, 2006
Last modified: August 12, 2020
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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