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Entry version 122 (08 May 2019)
Sequence version 2 (08 Apr 2008)
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Protein

Cysteine and histidine-rich protein 1

Gene

CYHR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri68 – 114RING-type; degenerateAdd BLAST47
Zinc fingeri110 – 183TRAF-typePROSITE-ProRule annotationAdd BLAST74

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine and histidine-rich protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYHR1
Synonyms:KIAA0496
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17806 CYHR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616635 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZMK1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000187954

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27081

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYHR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
182641989

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003288521 – 362Cysteine and histidine-rich protein 1Add BLAST362

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZMK1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZMK1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZMK1

PeptideAtlas

More...
PeptideAtlasi
Q6ZMK1

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZMK1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67884
67885 [Q6ZMK1-2]
67886 [Q6ZMK1-3]
67887 [Q6ZMK1-4]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6ZMK1

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZMK1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZMK1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187954 Expressed in 204 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZMK1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZMK1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053653
HPA059543

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LGALS3.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
KPNA4O006293EBI-3908824,EBI-396343

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119101, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZMK1, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387426

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZMK1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CYHR1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 114RING-type; degenerateAdd BLAST47
Zinc fingeri110 – 183TRAF-typePROSITE-ProRule annotationAdd BLAST74

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3002 Eukaryota
ENOG410XVP0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018258

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006931

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZMK1

Database of Orthologous Groups

More...
OrthoDBi
1174688at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZMK1

TreeFam database of animal gene trees

More...
TreeFami
TF324281

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039338 CYHR1
IPR008974 TRAF-like
IPR013083 Znf_RING/FYVE/PHD
IPR001293 Znf_TRAF

The PANTHER Classification System

More...
PANTHERi
PTHR23059 PTHR23059, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49599 SSF49599, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50145 ZF_TRAF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZMK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPKPGAEWS TALSHLVLGV VSLHAAVSTA EASRGAAAGF LLQVLAATTT
60 70 80 90 100
LAPGLSTHED CLAGAWVATV IGLPLLAFDF HWCTNGHLMC AGCFIHLLAD
110 120 130 140 150
ARLKEEQATC PNCRCEISKS LCCRNLAVEK AVSELPSECG FCLRQFPRSL
160 170 180 190 200
LERHQKEECQ DRVTQCKYKR IGCPWHGPFH ELTVHEAACA HPTKTGSELM
210 220 230 240 250
EILDGMDQSH RKEMQLYNSI FSLLSFEKIG YTEVQFRPYR TDDFITRLYY
260 270 280 290 300
ETPRFTVLNQ TWVLKARVND SERNPNLSCK RTLSFQLLLK SKVTAPLECS
310 320 330 340 350
FLLLKGPYDD VRISPVIYHF VFTNESNETD YVPLPIIDSV ECNKLLAAKN
360
INLRLFLFQI QK
Length:362
Mass (Da):40,703
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2409CCF532C6C868
GO
Isoform 2 (identifier: Q6ZMK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):31,760
Checksum:i9FD5C02DBB6DE4D5
GO
Isoform 3 (identifier: Q6ZMK1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-362: CTNGHLMCAG...LRLFLFQIQK → VNGDRSSANL...ALHTQRLQWE

Show »
Length:192
Mass (Da):19,949
Checksum:i9FF840F39E5354F3
GO
Isoform 4 (identifier: Q6ZMK1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     233-362: EVQFRPYRTD...LRLFLFQIQK → GEAPRRLLHA...TPRSRRQAGD

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,766
Checksum:i57AB92448DFF67EB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQ42E9PQ42_HUMAN
Cysteine and histidine-rich protein...
CYHR1
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJD7E9PJD7_HUMAN
Cysteine and histidine-rich protein...
CYHR1
404Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN77E9PN77_HUMAN
Cysteine and histidine-rich protein...
CYHR1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPA8E9PPA8_HUMAN
Cysteine and histidine-rich protein...
CYHR1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18724 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0328181 – 88Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_03281983 – 362CTNGH…FQIQK → VNGDRSSANLLLGGGMVLAV AGGHLGPEGRSVAGQAMLLV VAVTILIVAVFTANTYGMWG GAMLGVAGLLSRLEEDRLLL LPKEDVCRWALAVGSWAYCR ALHTQRLQWE in isoform 3. 1 PublicationAdd BLAST280
Alternative sequenceiVSP_032820233 – 362EVQFR…FQIQK → GEAPRRLLHATQVWVGGLAA RSLGAAGSGHWALTAPDSRA LDKLPVDRWTPRSRRQAGD in isoform 4. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007965 mRNA No translation available.
AK094514 mRNA Translation: BAG52882.1
AK160381 mRNA Translation: BAD18724.1 Different initiation.
CH471162 Genomic DNA Translation: EAW82088.1
CH471162 Genomic DNA Translation: EAW82089.1
CH471162 Genomic DNA Translation: EAW82091.1
BC004544 mRNA Translation: AAH04544.2
BC005073 mRNA Translation: AAH05073.1
BC065484 mRNA Translation: AAH65484.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47943.1 [Q6ZMK1-1]
CCDS6426.1 [Q6ZMK1-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001123360.1, NM_001129888.1 [Q6ZMK1-3]
NP_001317547.1, NM_001330618.1
NP_116076.1, NM_032687.3 [Q6ZMK1-3]
NP_612505.1, NM_138496.1 [Q6ZMK1-1]
XP_006716623.1, XM_006716560.3
XP_006716624.1, XM_006716561.3
XP_011515353.1, XM_011517051.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306145; ENSP00000304826; ENSG00000187954 [Q6ZMK1-3]
ENST00000403000; ENSP00000385962; ENSG00000187954 [Q6ZMK1-3]
ENST00000424149; ENSP00000414647; ENSG00000187954 [Q6ZMK1-3]
ENST00000438911; ENSP00000387426; ENSG00000187954 [Q6ZMK1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50626

UCSC genome browser

More...
UCSCi
uc003zcv.3 human [Q6ZMK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007965 mRNA No translation available.
AK094514 mRNA Translation: BAG52882.1
AK160381 mRNA Translation: BAD18724.1 Different initiation.
CH471162 Genomic DNA Translation: EAW82088.1
CH471162 Genomic DNA Translation: EAW82089.1
CH471162 Genomic DNA Translation: EAW82091.1
BC004544 mRNA Translation: AAH04544.2
BC005073 mRNA Translation: AAH05073.1
BC065484 mRNA Translation: AAH65484.1
CCDSiCCDS47943.1 [Q6ZMK1-1]
CCDS6426.1 [Q6ZMK1-3]
RefSeqiNP_001123360.1, NM_001129888.1 [Q6ZMK1-3]
NP_001317547.1, NM_001330618.1
NP_116076.1, NM_032687.3 [Q6ZMK1-3]
NP_612505.1, NM_138496.1 [Q6ZMK1-1]
XP_006716623.1, XM_006716560.3
XP_006716624.1, XM_006716561.3
XP_011515353.1, XM_011517051.1

3D structure databases

SMRiQ6ZMK1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119101, 30 interactors
IntActiQ6ZMK1, 10 interactors
STRINGi9606.ENSP00000387426

PTM databases

CarbonylDBiQ6ZMK1
iPTMnetiQ6ZMK1
PhosphoSitePlusiQ6ZMK1

Polymorphism and mutation databases

BioMutaiCYHR1
DMDMi182641989

Proteomic databases

jPOSTiQ6ZMK1
MaxQBiQ6ZMK1
PaxDbiQ6ZMK1
PeptideAtlasiQ6ZMK1
PRIDEiQ6ZMK1
ProteomicsDBi67884
67885 [Q6ZMK1-2]
67886 [Q6ZMK1-3]
67887 [Q6ZMK1-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306145; ENSP00000304826; ENSG00000187954 [Q6ZMK1-3]
ENST00000403000; ENSP00000385962; ENSG00000187954 [Q6ZMK1-3]
ENST00000424149; ENSP00000414647; ENSG00000187954 [Q6ZMK1-3]
ENST00000438911; ENSP00000387426; ENSG00000187954 [Q6ZMK1-1]
GeneIDi50626
KEGGihsa:50626
UCSCiuc003zcv.3 human [Q6ZMK1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50626

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYHR1
HGNCiHGNC:17806 CYHR1
HPAiHPA053653
HPA059543
MIMi616635 gene
neXtProtiNX_Q6ZMK1
OpenTargetsiENSG00000187954
PharmGKBiPA27081

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3002 Eukaryota
ENOG410XVP0 LUCA
GeneTreeiENSGT00390000018258
HOGENOMiHOG000006931
InParanoidiQ6ZMK1
OrthoDBi1174688at2759
PhylomeDBiQ6ZMK1
TreeFamiTF324281

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CYHR1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
50626

Protein Ontology

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PROi
PR:Q6ZMK1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000187954 Expressed in 204 organ(s), highest expression level in right testis
ExpressionAtlasiQ6ZMK1 baseline and differential
GenevisibleiQ6ZMK1 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039338 CYHR1
IPR008974 TRAF-like
IPR013083 Znf_RING/FYVE/PHD
IPR001293 Znf_TRAF
PANTHERiPTHR23059 PTHR23059, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50145 ZF_TRAF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYHR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMK1
Secondary accession number(s): B3KSX0
, D3DWM3, Q9BSF6, Q9BSU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 8, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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