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Entry version 140 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Scavenger receptor class A member 5

Gene

SCARA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZMJ2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000480, Scavenging by Class A Receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Scavenger receptor class A member 5UniRule annotation
Alternative name(s):
Scavenger receptor hlg
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCARA5UniRule annotation
ORF Names:UNQ2938/PRO28700
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168079.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28701, SCARA5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611306, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZMJ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 60CytoplasmicUniRule annotationAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei61 – 81Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd BLAST21
Topological domaini82 – 495ExtracellularUniRule annotationAdd BLAST414

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
286133

Open Targets

More...
OpenTargetsi
ENSG00000168079

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670948

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZMJ2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCARA5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749535

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002795181 – 495Scavenger receptor class A member 5Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagineUniRule annotation1
Glycosylationi134N-linked (GlcNAc...) asparagineUniRule annotation1
Glycosylationi193N-linked (GlcNAc...) asparagineUniRule annotation1
Glycosylationi231N-linked (GlcNAc...) asparagineUniRule annotation1
Glycosylationi254N-linked (GlcNAc...) asparagineUniRule annotation1
Glycosylationi397N-linked (GlcNAc...) asparagineUniRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi418 ↔ 482UniRule annotation
Disulfide bondi431 ↔ 492UniRule annotation
Disulfide bondi462 ↔ 472UniRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZMJ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZMJ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZMJ2

PeptideAtlas

More...
PeptideAtlasi
Q6ZMJ2

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZMJ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67878 [Q6ZMJ2-1]
67879 [Q6ZMJ2-2]
67880 [Q6ZMJ2-3]
67881 [Q6ZMJ2-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6ZMJ2, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZMJ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZMJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168079, Expressed in layer of synovial tissue and 189 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZMJ2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168079, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

UniRule annotation

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZMJ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini305 – 357Collagen-likeUniRule annotationAdd BLAST53
Domaini393 – 493SRCRUniRule annotationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili91 – 111UniRule annotationAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCARA5 family.UniRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSM1, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183074

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041152_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZMJ2

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQCKFSG

Database of Orthologous Groups

More...
OrthoDBi
711951at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZMJ2

TreeFam database of animal gene trees

More...
TreeFami
TF330855

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.250.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03070, SCARA5, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008160, Collagen
IPR034726, SCARA5
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391, Collagen, 2 hits
PF00530, SRCR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00258, SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00202, SR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56487, SSF56487, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00420, SRCR_1, 1 hit
PS50287, SRCR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZMJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENKAMYLHT VSDCDTSSIC EDSFDGRSLS KLNLCEDGPC HKRRASICCT
60 70 80 90 100
QLGSLSALKH AVLGLYLLVF LILVGIFILA VSRPRSSPDD LKALTRNVNR
110 120 130 140 150
LNESFRDLQL RLLQAPLQAD LTEQVWKVQD ALQNQSDSLL ALAGAVQRLE
160 170 180 190 200
GALWGLQAQA VQTEQAVALL RDRTGQQSDT AQLELYQLQV ESNSSQLLLR
210 220 230 240 250
RHAGLLDGLA RRVGILGEEL ADVGGVLRGL NHSLSYDVAL HRTRLQDLRV
260 270 280 290 300
LVSNASEDTR RLRLAHVGME LQLKQELAML NAVTEDLRLK DWEHSIALRN
310 320 330 340 350
ISLAKGPPGP KGDQGDEGKE GRPGIPGLPG LRGLPGERGT PGLPGPKGDD
360 370 380 390 400
GKLGATGPMG MRGFKGDRGP KGEKGEKGDR AGDASGVEAP MMIRLVNGSG
410 420 430 440 450
PHEGRVEVYH DRRWGTVCDD GWDKKDGDVV CRMLGFRGVE EVYRTARFGQ
460 470 480 490
GTGRIWMDDV ACKGTEETIF RCSFSKWGVT NCGHAEDASV TCNRH
Length:495
Mass (Da):53,994
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC37E94B2D2E3F5CF
GO
Isoform 2 (identifier: Q6ZMJ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-400: GVEAPMMIRLVNGSG → KDILLGPWDMVLAQG
     401-495: Missing.

Show »
Length:400
Mass (Da):43,293
Checksum:i4AE238BD2A24ECA5
GO
Isoform 3 (identifier: Q6ZMJ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-80: Missing.
     386-400: GVEAPMMIRLVNGSG → KDILLGPWDMVLAQG
     401-495: Missing.

Show »
Length:357
Mass (Da):38,702
Checksum:i57B0BFBF6F2CE183
GO
Isoform 4 (identifier: Q6ZMJ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-305: Missing.

Show »
Length:270
Mass (Da):28,871
Checksum:iCC626D37B06F19E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93A → S in AAQ17470 (Ref. 3) Curated1
Sequence conflicti95T → A in AAQ17470 (Ref. 3) Curated1
Sequence conflicti108L → S in AAQ17470 (Ref. 3) Curated1
Sequence conflicti246Q → R in AAQ17470 (Ref. 3) Curated1
Sequence conflicti377K → E in AAQ17470 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05206245A → T. Corresponds to variant dbSNP:rs17058374Ensembl.1
Natural variantiVAR_030915316D → H1 PublicationCorresponds to variant dbSNP:rs17058207Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02347238 – 80Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_02347381 – 305Missing in isoform 4. 1 PublicationAdd BLAST225
Alternative sequenceiVSP_023474386 – 400GVEAP…VNGSG → KDILLGPWDMVLAQG in isoform 2 and isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_023475401 – 495Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358150 mRNA Translation: AAQ88517.1
AK172746 mRNA Translation: BAD18733.1
AY337579 mRNA Translation: AAQ17470.1
BC033153 mRNA Translation: AAH33153.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6064.1 [Q6ZMJ2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_776194.2, NM_173833.5 [Q6ZMJ2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354914; ENSP00000346990; ENSG00000168079 [Q6ZMJ2-1]
ENST00000380385; ENSP00000369746; ENSG00000168079 [Q6ZMJ2-4]
ENST00000518030; ENSP00000430713; ENSG00000168079 [Q6ZMJ2-3]
ENST00000524352; ENSP00000428663; ENSG00000168079 [Q6ZMJ2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
286133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:286133

UCSC genome browser

More...
UCSCi
uc003xgj.4, human [Q6ZMJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358150 mRNA Translation: AAQ88517.1
AK172746 mRNA Translation: BAD18733.1
AY337579 mRNA Translation: AAQ17470.1
BC033153 mRNA Translation: AAH33153.1
CCDSiCCDS6064.1 [Q6ZMJ2-1]
RefSeqiNP_776194.2, NM_173833.5 [Q6ZMJ2-1]

3D structure databases

SMRiQ6ZMJ2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130309, 4 interactors
IntActiQ6ZMJ2, 17 interactors
STRINGi9606.ENSP00000346990

PTM databases

GlyGeniQ6ZMJ2, 6 sites
iPTMnetiQ6ZMJ2
PhosphoSitePlusiQ6ZMJ2

Polymorphism and mutation databases

BioMutaiSCARA5
DMDMi74749535

Proteomic databases

jPOSTiQ6ZMJ2
MassIVEiQ6ZMJ2
PaxDbiQ6ZMJ2
PeptideAtlasiQ6ZMJ2
PRIDEiQ6ZMJ2
ProteomicsDBi67878 [Q6ZMJ2-1]
67879 [Q6ZMJ2-2]
67880 [Q6ZMJ2-3]
67881 [Q6ZMJ2-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10358, 184 antibodies

Genome annotation databases

EnsembliENST00000354914; ENSP00000346990; ENSG00000168079 [Q6ZMJ2-1]
ENST00000380385; ENSP00000369746; ENSG00000168079 [Q6ZMJ2-4]
ENST00000518030; ENSP00000430713; ENSG00000168079 [Q6ZMJ2-3]
ENST00000524352; ENSP00000428663; ENSG00000168079 [Q6ZMJ2-2]
GeneIDi286133
KEGGihsa:286133
UCSCiuc003xgj.4, human [Q6ZMJ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
286133
DisGeNETi286133
EuPathDBiHostDB:ENSG00000168079.16

GeneCards: human genes, protein and diseases

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GeneCardsi
SCARA5
HGNCiHGNC:28701, SCARA5
HPAiENSG00000168079, Low tissue specificity
MIMi611306, gene
neXtProtiNX_Q6ZMJ2
OpenTargetsiENSG00000168079
PharmGKBiPA142670948

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QSM1, Eukaryota
GeneTreeiENSGT00950000183074
HOGENOMiCLU_041152_1_0_1
InParanoidiQ6ZMJ2
OMAiHQCKFSG
OrthoDBi711951at2759
PhylomeDBiQ6ZMJ2
TreeFamiTF330855

Enzyme and pathway databases

PathwayCommonsiQ6ZMJ2
ReactomeiR-HSA-3000480, Scavenging by Class A Receptors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
286133, 2 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SCARA5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
286133
PharosiQ6ZMJ2, Tbio

Protein Ontology

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PROi
PR:Q6ZMJ2
RNActiQ6ZMJ2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000168079, Expressed in layer of synovial tissue and 189 other tissues
GenevisibleiQ6ZMJ2, HS

Family and domain databases

Gene3Di3.10.250.10, 1 hit
HAMAPiMF_03070, SCARA5, 1 hit
InterProiView protein in InterPro
IPR008160, Collagen
IPR034726, SCARA5
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
PfamiView protein in Pfam
PF01391, Collagen, 2 hits
PF00530, SRCR, 1 hit
PRINTSiPR00258, SPERACTRCPTR
SMARTiView protein in SMART
SM00202, SR, 1 hit
SUPFAMiSSF56487, SSF56487, 1 hit
PROSITEiView protein in PROSITE
PS00420, SRCR_1, 1 hit
PS50287, SRCR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCAR5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMJ2
Secondary accession number(s): Q6UXZ1, Q7Z4A1, Q8N4Z7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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