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Entry version 124 (05 Jun 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Protein phosphatase 1 regulatory subunit 21

Gene

PPP1R21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 21
Alternative name(s):
Coiled-coil domain-containing protein 128
KLRAQ motif-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R21
Synonyms:CCDC128, KLRAQ1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30595 PPP1R21

Online Mendelian Inheritance in Man (OMIM)

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MIMi
618159 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZMI0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
129285

Open Targets

More...
OpenTargetsi
ENSG00000162869

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164722001

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R21

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74710533

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860981 – 780Protein phosphatase 1 regulatory subunit 21Add BLAST780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei652PhosphothreonineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZMI0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZMI0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZMI0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZMI0

PeptideAtlas

More...
PeptideAtlasi
Q6ZMI0

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZMI0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67871
67872 [Q6ZMI0-2]
67873 [Q6ZMI0-3]
67874 [Q6ZMI0-4]
67875 [Q6ZMI0-5]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2064

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZMI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZMI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162869 Expressed in 191 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZMI0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZMI0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036791
HPA036792

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPP1CA.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126187, 37 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZMI0, 24 interactors

Molecular INTeraction database

More...
MINTi
Q6ZMI0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000294952

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZMI0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 207Sequence analysisAdd BLAST207
Coiled coili556 – 607Sequence analysisAdd BLAST52
Coiled coili693 – 742Sequence analysisAdd BLAST50

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4421 Eukaryota
ENOG410YXM0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006820

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007280

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZMI0

KEGG Orthology (KO)

More...
KOi
K17562

Identification of Orthologs from Complete Genome Data

More...
OMAi
IATFFSN

Database of Orthologous Groups

More...
OrthoDBi
1295591at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZMI0

TreeFam database of animal gene trees

More...
TreeFami
TF320535

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019348 KLRAQ/TTKRSYEDQ_C
IPR040024 PPP1R21
IPR019343 Unchr_KLRAQ/TTKRSYEDQ_N

The PANTHER Classification System

More...
PANTHERi
PTHR21448 PTHR21448, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10205 KLRAQ, 1 hit
PF10212 TTKRSYEDQ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01254 KLRAQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZMI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASAELQGKY QKLAQEYSKL RAQNQVLKKG VVDEQANSAA LKEQLKMKDQ
60 70 80 90 100
SLRKLQQEMD SLTFRNLQLA KRVELLQDEL ALSEPRGKKN KKSGESSSQL
110 120 130 140 150
SQEQKSVFDE DLQKKIEENE RLHIQFFEAD EQHKHVEAEL RSRLATLETE
160 170 180 190 200
AAQHQAVVDG LTRKYMETIE KLQNDKAKLE VKSQTLEKEA KECRLRTEEC
210 220 230 240 250
QLQLKTLHED LSGRLEESLS IINEKVPFND TKYSQYNALN VPLHNRRHQL
260 270 280 290 300
KMRDIAGQAL AFVQDLVTAL LNFHTYTEQR IQIFPVDSAI DTISPLNQKF
310 320 330 340 350
SQYLHENASY VRPLEEGMLH LFESITEDTV TVLETTVKLK TFSEHLTSYI
360 370 380 390 400
CFLRKILPYQ LKSLEEECES SLCTSALRAR NLELSQDMKK MTAVFEKLQT
410 420 430 440 450
YIALLALPST EPDGLLRTNY SSVLTNVGAA LHGFHDVMKD ISKHYSQKAA
460 470 480 490 500
IEHELPTATQ KLITTNDCIL SSVVALTNGA GKIASFFSNN LDYFIASLSY
510 520 530 540 550
GPKAASGFIS PLSAECMLQY KKKAAAYMKS LRKPLLESVP YEEALANRRI
560 570 580 590 600
LLSSTESREG LAQQVQQSLE KISKLEQEKE HWMLEAQLAK IKLEKENQRI
610 620 630 640 650
ADKLKNTGSA QLVGLAQENA AVSNTAGQDE ATAKAVLEPI QSTSLIGTLT
660 670 680 690 700
RTSDSEVPDV ESREDLIKNH YMARIVELTS QLQLADSKSV HFYAECRALS
710 720 730 740 750
KRLALAEKSK EALTEEMKLA SQNISRLQDE LTTTKRSYED QLSMMSDHLC
760 770 780
SMNETLSKQR EEIDTLKMSS KGNSKKNKSR
Length:780
Mass (Da):88,314
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D265213DC80841A
GO
Isoform 2 (identifier: Q6ZMI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-656: Missing.

Note: No experimental confirmation available.
Show »
Length:769
Mass (Da):87,153
Checksum:i0D3BE0812C0BD9BB
GO
Isoform 5 (identifier: Q6ZMI0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-564: Missing.
     646-656: Missing.

Show »
Length:738
Mass (Da):83,700
Checksum:i2CE41C4CC7F8E607
GO
Isoform 3 (identifier: Q6ZMI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     566-574: QQSLEKISK → WHWENYGNC
     575-780: Missing.

Note: No experimental confirmation available.
Show »
Length:574
Mass (Da):65,351
Checksum:iE870F809190BC08B
GO
Isoform 4 (identifier: Q6ZMI0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-779: Missing.

Note: No experimental confirmation available.
Show »
Length:363
Mass (Da):42,133
Checksum:i0FD933949E4EAC5F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBY8F8WBY8_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R21
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W7E1F8W7E1_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R21
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE40F8WE40_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R21
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1Y1H7C1Y1_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R21
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH11978 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD18739 differs from that shown. Reason: Frameshift at position 115.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti235Q → R in BAD18739 (PubMed:14702039).Curated1
Sequence conflicti476L → S in BAD18739 (PubMed:14702039).Curated1
Sequence conflicti670H → R in BAD18739 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024984363 – 779Missing in isoform 4. 1 PublicationAdd BLAST417
Alternative sequenceiVSP_043216534 – 564Missing in isoform 5. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_024985566 – 574QQSLEKISK → WHWENYGNC in isoform 3. 1 Publication9
Alternative sequenceiVSP_024986575 – 780Missing in isoform 3. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_024987646 – 656Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK172753 mRNA Translation: BAD18739.1 Frameshift.
AK172762 mRNA Translation: BAD18745.1
AY134855 mRNA Translation: AAN08625.1
AC093635 Genomic DNA Translation: AAX93161.1
CH471053 Genomic DNA Translation: EAX00200.1
BC011978 mRNA Translation: AAH11978.2 Different initiation.
BC040721 mRNA Translation: AAH40721.1
BC111059 mRNA Translation: AAI11060.1
BC117279 mRNA Translation: AAI17280.1
BC143463 mRNA Translation: AAI43464.1
BC143466 mRNA Translation: AAI43467.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1839.1 [Q6ZMI0-2]
CCDS46278.1 [Q6ZMI0-1]
CCDS54358.1 [Q6ZMI0-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001129101.1, NM_001135629.2 [Q6ZMI0-1]
NP_001180404.1, NM_001193475.1 [Q6ZMI0-5]
NP_694539.1, NM_152994.4 [Q6ZMI0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000281394; ENSP00000281394; ENSG00000162869 [Q6ZMI0-2]
ENST00000294952; ENSP00000294952; ENSG00000162869 [Q6ZMI0-1]
ENST00000449090; ENSP00000415696; ENSG00000162869 [Q6ZMI0-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
129285

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:129285

UCSC genome browser

More...
UCSCi
uc002rwk.4 human [Q6ZMI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172753 mRNA Translation: BAD18739.1 Frameshift.
AK172762 mRNA Translation: BAD18745.1
AY134855 mRNA Translation: AAN08625.1
AC093635 Genomic DNA Translation: AAX93161.1
CH471053 Genomic DNA Translation: EAX00200.1
BC011978 mRNA Translation: AAH11978.2 Different initiation.
BC040721 mRNA Translation: AAH40721.1
BC111059 mRNA Translation: AAI11060.1
BC117279 mRNA Translation: AAI17280.1
BC143463 mRNA Translation: AAI43464.1
BC143466 mRNA Translation: AAI43467.1
CCDSiCCDS1839.1 [Q6ZMI0-2]
CCDS46278.1 [Q6ZMI0-1]
CCDS54358.1 [Q6ZMI0-5]
RefSeqiNP_001129101.1, NM_001135629.2 [Q6ZMI0-1]
NP_001180404.1, NM_001193475.1 [Q6ZMI0-5]
NP_694539.1, NM_152994.4 [Q6ZMI0-2]

3D structure databases

SMRiQ6ZMI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126187, 37 interactors
IntActiQ6ZMI0, 24 interactors
MINTiQ6ZMI0
STRINGi9606.ENSP00000294952

PTM databases

GlyConnecti2064
iPTMnetiQ6ZMI0
PhosphoSitePlusiQ6ZMI0

Polymorphism and mutation databases

BioMutaiPPP1R21
DMDMi74710533

Proteomic databases

EPDiQ6ZMI0
jPOSTiQ6ZMI0
MaxQBiQ6ZMI0
PaxDbiQ6ZMI0
PeptideAtlasiQ6ZMI0
PRIDEiQ6ZMI0
ProteomicsDBi67871
67872 [Q6ZMI0-2]
67873 [Q6ZMI0-3]
67874 [Q6ZMI0-4]
67875 [Q6ZMI0-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281394; ENSP00000281394; ENSG00000162869 [Q6ZMI0-2]
ENST00000294952; ENSP00000294952; ENSG00000162869 [Q6ZMI0-1]
ENST00000449090; ENSP00000415696; ENSG00000162869 [Q6ZMI0-5]
GeneIDi129285
KEGGihsa:129285
UCSCiuc002rwk.4 human [Q6ZMI0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
129285
DisGeNETi129285

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP1R21

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0200323
HGNCiHGNC:30595 PPP1R21
HPAiHPA036791
HPA036792
MIMi618159 gene
neXtProtiNX_Q6ZMI0
OpenTargetsiENSG00000162869
PharmGKBiPA164722001

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4421 Eukaryota
ENOG410YXM0 LUCA
GeneTreeiENSGT00390000006820
HOGENOMiHOG000007280
InParanoidiQ6ZMI0
KOiK17562
OMAiIATFFSN
OrthoDBi1295591at2759
PhylomeDBiQ6ZMI0
TreeFamiTF320535

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP1R21 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
129285

Protein Ontology

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PROi
PR:Q6ZMI0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162869 Expressed in 191 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ6ZMI0 baseline and differential
GenevisibleiQ6ZMI0 HS

Family and domain databases

InterProiView protein in InterPro
IPR019348 KLRAQ/TTKRSYEDQ_C
IPR040024 PPP1R21
IPR019343 Unchr_KLRAQ/TTKRSYEDQ_N
PANTHERiPTHR21448 PTHR21448, 1 hit
PfamiView protein in Pfam
PF10205 KLRAQ, 1 hit
PF10212 TTKRSYEDQ, 1 hit
SMARTiView protein in SMART
SM01254 KLRAQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPR21_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMI0
Secondary accession number(s): B7ZKY5
, B7ZKY7, E1B6W7, Q2TA78, Q6ZMI6, Q8IW83, Q8J029, Q96ES8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: June 5, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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