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Entry version 150 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Ceramide synthase 6

Gene

CERS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952). Can use other acyl donors, but with less efficiency (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity).By similarity4 Publications

Caution

Some prediction bioinformatics tools predict the presence of a homeobox domain (By similarity). However, the domain is degenerate and residues that are important for DNA-binding are absent (By similarity). Moreover, the protein localizes in the endoplasmic reticulum and not in the nucleus, strongly suggesting that it does not constitute a canonical homeobox domain (By similarity).Sequence analysisBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.0 µM for sphinganine1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sphingolipid metabolism

    This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.3 Publications
    View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    Biological processInflammatory response, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.3.1.24 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1660661 Sphingolipid de novo biosynthesis

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00222

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000700

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Ceramide synthase 6Curated (EC:2.3.1.-3 Publications)
    Short name:
    CerS6Curated
    Alternative name(s):
    LAG1 longevity assurance homolog 6By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CERS6Imported
    Synonyms:LASS6By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:23826 CERS6

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    615336 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6ZMG9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34Lumenal1 PublicationAdd BLAST34
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
    Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
    Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
    Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
    Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
    Topological domaini324 – 384Cytoplasmic1 PublicationAdd BLAST61

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131R → A: Abolished ceramide synthase activity. 1 Publication1
    Mutagenesisi131R → K: Does not affect ceramide synthase activity. 1 Publication1
    Mutagenesisi341 – 347SDIESSS → ADIEAAA: Decreased phosphorylation. 1 Publication7

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    253782

    Open Targets

    More...
    OpenTargetsi
    ENSG00000172292

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134925480

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6ZMG9

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CERS6

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    51316251

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001855161 – 384Ceramide synthase 6Add BLAST384

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi18N-linked (GlcNAc...) asparagine1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylated at the C-terminus by CK2.1 Publication
    Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q6ZMG9

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6ZMG9

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q6ZMG9

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q6ZMG9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6ZMG9

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6ZMG9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6ZMG9

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    61592
    67868 [Q6ZMG9-1]

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1107

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6ZMG9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6ZMG9

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q6ZMG9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated in adipose tissues in obese patients.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000172292 Expressed in 239 organ(s), highest expression level in cerebral cortex

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6ZMG9 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA044683
    HPA063527

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    128987, 43 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q6ZMG9, 18 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q6ZMG9

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000376453

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6ZMG9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini130 – 331TLCPROSITE-ProRule annotationAdd BLAST202

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 127Homeobox-likeCuratedAdd BLAST62

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1607 Eukaryota
    COG5058 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000182700

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000231977

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6ZMG9

    KEGG Orthology (KO)

    More...
    KOi
    K04710

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GVMFLHH

    Database of Orthologous Groups

    More...
    OrthoDBi
    987268at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6ZMG9

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314319

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00086 homeodomain, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR009057 Homeobox-like_sf
    IPR001356 Homeobox_dom
    IPR016439 Lag1/Lac1-like
    IPR006634 TLC-dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR12560 PTHR12560, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00046 Homeodomain, 1 hit
    PF03798 TRAM_LAG1_CLN8, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF005225 LAG1_LAC1, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00724 TLC, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF46689 SSF46689, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50922 TLC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: Q6ZMG9-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAGILAWFWN ERFWLPHNVT WADLKNTEEA TFPQAEDLYL AFPLAFCIFM
    60 70 80 90 100
    VRLIFERFVA KPCAIALNIQ ANGPQIAPPN AILEKVFTAI TKHPDEKRLE
    110 120 130 140 150
    GLSKQLDWDV RSIQRWFRQR RNQEKPSTLT RFCESMWRFS FYLYVFTYGV
    160 170 180 190 200
    RFLKKTPWLW NTRHCWYNYP YQPLTTDLHY YYILELSFYW SLMFSQFTDI
    210 220 230 240 250
    KRKDFGIMFL HHLVSIFLIT FSYVNNMARV GTLVLCLHDS ADALLEAAKM
    260 270 280 290 300
    ANYAKFQKMC DLLFVMFAVV FITTRLGIFP LWVLNTTLFE SWEIVGPYPS
    310 320 330 340 350
    WWVFNLLLLL VQGLNCFWSY LIVKIACKAV SRGKVSKDDR SDIESSSDEE
    360 370 380
    DSEPPGKNPH TATTTNGTSG TNGYLLTGSC SMDD
    Length:384
    Mass (Da):44,890
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3C400D6317D9E5E
    GO
    Isoform 2 (identifier: Q6ZMG9-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         334-334: K → KAGKWNPLH

    Show »
    Length:392
    Mass (Da):45,794
    Checksum:i8977CEFEEA561DE4
    GO

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH30800 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045162334K → KAGKWNPLH in isoform 2. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK172775 mRNA Translation: BAD18757.1
    AC009475 Genomic DNA No translation available.
    AC019086 Genomic DNA No translation available.
    AC097453 Genomic DNA No translation available.
    BC109284 mRNA Translation: AAI09285.1
    BC109285 mRNA Translation: AAI09286.1
    BC030800 mRNA Translation: AAH30800.2 Sequence problems.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS2228.1 [Q6ZMG9-1]
    CCDS58734.1 [Q6ZMG9-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001243055.1, NM_001256126.1 [Q6ZMG9-2]
    NP_982288.1, NM_203463.2 [Q6ZMG9-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000305747; ENSP00000306579; ENSG00000172292 [Q6ZMG9-1]
    ENST00000392687; ENSP00000376453; ENSG00000172292 [Q6ZMG9-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    253782

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:253782

    UCSC genome browser

    More...
    UCSCi
    uc002ueb.3 human [Q6ZMG9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK172775 mRNA Translation: BAD18757.1
    AC009475 Genomic DNA No translation available.
    AC019086 Genomic DNA No translation available.
    AC097453 Genomic DNA No translation available.
    BC109284 mRNA Translation: AAI09285.1
    BC109285 mRNA Translation: AAI09286.1
    BC030800 mRNA Translation: AAH30800.2 Sequence problems.
    CCDSiCCDS2228.1 [Q6ZMG9-1]
    CCDS58734.1 [Q6ZMG9-2]
    RefSeqiNP_001243055.1, NM_001256126.1 [Q6ZMG9-2]
    NP_982288.1, NM_203463.2 [Q6ZMG9-1]

    3D structure databases

    SMRiQ6ZMG9
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi128987, 43 interactors
    IntActiQ6ZMG9, 18 interactors
    MINTiQ6ZMG9
    STRINGi9606.ENSP00000376453

    Chemistry databases

    SwissLipidsiSLP:000000700

    PTM databases

    GlyConnecti1107
    iPTMnetiQ6ZMG9
    PhosphoSitePlusiQ6ZMG9
    SwissPalmiQ6ZMG9

    Polymorphism and mutation databases

    BioMutaiCERS6
    DMDMi51316251

    Proteomic databases

    EPDiQ6ZMG9
    jPOSTiQ6ZMG9
    MassIVEiQ6ZMG9
    MaxQBiQ6ZMG9
    PaxDbiQ6ZMG9
    PeptideAtlasiQ6ZMG9
    PRIDEiQ6ZMG9
    ProteomicsDBi61592
    67868 [Q6ZMG9-1]

    Genome annotation databases

    EnsembliENST00000305747; ENSP00000306579; ENSG00000172292 [Q6ZMG9-1]
    ENST00000392687; ENSP00000376453; ENSG00000172292 [Q6ZMG9-2]
    GeneIDi253782
    KEGGihsa:253782
    UCSCiuc002ueb.3 human [Q6ZMG9-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    253782
    DisGeNETi253782

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    CERS6
    HGNCiHGNC:23826 CERS6
    HPAiHPA044683
    HPA063527
    MIMi615336 gene
    neXtProtiNX_Q6ZMG9
    OpenTargetsiENSG00000172292
    PharmGKBiPA134925480

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1607 Eukaryota
    COG5058 LUCA
    GeneTreeiENSGT00950000182700
    HOGENOMiHOG000231977
    InParanoidiQ6ZMG9
    KOiK04710
    OMAiGVMFLHH
    OrthoDBi987268at2759
    PhylomeDBiQ6ZMG9
    TreeFamiTF314319

    Enzyme and pathway databases

    UniPathwayiUPA00222
    BRENDAi2.3.1.24 2681
    ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    CERS6 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    253782
    PharosiQ6ZMG9

    Protein Ontology

    More...
    PROi
    PR:Q6ZMG9

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000172292 Expressed in 239 organ(s), highest expression level in cerebral cortex
    GenevisibleiQ6ZMG9 HS

    Family and domain databases

    CDDicd00086 homeodomain, 1 hit
    InterProiView protein in InterPro
    IPR009057 Homeobox-like_sf
    IPR001356 Homeobox_dom
    IPR016439 Lag1/Lac1-like
    IPR006634 TLC-dom
    PANTHERiPTHR12560 PTHR12560, 1 hit
    PfamiView protein in Pfam
    PF00046 Homeodomain, 1 hit
    PF03798 TRAM_LAG1_CLN8, 1 hit
    PIRSFiPIRSF005225 LAG1_LAC1, 1 hit
    SMARTiView protein in SMART
    SM00724 TLC, 1 hit
    SUPFAMiSSF46689 SSF46689, 1 hit
    PROSITEiView protein in PROSITE
    PS50922 TLC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCERS6_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMG9
    Secondary accession number(s): Q32M63, Q8N617
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: July 5, 2004
    Last modified: October 16, 2019
    This is version 150 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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