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Entry version 162 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Ceramide synthase 6

Gene

CERS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624).

Can use other acyl donors, but with less efficiency (By similarity).

N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624).

Ceramides generated by CERS6 play a role in inflammatory response (By similarity).

Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity).

Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity).

By similarity5 Publications

Caution

Some prediction bioinformatics tools predict the presence of a homeobox domain (By similarity). However, the domain is degenerate and residues that are important for DNA-binding are absent (By similarity). Moreover, the protein localizes in the endoplasmic reticulum and not in the nucleus, strongly suggesting that it does not constitute a canonical homeobox domain (By similarity).Sequence analysisBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.0 µM for sphinganine1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.3 Publications
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processInflammatory response, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000172292-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.24, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6ZMG9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660661, Sphingolipid de novo biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00222

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000700

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ceramide synthase 6Curated
Short name:
CerS6Curated
Alternative name(s):
LAG1 longevity assurance homolog 6By similarity
Sphingoid base N-palmitoyltransferase CERS6Curated (EC:2.3.1.2914 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CERS6Imported
Synonyms:LASS6By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23826, CERS6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615336, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZMG9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000172292

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34Lumenal1 PublicationAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 384Cytoplasmic1 PublicationAdd BLAST61

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131R → A: Abolished ceramide synthase activity. 1 Publication1
Mutagenesisi131R → K: Does not affect ceramide synthase activity. 1 Publication1
Mutagenesisi341 – 347SDIESSS → ADIEAAA: Decreased phosphorylation. 1 Publication7

Organism-specific databases

DisGeNET

More...
DisGeNETi
253782

Open Targets

More...
OpenTargetsi
ENSG00000172292

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134925480

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6ZMG9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CERS6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316251

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001855161 – 384Ceramide synthase 6Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi18N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at the C-terminus by CK2.1 Publication
Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZMG9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZMG9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6ZMG9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZMG9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZMG9

PeptideAtlas

More...
PeptideAtlasi
Q6ZMG9

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZMG9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61592
67868 [Q6ZMG9-1]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1107, 4 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6ZMG9, 1 site, 4 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZMG9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZMG9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6ZMG9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in adipose tissues in obese patients.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172292, Expressed in cerebral cortex and 251 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZMG9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000172292, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128987, 54 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZMG9, 18 interactors

Molecular INTeraction database

More...
MINTi
Q6ZMG9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376453

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6ZMG9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZMG9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini130 – 331TLCPROSITE-ProRule annotationAdd BLAST202

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 127Homeobox-likeCuratedAdd BLAST62
Regioni338 – 384DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi357 – 384Polar residuesSequence analysisAdd BLAST28

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1607, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234515

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028277_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZMG9

Identification of Orthologs from Complete Genome Data

More...
OMAi
MGLKIQT

Database of Orthologous Groups

More...
OrthoDBi
987268at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZMG9

TreeFam database of animal gene trees

More...
TreeFami
TF314319

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR016439, Lag1/Lac1-like
IPR006634, TLC-dom

The PANTHER Classification System

More...
PANTHERi
PTHR12560, PTHR12560, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit
PF03798, TRAM_LAG1_CLN8, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005225, LAG1_LAC1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00724, TLC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50922, TLC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6ZMG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGILAWFWN ERFWLPHNVT WADLKNTEEA TFPQAEDLYL AFPLAFCIFM
60 70 80 90 100
VRLIFERFVA KPCAIALNIQ ANGPQIAPPN AILEKVFTAI TKHPDEKRLE
110 120 130 140 150
GLSKQLDWDV RSIQRWFRQR RNQEKPSTLT RFCESMWRFS FYLYVFTYGV
160 170 180 190 200
RFLKKTPWLW NTRHCWYNYP YQPLTTDLHY YYILELSFYW SLMFSQFTDI
210 220 230 240 250
KRKDFGIMFL HHLVSIFLIT FSYVNNMARV GTLVLCLHDS ADALLEAAKM
260 270 280 290 300
ANYAKFQKMC DLLFVMFAVV FITTRLGIFP LWVLNTTLFE SWEIVGPYPS
310 320 330 340 350
WWVFNLLLLL VQGLNCFWSY LIVKIACKAV SRGKVSKDDR SDIESSSDEE
360 370 380
DSEPPGKNPH TATTTNGTSG TNGYLLTGSC SMDD
Length:384
Mass (Da):44,890
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3C400D6317D9E5E
GO
Isoform 2 (identifier: Q6ZMG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: K → KAGKWNPLH

Show »
Length:392
Mass (Da):45,794
Checksum:i8977CEFEEA561DE4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH30800 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045162334K → KAGKWNPLH in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK172775 mRNA Translation: BAD18757.1
AC009475 Genomic DNA No translation available.
AC019086 Genomic DNA No translation available.
AC097453 Genomic DNA No translation available.
BC109284 mRNA Translation: AAI09285.1
BC109285 mRNA Translation: AAI09286.1
BC030800 mRNA Translation: AAH30800.2 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2228.1 [Q6ZMG9-1]
CCDS58734.1 [Q6ZMG9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001243055.1, NM_001256126.1 [Q6ZMG9-2]
NP_982288.1, NM_203463.2 [Q6ZMG9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305747; ENSP00000306579; ENSG00000172292 [Q6ZMG9-1]
ENST00000392687; ENSP00000376453; ENSG00000172292 [Q6ZMG9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
253782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:253782

UCSC genome browser

More...
UCSCi
uc002ueb.3, human [Q6ZMG9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172775 mRNA Translation: BAD18757.1
AC009475 Genomic DNA No translation available.
AC019086 Genomic DNA No translation available.
AC097453 Genomic DNA No translation available.
BC109284 mRNA Translation: AAI09285.1
BC109285 mRNA Translation: AAI09286.1
BC030800 mRNA Translation: AAH30800.2 Sequence problems.
CCDSiCCDS2228.1 [Q6ZMG9-1]
CCDS58734.1 [Q6ZMG9-2]
RefSeqiNP_001243055.1, NM_001256126.1 [Q6ZMG9-2]
NP_982288.1, NM_203463.2 [Q6ZMG9-1]

3D structure databases

SMRiQ6ZMG9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128987, 54 interactors
IntActiQ6ZMG9, 18 interactors
MINTiQ6ZMG9
STRINGi9606.ENSP00000376453

Chemistry databases

SwissLipidsiSLP:000000700

PTM databases

GlyConnecti1107, 4 N-Linked glycans (1 site)
GlyGeniQ6ZMG9, 1 site, 4 N-linked glycans (1 site)
iPTMnetiQ6ZMG9
PhosphoSitePlusiQ6ZMG9
SwissPalmiQ6ZMG9

Genetic variation databases

BioMutaiCERS6
DMDMi51316251

Proteomic databases

EPDiQ6ZMG9
jPOSTiQ6ZMG9
MassIVEiQ6ZMG9
MaxQBiQ6ZMG9
PaxDbiQ6ZMG9
PeptideAtlasiQ6ZMG9
PRIDEiQ6ZMG9
ProteomicsDBi61592
67868 [Q6ZMG9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33795, 233 antibodies

The DNASU plasmid repository

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DNASUi
253782

Genome annotation databases

EnsembliENST00000305747; ENSP00000306579; ENSG00000172292 [Q6ZMG9-1]
ENST00000392687; ENSP00000376453; ENSG00000172292 [Q6ZMG9-2]
GeneIDi253782
KEGGihsa:253782
UCSCiuc002ueb.3, human [Q6ZMG9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
253782
DisGeNETi253782

GeneCards: human genes, protein and diseases

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GeneCardsi
CERS6
HGNCiHGNC:23826, CERS6
HPAiENSG00000172292, Low tissue specificity
MIMi615336, gene
neXtProtiNX_Q6ZMG9
OpenTargetsiENSG00000172292
PharmGKBiPA134925480
VEuPathDBiHostDB:ENSG00000172292

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1607, Eukaryota
GeneTreeiENSGT01030000234515
HOGENOMiCLU_028277_1_2_1
InParanoidiQ6ZMG9
OMAiMGLKIQT
OrthoDBi987268at2759
PhylomeDBiQ6ZMG9
TreeFamiTF314319

Enzyme and pathway databases

UniPathwayiUPA00222
BioCyciMetaCyc:ENSG00000172292-MONOMER
BRENDAi2.3.1.24, 2681
PathwayCommonsiQ6ZMG9
ReactomeiR-HSA-1660661, Sphingolipid de novo biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
253782, 10 hits in 1044 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CERS6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
253782
PharosiQ6ZMG9, Tbio

Protein Ontology

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PROi
PR:Q6ZMG9
RNActiQ6ZMG9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172292, Expressed in cerebral cortex and 251 other tissues
GenevisibleiQ6ZMG9, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR016439, Lag1/Lac1-like
IPR006634, TLC-dom
PANTHERiPTHR12560, PTHR12560, 1 hit
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF03798, TRAM_LAG1_CLN8, 1 hit
PIRSFiPIRSF005225, LAG1_LAC1, 1 hit
SMARTiView protein in SMART
SM00724, TLC, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50922, TLC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCERS6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZMG9
Secondary accession number(s): Q32M63, Q8N617
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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