UniProtKB - Q6ZMC9 (SIG15_HUMAN)
Protein
Sialic acid-binding Ig-like lectin 15
Gene
SIGLEC15
Organism
Homo sapiens (Human)
Status
Functioni
Binds sialylated glycoproteins.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 143 | Sialic acidBy similarity | 1 |
GO - Biological processi
- innate immune response Source: Reactome
- regulation of actin cytoskeleton organization Source: GO_Central
- regulation of bone resorption Source: GO_Central
- regulation of osteoclast development Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q6ZMC9 |
Reactomei | R-HSA-2172127, DAP12 interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Sialic acid-binding Ig-like lectin 15Short name: Siglec-15 Alternative name(s): CD33 antigen-like 3 |
Gene namesi | Name:SIGLEC15 Synonyms:CD33L3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27596, SIGLEC15 |
MIMi | 618105, gene |
neXtProti | NX_Q6ZMC9 |
VEuPathDBi | HostDB:ENSG00000197046.11 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 263 | ExtracellularSequence analysisAdd BLAST | 244 | |
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 285 – 328 | CytoplasmicSequence analysisAdd BLAST | 44 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 143 | R → A: Abrogates glycan-binding. 1 Publication | 1 | |
Mutagenesisi | 274 | K → A: Abrogates interaction with HCST and TYROBP. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 284266 |
OpenTargetsi | ENSG00000197046 |
PharmGKBi | PA162403350 |
Miscellaneous databases
Pharosi | Q6ZMC9, Tbio |
Genetic variation databases
BioMutai | SIGLEC15 |
DMDMi | 74762385 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000294369 | 20 – 328 | Sialic acid-binding Ig-like lectin 15Add BLAST | 309 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 64 ↔ 142 | PROSITE-ProRule annotation | ||
Disulfide bondi | 95 ↔ 104 | PROSITE-ProRule annotation | ||
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 187 ↔ 237 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q6ZMC9 |
PeptideAtlasi | Q6ZMC9 |
PRIDEi | Q6ZMC9 |
ProteomicsDBi | 5292 67864 [Q6ZMC9-1] |
PTM databases
GlyGeni | Q6ZMC9, 1 site |
iPTMneti | Q6ZMC9 |
PhosphoSitePlusi | Q6ZMC9 |
Expressioni
Tissue specificityi
Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.
Gene expression databases
Bgeei | ENSG00000197046, Expressed in amniotic fluid and 157 other tissues |
ExpressionAtlasi | Q6ZMC9, baseline and differential |
Organism-specific databases
HPAi | ENSG00000197046, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Interacts with TYROBP and HCST.
1 PublicationProtein-protein interaction databases
STRINGi | 9606.ENSP00000374125 |
Miscellaneous databases
RNActi | Q6ZMC9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 158 | Ig-like V-typeAdd BLAST | 119 | |
Domaini | 168 – 251 | Ig-like C2-typeAdd BLAST | 84 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 276 – 279 | Poly-Leu | 4 |
Sequence similaritiesi
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.Curated
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RFMV, Eukaryota |
GeneTreei | ENSGT01020000230393 |
HOGENOMi | CLU_076258_0_0_1 |
InParanoidi | Q6ZMC9 |
OMAi | VYLFRFR |
OrthoDBi | 42984at2759 |
PhylomeDBi | Q6ZMC9 |
TreeFami | TF351096 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR042836, SIG15 |
PANTHERi | PTHR46942, PTHR46942, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ZMC9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEKSIWLLAC LAWVLPTGSF VRTKIDTTEN LLNTEVHSSP AQRWSMQVPP
60 70 80 90 100
EVSAEAGDAA VLPCTFTHPH RHYDGPLTAI WRAGEPYAGP QVFRCAAARG
110 120 130 140 150
SELCQTALSL HGRFRLLGNP RRNDLSLRVE RLALADDRRY FCRVEFAGDV
160 170 180 190 200
HDRYESRHGV RLHVTAAPRI VNISVLPSPA HAFRALCTAE GEPPPALAWS
210 220 230 240 250
GPALGNSLAA VRSPREGHGH LVTAELPALT HDGRYTCTAA NSLGRSEASV
260 270 280 290 300
YLFRFHGASG ASTVALLLGA LGFKALLLLG VLAARAARRR PEHLDTPDTP
310 320
PRSQAQESNY ENLSQMNPRS PPATMCSP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EN40 | K7EN40_HUMAN | Sialic acid-binding Ig-like lectin ... | SIGLEC15 | 174 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033174 | 273 | F → L. Corresponds to variant dbSNP:rs2919643Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056817 | 1 – 12 | MEKSI…LACLA → MTATRAATASGS in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_056818 | 13 – 166 | Missing in isoform 2. 1 PublicationAdd BLAST | 154 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK172835 mRNA Translation: BAD18800.1 AK290400 mRNA Translation: BAF83089.1 AK290402 mRNA Translation: BAF83091.1 AK301189 mRNA Translation: BAG62771.1 AC087685 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01463.1 |
CCDSi | CCDS32819.1 [Q6ZMC9-1] |
RefSeqi | NP_998767.1, NM_213602.2 [Q6ZMC9-1] |
Genome annotation databases
Ensembli | ENST00000389474; ENSP00000374125; ENSG00000197046 [Q6ZMC9-1] ENST00000546268; ENSP00000443509; ENSG00000197046 [Q6ZMC9-2] |
GeneIDi | 284266 |
KEGGi | hsa:284266 |
UCSCi | uc002lbl.2, human [Q6ZMC9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK172835 mRNA Translation: BAD18800.1 AK290400 mRNA Translation: BAF83089.1 AK290402 mRNA Translation: BAF83091.1 AK301189 mRNA Translation: BAG62771.1 AC087685 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01463.1 |
CCDSi | CCDS32819.1 [Q6ZMC9-1] |
RefSeqi | NP_998767.1, NM_213602.2 [Q6ZMC9-1] |
3D structure databases
SMRi | Q6ZMC9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000374125 |
PTM databases
GlyGeni | Q6ZMC9, 1 site |
iPTMneti | Q6ZMC9 |
PhosphoSitePlusi | Q6ZMC9 |
Genetic variation databases
BioMutai | SIGLEC15 |
DMDMi | 74762385 |
Proteomic databases
PaxDbi | Q6ZMC9 |
PeptideAtlasi | Q6ZMC9 |
PRIDEi | Q6ZMC9 |
ProteomicsDBi | 5292 67864 [Q6ZMC9-1] |
Protocols and materials databases
ABCDi | Q6ZMC9, 1 sequenced antibody |
Antibodypediai | 60463, 164 antibodies |
Genome annotation databases
Ensembli | ENST00000389474; ENSP00000374125; ENSG00000197046 [Q6ZMC9-1] ENST00000546268; ENSP00000443509; ENSG00000197046 [Q6ZMC9-2] |
GeneIDi | 284266 |
KEGGi | hsa:284266 |
UCSCi | uc002lbl.2, human [Q6ZMC9-1] |
Organism-specific databases
CTDi | 284266 |
DisGeNETi | 284266 |
GeneCardsi | SIGLEC15 |
HGNCi | HGNC:27596, SIGLEC15 |
HPAi | ENSG00000197046, Tissue enhanced (blood) |
MIMi | 618105, gene |
neXtProti | NX_Q6ZMC9 |
OpenTargetsi | ENSG00000197046 |
PharmGKBi | PA162403350 |
VEuPathDBi | HostDB:ENSG00000197046.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RFMV, Eukaryota |
GeneTreei | ENSGT01020000230393 |
HOGENOMi | CLU_076258_0_0_1 |
InParanoidi | Q6ZMC9 |
OMAi | VYLFRFR |
OrthoDBi | 42984at2759 |
PhylomeDBi | Q6ZMC9 |
TreeFami | TF351096 |
Enzyme and pathway databases
PathwayCommonsi | Q6ZMC9 |
Reactomei | R-HSA-2172127, DAP12 interactions |
Miscellaneous databases
BioGRID-ORCSi | 284266, 5 hits in 983 CRISPR screens |
GenomeRNAii | 284266 |
Pharosi | Q6ZMC9, Tbio |
PROi | PR:Q6ZMC9 |
RNActi | Q6ZMC9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197046, Expressed in amniotic fluid and 157 other tissues |
ExpressionAtlasi | Q6ZMC9, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR042836, SIG15 |
PANTHERi | PTHR46942, PTHR46942, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SIG15_HUMAN | |
Accessioni | Q6ZMC9Primary (citable) accession number: Q6ZMC9 Secondary accession number(s): A8K2Y5, B4DVQ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families