UniProtKB - Q6Z6M4 (ACEA_ORYSJ)
Protein
Isocitrate lyase
Gene
ICL
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Involved in storage lipid mobilization during the growth of higher plant seedling.1 Publication
Catalytic activityi
- EC:4.1.3.11 Publication
Cofactori
Mg2+By similarity
: glyoxylate cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from isocitrate.CuratedProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Isocitrate lyase, Isocitrate lyase (ICL), Uncharacterized protein P0685G12.12 (P0685G12.12), Isocitrate lyase
- Malate synthase (MS), Malate synthase (OsJ_15256)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 175 | MagnesiumBy similarity | 1 | |
Active sitei | 213 | Proton acceptorCurated | 1 | |
Binding sitei | 250 | SubstrateBy similarity | 1 | |
Binding sitei | 472 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- isocitrate lyase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- glyoxylate cycle Source: UniProtKB
- tricarboxylic acid cycle Source: UniProtKB-KW
Keywordsi
Molecular function | Lyase |
Biological process | Glyoxylate bypass, Tricarboxylic acid cycle |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00703;UER00719 |
Names & Taxonomyi
Protein namesi | Recommended name: Isocitrate lyase1 Publication (EC:4.1.3.11 Publication)Short name: ICL1 Publication Alternative name(s): IsocitraseCurated IsocitrataseCurated |
Gene namesi | Name:ICL1 Publication Ordered Locus Names:Os07g0529000Imported, LOC_Os07g34520Curated ORF Names:OsJ_24528Imported, OSJNBa0007H12.39Imported |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Peroxisome
- Glyoxysome 1 Publication
Peroxisome
- glyoxysome Source: UniProtKB
Keywords - Cellular componenti
Glyoxysome, PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000430878 | 1 – 572 | Isocitrate lyaseAdd BLAST | 572 |
Proteomic databases
PaxDbi | Q6Z6M4 |
PRIDEi | Q6Z6M4 |
Expressioni
Tissue specificityi
Expressed in leaves.1 Publication
Inductioni
By submergence in seedlings (PubMed:15944756). By dark-induced senescence in leaves (PubMed:11432928, PubMed:23296688).3 Publications
Gene expression databases
ExpressionAtlasi | Q6Z6M4, baseline and differential |
Genevisiblei | Q6Z6M4, OS |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 104 – 106 | Substrate bindingBy similarity | 3 | |
Regioni | 214 – 215 | Substrate bindingBy similarity | 2 | |
Regioni | 437 – 441 | Substrate bindingBy similarity | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 570 – 572 | Microbody targeting signalCurated | 3 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1260, Eukaryota |
HOGENOMi | CLU_019214_2_2_1 |
InParanoidi | Q6Z6M4 |
OMAi | LEKDWAE |
OrthoDBi | 905115at2759 |
Family and domain databases
CDDi | cd00377, ICL_PEPM, 1 hit |
Gene3Di | 3.20.20.60, 1 hit |
InterProi | View protein in InterPro IPR039556, ICL/PEPM IPR006254, Isocitrate_lyase IPR018523, Isocitrate_lyase_ph_CS IPR015813, Pyrv/PenolPyrv_Kinase-like_dom IPR040442, Pyrv_Kinase-like_dom_sf |
PANTHERi | PTHR21631, PTHR21631, 1 hit |
Pfami | View protein in Pfam PF00463, ICL, 1 hit |
PIRSFi | PIRSF001362, Isocit_lyase, 1 hit |
SUPFAMi | SSF51621, SSF51621, 1 hit |
TIGRFAMsi | TIGR01346, isocit_lyase, 1 hit |
PROSITEi | View protein in PROSITE PS00161, ISOCITRATE_LYASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6Z6M4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSPFSVPSL IMEEEGRFEA EVAEVEAWWG TDRFRLTKRP YTARDVALLR
60 70 80 90 100
GTLRQSYASG DMAKKLWRTL RAHQANGTAS RTFGALDPVQ VAMMAKHLDT
110 120 130 140 150
VYVSGWQCSS THTSTNEPGP DLADYPYDTV PNKVEHLFFA QLYHDRKQRE
160 170 180 190 200
ARMSMSRAER AHEPYVDYLK PIIADGDTGF GGATATVKLC KLFVERGAAG
210 220 230 240 250
VHLEDQSSVT KKCGHMAGKV LVAVSEHVNR LVAARLQFDI MGVETVLVAR
260 270 280 290 300
TDAVAATLIQ TNVDARDHQF ILGATNPRLR NRSLAAVLSD AMSAGKNGRE
310 320 330 340 350
LQAIEDEWLA TAQLKTFSDC VRDAIASLNA TDADKQRKLQ EWSAATSHDK
360 370 380 390 400
CVPLEQARDI AAGLGVTSLF WDWDLPRTRE GFYRFRGSVA AAVVRGRAFA
410 420 430 440 450
PHADVLWMET SSPNIAECTA FAEGVRAASP GAMLAYNLSP SFNWDASGMT
460 470 480 490 500
DADMSEFIPR VARLGYVWQF ITLAGFHADA LVTDTFARDF ARRGMLAYVE
510 520 530 540 550
RIQREERSNG VETLQHQKWS GANFYDRVLK TVQGGISSTA AMGKGVTEEQ
560 570
FKGSWTGPGS ESSSHVLAKS RM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP004990 Genomic DNA Translation: BAC83656.1 AP008213 Genomic DNA Translation: BAF21753.1 AP014963 Genomic DNA Translation: BAT01864.1 CM000144 Genomic DNA Translation: EEE67304.1 AF251075 mRNA Translation: AAL65398.1 |
RefSeqi | XP_015644942.1, XM_015789456.1 |
Genome annotation databases
EnsemblPlantsi | Os07t0529000-01; Os07t0529000-01; Os07g0529000 |
GeneIDi | 4343441 |
Gramenei | Os07t0529000-01; Os07t0529000-01; Os07g0529000 |
KEGGi | osa:4343441 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP004990 Genomic DNA Translation: BAC83656.1 AP008213 Genomic DNA Translation: BAF21753.1 AP014963 Genomic DNA Translation: BAT01864.1 CM000144 Genomic DNA Translation: EEE67304.1 AF251075 mRNA Translation: AAL65398.1 |
RefSeqi | XP_015644942.1, XM_015789456.1 |
3D structure databases
SMRi | Q6Z6M4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS07T0529000-01 |
Proteomic databases
PaxDbi | Q6Z6M4 |
PRIDEi | Q6Z6M4 |
Genome annotation databases
EnsemblPlantsi | Os07t0529000-01; Os07t0529000-01; Os07g0529000 |
GeneIDi | 4343441 |
Gramenei | Os07t0529000-01; Os07t0529000-01; Os07g0529000 |
KEGGi | osa:4343441 |
Phylogenomic databases
eggNOGi | KOG1260, Eukaryota |
HOGENOMi | CLU_019214_2_2_1 |
InParanoidi | Q6Z6M4 |
OMAi | LEKDWAE |
OrthoDBi | 905115at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00703;UER00719 |
Gene expression databases
ExpressionAtlasi | Q6Z6M4, baseline and differential |
Genevisiblei | Q6Z6M4, OS |
Family and domain databases
CDDi | cd00377, ICL_PEPM, 1 hit |
Gene3Di | 3.20.20.60, 1 hit |
InterProi | View protein in InterPro IPR039556, ICL/PEPM IPR006254, Isocitrate_lyase IPR018523, Isocitrate_lyase_ph_CS IPR015813, Pyrv/PenolPyrv_Kinase-like_dom IPR040442, Pyrv_Kinase-like_dom_sf |
PANTHERi | PTHR21631, PTHR21631, 1 hit |
Pfami | View protein in Pfam PF00463, ICL, 1 hit |
PIRSFi | PIRSF001362, Isocit_lyase, 1 hit |
SUPFAMi | SSF51621, SSF51621, 1 hit |
TIGRFAMsi | TIGR01346, isocit_lyase, 1 hit |
PROSITEi | View protein in PROSITE PS00161, ISOCITRATE_LYASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACEA_ORYSJ | |
Accessioni | Q6Z6M4Primary (citable) accession number: Q6Z6M4 Secondary accession number(s): Q8W2F9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 29, 2014 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families