UniProtKB - Q6YXZ7 (ANM5_ORYSJ)
Protein
Protein arginine N-methyltransferase 5
Gene
PRMT5
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Methylates arginine residues in proteins such as histone H4.By similarity
Catalytic activityi
- L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H+ + Nω,Nω'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteineEC:2.1.1.320
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 317 | Peptide substrateBy similarity | 1 | |
Binding sitei | 337 | S-adenosyl-L-methionineBy similarity | 1 | |
Sitei | 340 | Critical for specifying symmetric addition of methyl groupsBy similarity | 1 | |
Binding sitei | 405 | S-adenosyl-L-methionineBy similarity | 1 | |
Active sitei | 449 | Proton donor/acceptorBy similarity | 1 | |
Active sitei | 458 | Proton donor/acceptorBy similarity | 1 |
GO - Molecular functioni
- histone-arginine N-methyltransferase activity Source: GO_Central
- protein-arginine omega-N symmetric methyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- histone arginine methylation Source: GO_Central
- histone H4-R3 methylation Source: EnsemblPlants
- positive regulation of vernalization response Source: EnsemblPlants
- regulation of flower development Source: EnsemblPlants
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Protein arginine N-methyltransferase 5 (EC:2.1.1.320)Alternative name(s): Shk1 kinase-binding protein 1 homolog |
Gene namesi | Name:PRMT5 Synonyms:SKB1 Ordered Locus Names:Os02g0139200, LOC_Os02g04660 ORF Names:OJ1679_B08.2, OsJ_005168, OSJNBa0026E05.36 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000293995 | 1 – 649 | Protein arginine N-methyltransferase 5Add BLAST | 649 |
Proteomic databases
PaxDbi | Q6YXZ7 |
PRIDEi | Q6YXZ7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 321 – 627 | SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST | 307 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 10 – 300 | TIM barrelBy similarityAdd BLAST | 291 | |
Regioni | 346 – 347 | S-adenosyl-L-methionine bindingBy similarity | 2 | |
Regioni | 433 – 434 | S-adenosyl-L-methionine bindingBy similarity | 2 | |
Regioni | 479 – 649 | Beta barrelBy similarityAdd BLAST | 171 | |
Regioni | 491 – 507 | DimerizationBy similarityAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0822, Eukaryota |
HOGENOMi | CLU_010247_3_0_1 |
InParanoidi | Q6YXZ7 |
OMAi | FPMFFPT |
OrthoDBi | 475852at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR025799, Arg_MeTrfase IPR007857, Arg_MeTrfase_PRMT5 IPR035075, PRMT5 IPR035248, PRMT5_C IPR035247, PRMT5_TIM IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR10738, PTHR10738, 1 hit |
Pfami | View protein in Pfam PF05185, PRMT5, 1 hit PF17286, PRMT5_C, 1 hit PF17285, PRMT5_TIM, 1 hit |
PIRSFi | PIRSF015894, Skb1_MeTrfase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51678, SAM_MT_PRMT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6YXZ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLGQRAGDK SESRYCGVEV LDFPAGEELP AVLSHSLSSS FDFLLAPLVD
60 70 80 90 100
PDYRPTPGSV LPVAASDLVL GPAQWSSHIV GKISEWIDLD AEDEQLRLDS
110 120 130 140 150
EITLKQEIAW ASHLSLQACV LPPPKRSSCA NYARVVNHIL QGLTNLQLWL
160 170 180 190 200
RIPLEKSEPM DEDHDGAKDN SDMSDTVDSW EWWNSFRLLC EHSSQLCVAL
210 220 230 240 250
DVLSTLPSMN SLGRWFGEPV RAAILQTNAF LTNARGYPCL SKRHQKLLTG
260 270 280 290 300
FFNHSVQVII SGRSNHNVSQ GGVLSGDENH TEDTAVRHAL SPYLDYIAYI
310 320 330 340 350
YQRMDPLPEQ ERFEINYRDF LQSPLQPLMD NLEAQTYETF EKDTVKYTQY
360 370 380 390 400
QRAIAKALVD RVSDDDVSTT KTVLMVVGAG RGPLVRASLQ AAEETGRKLK
410 420 430 440 450
VYAVEKNPNA VITLHSLIKL EGWESLVTII SSDMRCWEAP EKADILVSEL
460 470 480 490 500
LGSFGDNELS PECLDGAQRF LKPDGISIPS SYTSFIEPIT ASKLHNDIKA
510 520 530 540 550
HKDIAHFETA YVVKLHRIAR LAPTQSVFTF DHPNPSPNAS NQRYTKLKFE
560 570 580 590 600
IPQETGSCLV HGFAGYFDAV LYKDVHLGIE PNTATPNMFS WFPIFFPLRK
610 620 630 640
PIYVPSKTPI EVHFWRCCGA TKVWYEWAVT APSPSPIHNS NGRSYWVGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP005294 Genomic DNA Translation: BAD10250.1 AP005647 Genomic DNA Translation: BAD10543.1 AP008208 Genomic DNA Translation: BAF07757.1 AP014958 Genomic DNA Translation: BAS76901.1 CM000139 Genomic DNA No translation available. AK073412 mRNA Translation: BAG93445.1 AK103804 mRNA Translation: BAG96268.1 |
RefSeqi | XP_015627032.1, XM_015771546.1 |
Genome annotation databases
EnsemblPlantsi | Os02t0139200-01; Os02t0139200-01; Os02g0139200 |
GeneIDi | 4328251 |
Gramenei | Os02t0139200-01; Os02t0139200-01; Os02g0139200 |
KEGGi | osa:4328251 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP005294 Genomic DNA Translation: BAD10250.1 AP005647 Genomic DNA Translation: BAD10543.1 AP008208 Genomic DNA Translation: BAF07757.1 AP014958 Genomic DNA Translation: BAS76901.1 CM000139 Genomic DNA No translation available. AK073412 mRNA Translation: BAG93445.1 AK103804 mRNA Translation: BAG96268.1 |
RefSeqi | XP_015627032.1, XM_015771546.1 |
3D structure databases
SMRi | Q6YXZ7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS02T0139200-01 |
Proteomic databases
PaxDbi | Q6YXZ7 |
PRIDEi | Q6YXZ7 |
Genome annotation databases
EnsemblPlantsi | Os02t0139200-01; Os02t0139200-01; Os02g0139200 |
GeneIDi | 4328251 |
Gramenei | Os02t0139200-01; Os02t0139200-01; Os02g0139200 |
KEGGi | osa:4328251 |
Phylogenomic databases
eggNOGi | KOG0822, Eukaryota |
HOGENOMi | CLU_010247_3_0_1 |
InParanoidi | Q6YXZ7 |
OMAi | FPMFFPT |
OrthoDBi | 475852at2759 |
Gene expression databases
Genevisiblei | Q6YXZ7, OS |
Family and domain databases
InterProi | View protein in InterPro IPR025799, Arg_MeTrfase IPR007857, Arg_MeTrfase_PRMT5 IPR035075, PRMT5 IPR035248, PRMT5_C IPR035247, PRMT5_TIM IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR10738, PTHR10738, 1 hit |
Pfami | View protein in Pfam PF05185, PRMT5, 1 hit PF17286, PRMT5_C, 1 hit PF17285, PRMT5_TIM, 1 hit |
PIRSFi | PIRSF015894, Skb1_MeTrfase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51678, SAM_MT_PRMT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANM5_ORYSJ | |
Accessioni | Q6YXZ7Primary (citable) accession number: Q6YXZ7 Secondary accession number(s): A3A2Z6, B7EM48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families