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UniProtKB - Q6YWS8 (ASCL2_ORYSJ)
Protein
ASC1-like protein 2
Gene
Os02g0728300
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Mediates resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis. Could salvage the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in ceramides-depleted cells after SAM exposure (By similarity).
By similarityGO - Molecular functioni
- N-acyltransferase activity Source: GO_Central
- sphingosine N-acyltransferase activity Source: GO_Central
GO - Biological processi
- ceramide biosynthetic process Source: GO_Central
Keywordsi
Biological process | Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
PlantReactomei | R-OSA-1119325, Sphingolipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: ASC1-like protein 2Alternative name(s): Alternaria stem canker resistance-like protein 2 |
Gene namesi | Ordered Locus Names:Os02g0728300, LOC_Os02g49590 ORF Names:B1121A12.39, OSJNBa0072H09.2 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 124 – 144 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 253 – 273 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185524 | 1 – 303 | ASC1-like protein 2Add BLAST | 303 |
Proteomic databases
PaxDbi | Q6YWS8 |
PTM databases
iPTMneti | Q6YWS8 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 282 | TLCPROSITE-ProRule annotationAdd BLAST | 215 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1607, Eukaryota |
HOGENOMi | CLU_028277_5_0_1 |
InParanoidi | Q6YWS8 |
Family and domain databases
InterProi | View protein in InterPro IPR016439, Lag1/Lac1-like IPR006634, TLC-dom |
PANTHERi | PTHR12560, PTHR12560, 1 hit |
Pfami | View protein in Pfam PF03798, TRAM_LAG1_CLN8, 1 hit |
SMARTi | View protein in SMART SM00724, TLC, 1 hit |
PROSITEi | View protein in PROSITE PS50922, TLC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6YWS8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVPPVDWEA ESYPAYSDFA AIPLFAVFLF AVRYLLDRFV FEWLARRLIF
60 70 80 90 100
EKDEKLDLAT HAGRIKIRKF KESAWKCIYF LSAELLALSV TYKESWFTST
110 120 130 140 150
KNFWVGPGDQ VWPDQRIKFK LKLVYMYAAG FYTYSIFALQ FWEIKRSDFG
160 170 180 190 200
ISMVHHVVSV ILIALSYIFR FARVGSIVLA IHDASDVFLE LGKISKYSGY
210 220 230 240 250
QLLADVSFLI FVCSWAVLRL IYYPFWILWS TSYEVVPMLD KKKHKFDGPL
260 270 280 290 300
HYYVFNCLLF SLLVLNIYWW VLMYRMLVEQ ILSKGHVGDD VRSGRFSPPF
IPP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0P0VP27 | A0A0P0VP27_ORYSJ | Os02g0728300 protein | Os02g0728300, OSNPB_020728300 | 378 | Annotation score: |
Sequence cautioni
The sequence BAD16097 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD16340 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP005284 Genomic DNA Translation: BAD16097.1 Sequence problems. AP005751 Genomic DNA Translation: BAD16340.1 Sequence problems. AP014958 Genomic DNA No translation available. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP005284 Genomic DNA Translation: BAD16097.1 Sequence problems. AP005751 Genomic DNA Translation: BAD16340.1 Sequence problems. AP014958 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 4530.OS02T0728300-00 |
PTM databases
iPTMneti | Q6YWS8 |
Proteomic databases
PaxDbi | Q6YWS8 |
Phylogenomic databases
eggNOGi | KOG1607, Eukaryota |
HOGENOMi | CLU_028277_5_0_1 |
InParanoidi | Q6YWS8 |
Enzyme and pathway databases
PlantReactomei | R-OSA-1119325, Sphingolipid metabolism |
Gene expression databases
Genevisiblei | Q6YWS8, OS |
Family and domain databases
InterProi | View protein in InterPro IPR016439, Lag1/Lac1-like IPR006634, TLC-dom |
PANTHERi | PTHR12560, PTHR12560, 1 hit |
Pfami | View protein in Pfam PF03798, TRAM_LAG1_CLN8, 1 hit |
SMARTi | View protein in SMART SM00724, TLC, 1 hit |
PROSITEi | View protein in PROSITE PS50922, TLC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ASCL2_ORYSJ | |
Accessioni | Q6YWS8Primary (citable) accession number: Q6YWS8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | February 23, 2022 | |
This is version 84 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations