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Entry version 123 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Oryzalexin D synthase

Gene

CYP76M8

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme of the diterpenoid metabolism involved in the biosynthesis of both phytocassane and the oryzalexin class of phytoalexins. Can hydroxylate syn-pimaradiene, ent-pimaradiene, ent-sandaracopimaradiene, ent-isokaurene, ent-kaurene, and ent-cassadiene, but no activity with syn-stemodene, syn-stemarene, syn-labdatriene, C11-alpha-hydroxy-ent-cassadiene or syn-pimadien-19-oic acid as substrates. Hydroxylates 3-alpha-hydroxy-ent-sandaracopimaradiene at C-7-beta, resulting in a 3-alpha,7-beta-diol corresponding to oryzalexins D.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.011 sec(-1) with ent-sandaracopimaradien as substrate. kcat is 0.009 sec(-1) with ent-pimaradiene as substrate. kcat is 0.015 sec(-1) with ent-isokaurene as substrate. kcat is 0.006 sec(-1) with ent-cassadiene as substrate. kcat is 0.009 sec(-1) with ent-kaurene as substrate. kcat is 0.006 sec(-1) with syn-pimaradiene as substrate.1 Publication
  1. KM=4 µM for ent-cassadiene2 Publications
  2. KM=4 µM for ent-pimaradiene1 Publication
  3. KM=15 µM for ent-isokaurene1 Publication
  4. KM=7 µM for ent-sandaracopimaradiene1 Publication
  5. KM=5 µM for ent-kaurene1 Publication
  6. KM=2 µM for syn-pimaradiene1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi442Iron (heme axial ligand)By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMonooxygenase, Oxidoreductase
    Biological processPlant defense
    LigandHeme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER-18617

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Oryzalexin D synthase (EC:1.14.14.1122 Publications, EC:1.14.14.1231 Publication)
    Alternative name(s):
    Cytochrome P450 76M81 Publication
    Ent-cassadiene C11-alpha-hydroxylase 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CYP76M81 Publication
    Ordered Locus Names:Os02g0569400Imported, LOC_Os02g36070Curated
    ORF Names:OsJ_07203Imported, OSJNBa0008E01.2Imported, P0025F02.31Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000007752 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2
    • UP000059680 Componenti: Chromosome 2
    • UP000000763 Componenti: Chromosome 2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004188671 – 500Oryzalexin D synthaseAdd BLAST500

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6YTF1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6YTF1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by methyl jasmonate.1 Publication

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6YTF1, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6YTF1, OS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    4530.OS02T0569400-01

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6YTF1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0156, Eukaryota

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6YTF1

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DLWKWRT

    Database of Orthologous Groups

    More...
    OrthoDBi
    702827at2759

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.630.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001128, Cyt_P450
    IPR017972, Cyt_P450_CS
    IPR002401, Cyt_P450_E_grp-I
    IPR036396, Cyt_P450_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00067, p450, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00463, EP450I
    PR00385, P450

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48264, SSF48264, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00086, CYTOCHROME_P450, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q6YTF1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MENSQMWLLW GALSVALFFY FSTLRRRYAG GKPLPPGPTP LPLIGNLHLV
    60 70 80 90 100
    GGGTFHHKLR DLARVHGPVM TLKLGLATNV VISSREAAIE AYTKYDRHLA
    110 120 130 140 150
    ARATPDTFRA CGFADRSMVF IPSSDPQWKA LRGIHASHVF TPRVLAAVRP
    160 170 180 190 200
    IRERKVGDLI AYLRAHAGEE VLVGHAMYTG ILNMVSFSYF SVDIVDMGSQ
    210 220 230 240 250
    MARELREVVD DIILVVGKPN VSDFYPFLRP LDLQGLRRWT TKRFNRVFSI
    260 270 280 290 300
    MGDIIDRRLA HIRDNKPRHD DFLDSILELM AAGKIDRVNV LNMLFEAFVA
    310 320 330 340 350
    GADTMALTLE WVMAELLKNP SVMAKARAEL RDVLGDKEIV EEADAARLPY
    360 370 380 390 400
    LQAVLKEAMR LHPVGALLLP HFAMEDGVEV GGYAVPKGST VLFNAWAIMR
    410 420 430 440 450
    DAAAWERPDE FVPERFVERT PQLDFRGKDV EFMPFGSGRR LCPGLPLAER
    460 470 480 490 500
    VVPFILASML HTFEWELPGG MTAEELDVSE KFKTANVLAV PLKAVPVLIK
    Length:500
    Mass (Da):55,933
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB8D1A60BC66BD58
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0P0VKN4A0A0P0VKN4_ORYSJ
    Os02g0569400 protein
    Os02g0569400, OSNPB_020569400
    392Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AP005835 Genomic DNA Translation: BAD17658.1
    AP006069 Genomic DNA Translation: BAD17786.1
    AP008208 Genomic DNA Translation: BAF09098.1
    AP014958 Genomic DNA Translation: BAS79332.1
    CM000139 Genomic DNA Translation: EAZ23507.1
    AK069701 mRNA Translation: BAG91560.1

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_015623630.1, XM_015768144.1

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    Os02t0569400-01; Os02t0569400-01; Os02g0569400

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    4329722

    Gramene; a comparative resource for plants

    More...
    Gramenei
    Os02t0569400-01; Os02t0569400-01; Os02g0569400

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    osa:4329722

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Cytochrome P450 Homepage

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AP005835 Genomic DNA Translation: BAD17658.1
    AP006069 Genomic DNA Translation: BAD17786.1
    AP008208 Genomic DNA Translation: BAF09098.1
    AP014958 Genomic DNA Translation: BAS79332.1
    CM000139 Genomic DNA Translation: EAZ23507.1
    AK069701 mRNA Translation: BAG91560.1
    RefSeqiXP_015623630.1, XM_015768144.1

    3D structure databases

    SMRiQ6YTF1
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi4530.OS02T0569400-01

    Proteomic databases

    PaxDbiQ6YTF1
    PRIDEiQ6YTF1

    Genome annotation databases

    EnsemblPlantsiOs02t0569400-01; Os02t0569400-01; Os02g0569400
    GeneIDi4329722
    GrameneiOs02t0569400-01; Os02t0569400-01; Os02g0569400
    KEGGiosa:4329722

    Phylogenomic databases

    eggNOGiKOG0156, Eukaryota
    InParanoidiQ6YTF1
    OMAiDLWKWRT
    OrthoDBi702827at2759

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-18617

    Gene expression databases

    ExpressionAtlasiQ6YTF1, baseline and differential
    GenevisibleiQ6YTF1, OS

    Family and domain databases

    Gene3Di1.10.630.10, 1 hit
    InterProiView protein in InterPro
    IPR001128, Cyt_P450
    IPR017972, Cyt_P450_CS
    IPR002401, Cyt_P450_E_grp-I
    IPR036396, Cyt_P450_sf
    PfamiView protein in Pfam
    PF00067, p450, 1 hit
    PRINTSiPR00463, EP450I
    PR00385, P450
    SUPFAMiSSF48264, SSF48264, 1 hit
    PROSITEiView protein in PROSITE
    PS00086, CYTOCHROME_P450, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC76M8_ORYSJ
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6YTF1
    Secondary accession number(s): A0A0P0VKN5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
    Last sequence update: July 5, 2004
    Last modified: April 7, 2021
    This is version 123 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families
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