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Protein

Peroxisomal (S)-2-hydroxy-acid oxidase GLO5

Gene

GLO5

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Photorespiratory enzyme that can exert a strong regulation over photosynthesis, possibly through a feed-back inhibition on Rubisco activase. Not required for oxalate accumulation (By similarity).By similarity

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMNPROSITE-ProRule annotation

Pathwayi: photorespiration

This protein is involved in step 2 of the subpathway that synthesizes glycine from 2-phosphoglycolate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Peroxisomal (S)-2-hydroxy-acid oxidase GLO4 (GLO4), Peroxisomal (S)-2-hydroxy-acid oxidase GLO1 (GLO1), Peroxisomal (S)-2-hydroxy-acid oxidase GLO5 (GLO5), Peroxisomal (S)-2-hydroxy-acid oxidase GLO2 (GLO2), Peroxisomal (S)-2-hydroxy-acid oxidase GLO3 (GLO3)
  3. no protein annotated in this organism
This subpathway is part of the pathway photorespiration, which is itself part of Photosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycine from 2-phosphoglycolate, the pathway photorespiration and in Photosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25SubstratePROSITE-ProRule annotation1
Binding sitei107FMNPROSITE-ProRule annotation1
Binding sitei128FMNPROSITE-ProRule annotation1
Binding sitei130SubstratePROSITE-ProRule annotation1
Binding sitei156FMNPROSITE-ProRule annotation1
Binding sitei165SubstratePROSITE-ProRule annotation1
Binding sitei231FMNPROSITE-ProRule annotation1
Active sitei255Proton acceptorPROSITE-ProRule annotation1
Binding sitei258SubstratePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi286 – 310FMNPROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolate pathway, Host-virus interaction, Photorespiration
LigandFlavoprotein, FMN

Enzyme and pathway databases

ReactomeiR-OSA-389661 Glyoxylate metabolism and glycine degradation
R-OSA-390918 Peroxisomal lipid metabolism
UniPathwayiUPA00951; UER00912

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal (S)-2-hydroxy-acid oxidase GLO5 (EC:1.1.3.15)
Alternative name(s):
Glycolate oxidase 5
Short name:
GOX 5
Short name:
OsGLO5
Short chain alpha-hydroxy acid oxidase GLO5
Gene namesi
Name:GLO5
Ordered Locus Names:Os07g0152900, LOC_Os07g05820
ORF Names:B1364A02.33-1, OsJ_23125, OSJNBb0050B07.1-1
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004034171 – 369Peroxisomal (S)-2-hydroxy-acid oxidase GLO5Add BLAST369

Proteomic databases

PaxDbiQ6YT73
PRIDEiQ6YT73

Expressioni

Gene expression databases

ExpressionAtlasiQ6YT73 differential
GenevisibleiQ6YT73 OS

Interactioni

Subunit structurei

Homotetramer or homooctamer. Interacts with rice dwarf virus (RDV) P8. This interaction promotes viral P8 relocation to virus factories peripheral to peroxisomes (By similarity).By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os07g05820.1

Structurei

3D structure databases

ProteinModelPortaliQ6YT73
SMRiQ6YT73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 360FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST360

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi367 – 369Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0538 Eukaryota
COG1304 LUCA
InParanoidiQ6YT73
KOiK11517
OMAiMQLYIYK
OrthoDBiEOG09360EDE

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6YT73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEITNVTEY QAIAKQKLPK MIYDYYASGA EDEWTLQENR EAFARILFRP
60 70 80 90 100
RILIDVSKID MATTVLGFKI SMPIMIAPSA MQKMAHPDGE YATARAASAA
110 120 130 140 150
GTIMTLSSWA TSSVEEVAST GPGIRFFQLY VYKDRRVVEQ LVRRAERAGF
160 170 180 190 200
KAIALTVDTP RLGRREADIK NRFVLPPFLT LKNFEGLELG KMDQASDSGL
210 220 230 240 250
ASYVAGQIDR TLSWKDVKWL QTITTLPILV KGVITAEDTR LAVENGAAGI
260 270 280 290 300
IVSNHGARQL DYVPATISAL EEVVKAARGQ LPVFLDGGVR RGTDVFKALA
310 320 330 340 350
LGAAGVFIGR PVVFSLAAAG EAGVRNVLQM LRDEFELTMA LSGCTSLADI
360
TRNHVITEAD KLGVMPSRL
Length:369
Mass (Da):40,245
Last modified:July 5, 2004 - v1
Checksum:iFE652FD1115F2681
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265A → S in EEE66581 (PubMed:15685292).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005632 Genomic DNA Translation: BAD31578.1
AP006163 Genomic DNA Translation: BAC84719.1
AP008213 Genomic DNA Translation: BAF20823.1
AP014963 Genomic DNA Translation: BAT00100.1
CM000144 Genomic DNA Translation: EEE66581.1
AK062189 mRNA Translation: BAG88242.1
AK103933 mRNA Translation: BAG96328.1
RefSeqiXP_015646859.1, XM_015791373.1
UniGeneiOs.51287

Genome annotation databases

EnsemblPlantsiOs07t0152900-01; Os07t0152900-01; Os07g0152900
Os07t0152900-03; Os07t0152900-03; Os07g0152900
Os07t0152900-04; Os07t0152900-04; Os07g0152900
GeneIDi4342420
GrameneiOs07t0152900-01; Os07t0152900-01; Os07g0152900
Os07t0152900-03; Os07t0152900-03; Os07g0152900
Os07t0152900-04; Os07t0152900-04; Os07g0152900
KEGGiosa:4342420

Similar proteinsi

Entry informationi

Entry nameiGLO5_ORYSJ
AccessioniPrimary (citable) accession number: Q6YT73
Secondary accession number(s): A0A0P0X2P6, B9FVJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

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