UniProtKB - Q6YP21 (KAT3_HUMAN)

BLAST

>sp|Q6YP21|KAT3_HUMAN Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1
MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLA
ADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQK
QIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRS
KPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYD
TLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIK
HLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESV
GLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSET
KSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS

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History
Entry version 128 (07 Nov 2018)
Sequence version 1 (05 Jul 2004)
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Protein

Kynurenine--oxoglutarate transaminase 3

Gene

KYAT3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).By similarity

Caution

The first non-coding exon of CCBL2 is in common with that of RBMXL1.Curated

Catalytic activityⁱ

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.

An L-cysteine-S-conjugate + H₂O = RSH + NH₃ + pyruvate.

L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.

Cofactorⁱ

pyridoxal 5'-phosphateBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	53	SubstrateBy similarity	1
Binding siteⁱ	71	Substrate; via amide nitrogenBy similarity	1
Binding siteⁱ	218	SubstrateBy similarity	1
Binding siteⁱ	429	SubstrateBy similarity	1

GO - Molecular functionⁱ

cysteine-S-conjugate beta-lyase activity Source: UniProtKB-EC
kynurenine-glyoxylate transaminase activity Source: UniProtKB
kynurenine-oxoglutarate transaminase activity Source: UniProtKB
protein homodimerization activity Source: Ensembl
pyridoxal phosphate binding Source: InterPro
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

2-oxoglutarate metabolic process Source: Ensembl
biosynthetic process Source: InterPro
cellular amino acid metabolic process Source: UniProtKB
kynurenine metabolic process Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminotransferase, Lyase, Transferase
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06422-MONOMER
BRENDAⁱ	2.6.1.7 2681
Reactomeⁱ	R-HSA-71240 Tryptophan catabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kynurenine--oxoglutarate transaminase 3 (EC:2.6.1.7) Alternative name(s): Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13) Kynurenine aminotransferase 3Imported Kynurenine aminotransferase III Short name: KATIII Kynurenine--glyoxylate transaminase (EC:2.6.1.63) Kynurenine--oxoglutarate transaminase III
Gene namesⁱ	Name:KYAT3Imported Synonyms:CCBL2, KAT3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137944.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33238 KYAT3
MIMⁱ	610656 gene
neXtProtⁱ	NX_Q6YP21

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56267
Open Targets More...OpenTargetsⁱ	ENSG00000137944
PharmGKBⁱ	PA162381274

Chemistry databases

ChEMBLⁱ	CHEMBL2046260
Drug and drug target database More...DrugBankⁱ	DB00142 L-Glutamic Acid DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMutaⁱ	CCBL2
DMDMⁱ	74710502

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000287704	1 – 454	Kynurenine--oxoglutarate transaminase 3Add BLAST	454
Isoform 3 (identifier: Q6YP21-3)
Initiator methionineⁱ		RemovedCombined sources

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	116	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	116	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	280	N6-(pyridoxal phosphate)lysineBy similarity	1
Isoform 3 (identifier: Q6YP21-3)
Modified residueⁱ	2	N-acetylserineCombined sources	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q6YP21
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6YP21
PaxDbⁱ	Q6YP21
PeptideAtlas More...PeptideAtlasⁱ	Q6YP21
PRIDEⁱ	Q6YP21
ProteomicsDBⁱ	67858 67859 [Q6YP21-2] 67860 [Q6YP21-3]

PTM databases

iPTMnetⁱ	Q6YP21
PhosphoSitePlusⁱ	Q6YP21

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000137944 Expressed in 230 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_CCBL2
ExpressionAtlasⁱ	Q6YP21 baseline and differential
Genevisibleⁱ	Q6YP21 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026538 HPA027168

HPAⁱ

HPA026538
HPA027168

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121128, 15 interactors
IntActⁱ	Q6YP21, 6 interactors
STRINGⁱ	9606.ENSP00000260508

Chemistry databases

BindingDBⁱ

Q6YP21

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6YP21
SMRⁱ	Q6YP21
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0257 Eukaryota COG0436 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00650000093238
HOGENOMⁱ	HOG000223045
HOVERGENⁱ	HBG008391
InParanoidⁱ	Q6YP21
KEGG Orthology (KO) More...KOⁱ	K00816
OMAⁱ	VAMTGWR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06LU
PhylomeDBⁱ	Q6YP21
TreeFamⁱ	TF352342

Family and domain databases

Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR004839 Aminotransferase_I/II IPR034612 KAT_III IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
PANTHERⁱ	PTHR43807:SF6 PTHR43807:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00155 Aminotran_1_2, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q6YP21-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLAQRSLCS LSGRAKFLKT ISSSKILGFS TSAKMSLKFT NAKRIEGLDS 
        60         70         80         90        100
NVWIEFTKLA ADPSVVNLGQ GFPDISPPTY VKEELSKIAA IDSLNQYTRG 
       110        120        130        140        150
FGHPSLVKAL SYLYEKLYQK QIDSNKEILV TVGAYGSLFN TIQALIDEGD 
       160        170        180        190        200
EVILIVPFYD CYEPMVRMAG ATPVFIPLRS KPVYGKRWSS SDWTLDPQEL 
       210        220        230        240        250
ESKFNSKTKA IILNTPHNPL GKVYNREELQ VIADLCIKYD TLCISDEVYE 
       260        270        280        290        300
WLVYSGNKHL KIATFPGMWE RTITIGSAGK TFSVTGWKLG WSIGPNHLIK 
       310        320        330        340        350
HLQTVQQNTI YTCATPLQEA LAQAFWIDIK RMDDPECYFN SLPKELEVKR 
       360        370        380        390        400
DRMVRLLESV GLKPIVPDGG YFIIADVSLL DPDLSDMKNN EPYDYKFVKW 
       410        420        430        440        450
MTKHKKLSAI PVSAFCNSET KSQFEKFVRF CFIKKDSTLD AAEEIIKAWS 

VQKS

Length:454

Mass (Da):51,400

Last modified:July 5, 2004 - v1

Checksum:ⁱ2059D4646058BBB3

Isoform 2 (identifier: Q6YP21-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
152-167: VILIVPFYDCYEPMVR → YNACTVKFTNLKCTAG
168-454: Missing.

« Hide

        10         20         30         40         50
MFLAQRSLCS LSGRAKFLKT ISSSKILGFS TSAKMSLKFT NAKRIEGLDS 
        60         70         80         90        100
NVWIEFTKLA ADPSVVNLGQ GFPDISPPTY VKEELSKIAA IDSLNQYTRG 
       110        120        130        140        150
FGHPSLVKAL SYLYEKLYQK QIDSNKEILV TVGAYGSLFN TIQALIDEGD 
       160 
EYNACTVKFT NLKCTAG

Note: No experimental confirmation available.

Show »

Length:167

Mass (Da):18,352

Checksum:ⁱ6CA0C2A9BC6BA211

Isoform 3 (identifier: Q6YP21-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-34: Missing.

« Hide

        10         20         30         40         50
MSLKFTNAKR IEGLDSNVWI EFTKLAADPS VVNLGQGFPD ISPPTYVKEE 
        60         70         80         90        100
LSKIAAIDSL NQYTRGFGHP SLVKALSYLY EKLYQKQIDS NKEILVTVGA 
       110        120        130        140        150
YGSLFNTIQA LIDEGDEVIL IVPFYDCYEP MVRMAGATPV FIPLRSKPVY 
       160        170        180        190        200
GKRWSSSDWT LDPQELESKF NSKTKAIILN TPHNPLGKVY NREELQVIAD 
       210        220        230        240        250
LCIKYDTLCI SDEVYEWLVY SGNKHLKIAT FPGMWERTIT IGSAGKTFSV 
       260        270        280        290        300
TGWKLGWSIG PNHLIKHLQT VQQNTIYTCA TPLQEALAQA FWIDIKRMDD 
       310        320        330        340        350
PECYFNSLPK ELEVKRDRMV RLLESVGLKP IVPDGGYFII ADVSLLDPDL 
       360        370        380        390        400
SDMKNNEPYD YKFVKWMTKH KKLSAIPVSA FCNSETKSQF EKFVRFCFIK 
       410        420
KDSTLDAAEE IIKAWSVQKS

Show »

Length:420

Mass (Da):47,753

Checksum:ⁱ1BB37BC0D96DB2EE

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0A0MRN7	A0A0A0MRN7_HUMAN		Kynurenine--oxoglutarate transamina... Kynurenine--oxoglutarate transaminase 3	KYAT3	262	Annotation score:

Sequence cautionⁱ

The sequence AAC72959 differs from that shown. Reason: Frameshift at position 336.Curated

The sequence AAH00819 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAG29278 differs from that shown. Reason: Frameshift at position 336.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	251	W → R in CAG29278 (Ref. 7) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032352	206	S → P2 PublicationsCorresponds to variant dbSNP:rs1059370Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_042841	1 – 34	Missing in isoform 3. 1 PublicationAdd BLAST	34
Alternative sequenceⁱVSP_025603	152 – 167	VILIV…EPMVR → YNACTVKFTNLKCTAG in isoform 2. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_025604	168 – 454	Missing in isoform 2. 1 PublicationAdd BLAST	287

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY028624 mRNA Translation: AAK26163.1 CR627392 mRNA Translation: CAH10487.1 AK057176 mRNA Translation: BAG51875.1 AL139416 Genomic DNA No translation available. AL445991 Genomic DNA No translation available. BC000819 mRNA Translation: AAH00819.1 Different initiation. AF091090 mRNA Translation: AAC72959.1 Frameshift. CR450282 mRNA Translation: CAG29278.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30766.1 [Q6YP21-1] CCDS30767.1 [Q6YP21-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001008661.1, NM_001008661.2 [Q6YP21-1] NP_001008662.1, NM_001008662.2 [Q6YP21-3]
UniGeneⁱ	Hs.481898

Genome annotation databases

Ensemblⁱ	ENST00000260508; ENSP00000260508; ENSG00000137944 [Q6YP21-1] ENST00000370491; ENSP00000359522; ENSG00000137944 [Q6YP21-3]
GeneIDⁱ	56267
KEGGⁱ	hsa:56267
UCSC genome browser More...UCSCⁱ	uc001dmp.3 human [Q6YP21-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q6YP21	HCG23341, isoform CRA_d		HUMAN		454	UniRef100_Q6YP21
Isoform 3 of Kynurenine--oxoglutarate transaminase 3		HUMAN		420
Kynurenine--oxoglutarate transaminase 3 (Fragment)		HUMAN		262
UPI000006D608		HUMAN		290

Protein	Similar proteins		Species	Score	Length	Source
Q6YP21	HCG23341, isoform CRA_d		HUMAN		454	UniRef90_Q6YP21
Uncharacterized protein		Cebus capucinus imitator		481
Uncharacterized protein		AOTNA		473
kynurenine--oxoglutarate transaminase 3 isoform X4		NEOSC		455
Kynurenine aminotransferase 3		SAIBB		454
+67

Protein	Similar proteins		Species	Score	Length	Source
Q6YP21	HCG23341, isoform CRA_d		HUMAN		454	UniRef50_Q6YP21
Uncharacterized protein		Cebus capucinus imitator		481
Uncharacterized protein		AOTNA		473
kynurenine--oxoglutarate transaminase 3 isoform X4		NEOSC		455
Uncharacterized protein		RHIRO		454
+81
Q6YP21-2	Uncharacterized protein		MELGA		160	UniRef50_Q6YP21-2
Cysteine conjugate-beta lyase 2		COLLI		200
LOC100124821 protein		XENTR		160

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY028624 mRNA Translation: AAK26163.1 CR627392 mRNA Translation: CAH10487.1 AK057176 mRNA Translation: BAG51875.1 AL139416 Genomic DNA No translation available. AL445991 Genomic DNA No translation available. BC000819 mRNA Translation: AAH00819.1 Different initiation. AF091090 mRNA Translation: AAC72959.1 Frameshift. CR450282 mRNA Translation: CAG29278.1 Frameshift.
CCDSⁱ	CCDS30766.1 [Q6YP21-1] CCDS30767.1 [Q6YP21-3]
RefSeqⁱ	NP_001008661.1, NM_001008661.2 [Q6YP21-1] NP_001008662.1, NM_001008662.2 [Q6YP21-3]
UniGeneⁱ	Hs.481898

3D structure databases

ProteinModelPortalⁱ	Q6YP21
SMRⁱ	Q6YP21
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121128, 15 interactors
IntActⁱ	Q6YP21, 6 interactors
STRINGⁱ	9606.ENSP00000260508

Chemistry databases

BindingDBⁱ	Q6YP21
ChEMBLⁱ	CHEMBL2046260
DrugBankⁱ	DB00142 L-Glutamic Acid DB00114 Pyridoxal Phosphate

PTM databases

iPTMnetⁱ	Q6YP21
PhosphoSitePlusⁱ	Q6YP21

Polymorphism and mutation databases

BioMutaⁱ	CCBL2
DMDMⁱ	74710502

Proteomic databases

EPDⁱ	Q6YP21
MaxQBⁱ	Q6YP21
PaxDbⁱ	Q6YP21
PeptideAtlasⁱ	Q6YP21
PRIDEⁱ	Q6YP21
ProteomicsDBⁱ	67858 67859 [Q6YP21-2] 67860 [Q6YP21-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000260508; ENSP00000260508; ENSG00000137944 [Q6YP21-1] ENST00000370491; ENSP00000359522; ENSG00000137944 [Q6YP21-3]
GeneIDⁱ	56267
KEGGⁱ	hsa:56267
UCSCⁱ	uc001dmp.3 human [Q6YP21-1]

Organism-specific databases

CTDⁱ	56267
DisGeNETⁱ	56267
EuPathDBⁱ	HostDB:ENSG00000137944.16
GeneCardsⁱ	KYAT3
HGNCⁱ	HGNC:33238 KYAT3
HPAⁱ	HPA026538 HPA027168
MIMⁱ	610656 gene
neXtProtⁱ	NX_Q6YP21
OpenTargetsⁱ	ENSG00000137944
PharmGKBⁱ	PA162381274
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0257 Eukaryota COG0436 LUCA
GeneTreeⁱ	ENSGT00650000093238
HOGENOMⁱ	HOG000223045
HOVERGENⁱ	HBG008391
InParanoidⁱ	Q6YP21
KOⁱ	K00816
OMAⁱ	VAMTGWR
OrthoDBⁱ	EOG091G06LU
PhylomeDBⁱ	Q6YP21
TreeFamⁱ	TF352342

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06422-MONOMER
BRENDAⁱ	2.6.1.7 2681
Reactomeⁱ	R-HSA-71240 Tryptophan catabolism

Miscellaneous databases

ChiTaRSⁱ	KYAT3 human
GenomeRNAiⁱ	56267
Protein Ontology More...PROⁱ	PR:Q6YP21
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137944 Expressed in 230 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_CCBL2
ExpressionAtlasⁱ	Q6YP21 baseline and differential
Genevisibleⁱ	Q6YP21 HS

Family and domain databases

Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR004839 Aminotransferase_I/II IPR034612 KAT_III IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
PANTHERⁱ	PTHR43807:SF6 PTHR43807:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF00155 Aminotran_1_2, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KAT3_HUMAN
Accessionⁱ	Q6YP21Primary (citable) accession number: Q6YP21 Secondary accession number(s): B3KQ13 Q9BVY5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6YP21 (KAT3_HUMAN)

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Kynurenine--oxoglutarate transaminase 3

KYAT3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ