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Protein

Zinc finger protein 653

Gene

Znf653

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri467 – 492C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri498 – 522C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri528 – 550C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 609C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 653
Alternative name(s):
67 kDa zinc finger protein
Zinc finger protein Zip67
Gene namesi
Name:Znf653
Synonyms:Zfp653, Zip67
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2442362 Zfp653

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002533451 – 615Zinc finger protein 653Add BLAST615

Proteomic databases

PaxDbiQ6YND2
PRIDEiQ6YND2

PTM databases

iPTMnetiQ6YND2
PhosphoSitePlusiQ6YND2

Expressioni

Tissue specificityi

Highly expressed in testis and spleen. Moderately expressed in lung, adrenal gland, uterus, and ovary. Very low expression in pancreas, heart, skeletal muscle, adipose tissue, kidney, and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000038895 Expressed in 181 organ(s), highest expression level in primary oocyte
CleanExiMM_ZFP653
GenevisibleiQ6YND2 MM

Interactioni

Subunit structurei

Interacts with NR5A1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045895

Structurei

3D structure databases

ProteinModelPortaliQ6YND2
SMRiQ6YND2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 116Poly-Arg4
Compositional biasi193 – 205Poly-SerAdd BLAST13
Compositional biasi214 – 222Poly-Ala9

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri467 – 492C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri498 – 522C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri528 – 550C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 609C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155806
HOVERGENiHBG082431
InParanoidiQ6YND2
OMAiEEVPCAM
OrthoDBiEOG091G04KR
PhylomeDBiQ6YND2
TreeFamiTF332664

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6YND2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAERAPEPGA EAEAGAGGEA AAEEGAAGRK ARGRPRLTES DRARRRLESR
60 70 80 90 100
KKYDVRRVYL GEAHGPWVDL RRRSGWSDAK LAAYLISLER GQRSGRHGKP
110 120 130 140 150
WEQVPKKPKR KKRRRRNVNC LKNVVIWYED HKHRCPYEPH LAELDPTFGL
160 170 180 190 200
YTTAVWQCEA GHRYFQDLHS PLKPLSDSEP DSDKVGSGLV AGSSDSSSSG
210 220 230 240 250
SSSDSEEPPE TQPAKASAAA AALTPASPTG SSGLITQEGV HIPFDVHHVE
260 270 280 290 300
SLAEQGTPLC QNPAGSGPEA LETVVCVPVP MQVGTGPGTL FENMPQEALG
310 320 330 340 350
EVVASCPVSG MVPGSQVIII AGPGYDALTA EGIRLNVAAG GGTPSSSLGE
360 370 380 390 400
EVPCAMMEGV AAYTQTEPEG TQHSTMDTTS IASIETKKEK EDLYMLKEEK
410 420 430 440 450
EDSVAPELAE LAATVPENAE AEAEVDGEEL DSSEMSAIIY EIPKEPEKRR
460 470 480 490 500
RSKRSRVMDA DGLLEMFHCP YEGCSQVYVA LSSFQNHVNL VHRKGKTKVC
510 520 530 540 550
PHPGCGKKFY LSNHLRRHMI IHSGVREFTC ETCGKSFKRK NHLEVHRRTH
560 570 580 590 600
TGETPLQCEI CGYQCRQRAS LNWHMKKHTA EVQYNFTCDR CGKRFEKLDS
610
VKFHTLKSHP DHKPT
Length:615
Mass (Da):67,517
Last modified:October 17, 2006 - v2
Checksum:iC89971AD817AB43D
GO
Isoform 2 (identifier: Q6YND2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     388-388: K → KDTTPCHPV

Show »
Length:623
Mass (Da):68,368
Checksum:i3512EC46A0646B7F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41D → V in AAL66764 (PubMed:12920234).Curated1
Sequence conflicti275V → A in AAL66764 (PubMed:12920234).Curated1
Sequence conflicti504G → D in AAL66764 (PubMed:12920234).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021015388K → KDTTPCHPV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072705 mRNA Translation: AAL66764.1
AK089104 mRNA Translation: BAC40752.1
BC038037 mRNA Translation: AAH38037.1
CCDSiCCDS22919.1 [Q6YND2-1]
CCDS80968.1 [Q6YND2-2]
RefSeqiNP_796292.1, NM_177318.3 [Q6YND2-1]
UniGeneiMm.347707

Genome annotation databases

EnsembliENSMUST00000043922; ENSMUSP00000045895; ENSMUSG00000038895 [Q6YND2-1]
ENSMUST00000179605; ENSMUSP00000137064; ENSMUSG00000038895 [Q6YND2-2]
GeneIDi319601
KEGGimmu:319601
UCSCiuc009onp.1 mouse [Q6YND2-1]
uc012gpl.1 mouse [Q6YND2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072705 mRNA Translation: AAL66764.1
AK089104 mRNA Translation: BAC40752.1
BC038037 mRNA Translation: AAH38037.1
CCDSiCCDS22919.1 [Q6YND2-1]
CCDS80968.1 [Q6YND2-2]
RefSeqiNP_796292.1, NM_177318.3 [Q6YND2-1]
UniGeneiMm.347707

3D structure databases

ProteinModelPortaliQ6YND2
SMRiQ6YND2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045895

PTM databases

iPTMnetiQ6YND2
PhosphoSitePlusiQ6YND2

Proteomic databases

PaxDbiQ6YND2
PRIDEiQ6YND2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043922; ENSMUSP00000045895; ENSMUSG00000038895 [Q6YND2-1]
ENSMUST00000179605; ENSMUSP00000137064; ENSMUSG00000038895 [Q6YND2-2]
GeneIDi319601
KEGGimmu:319601
UCSCiuc009onp.1 mouse [Q6YND2-1]
uc012gpl.1 mouse [Q6YND2-2]

Organism-specific databases

CTDi319601
MGIiMGI:2442362 Zfp653

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155806
HOVERGENiHBG082431
InParanoidiQ6YND2
OMAiEEVPCAM
OrthoDBiEOG091G04KR
PhylomeDBiQ6YND2
TreeFamiTF332664

Miscellaneous databases

PROiPR:Q6YND2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038895 Expressed in 181 organ(s), highest expression level in primary oocyte
CleanExiMM_ZFP653
GenevisibleiQ6YND2 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN653_MOUSE
AccessioniPrimary (citable) accession number: Q6YND2
Secondary accession number(s): Q8BHT8, Q8CI02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: October 10, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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