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UniProtKB - Q6YND2 (ZN653_MOUSE)
Protein
Zinc finger protein 653
Gene
Znf653
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 467 – 492 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 498 – 522 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 528 – 550 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 556 – 578 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 586 – 609 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- AF-2 domain binding Source: MGI
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- transcription coregulator activity Source: GO_Central
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- extracellular negative regulation of signal transduction Source: UniProtKB
- negative regulation of nucleic acid-templated transcription Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 653Alternative name(s): 67 kDa zinc finger protein Zinc finger protein Zip67 |
Gene namesi | Name:Znf653 Synonyms:Zfp653, Zip67 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442362, Zfp653 |
VEuPathDBi | HostDB:ENSMUSG00000038895 |
Subcellular locationi
Nucleus
- Nucleus Curated
Extracellular region or secreted
- extracellular region Source: GOC
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253345 | 1 – 615 | Zinc finger protein 653Add BLAST | 615 |
Proteomic databases
EPDi | Q6YND2 |
MaxQBi | Q6YND2 |
PaxDbi | Q6YND2 |
PRIDEi | Q6YND2 |
ProteomicsDBi | 275028 [Q6YND2-1] 275029 [Q6YND2-2] |
PTM databases
iPTMneti | Q6YND2 |
PhosphoSitePlusi | Q6YND2 |
Expressioni
Tissue specificityi
Highly expressed in testis and spleen. Moderately expressed in lung, adrenal gland, uterus, and ovary. Very low expression in pancreas, heart, skeletal muscle, adipose tissue, kidney, and liver.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000038895, Expressed in oocyte and 211 other tissues |
Genevisiblei | Q6YND2, MM |
Interactioni
Subunit structurei
Interacts with NR5A1.
By similarityGO - Molecular functioni
- AF-2 domain binding Source: MGI
- DNA-binding transcription factor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000137064 |
Miscellaneous databases
RNActi | Q6YND2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 46 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 93 – 115 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 174 – 235 | DisorderedSequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 46 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 189 – 210 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 467 – 492 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 498 – 522 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 528 – 550 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 556 – 578 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 586 – 609 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160257 |
HOGENOMi | CLU_037389_0_0_1 |
InParanoidi | Q6YND2 |
OMAi | GAPLCPN |
PhylomeDBi | Q6YND2 |
TreeFami | TF332664 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6YND2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAERAPEPGA EAEAGAGGEA AAEEGAAGRK ARGRPRLTES DRARRRLESR
60 70 80 90 100
KKYDVRRVYL GEAHGPWVDL RRRSGWSDAK LAAYLISLER GQRSGRHGKP
110 120 130 140 150
WEQVPKKPKR KKRRRRNVNC LKNVVIWYED HKHRCPYEPH LAELDPTFGL
160 170 180 190 200
YTTAVWQCEA GHRYFQDLHS PLKPLSDSEP DSDKVGSGLV AGSSDSSSSG
210 220 230 240 250
SSSDSEEPPE TQPAKASAAA AALTPASPTG SSGLITQEGV HIPFDVHHVE
260 270 280 290 300
SLAEQGTPLC QNPAGSGPEA LETVVCVPVP MQVGTGPGTL FENMPQEALG
310 320 330 340 350
EVVASCPVSG MVPGSQVIII AGPGYDALTA EGIRLNVAAG GGTPSSSLGE
360 370 380 390 400
EVPCAMMEGV AAYTQTEPEG TQHSTMDTTS IASIETKKEK EDLYMLKEEK
410 420 430 440 450
EDSVAPELAE LAATVPENAE AEAEVDGEEL DSSEMSAIIY EIPKEPEKRR
460 470 480 490 500
RSKRSRVMDA DGLLEMFHCP YEGCSQVYVA LSSFQNHVNL VHRKGKTKVC
510 520 530 540 550
PHPGCGKKFY LSNHLRRHMI IHSGVREFTC ETCGKSFKRK NHLEVHRRTH
560 570 580 590 600
TGETPLQCEI CGYQCRQRAS LNWHMKKHTA EVQYNFTCDR CGKRFEKLDS
610
VKFHTLKSHP DHKPT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | D → V in AAL66764 (PubMed:12920234).Curated | 1 | |
Sequence conflicti | 275 | V → A in AAL66764 (PubMed:12920234).Curated | 1 | |
Sequence conflicti | 504 | G → D in AAL66764 (PubMed:12920234).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021015 | 388 | K → KDTTPCHPV in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY072705 mRNA Translation: AAL66764.1 AK089104 mRNA Translation: BAC40752.1 BC038037 mRNA Translation: AAH38037.1 |
CCDSi | CCDS22919.1 [Q6YND2-1] CCDS80968.1 [Q6YND2-2] |
RefSeqi | NP_796292.1, NM_177318.3 [Q6YND2-1] |
Genome annotation databases
Ensembli | ENSMUST00000043922; ENSMUSP00000045895; ENSMUSG00000038895 [Q6YND2-1] ENSMUST00000179605; ENSMUSP00000137064; ENSMUSG00000038895 [Q6YND2-2] |
GeneIDi | 319601 |
KEGGi | mmu:319601 |
UCSCi | uc009onp.1, mouse [Q6YND2-1] uc012gpl.1, mouse [Q6YND2-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY072705 mRNA Translation: AAL66764.1 AK089104 mRNA Translation: BAC40752.1 BC038037 mRNA Translation: AAH38037.1 |
CCDSi | CCDS22919.1 [Q6YND2-1] CCDS80968.1 [Q6YND2-2] |
RefSeqi | NP_796292.1, NM_177318.3 [Q6YND2-1] |
3D structure databases
SMRi | Q6YND2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000137064 |
PTM databases
iPTMneti | Q6YND2 |
PhosphoSitePlusi | Q6YND2 |
Proteomic databases
EPDi | Q6YND2 |
MaxQBi | Q6YND2 |
PaxDbi | Q6YND2 |
PRIDEi | Q6YND2 |
ProteomicsDBi | 275028 [Q6YND2-1] 275029 [Q6YND2-2] |
Protocols and materials databases
Antibodypediai | 25888, 23 antibodies from 9 providers |
DNASUi | 319601 |
Genome annotation databases
Ensembli | ENSMUST00000043922; ENSMUSP00000045895; ENSMUSG00000038895 [Q6YND2-1] ENSMUST00000179605; ENSMUSP00000137064; ENSMUSG00000038895 [Q6YND2-2] |
GeneIDi | 319601 |
KEGGi | mmu:319601 |
UCSCi | uc009onp.1, mouse [Q6YND2-1] uc012gpl.1, mouse [Q6YND2-2] |
Organism-specific databases
CTDi | 319601 |
MGIi | MGI:2442362, Zfp653 |
VEuPathDBi | HostDB:ENSMUSG00000038895 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160257 |
HOGENOMi | CLU_037389_0_0_1 |
InParanoidi | Q6YND2 |
OMAi | GAPLCPN |
PhylomeDBi | Q6YND2 |
TreeFami | TF332664 |
Miscellaneous databases
BioGRID-ORCSi | 319601, 1 hit in 49 CRISPR screens |
ChiTaRSi | Zfp653, mouse |
PROi | PR:Q6YND2 |
RNActi | Q6YND2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038895, Expressed in oocyte and 211 other tissues |
Genevisiblei | Q6YND2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN653_MOUSE | |
Accessioni | Q6YND2Primary (citable) accession number: Q6YND2 Secondary accession number(s): Q8BHT8, Q8CI02 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families