Znf653

Functionⁱ

Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	467 – 492	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	498 – 522	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	528 – 550	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	556 – 578	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	586 – 609	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

AF-2 domain binding Source: MGI
DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
receptor antagonist activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 12920234
transcription corepressor activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 12920234
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 653 Alternative name(s): 67 kDa zinc finger protein Zinc finger protein Zip67
Gene namesⁱ	Name:Znf653 Synonyms:Zfp653, Zip67
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:2442362 Zfp653

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000253345	1 – 615	Zinc finger protein 653Add BLAST		615

Proteomic databases

PaxDbⁱ	Q6YND2
PRIDEⁱ	Q6YND2

PTM databases

iPTMnetⁱ	Q6YND2
PhosphoSitePlusⁱ	Q6YND2

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis and spleen. Moderately expressed in lung, adrenal gland, uterus, and ovary. Very low expression in pancreas, heart, skeletal muscle, adipose tissue, kidney, and liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000038895 Expressed in 181 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_ZFP653
Genevisibleⁱ	Q6YND2 MM

Interactionⁱ

Subunit structureⁱ

Interacts with NR5A1.By similarity

GO - Molecular functionⁱ

AF-2 domain binding Source: MGI
receptor antagonist activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 12920234
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000045895

STRINGⁱ

10090.ENSMUSP00000045895

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6YND2
SMRⁱ	Q6YND2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	113 – 116	Poly-Arg	4
Compositional biasⁱ	193 – 205	Poly-SerAdd BLAST	13
Compositional biasⁱ	214 – 222	Poly-Ala	9

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	467 – 492	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	498 – 522	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	528 – 550	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	556 – 578	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	586 – 609	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063153
HOGENOMⁱ	HOG000155806
HOVERGENⁱ	HBG082431
InParanoidⁱ	Q6YND2
OMAⁱ	HLNMAAG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04KR
PhylomeDBⁱ	Q6YND2
TreeFamⁱ	TF332664

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q6YND2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAERAPEPGA EAEAGAGGEA AAEEGAAGRK ARGRPRLTES DRARRRLESR 
        60         70         80         90        100
KKYDVRRVYL GEAHGPWVDL RRRSGWSDAK LAAYLISLER GQRSGRHGKP 
       110        120        130        140        150
WEQVPKKPKR KKRRRRNVNC LKNVVIWYED HKHRCPYEPH LAELDPTFGL 
       160        170        180        190        200
YTTAVWQCEA GHRYFQDLHS PLKPLSDSEP DSDKVGSGLV AGSSDSSSSG 
       210        220        230        240        250
SSSDSEEPPE TQPAKASAAA AALTPASPTG SSGLITQEGV HIPFDVHHVE 
       260        270        280        290        300
SLAEQGTPLC QNPAGSGPEA LETVVCVPVP MQVGTGPGTL FENMPQEALG 
       310        320        330        340        350
EVVASCPVSG MVPGSQVIII AGPGYDALTA EGIRLNVAAG GGTPSSSLGE 
       360        370        380        390        400
EVPCAMMEGV AAYTQTEPEG TQHSTMDTTS IASIETKKEK EDLYMLKEEK 
       410        420        430        440        450
EDSVAPELAE LAATVPENAE AEAEVDGEEL DSSEMSAIIY EIPKEPEKRR 
       460        470        480        490        500
RSKRSRVMDA DGLLEMFHCP YEGCSQVYVA LSSFQNHVNL VHRKGKTKVC 
       510        520        530        540        550
PHPGCGKKFY LSNHLRRHMI IHSGVREFTC ETCGKSFKRK NHLEVHRRTH 
       560        570        580        590        600
TGETPLQCEI CGYQCRQRAS LNWHMKKHTA EVQYNFTCDR CGKRFEKLDS 
       610 
VKFHTLKSHP DHKPT

Length:615

Mass (Da):67,517

Last modified:October 17, 2006 - v2

Checksum:ⁱC89971AD817AB43D

GO

Isoform 2 (identifier: Q6YND2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
388-388: K → KDTTPCHPV

« Hide

        10         20         30         40         50
MAERAPEPGA EAEAGAGGEA AAEEGAAGRK ARGRPRLTES DRARRRLESR 
        60         70         80         90        100
KKYDVRRVYL GEAHGPWVDL RRRSGWSDAK LAAYLISLER GQRSGRHGKP 
       110        120        130        140        150
WEQVPKKPKR KKRRRRNVNC LKNVVIWYED HKHRCPYEPH LAELDPTFGL 
       160        170        180        190        200
YTTAVWQCEA GHRYFQDLHS PLKPLSDSEP DSDKVGSGLV AGSSDSSSSG 
       210        220        230        240        250
SSSDSEEPPE TQPAKASAAA AALTPASPTG SSGLITQEGV HIPFDVHHVE 
       260        270        280        290        300
SLAEQGTPLC QNPAGSGPEA LETVVCVPVP MQVGTGPGTL FENMPQEALG 
       310        320        330        340        350
EVVASCPVSG MVPGSQVIII AGPGYDALTA EGIRLNVAAG GGTPSSSLGE 
       360        370        380        390        400
EVPCAMMEGV AAYTQTEPEG TQHSTMDTTS IASIETKKDT TPCHPVEKED 
       410        420        430        440        450
LYMLKEEKED SVAPELAELA ATVPENAEAE AEVDGEELDS SEMSAIIYEI 
       460        470        480        490        500
PKEPEKRRRS KRSRVMDADG LLEMFHCPYE GCSQVYVALS SFQNHVNLVH 
       510        520        530        540        550
RKGKTKVCPH PGCGKKFYLS NHLRRHMIIH SGVREFTCET CGKSFKRKNH 
       560        570        580        590        600
LEVHRRTHTG ETPLQCEICG YQCRQRASLN WHMKKHTAEV QYNFTCDRCG 
       610        620 
KRFEKLDSVK FHTLKSHPDH KPT

Show »

Length:623

Mass (Da):68,368

Checksum:ⁱ3512EC46A0646B7F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	41	D → V in AAL66764 (PubMed:12920234).Curated	1
Sequence conflictⁱ	275	V → A in AAL66764 (PubMed:12920234).Curated	1
Sequence conflictⁱ	504	G → D in AAL66764 (PubMed:12920234).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_021015	388	K → KDTTPCHPV in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY072705 mRNA Translation: AAL66764.1 AK089104 mRNA Translation: BAC40752.1 BC038037 mRNA Translation: AAH38037.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22919.1 [Q6YND2-1] CCDS80968.1 [Q6YND2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_796292.1, NM_177318.3 [Q6YND2-1]
UniGeneⁱ	Mm.347707

Genome annotation databases

Ensemblⁱ	ENSMUST00000043922; ENSMUSP00000045895; ENSMUSG00000038895 [Q6YND2-1] ENSMUST00000179605; ENSMUSP00000137064; ENSMUSG00000038895 [Q6YND2-2]
GeneIDⁱ	319601
KEGGⁱ	mmu:319601
UCSC genome browser More...UCSCⁱ	uc009onp.1 mouse [Q6YND2-1] uc012gpl.1 mouse [Q6YND2-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6YND2	Isoform 2 of Zinc finger protein 653		MOUSE		623	UniRef90_Q6YND2
Uncharacterized protein		PROCO		622
zinc finger protein 653		Florida manatee		622
zinc finger protein 653		Enhydra lutris kenyoni		620
Zinc finger protein 653 (Fragment)		MUSPF		202
+27

Protein	Similar proteins		Species	Score	Length	Source
Q6YND2	Zinc finger protein 653		HUMAN		615	UniRef50_Q96CK0
Uncharacterized protein		RHIRO		615
Zinc finger protein 653		CALJA		614
Uncharacterized protein		AOTNA		613
Uncharacterized protein		Cebus capucinus imitator		612
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY072705 mRNA Translation: AAL66764.1 AK089104 mRNA Translation: BAC40752.1 BC038037 mRNA Translation: AAH38037.1
CCDSⁱ	CCDS22919.1 [Q6YND2-1] CCDS80968.1 [Q6YND2-2]
RefSeqⁱ	NP_796292.1, NM_177318.3 [Q6YND2-1]
UniGeneⁱ	Mm.347707

3D structure databases

ProteinModelPortalⁱ	Q6YND2
SMRⁱ	Q6YND2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000045895

STRINGⁱ

10090.ENSMUSP00000045895

PTM databases

iPTMnetⁱ	Q6YND2
PhosphoSitePlusⁱ	Q6YND2

Proteomic databases

PaxDbⁱ	Q6YND2
PRIDEⁱ	Q6YND2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000043922; ENSMUSP00000045895; ENSMUSG00000038895 [Q6YND2-1] ENSMUST00000179605; ENSMUSP00000137064; ENSMUSG00000038895 [Q6YND2-2]
GeneIDⁱ	319601
KEGGⁱ	mmu:319601
UCSCⁱ	uc009onp.1 mouse [Q6YND2-1] uc012gpl.1 mouse [Q6YND2-2]

Organism-specific databases

CTDⁱ	319601
MGIⁱ	MGI:2442362 Zfp653

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063153
HOGENOMⁱ	HOG000155806
HOVERGENⁱ	HBG082431
InParanoidⁱ	Q6YND2
OMAⁱ	HLNMAAG
OrthoDBⁱ	EOG091G04KR
PhylomeDBⁱ	Q6YND2
TreeFamⁱ	TF332664

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6YND2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000038895 Expressed in 181 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_ZFP653
Genevisibleⁱ	Q6YND2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN653_MOUSE
Accessionⁱ	Q6YND2Primary (citable) accession number: Q6YND2 Secondary accession number(s): Q8BHT8, Q8CI02
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6YND2 (ZN653_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Zinc finger protein 653

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Extracellular region or secreted

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ