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Protein

Hydroxysteroid dehydrogenase-like protein 2

Gene

HSDL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has apparently no steroid dehydrogenase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42NADP1 Publication1
Binding sitei74NADP1 Publication1
Active sitei168Proton acceptorPROSITE-ProRule annotation1
Binding sitei172NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 23NADP1 Publication7

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxysteroid dehydrogenase-like protein 2 (EC:1.-.-.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 13C member 1
Gene namesi
Name:HSDL2
Synonyms:C9orf99, SDR13C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000119471.14
HGNCiHGNC:18572 HSDL2
neXtProtiNX_Q6YN16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi84263
OpenTargetsiENSG00000119471
PharmGKBiPA134980105

Polymorphism and mutation databases

BioMutaiHSDL2
DMDMi74749521

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003198881 – 418Hydroxysteroid dehydrogenase-like protein 2Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116N6-acetyllysineBy similarity1
Modified residuei318N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6YN16
MaxQBiQ6YN16
PaxDbiQ6YN16
PeptideAtlasiQ6YN16
PRIDEiQ6YN16
ProteomicsDBi67855
67856 [Q6YN16-2]

2D gel databases

UCD-2DPAGEiQ6YN16

PTM databases

iPTMnetiQ6YN16
PhosphoSitePlusiQ6YN16
SwissPalmiQ6YN16

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000119471 Expressed in 228 organ(s), highest expression level in biceps brachii
CleanExiHS_HSDL2
ExpressionAtlasiQ6YN16 baseline and differential
GenevisibleiQ6YN16 HS

Organism-specific databases

HPAiHPA042890
HPA050453

Interactioni

Protein-protein interaction databases

BioGridi123990, 32 interactors
IntActiQ6YN16, 24 interactors
MINTiQ6YN16
STRINGi9606.ENSP00000381785

Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6YN16
SMRiQ6YN16
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6YN16

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini306 – 415SCP2Add BLAST110

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
KOG4170 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00900000140982
HOVERGENiHBG107982
InParanoidiQ6YN16
OMAiTAYTMAK
OrthoDBiEOG091G0EVM
PhylomeDBiQ6YN16
TreeFamiTF101523

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PF02036 SCP2, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit
SSF55718 SSF55718, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6YN16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPNTGRLAG CTVFITGASR GIGKAIALKA AKDGANIVIA AKTAQPHPKL
60 70 80 90 100
LGTIYTAAEE IEAVGGKALP CIVDVRDEQQ ISAAVEKAIK KFGGIDILVN
110 120 130 140 150
NASAISLTNT LDTPTKRLDL MMNVNTRGTY LASKACIPYL KKSKVAHILN
160 170 180 190 200
ISPPLNLNPV WFKQHCAYTI AKYGMSMYVL GMAEEFKGEI AVNALWPKTA
210 220 230 240 250
IHTAAMDMLG GPGIESQCRK VDIIADAAYS IFQKPKSFTG NFVIDENILK
260 270 280 290 300
EEGIENFDVY AIKPGHPLQP DFFLDEYPEA VSKKVESTGA VPEFKEEKLQ
310 320 330 340 350
LQPKPRSGAV EETFRIVKDS LSDDVVKATQ AIYLFELSGE DGGTWFLDLK
360 370 380 390 400
SKGGNVGYGE PSDQADVVMS MTTDDFVKMF SGKLKPTMAF MSGKLKIKGN
410
MALAIKLEKL MNQMNARL
Length:418
Mass (Da):45,395
Last modified:July 5, 2004 - v1
Checksum:iA8B27CC7D6F1B636
GO
Isoform 2 (identifier: Q6YN16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-166: Missing.

Show »
Length:345
Mass (Da):37,320
Checksum:iA8CE6A7AC163A2D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62E → G in BAF82618 (PubMed:14702039).Curated1
Sequence conflicti89I → V in BAF85175 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03152994 – 166Missing in isoform 2. 2 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093428 mRNA Translation: AAM14670.1
AK292486 mRNA Translation: BAF85175.1
AK289929 mRNA Translation: BAF82618.1
AL162732 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59105.1
CH471105 Genomic DNA Translation: EAW59106.1
BC004331 mRNA Translation: AAH04331.1
BC095451 mRNA Translation: AAH95451.1
AL833735 mRNA Translation: CAH56256.1
CCDSiCCDS43864.1 [Q6YN16-1]
CCDS56582.1 [Q6YN16-2]
RefSeqiNP_001182751.1, NM_001195822.1 [Q6YN16-2]
NP_115679.2, NM_032303.4 [Q6YN16-1]
UniGeneiHs.59486

Genome annotation databases

EnsembliENST00000398803; ENSP00000381783; ENSG00000119471 [Q6YN16-2]
ENST00000398805; ENSP00000381785; ENSG00000119471 [Q6YN16-1]
GeneIDi84263
KEGGihsa:84263
UCSCiuc004bga.3 human [Q6YN16-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093428 mRNA Translation: AAM14670.1
AK292486 mRNA Translation: BAF85175.1
AK289929 mRNA Translation: BAF82618.1
AL162732 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59105.1
CH471105 Genomic DNA Translation: EAW59106.1
BC004331 mRNA Translation: AAH04331.1
BC095451 mRNA Translation: AAH95451.1
AL833735 mRNA Translation: CAH56256.1
CCDSiCCDS43864.1 [Q6YN16-1]
CCDS56582.1 [Q6YN16-2]
RefSeqiNP_001182751.1, NM_001195822.1 [Q6YN16-2]
NP_115679.2, NM_032303.4 [Q6YN16-1]
UniGeneiHs.59486

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KVOX-ray2.25A/B1-293[»]
ProteinModelPortaliQ6YN16
SMRiQ6YN16
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123990, 32 interactors
IntActiQ6YN16, 24 interactors
MINTiQ6YN16
STRINGi9606.ENSP00000381785

PTM databases

iPTMnetiQ6YN16
PhosphoSitePlusiQ6YN16
SwissPalmiQ6YN16

Polymorphism and mutation databases

BioMutaiHSDL2
DMDMi74749521

2D gel databases

UCD-2DPAGEiQ6YN16

Proteomic databases

EPDiQ6YN16
MaxQBiQ6YN16
PaxDbiQ6YN16
PeptideAtlasiQ6YN16
PRIDEiQ6YN16
ProteomicsDBi67855
67856 [Q6YN16-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398803; ENSP00000381783; ENSG00000119471 [Q6YN16-2]
ENST00000398805; ENSP00000381785; ENSG00000119471 [Q6YN16-1]
GeneIDi84263
KEGGihsa:84263
UCSCiuc004bga.3 human [Q6YN16-1]

Organism-specific databases

CTDi84263
DisGeNETi84263
EuPathDBiHostDB:ENSG00000119471.14
GeneCardsiHSDL2
HGNCiHGNC:18572 HSDL2
HPAiHPA042890
HPA050453
neXtProtiNX_Q6YN16
OpenTargetsiENSG00000119471
PharmGKBiPA134980105
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
KOG4170 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00900000140982
HOVERGENiHBG107982
InParanoidiQ6YN16
OMAiTAYTMAK
OrthoDBiEOG091G0EVM
PhylomeDBiQ6YN16
TreeFamiTF101523

Miscellaneous databases

ChiTaRSiHSDL2 human
EvolutionaryTraceiQ6YN16
GenomeRNAii84263
PROiPR:Q6YN16

Gene expression databases

BgeeiENSG00000119471 Expressed in 228 organ(s), highest expression level in biceps brachii
CleanExiHS_HSDL2
ExpressionAtlasiQ6YN16 baseline and differential
GenevisibleiQ6YN16 HS

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PF02036 SCP2, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit
SSF55718 SSF55718, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSDL2_HUMAN
AccessioniPrimary (citable) accession number: Q6YN16
Secondary accession number(s): A8K1L4
, A8K8X1, A8MSV3, Q658M8, Q9BT58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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