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Entry version 140 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Thyroid adenoma-associated protein

Gene

THADA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6YHU6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6782315, tRNA modification in the nucleus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroid adenoma-associated protein
Alternative name(s):
Gene inducing thyroid adenomas protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THADA
Synonyms:GITA, KIAA1767
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000115970.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19217, THADA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611800, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6YHU6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas. Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from chromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probably result in truncated THADA proteins.

Organism-specific databases

DisGeNET

More...
DisGeNETi
63892

Open Targets

More...
OpenTargetsi
ENSG00000115970

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134882460

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6YHU6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THADA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749519

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003440571 – 1953Thyroid adenoma-associated proteinAdd BLAST1953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1015PhosphoserineCombined sources1
Modified residuei1024PhosphoserineCombined sources1
Modified residuei1161PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6YHU6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6YHU6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6YHU6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6YHU6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6YHU6

PeptideAtlas

More...
PeptideAtlasi
Q6YHU6

PRoteomics IDEntifications database

More...
PRIDEi
Q6YHU6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67846 [Q6YHU6-1]
67847 [Q6YHU6-2]
67848 [Q6YHU6-3]
67849 [Q6YHU6-4]
67850 [Q6YHU6-5]
71096

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6YHU6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6YHU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis, thymus, small intestine and stomach.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115970, Expressed in kidney and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6YHU6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6YHU6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000115970, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121972, 58 interactors

Protein interaction database and analysis system

More...
IntActi
Q6YHU6, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385995

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6YHU6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11953
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6YHU6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili886 – 918Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 7Poly-Lys4
Compositional biasi1322 – 1327Poly-Leu6
Compositional biasi1529 – 1532Poly-Ala4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the THADA family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1810, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015500

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002048_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6YHU6

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKLLNCN

Database of Orthologous Groups

More...
OrthoDBi
59905at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6YHU6

TreeFam database of animal gene trees

More...
TreeFami
TF319713

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR019442, DUF2428_death-receptor-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10350, DUF2428, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6YHU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVKKKKEMQ VAALTICHQD LETLKSFADV EGKNLASLLL HCVQLTDGVS
60 70 80 90 100
QIHYIKQIVP LLEKADKNGM CDPTIQSCLD ILAGIYLSLS LKNPLKKVLA
110 120 130 140 150
SSLNSLPDFF LPEAMHRFTS RLQEELNTTD LYSYRKVTDN ISSCMENFNL
160 170 180 190 200
GRASVNNLLK NVLHFLQKSL IEILEENRKC AGNHIIQTQL MNDLLVGIRV
210 220 230 240 250
SMMLVQKVQD FQGNLWKTSD SPIWQNMCGL LSIFTKVLSD DDLLQTVQST
260 270 280 290 300
SGLAIILFIK TMFHPSEKIP HLISSVLLRS VDCTSVPEWF MSSCRSLCCG
310 320 330 340 350
DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP
360 370 380 390 400
TLEMFLSRIL ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW
410 420 430 440 450
EHPLDALRHQ TKIMFKNLLQ MHRLTVEGAD FVPDPFFVEL TESLLRLEWH
460 470 480 490 500
IKGKYTCLGC LVECIGVEHI LAIDKTIPSQ ILEVMGDQSL VPYASDLLET
510 520 530 540 550
MFRNHKSHLK SQTAESSWID QWHETWVSPL LFILCEGNLD QKSYVIDYYL
560 570 580 590 600
PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS RGALGALMAC
610 620 630 640 650
LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR
660 670 680 690 700
STEIVSMEEM QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL
710 720 730 740 750
YKLEQSKSKR EPENELTKQH PSVSLQQYKN FMSSICNSLF EALFPGSSYS
760 770 780 790 800
TRFSALTILG SIAEVFHVPE GRIYTVYQLS HDIDVGRFQT LMECFTSTFE
810 820 830 840 850
DVKILAFDLL MKLSKTAVHF QDSGKLQGLF QAALELSTST KPYDCVTASY
860 870 880 890 900
LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL MVIKCLMENL
910 920 930 940 950
EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLNSLQ LVSEWRPVVE
960 970 980 990 1000
KLLLMSYRLS TVVSPVIQSS SPEGLIPMDT DSESASRLQM ILNEIQPRDT
1010 1020 1030 1040 1050
NDYFNQAKIL KEHDSFDMKD LNASVVNIDT STEIKGKEVK TCDVTAQMVL
1060 1070 1080 1090 1100
VCCWRSMKEV ALLLGMLCQL LPMQPVPESS DGLLTVEQVK EIGDYFKQHL
1110 1120 1130 1140 1150
LQSRHRGAFE LAYTGFVKLT EVLNRCPNVS LQKLPEQWLW SVLEEIKCSD
1160 1170 1180 1190 1200
PSSKLCATRR SAGIPFYIQA LLASEPKKGR MDLLKITMKE LISLAGPTDD
1210 1220 1230 1240 1250
IQSTVPQVHA LNILRALFRD TRLGENIIPY VADGAKAAIL GFTSPVWAVR
1260 1270 1280 1290 1300
NSSTLLFSAL ITRIFGVKRA KDEHSKTNRM TGREFFSRFP ELYPFLLKQL
1310 1320 1330 1340 1350
ETVANTVDSD MGEPNRHPSM FLLLLVLERL YASPMDGTSS ALSMGPFVPF
1360 1370 1380 1390 1400
IMRCGHSPVY HSREMAARAL VPFVMIDHIP NTIRTLLSTL PSCTDQCFRQ
1410 1420 1430 1440 1450
NHIHGTLLQV FHLLQAYSDS KHGTNSDFQH ELTDITVCTK AKLWLAKRQN
1460 1470 1480 1490 1500
PCLVTRAVYI DILFLLTCCL NRSAKDNQPV LESLGFWEEV RGIISGSELI
1510 1520 1530 1540 1550
TGFPWAFKVP GLPQYLQSLT RLAIAAVWAA AAKSGERETN VPISFSQLLE
1560 1570 1580 1590 1600
SAFPEVRSLT LEALLEKFLA AASGLGEKGV PPLLCNMGEK FLLLAMKENH
1610 1620 1630 1640 1650
PECFCKILKI LHCMDPGEWL PQTEHCVHLT PKEFLIWTMD IASNERSEIQ
1660 1670 1680 1690 1700
SVALRLASKV ISHHMQTCVE NRELIAAELK QWVQLVILSC EDHLPTESRL
1710 1720 1730 1740 1750
AVVEVLTSTT PLFLTNPHPI LELQDTLALW KCVLTLLQSE EQAVRDAATE
1760 1770 1780 1790 1800
TVTTAMSQEN TCQSTEFAFC QVDASIALAL ALAVLCDLLQ QWDQLAPGLP
1810 1820 1830 1840 1850
ILLGWLLGES DDLVACVESM HQVEEDYLFE KAEVNFWAET LIFVKYLCKH
1860 1870 1880 1890 1900
LFCLLSKSGW RPPSPEMLCH LQRMVSEQCH LLSQFFRELP PAAEFVKTVE
1910 1920 1930 1940 1950
FTRLRIQEER TLACLRLLAF LEGKEGEDTL VLSVWDSYAE SRQLTLPRTE

AAC
Length:1,953
Mass (Da):219,607
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53099534C8B1D80E
GO
Isoform 2 (identifier: Q6YHU6-2) [UniParc]FASTAAdd to basket
Also known as: GITA-A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-290: Missing.
     1249-1279: Missing.

Show »
Length:1,632
Mass (Da):183,444
Checksum:iB08341A3BA07CDC2
GO
Isoform 3 (identifier: Q6YHU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1280-1353: Missing.

Show »
Length:1,879
Mass (Da):211,180
Checksum:i4FF939966B462137
GO
Isoform 4 (identifier: Q6YHU6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1279: Missing.

Show »
Length:674
Mass (Da):75,966
Checksum:iE1AFFD757D82C1AA
GO
Isoform 5 (identifier: Q6YHU6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     937-937: N → K
     938-1953: Missing.

Show »
Length:937
Mass (Da):105,383
Checksum:iD2093158F2BFBE6B
GO
Isoform 6 (identifier: Q6YHU6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     892-894: VIK → GLY
     895-1953: Missing.

Show »
Length:894
Mass (Da):100,685
Checksum:iE94748967CE07F50
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y3V5H0Y3V5_HUMAN
Thyroid adenoma-associated protein
THADA
1,193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MC89B5MC89_HUMAN
Thyroid adenoma-associated protein
THADA
870Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYZ4H7BYZ4_HUMAN
Thyroid adenoma-associated protein
THADA
408Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3M9F5H3M9_HUMAN
Thyroid adenoma-associated protein
THADA
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B6ZDE5B6ZDE5_HUMAN
Thyroid adenoma-associated protein
THADA
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15133 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15162 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB21858 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245Q → R in BAC86389 (PubMed:14702039).Curated1
Sequence conflicti1507F → L in BAB15133 (PubMed:14702039).Curated1
Sequence conflicti1709T → I in BAB15133 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05407063E → G. Corresponds to variant dbSNP:rs10210191Ensembl.1
Natural variantiVAR_054071699V → I2 PublicationsCorresponds to variant dbSNP:rs17031056Ensembl.1
Natural variantiVAR_0540721187T → A. Corresponds to variant dbSNP:rs7578597Ensembl.1
Natural variantiVAR_0540731385T → S1 PublicationCorresponds to variant dbSNP:rs33979934Ensembl.1
Natural variantiVAR_0540741451P → S. Corresponds to variant dbSNP:rs17334247Ensembl.1
Natural variantiVAR_0540751605C → Y1 PublicationCorresponds to variant dbSNP:rs35720761Ensembl.1
Natural variantiVAR_0540761668C → R. Corresponds to variant dbSNP:rs17030648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0347301 – 1279Missing in isoform 4. 1 PublicationAdd BLAST1279
Alternative sequenceiVSP_0347311 – 290Missing in isoform 2. 1 PublicationAdd BLAST290
Alternative sequenceiVSP_054421892 – 894VIK → GLY in isoform 6. 1 Publication3
Alternative sequenceiVSP_054422895 – 1953Missing in isoform 6. 1 PublicationAdd BLAST1059
Alternative sequenceiVSP_034732937N → K in isoform 5. 1 Publication1
Alternative sequenceiVSP_034733938 – 1953Missing in isoform 5. 1 PublicationAdd BLAST1016
Alternative sequenceiVSP_0347341249 – 1279Missing in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0347351280 – 1353Missing in isoform 3. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY149629 mRNA Translation: AAO46785.1
AY149633 mRNA Translation: AAO46789.1
AB051554 mRNA Translation: BAB21858.2 Different initiation.
AK025530 mRNA Translation: BAB15162.1 Different initiation.
AK025445 mRNA Translation: BAB15133.1 Different initiation.
AK126004 mRNA Translation: BAC86389.1
AK290023 mRNA Translation: BAF82712.1
AC010883 Genomic DNA Translation: AAY14994.1
AC092615 Genomic DNA Translation: AAX93152.1
AC092838 Genomic DNA Translation: AAX93154.1
AC104138 Genomic DNA No translation available.
BC007743 mRNA Translation: AAH07743.1
BC025773 mRNA Translation: AAH25773.1
BC037990 mRNA Translation: AAH37990.1
BC105976 mRNA Translation: AAI05977.1
AF323176 mRNA Translation: AAK11318.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46268.1 [Q6YHU6-1]
CCDS62901.1 [Q6YHU6-6]
CCDS62902.1 [Q6YHU6-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001077422.1, NM_001083953.1 [Q6YHU6-1]
NP_001258572.1, NM_001271643.1 [Q6YHU6-5]
NP_001258573.1, NM_001271644.1 [Q6YHU6-6]
NP_001332854.1, NM_001345925.1 [Q6YHU6-1]
NP_071348.3, NM_022065.4 [Q6YHU6-1]
XP_006712128.1, XM_006712065.1 [Q6YHU6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000402360; ENSP00000385441; ENSG00000115970 [Q6YHU6-5]
ENST00000404790; ENSP00000384266; ENSG00000115970 [Q6YHU6-6]
ENST00000405006; ENSP00000385995; ENSG00000115970 [Q6YHU6-1]
ENST00000405975; ENSP00000386088; ENSG00000115970 [Q6YHU6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
63892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63892

UCSC genome browser

More...
UCSCi
uc002rsw.5, human [Q6YHU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149629 mRNA Translation: AAO46785.1
AY149633 mRNA Translation: AAO46789.1
AB051554 mRNA Translation: BAB21858.2 Different initiation.
AK025530 mRNA Translation: BAB15162.1 Different initiation.
AK025445 mRNA Translation: BAB15133.1 Different initiation.
AK126004 mRNA Translation: BAC86389.1
AK290023 mRNA Translation: BAF82712.1
AC010883 Genomic DNA Translation: AAY14994.1
AC092615 Genomic DNA Translation: AAX93152.1
AC092838 Genomic DNA Translation: AAX93154.1
AC104138 Genomic DNA No translation available.
BC007743 mRNA Translation: AAH07743.1
BC025773 mRNA Translation: AAH25773.1
BC037990 mRNA Translation: AAH37990.1
BC105976 mRNA Translation: AAI05977.1
AF323176 mRNA Translation: AAK11318.1
CCDSiCCDS46268.1 [Q6YHU6-1]
CCDS62901.1 [Q6YHU6-6]
CCDS62902.1 [Q6YHU6-5]
RefSeqiNP_001077422.1, NM_001083953.1 [Q6YHU6-1]
NP_001258572.1, NM_001271643.1 [Q6YHU6-5]
NP_001258573.1, NM_001271644.1 [Q6YHU6-6]
NP_001332854.1, NM_001345925.1 [Q6YHU6-1]
NP_071348.3, NM_022065.4 [Q6YHU6-1]
XP_006712128.1, XM_006712065.1 [Q6YHU6-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T6YX-ray1.76C796-807[»]
SMRiQ6YHU6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121972, 58 interactors
IntActiQ6YHU6, 27 interactors
STRINGi9606.ENSP00000385995

PTM databases

iPTMnetiQ6YHU6
PhosphoSitePlusiQ6YHU6

Polymorphism and mutation databases

BioMutaiTHADA
DMDMi74749519

Proteomic databases

EPDiQ6YHU6
jPOSTiQ6YHU6
MassIVEiQ6YHU6
MaxQBiQ6YHU6
PaxDbiQ6YHU6
PeptideAtlasiQ6YHU6
PRIDEiQ6YHU6
ProteomicsDBi67846 [Q6YHU6-1]
67847 [Q6YHU6-2]
67848 [Q6YHU6-3]
67849 [Q6YHU6-4]
67850 [Q6YHU6-5]
71096

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
47396, 101 antibodies

The DNASU plasmid repository

More...
DNASUi
63892

Genome annotation databases

EnsembliENST00000402360; ENSP00000385441; ENSG00000115970 [Q6YHU6-5]
ENST00000404790; ENSP00000384266; ENSG00000115970 [Q6YHU6-6]
ENST00000405006; ENSP00000385995; ENSG00000115970 [Q6YHU6-1]
ENST00000405975; ENSP00000386088; ENSG00000115970 [Q6YHU6-1]
GeneIDi63892
KEGGihsa:63892
UCSCiuc002rsw.5, human [Q6YHU6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63892
DisGeNETi63892
EuPathDBiHostDB:ENSG00000115970.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
THADA
HGNCiHGNC:19217, THADA
HPAiENSG00000115970, Low tissue specificity
MIMi611800, gene
neXtProtiNX_Q6YHU6
OpenTargetsiENSG00000115970
PharmGKBiPA134882460

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1810, Eukaryota
GeneTreeiENSGT00390000015500
HOGENOMiCLU_002048_0_0_1
InParanoidiQ6YHU6
OMAiPKLLNCN
OrthoDBi59905at2759
PhylomeDBiQ6YHU6
TreeFamiTF319713

Enzyme and pathway databases

PathwayCommonsiQ6YHU6
ReactomeiR-HSA-6782315, tRNA modification in the nucleus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
63892, 3 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
THADA, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63892
PharosiQ6YHU6, Tbio

Protein Ontology

More...
PROi
PR:Q6YHU6
RNActiQ6YHU6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115970, Expressed in kidney and 224 other tissues
ExpressionAtlasiQ6YHU6, baseline and differential
GenevisibleiQ6YHU6, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR019442, DUF2428_death-receptor-like
PfamiView protein in Pfam
PF10350, DUF2428, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHADA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6YHU6
Secondary accession number(s): A8K1V8
, B7WNS6, Q3KR04, Q53RC6, Q53TB2, Q6YHU2, Q6ZU38, Q8IY32, Q8TAU8, Q96I88, Q9BZF7, Q9C096, Q9H6U0, Q9H6W7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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