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Entry version 132 (16 Oct 2019)
Sequence version 2 (31 Oct 2006)
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Protein

CD109 antigen

Gene

CD109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates negatively TGFB1 signaling in keratinocytes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD109 antigen
Alternative name(s):
150 kDa TGF-beta-1-binding protein
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
Platelet-specific Gov antigen
p180
r150
CD_antigen: CD109
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD109
Synonyms:CPAMD7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21685 CD109

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608859 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6YHK3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
135228

MalaCards human disease database

More...
MalaCardsi
CD109

Open Targets

More...
OpenTargetsi
ENSG00000156535

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
853 Fetal and neonatal alloimmune thrombocytopenia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134949237

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6YHK3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD109

Domain mapping of disease mutations (DMDM)

More...
DMDMi
117949389

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025594522 – 1420CD109 antigenAdd BLAST1399
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00002559461421 – 1445Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi68N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi118N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi247N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi513N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi645N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki921 ↔ 924Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Glycosylationi1086N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1355N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1420GPI-anchor amidated alanineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.5 Publications
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Thioester bond

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6YHK3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6YHK3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6YHK3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6YHK3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6YHK3

PeptideAtlas

More...
PeptideAtlasi
Q6YHK3

PRoteomics IDEntifications database

More...
PRIDEi
Q6YHK3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67842 [Q6YHK3-1]
67843 [Q6YHK3-2]
67844 [Q6YHK3-3]
67845 [Q6YHK3-4]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6YHK3

GlyConnect protein glycosylation platform

More...
GlyConnecti
795

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6YHK3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6YHK3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6YHK3

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q6YHK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156535 Expressed in 204 organ(s), highest expression level in tibia

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6YHK3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015723

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; disulfide-linked.

Interacts with TGFB1 and TGFBR1.

Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126424, 54 interactors

Protein interaction database and analysis system

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IntActi
Q6YHK3, 37 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000287097

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6YHK3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni593 – 702Bait region (approximate)By similarityAdd BLAST110

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMYI Eukaryota
COG2373 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155926

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6YHK3

KEGG Orthology (KO)

More...
KOi
K06530

Identification of Orthologs from Complete Genome Data

More...
OMAi
EIKLFWS

Database of Orthologous Groups

More...
OrthoDBi
354230at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6YHK3

TreeFam database of animal gene trees

More...
TreeFami
TF313285

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02897 A2M_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR041813 A2M_TED
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR008930 Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF07678 TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6YHK3-1) [UniParc]FASTAAdd to basket
Also known as: CD109 180-kDa

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE
60 70 80 90 100
HCPSQVTVKA ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE
110 120 130 140 150
IYELRVTGRT QDEILFSNST RLSFETKRIS VFIQTDKALY KPKQEVKFRI
160 170 180 190 200
VTLFSDFKPY KTSLNILIKD PKSNLIQQWL SQQSDLGVIS KTFQLSSHPI
210 220 230 240 250
LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS MNSKHLNGTI
260 270 280 290 300
TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK
310 320 330 340 350
NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI
360 370 380 390 400
IEFFDYTTVL KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE
410 420 430 440 450
YWSGSNSGNQ KMEAVQKINY TVPQSGTFKI EFPILEDSSE LQLKAYFLGS
460 470 480 490 500
KSSMAVHSLF KSPSKTYIQL KTRDENIKVG SPFELVVSGN KRLKELSYMV
510 520 530 540 550
VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG EIISDVLKIP
560 570 580 590 600
VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN
610 620 630 640 650
ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY
660 670 680 690 700
IDGVYDNAEY AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN
710 720 730 740 750
MGYRIYQEFE VTVPDSITSW VATGFVISED LGLGLTTTPV ELQAFQPFFI
760 770 780 790 800
FLNLPYSVIR GEEFALEITI FNYLKDATEV KVIIEKSDKF DILMTSNEIN
810 820 830 840 850
ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT ASDAVTQMIL
860 870 880 890 900
VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI
910 920 930 940 950
GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK
960 970 980 990 1000
EKALSFMRQG YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD
1010 1020 1030 1040 1050
PYIDIDQNVL HRTYTWLKGH QKSNGEFWDP GRVIHSELQG GNKSPVTLTA
1060 1070 1080 1090 1100
YIVTSLLGYR KYQPNIDVQE SIHFLESEFS RGISDNYTLA LITYALSSVG
1110 1120 1130 1140 1150
SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL DIEVAAYALL
1160 1170 1180 1190 1200
SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT
1210 1220 1230 1240 1250
ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF
1260 1270 1280 1290 1300
GFAICQLNVV YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN
1310 1320 1330 1340 1350
VCTSFSGPGR SGMALMEVNL LSGFMVPSEA ISLSETVKKV EYDHGKLNLY
1360 1370 1380 1390 1400
LDSVNETQFC VNIPAVRNFK VSNTQDASVS IVDYYEPRRQ AVRSYNSEVK
1410 1420 1430 1440
LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF MELWL
Length:1,445
Mass (Da):161,689
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C5B1C3B8CCAF195
GO
Isoform 2 (identifier: Q6YHK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-169: Missing.

Note: No experimental confirmation available.
Show »
Length:1,368
Mass (Da):152,663
Checksum:i9F326D3F69033813
GO
Isoform 3 (identifier: Q6YHK3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     658-665: AEYAERFM → LFGTQEAL
     666-1445: Missing.

Note: No experimental confirmation available.
Show »
Length:665
Mass (Da):74,411
Checksum:iCC73982C8E88647E
GO
Isoform 4 (identifier: Q6YHK3-4) [UniParc]FASTAAdd to basket
Also known as: CD109S

The sequence of this isoform differs from the canonical sequence as follows:
     1218-1234: Missing.

Show »
Length:1,428
Mass (Da):159,696
Checksum:i9DBA3F0AA03660F5
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG53987 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAE46045 differs from that shown. Reason: Frameshift.Curated
The sequence CAE46045 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti627M → I in AAN78483 (PubMed:14980714).Curated1
Sequence conflicti789K → E in BAG36395 (PubMed:14702039).Curated1
Sequence conflicti803G → S in AAN78483 (PubMed:14980714).Curated1
Sequence conflicti1046V → A in ABQ66266 (PubMed:17974005).Curated1
Sequence conflicti1418D → N in BAG53987 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The Gov(b) variant in position 703 defines the Gov alloantigenic determinants.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02887545G → V. Corresponds to variant dbSNP:rs9446983Ensembl.1
Natural variantiVAR_048105377G → D. Corresponds to variant dbSNP:rs7741152Ensembl.1
Natural variantiVAR_048106641L → F. Corresponds to variant dbSNP:rs7742662Ensembl.1
Natural variantiVAR_028876703Y → S in allele Gov(b). 5 PublicationsCorresponds to variant dbSNP:rs10455097Ensembl.1
Natural variantiVAR_074179791D → G1 Publication1
Natural variantiVAR_028877797N → S4 PublicationsCorresponds to variant dbSNP:rs2351528Ensembl.1
Natural variantiVAR_028878845V → I4 PublicationsCorresponds to variant dbSNP:rs5023688Ensembl.1
Natural variantiVAR_0362361007Q → E in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1454572681Ensembl.1
Natural variantiVAR_0481071009V → M. Corresponds to variant dbSNP:rs35630075Ensembl.1
Natural variantiVAR_0362371065N → K in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0288791241T → M2 PublicationsCorresponds to variant dbSNP:rs2917862Ensembl.1
Natural variantiVAR_0481081296H → R. Corresponds to variant dbSNP:rs13207595Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02131293 – 169Missing in isoform 2. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_021313658 – 665AEYAERFM → LFGTQEAL in isoform 3. 1 Publication8
Alternative sequenceiVSP_021314666 – 1445Missing in isoform 3. 1 PublicationAdd BLAST780
Alternative sequenceiVSP_0213151218 – 1234Missing in isoform 4. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF410459 mRNA Translation: AAL84159.1
AY149920 mRNA Translation: AAN78483.1
AY788891 mRNA Translation: AAX14639.1
AK095888 mRNA Translation: BAC04642.1
AK123960 mRNA Translation: BAG53987.1 Different initiation.
AK313636 mRNA Translation: BAG36395.1
AL834478 mRNA Translation: CAD39137.1
BX641095 mRNA Translation: CAE46045.1 Sequence problems.
EF553520 mRNA Translation: ABQ66266.1
AL590428 Genomic DNA No translation available.
AL591480 Genomic DNA No translation available.
AY736555 Genomic DNA Translation: AAU94642.1
AY736557 Genomic DNA Translation: AAU94644.1
AF410460 Genomic DNA Translation: AAL84160.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4982.1 [Q6YHK3-1]
CCDS55038.1 [Q6YHK3-4]
CCDS55039.1 [Q6YHK3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001153059.1, NM_001159587.2 [Q6YHK3-4]
NP_001153060.1, NM_001159588.2 [Q6YHK3-2]
NP_598000.2, NM_133493.4 [Q6YHK3-1]
XP_005248716.1, XM_005248659.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000287097; ENSP00000287097; ENSG00000156535 [Q6YHK3-1]
ENST00000422508; ENSP00000404475; ENSG00000156535 [Q6YHK3-2]
ENST00000437994; ENSP00000388062; ENSG00000156535 [Q6YHK3-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
135228

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:135228

UCSC genome browser

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UCSCi
uc003php.4 human [Q6YHK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410459 mRNA Translation: AAL84159.1
AY149920 mRNA Translation: AAN78483.1
AY788891 mRNA Translation: AAX14639.1
AK095888 mRNA Translation: BAC04642.1
AK123960 mRNA Translation: BAG53987.1 Different initiation.
AK313636 mRNA Translation: BAG36395.1
AL834478 mRNA Translation: CAD39137.1
BX641095 mRNA Translation: CAE46045.1 Sequence problems.
EF553520 mRNA Translation: ABQ66266.1
AL590428 Genomic DNA No translation available.
AL591480 Genomic DNA No translation available.
AY736555 Genomic DNA Translation: AAU94642.1
AY736557 Genomic DNA Translation: AAU94644.1
AF410460 Genomic DNA Translation: AAL84160.1
CCDSiCCDS4982.1 [Q6YHK3-1]
CCDS55038.1 [Q6YHK3-4]
CCDS55039.1 [Q6YHK3-2]
RefSeqiNP_001153059.1, NM_001159587.2 [Q6YHK3-4]
NP_001153060.1, NM_001159588.2 [Q6YHK3-2]
NP_598000.2, NM_133493.4 [Q6YHK3-1]
XP_005248716.1, XM_005248659.3

3D structure databases

SMRiQ6YHK3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126424, 54 interactors
IntActiQ6YHK3, 37 interactors
STRINGi9606.ENSP00000287097

Protein family/group databases

MEROPSiI39.006

PTM databases

CarbonylDBiQ6YHK3
GlyConnecti795
iPTMnetiQ6YHK3
PhosphoSitePlusiQ6YHK3
SwissPalmiQ6YHK3
UniCarbKBiQ6YHK3

Polymorphism and mutation databases

BioMutaiCD109
DMDMi117949389

Proteomic databases

EPDiQ6YHK3
jPOSTiQ6YHK3
MassIVEiQ6YHK3
MaxQBiQ6YHK3
PaxDbiQ6YHK3
PeptideAtlasiQ6YHK3
PRIDEiQ6YHK3
ProteomicsDBi67842 [Q6YHK3-1]
67843 [Q6YHK3-2]
67844 [Q6YHK3-3]
67845 [Q6YHK3-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
135228

Genome annotation databases

EnsembliENST00000287097; ENSP00000287097; ENSG00000156535 [Q6YHK3-1]
ENST00000422508; ENSP00000404475; ENSG00000156535 [Q6YHK3-2]
ENST00000437994; ENSP00000388062; ENSG00000156535 [Q6YHK3-4]
GeneIDi135228
KEGGihsa:135228
UCSCiuc003php.4 human [Q6YHK3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
135228
DisGeNETi135228

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD109
HGNCiHGNC:21685 CD109
HPAiHPA015723
MalaCardsiCD109
MIMi608859 gene
neXtProtiNX_Q6YHK3
OpenTargetsiENSG00000156535
Orphaneti853 Fetal and neonatal alloimmune thrombocytopenia
PharmGKBiPA134949237

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMYI Eukaryota
COG2373 LUCA
GeneTreeiENSGT00940000155926
InParanoidiQ6YHK3
KOiK06530
OMAiEIKLFWS
OrthoDBi354230at2759
PhylomeDBiQ6YHK3
TreeFamiTF313285

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CD109 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD109

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
135228
PharosiQ6YHK3

Protein Ontology

More...
PROi
PR:Q6YHK3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156535 Expressed in 204 organ(s), highest expression level in tibia
GenevisibleiQ6YHK3 HS

Family and domain databases

CDDicd02897 A2M_2, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR041813 A2M_TED
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF07678 TED_complement, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD109_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6YHK3
Secondary accession number(s): A5YKK4
, B2R948, B3KW25, Q0P6K7, Q5SYA8, Q5XUM7, Q5XUM9, Q6MZI7, Q8N3A7, Q8N915, Q8TDJ2, Q8TDJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 16, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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