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Entry version 121 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Proton-coupled amino acid transporter 4

Gene

SLC36A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.

1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.1 µM for L-proline1 Publication
  2. KM=1.7 µM for L-tryptophan1 Publication

pH dependencei

Optimum pH is 7.4 (for proline transport).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Symport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6YBV0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-352230, Amino acid transport across the plasma membrane
R-HSA-71240, Tryptophan catabolism

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6YBV0

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.18.8.5, the amino acid/auxin permease (aaap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proton-coupled amino acid transporter 4
Short name:
Proton/amino acid transporter 4
Alternative name(s):
Solute carrier family 36 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC36A4
Synonyms:PAT4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19660, SLC36A4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613760, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6YBV0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000180773

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
120103

Open Targets

More...
OpenTargetsi
ENSG00000180773

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134908925

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6YBV0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC36A4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749514

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003083181 – 504Proton-coupled amino acid transporter 4Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi495N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6YBV0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6YBV0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6YBV0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6YBV0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6YBV0

PeptideAtlas

More...
PeptideAtlasi
Q6YBV0

PRoteomics IDEntifications database

More...
PRIDEi
Q6YBV0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67839 [Q6YBV0-1]
67840 [Q6YBV0-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6YBV0, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6YBV0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6YBV0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180773, Expressed in islet of Langerhans and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6YBV0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6YBV0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000180773, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6YBV0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317382

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6YBV0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1304, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160117

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009646_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6YBV0

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKFHAKW

Database of Orthologous Groups

More...
OrthoDBi
697331at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6YBV0

TreeFam database of animal gene trees

More...
TreeFami
TF314873

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013057, AA_transpt_TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01490, Aa_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6YBV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAAATPAAA GAARREELDM DVMRPLINEQ NFDGTSDEEH EQELLPVQKH
60 70 80 90 100
YQLDDQEGIS FVQTLMHLLK GNIGTGLLGL PLAIKNAGIV LGPISLVFIG
110 120 130 140 150
IISVHCMHIL VRCSHFLCLR FKKSTLGYSD TVSFAMEVSP WSCLQKQAAW
160 170 180 190 200
GRSVVDFFLV ITQLGFCSVY IVFLAENVKQ VHEGFLESKV FISNSTNSSN
210 220 230 240 250
PCERRSVDLR IYMLCFLPFI ILLVFIRELK NLFVLSFLAN VSMAVSLVII
260 270 280 290 300
YQYVVRNMPD PHNLPIVAGW KKYPLFFGTA VFAFEGIGVV LPLENQMKES
310 320 330 340 350
KRFPQALNIG MGIVTTLYVT LATLGYMCFH DEIKGSITLN LPQDVWLYQS
360 370 380 390 400
VKILYSFGIF VTYSIQFYVP AEIIIPGITS KFHTKWKQIC EFGIRSFLVS
410 420 430 440 450
ITCAGAILIP RLDIVISFVG AVSSSTLALI LPPLVEILTF SKEHYNIWMV
460 470 480 490 500
LKNISIAFTG VVGFLLGTYI TVEEIIYPTP KVVAGTPQSP FLNLNSTCLT

SGLK
Length:504
Mass (Da):56,157
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i066CCC585EB2F170
GO
Isoform 2 (identifier: Q6YBV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Show »
Length:369
Mass (Da):41,385
Checksum:iF2F3C1A051D9752C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PID7E9PID7_HUMAN
Proton-coupled amino acid transport...
SLC36A4
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN09E9PN09_HUMAN
Proton-coupled amino acid transport...
SLC36A4
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC82496 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti330H → R in BAC04737 (PubMed:14702039).Curated1
Sequence conflicti387K → E in CAC82496 (Ref. 4) Curated1
Sequence conflicti391 – 392EF → GI in CAC82496 (Ref. 4) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036791209L → I1 PublicationCorresponds to variant dbSNP:rs17854446Ensembl.1
Natural variantiVAR_036792376P → H1 PublicationCorresponds to variant dbSNP:rs17854445Ensembl.1
Natural variantiVAR_036793429L → I1 PublicationCorresponds to variant dbSNP:rs17854443Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0289591 – 135Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY162216 mRNA Translation: AAO11790.1
AK096251 mRNA Translation: BAC04737.1
BC047374 mRNA Translation: AAH47374.1
AJ295983 mRNA Translation: CAC82496.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS66202.1 [Q6YBV0-2]
CCDS8291.1 [Q6YBV0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001273068.1, NM_001286139.1 [Q6YBV0-2]
NP_689526.2, NM_152313.3 [Q6YBV0-1]
XP_016872665.1, XM_017017176.1 [Q6YBV0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326402; ENSP00000317382; ENSG00000180773 [Q6YBV0-1]
ENST00000529184; ENSP00000436570; ENSG00000180773 [Q6YBV0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
120103

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:120103

UCSC genome browser

More...
UCSCi
uc001pdl.3, human [Q6YBV0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162216 mRNA Translation: AAO11790.1
AK096251 mRNA Translation: BAC04737.1
BC047374 mRNA Translation: AAH47374.1
AJ295983 mRNA Translation: CAC82496.1 Frameshift.
CCDSiCCDS66202.1 [Q6YBV0-2]
CCDS8291.1 [Q6YBV0-1]
RefSeqiNP_001273068.1, NM_001286139.1 [Q6YBV0-2]
NP_689526.2, NM_152313.3 [Q6YBV0-1]
XP_016872665.1, XM_017017176.1 [Q6YBV0-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6YBV0, 1 interactor
STRINGi9606.ENSP00000317382

Protein family/group databases

TCDBi2.A.18.8.5, the amino acid/auxin permease (aaap) family

PTM databases

GlyGeniQ6YBV0, 2 sites
iPTMnetiQ6YBV0
PhosphoSitePlusiQ6YBV0

Genetic variation databases

BioMutaiSLC36A4
DMDMi74749514

Proteomic databases

EPDiQ6YBV0
jPOSTiQ6YBV0
MassIVEiQ6YBV0
MaxQBiQ6YBV0
PaxDbiQ6YBV0
PeptideAtlasiQ6YBV0
PRIDEiQ6YBV0
ProteomicsDBi67839 [Q6YBV0-1]
67840 [Q6YBV0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17800, 126 antibodies

The DNASU plasmid repository

More...
DNASUi
120103

Genome annotation databases

EnsembliENST00000326402; ENSP00000317382; ENSG00000180773 [Q6YBV0-1]
ENST00000529184; ENSP00000436570; ENSG00000180773 [Q6YBV0-2]
GeneIDi120103
KEGGihsa:120103
UCSCiuc001pdl.3, human [Q6YBV0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
120103
DisGeNETi120103

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC36A4
HGNCiHGNC:19660, SLC36A4
HPAiENSG00000180773, Low tissue specificity
MIMi613760, gene
neXtProtiNX_Q6YBV0
OpenTargetsiENSG00000180773
PharmGKBiPA134908925
VEuPathDBiHostDB:ENSG00000180773

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1304, Eukaryota
GeneTreeiENSGT00940000160117
HOGENOMiCLU_009646_0_0_1
InParanoidiQ6YBV0
OMAiSKFHAKW
OrthoDBi697331at2759
PhylomeDBiQ6YBV0
TreeFamiTF314873

Enzyme and pathway databases

PathwayCommonsiQ6YBV0
ReactomeiR-HSA-352230, Amino acid transport across the plasma membrane
R-HSA-71240, Tryptophan catabolism
SIGNORiQ6YBV0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
120103, 8 hits in 1019 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC36A4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
120103
PharosiQ6YBV0, Tbio

Protein Ontology

More...
PROi
PR:Q6YBV0
RNActiQ6YBV0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000180773, Expressed in islet of Langerhans and 188 other tissues
ExpressionAtlasiQ6YBV0, baseline and differential
GenevisibleiQ6YBV0, HS

Family and domain databases

InterProiView protein in InterPro
IPR013057, AA_transpt_TM
PfamiView protein in Pfam
PF01490, Aa_trans, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS36A4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6YBV0
Secondary accession number(s): Q86X30, Q8IVM5, Q8N8S6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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