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Entry version 110 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Proton-coupled amino acid transporter 4

Gene

SLC36A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.1 µM for L-proline1 Publication
  2. KM=1.7 µM for L-tryptophan1 Publication

    pH dependencei

    Optimum pH is 7.4 (for proline transport).1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Symport, Transport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-352230 Amino acid transport across the plasma membrane
    R-HSA-71240 Tryptophan catabolism

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.18.8.5 the amino acid/auxin permease (aaap) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Proton-coupled amino acid transporter 4
    Short name:
    Proton/amino acid transporter 4
    Alternative name(s):
    Solute carrier family 36 member 4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC36A4
    Synonyms:PAT4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:19660 SLC36A4

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    613760 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6YBV0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
    Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
    Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
    Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
    Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
    Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
    Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
    Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
    Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
    Transmembranei456 – 476HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    Open Targets

    More...
    OpenTargetsi
    ENSG00000180773

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134908925

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6YBV0

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC36A4

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74749514

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003083181 – 504Proton-coupled amino acid transporter 4Add BLAST504

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi495N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q6YBV0

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6YBV0

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q6YBV0

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q6YBV0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6YBV0

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6YBV0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6YBV0

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    67839 [Q6YBV0-1]
    67840 [Q6YBV0-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6YBV0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6YBV0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000180773 Expressed in 174 organ(s), highest expression level in adrenal tissue

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6YBV0 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6YBV0 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA017887

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    Q6YBV0, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000317382

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1304 Eukaryota
    COG0814 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160117

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000006823

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6YBV0

    KEGG Orthology (KO)

    More...
    KOi
    K14209

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SKFHAKW

    Database of Orthologous Groups

    More...
    OrthoDBi
    697331at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6YBV0

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314873

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013057 AA_transpt_TM

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01490 Aa_trans, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6YBV0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEAAATPAAA GAARREELDM DVMRPLINEQ NFDGTSDEEH EQELLPVQKH
    60 70 80 90 100
    YQLDDQEGIS FVQTLMHLLK GNIGTGLLGL PLAIKNAGIV LGPISLVFIG
    110 120 130 140 150
    IISVHCMHIL VRCSHFLCLR FKKSTLGYSD TVSFAMEVSP WSCLQKQAAW
    160 170 180 190 200
    GRSVVDFFLV ITQLGFCSVY IVFLAENVKQ VHEGFLESKV FISNSTNSSN
    210 220 230 240 250
    PCERRSVDLR IYMLCFLPFI ILLVFIRELK NLFVLSFLAN VSMAVSLVII
    260 270 280 290 300
    YQYVVRNMPD PHNLPIVAGW KKYPLFFGTA VFAFEGIGVV LPLENQMKES
    310 320 330 340 350
    KRFPQALNIG MGIVTTLYVT LATLGYMCFH DEIKGSITLN LPQDVWLYQS
    360 370 380 390 400
    VKILYSFGIF VTYSIQFYVP AEIIIPGITS KFHTKWKQIC EFGIRSFLVS
    410 420 430 440 450
    ITCAGAILIP RLDIVISFVG AVSSSTLALI LPPLVEILTF SKEHYNIWMV
    460 470 480 490 500
    LKNISIAFTG VVGFLLGTYI TVEEIIYPTP KVVAGTPQSP FLNLNSTCLT

    SGLK
    Length:504
    Mass (Da):56,157
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i066CCC585EB2F170
    GO
    Isoform 2 (identifier: Q6YBV0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-135: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:369
    Mass (Da):41,385
    Checksum:iF2F3C1A051D9752C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PN09E9PN09_HUMAN
    Proton-coupled amino acid transport...
    SLC36A4
    111Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PID7E9PID7_HUMAN
    Proton-coupled amino acid transport...
    SLC36A4
    280Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAC82496 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti330H → R in BAC04737 (PubMed:14702039).Curated1
    Sequence conflicti387K → E in CAC82496 (Ref. 4) Curated1
    Sequence conflicti391 – 392EF → GI in CAC82496 (Ref. 4) Curated2

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036791209L → I1 PublicationCorresponds to variant dbSNP:rs17854446Ensembl.1
    Natural variantiVAR_036792376P → H1 PublicationCorresponds to variant dbSNP:rs17854445Ensembl.1
    Natural variantiVAR_036793429L → I1 PublicationCorresponds to variant dbSNP:rs17854443Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0289591 – 135Missing in isoform 2. 1 PublicationAdd BLAST135

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY162216 mRNA Translation: AAO11790.1
    AK096251 mRNA Translation: BAC04737.1
    BC047374 mRNA Translation: AAH47374.1
    AJ295983 mRNA Translation: CAC82496.1 Frameshift.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS66202.1 [Q6YBV0-2]
    CCDS8291.1 [Q6YBV0-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001273068.1, NM_001286139.1 [Q6YBV0-2]
    NP_689526.2, NM_152313.3 [Q6YBV0-1]
    XP_016872665.1, XM_017017176.1 [Q6YBV0-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000326402; ENSP00000317382; ENSG00000180773 [Q6YBV0-1]
    ENST00000529184; ENSP00000436570; ENSG00000180773 [Q6YBV0-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    120103

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:120103

    UCSC genome browser

    More...
    UCSCi
    uc001pdl.3 human [Q6YBV0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY162216 mRNA Translation: AAO11790.1
    AK096251 mRNA Translation: BAC04737.1
    BC047374 mRNA Translation: AAH47374.1
    AJ295983 mRNA Translation: CAC82496.1 Frameshift.
    CCDSiCCDS66202.1 [Q6YBV0-2]
    CCDS8291.1 [Q6YBV0-1]
    RefSeqiNP_001273068.1, NM_001286139.1 [Q6YBV0-2]
    NP_689526.2, NM_152313.3 [Q6YBV0-1]
    XP_016872665.1, XM_017017176.1 [Q6YBV0-2]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    IntActiQ6YBV0, 1 interactor
    STRINGi9606.ENSP00000317382

    Protein family/group databases

    TCDBi2.A.18.8.5 the amino acid/auxin permease (aaap) family

    PTM databases

    iPTMnetiQ6YBV0
    PhosphoSitePlusiQ6YBV0

    Polymorphism and mutation databases

    BioMutaiSLC36A4
    DMDMi74749514

    Proteomic databases

    EPDiQ6YBV0
    jPOSTiQ6YBV0
    MassIVEiQ6YBV0
    MaxQBiQ6YBV0
    PaxDbiQ6YBV0
    PeptideAtlasiQ6YBV0
    PRIDEiQ6YBV0
    ProteomicsDBi67839 [Q6YBV0-1]
    67840 [Q6YBV0-2]

    Genome annotation databases

    EnsembliENST00000326402; ENSP00000317382; ENSG00000180773 [Q6YBV0-1]
    ENST00000529184; ENSP00000436570; ENSG00000180773 [Q6YBV0-2]
    GeneIDi120103
    KEGGihsa:120103
    UCSCiuc001pdl.3 human [Q6YBV0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    120103

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC36A4
    HGNCiHGNC:19660 SLC36A4
    HPAiHPA017887
    MIMi613760 gene
    neXtProtiNX_Q6YBV0
    OpenTargetsiENSG00000180773
    PharmGKBiPA134908925

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1304 Eukaryota
    COG0814 LUCA
    GeneTreeiENSGT00940000160117
    HOGENOMiHOG000006823
    InParanoidiQ6YBV0
    KOiK14209
    OMAiSKFHAKW
    OrthoDBi697331at2759
    PhylomeDBiQ6YBV0
    TreeFamiTF314873

    Enzyme and pathway databases

    ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane
    R-HSA-71240 Tryptophan catabolism

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    SLC36A4 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    120103
    PharosiQ6YBV0

    Protein Ontology

    More...
    PROi
    PR:Q6YBV0

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000180773 Expressed in 174 organ(s), highest expression level in adrenal tissue
    ExpressionAtlasiQ6YBV0 baseline and differential
    GenevisibleiQ6YBV0 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR013057 AA_transpt_TM
    PfamiView protein in Pfam
    PF01490 Aa_trans, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS36A4_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6YBV0
    Secondary accession number(s): Q86X30, Q8IVM5, Q8N8S6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 5, 2004
    Last modified: October 16, 2019
    This is version 110 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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