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Entry version 121 (07 Oct 2020)
Sequence version 2 (09 Jan 2007)
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Protein

GRB10-interacting GYF protein 2

Gene

Gigyf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:26763119). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:26763119). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRB10-interacting GYF protein 21 Publication
Alternative name(s):
PERQ amino acid-rich with GYF domain-containing protein 2
Trinucleotide repeat-containing gene 15 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gigyf21 Publication
Synonyms:Kiaa0642, Perq2, Tnrc15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2138584, Gigyf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice undergo normal embryonic development, but fail to feed and die within the first 2 postnatal days. Heterozygous mice survive to adulthood with no evident metabolic or growth defects. At 12-15 months of age, heterozygous mice show motor dysfunction associated with histopathologic evidence of neurodegeneration and rare intracytoplasmic Lewy body-like inclusions in spinal anterior horn motor neurons.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002708382 – 1291GRB10-interacting GYF protein 2Add BLAST1290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei26PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei107Omega-N-methylarginineCombined sources1
Modified residuei119Omega-N-methylarginineCombined sources1
Modified residuei121Omega-N-methylarginineCombined sources1
Modified residuei140PhosphoserineBy similarity1
Modified residuei150Omega-N-methylarginineCombined sources1
Modified residuei161PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei237PhosphoserineBy similarity1
Modified residuei383PhosphothreonineCombined sources1
Modified residuei594PhosphoserineBy similarity1
Modified residuei995PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1276PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6Y7W8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6Y7W8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6Y7W8

PeptideAtlas

More...
PeptideAtlasi
Q6Y7W8

PRoteomics IDEntifications database

More...
PRIDEi
Q6Y7W8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6Y7W8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6Y7W8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, liver, kidney and brain as well as in testis (PubMed:12771153).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely expressed in embryonic tissues, including strong expression in the central nervous system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048000, Expressed in zygote and 280 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6Y7W8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598 (PubMed:26763119).

Interacts (via the 4EHP-binding motif) with EIF4E2; the interaction is direct (By similarity).

Interacts with ZFP36/TTP (via P-P-P-P-G repeats); the interaction is direct (PubMed:26763119).

Interacts with GRB10 (PubMed:12771153).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230615, 18 interactors

Protein interaction database and analysis system

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IntActi
Q6Y7W8, 3 interactors

Molecular INTeraction database

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MINTi
Q6Y7W8

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000027475

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6Y7W8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6Y7W8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini534 – 582GYFPROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni548 – 564Required for GRB10-bindingAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi119 – 273Arg-richAdd BLAST155
Compositional biasi437 – 474Pro-richAdd BLAST38
Compositional biasi608 – 1031Gln-richAdd BLAST424
Compositional biasi739 – 889Glu-richAdd BLAST151
Compositional biasi1204 – 1244Gln-richAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GIGYF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1862, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156108

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007300_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6Y7W8

KEGG Orthology (KO)

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KOi
K18730

Identification of Orthologs from Complete Genome Data

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OMAi
MLQDQYL

Database of Orthologous Groups

More...
OrthoDBi
412069at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6Y7W8

TreeFam database of animal gene trees

More...
TreeFami
TF325513

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00072, GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02213, GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00444, GYF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55277, SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50829, GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6Y7W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAETQTLNF GPEWLRALSS GGSITSPPLS PALPKYKLAD YRYGREEMLA
60 70 80 90 100
LFLKDYKIPF DLLEKEFLPI LQEEPLPPLA LVPFTEEEQR NFSMSVNSAA
110 120 130 140 150
VLRLTGRGGG GGTVVGAPRG RSSSRGRGRG RGECGFYQRS FDEVEGVFGR
160 170 180 190 200
GGGREMHRSQ SWEERGDRRF EKPGRKDVGR PNFEESGPTS VGRKHEFIRS
210 220 230 240 250
ESENWRIFRE EQNGEDEDGG WRLAGSRRDG ERWRPHSPDG PRSTGWREHM
260 270 280 290 300
ERRRRFEFDF RDRDDERGYR RVRSGSGSID DDRDSLPEWC LEDAEEEMGT
310 320 330 340 350
FDSSGAFLSL KKVQKEPIPE EQEMDFRPVE EGEERSDSDS SHNEEAKEPD
360 370 380 390 400
KTNRREGEKT DRAGAEASEE VPQTSLSSAR PGTPSDHQPQ EATQFERKDE
410 420 430 440 450
PKAEQVEKAE EENRSENSLS AKVPSRGDET VPASQQPSTP LPPDTASPLL
460 470 480 490 500
ILSPPVPTPS SASRPVETAA VEAPGMSSVS TEPDDEEGLK HLEQQAEKMV
510 520 530 540 550
AYLQDSALDD ERLTSKLQEH RAKGVSIPLM HEAMQKWYYK DPQGEIQGPF
560 570 580 590 600
NNQEMAEWFQ AGYFTMSLLV KRACDESFQP LGDIMKMWGR VPFSPGPAPP
610 620 630 640 650
PHMGELDQER LTRQQELTAL YQMQHLQYQQ FLIQQQYAQV LAQQQKAALS
660 670 680 690 700
SQQQQQLALL LQQFQALKMR MSDQNIIPSV TRSVSVPDTG SIWELQPAAS
710 720 730 740 750
QPAVWEGGSV WDLPLDTTAP GPSLEQLQQL EKAKAAKLEQ ERREAEMRAK
760 770 780 790 800
REEEERKRQE ELRRQQEEIL RRQQEEERKR REEEELARRK QEEALRRQRE
810 820 830 840 850
QEIALRRQRE EEERQQQEEA LRRLEERRRE EEERRKQEEL LRKQEEEAAK
860 870 880 890 900
WAREEEEAQR RLEENRLRME EEAARLRHEE EERKRKELEL QRQKDLMRQR
910 920 930 940 950
QQQQEALRRL QQQQQQQQLA QMKLPSSSTW GQQSNTATCQ SQATLSLAEI
960 970 980 990 1000
QKLEEERERQ LREEQRRQQR ELMKALQQQQ QQQQQQKLSG WGNVSKPAGT
1010 1020 1030 1040 1050
TKSLLEIQQE EARQMQKQQQ QQQQQQQQHQ QSNRARNSTH SNLHTSLGNS
1060 1070 1080 1090 1100
VWGSINTGPS NQWASELVSS IWSNADTKNS NMGFWDDAVK EVGPRNSTNK
1110 1120 1130 1140 1150
NKNNASLSKS VGVSNRQNKK VEEEEKLLKL FQGVNKAQDG FTQWCEQMLH
1160 1170 1180 1190 1200
ALNTANNLDV PTFVSFLKEV ESPYEVHDYT RAYLGDTSEA KEFAKQFLER
1210 1220 1230 1240 1250
RAKQKVNQQR QQQQQQQQQQ DSVWGMNHST LHSVFQTNQS NNQQSNFEAV
1260 1270 1280 1290
QSGKKKKKQK MVRADPSLLG FSVNASSERL NMGEIETLDD Y
Length:1,291
Mass (Da):149,193
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD05938427E72580A
GO
Isoform 2 (identifier: Q6Y7W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-868: Missing.

Show »
Length:423
Mass (Da):49,140
Checksum:iCEE62BEA76486B59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZX7G3UZX7_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
787Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UYG6G3UYG6_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
1,285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q2M5E9Q2M5_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
721Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWR2G3UWR2_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
1,122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UYR9G3UYR9_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
877Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZS9G3UZS9_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZW5G3UZW5_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWT6G3UWT6_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UYH4G3UYH4_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UXF2G3UXF2_MOUSE
GRB10-interacting GYF protein 2
Gigyf2
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13E → G in BAE25675 (PubMed:16141072).Curated1
Sequence conflicti549P → S in BAC65619 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0222471 – 868Missing in isoform 2. 1 PublicationAdd BLAST868

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY176043 mRNA Translation: AAO46887.1
BC027137 mRNA Translation: AAH27137.1
BC030845 mRNA Translation: AAH30845.1
BC082811 mRNA Translation: AAH82811.1
BC089036 mRNA Translation: AAH89036.1
AK144058 mRNA Translation: BAE25675.1
AK122337 mRNA Translation: BAC65619.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS15133.1 [Q6Y7W8-1]

NCBI Reference Sequences

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RefSeqi
NP_001103682.1, NM_001110212.2
NP_666224.3, NM_146112.4 [Q6Y7W8-1]
XP_006529527.1, XM_006529464.2 [Q6Y7W8-1]
XP_006529528.1, XM_006529465.3 [Q6Y7W8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000027475; ENSMUSP00000027475; ENSMUSG00000048000 [Q6Y7W8-1]
ENSMUST00000174501; ENSMUSP00000133327; ENSMUSG00000048000 [Q6Y7W8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
227331

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:227331

UCSC genome browser

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UCSCi
uc007bwt.2, mouse [Q6Y7W8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY176043 mRNA Translation: AAO46887.1
BC027137 mRNA Translation: AAH27137.1
BC030845 mRNA Translation: AAH30845.1
BC082811 mRNA Translation: AAH82811.1
BC089036 mRNA Translation: AAH89036.1
AK144058 mRNA Translation: BAE25675.1
AK122337 mRNA Translation: BAC65619.1
CCDSiCCDS15133.1 [Q6Y7W8-1]
RefSeqiNP_001103682.1, NM_001110212.2
NP_666224.3, NM_146112.4 [Q6Y7W8-1]
XP_006529527.1, XM_006529464.2 [Q6Y7W8-1]
XP_006529528.1, XM_006529465.3 [Q6Y7W8-1]

3D structure databases

SMRiQ6Y7W8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230615, 18 interactors
IntActiQ6Y7W8, 3 interactors
MINTiQ6Y7W8
STRINGi10090.ENSMUSP00000027475

PTM databases

iPTMnetiQ6Y7W8
PhosphoSitePlusiQ6Y7W8

Proteomic databases

EPDiQ6Y7W8
jPOSTiQ6Y7W8
PaxDbiQ6Y7W8
PeptideAtlasiQ6Y7W8
PRIDEiQ6Y7W8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62944, 79 antibodies

Genome annotation databases

EnsembliENSMUST00000027475; ENSMUSP00000027475; ENSMUSG00000048000 [Q6Y7W8-1]
ENSMUST00000174501; ENSMUSP00000133327; ENSMUSG00000048000 [Q6Y7W8-1]
GeneIDi227331
KEGGimmu:227331
UCSCiuc007bwt.2, mouse [Q6Y7W8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26058
MGIiMGI:2138584, Gigyf2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1862, Eukaryota
GeneTreeiENSGT00940000156108
HOGENOMiCLU_007300_0_0_1
InParanoidiQ6Y7W8
KOiK18730
OMAiMLQDQYL
OrthoDBi412069at2759
PhylomeDBiQ6Y7W8
TreeFamiTF325513

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
227331, 5 hits in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Gigyf2, mouse

Protein Ontology

More...
PROi
PR:Q6Y7W8
RNActiQ6Y7W8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048000, Expressed in zygote and 280 other tissues
GenevisibleiQ6Y7W8, MM

Family and domain databases

CDDicd00072, GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf
PfamiView protein in Pfam
PF02213, GYF, 1 hit
SMARTiView protein in SMART
SM00444, GYF, 1 hit
SUPFAMiSSF55277, SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829, GYF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGYF2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6Y7W8
Secondary accession number(s): Q0VGQ7
, Q3UNS2, Q63ZU9, Q80TV1, Q8K0R0, Q8R0A3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 7, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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