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Protein

GRB10-interacting GYF protein 2

Gene

GIGYF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • proline-rich region binding Source: ParkinsonsUK-UCL
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRB10-interacting GYF protein 21 Publication
Alternative name(s):
PERQ amino acid-rich with GYF domain-containing protein 2
Trinucleotide repeat-containing gene 15 protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GIGYF21 PublicationImported
Synonyms:KIAA06421 Publication, PERQ2, TNRC151 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204120.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11960 GIGYF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612003 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6Y7W6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Parkinson disease 11 (PARK11)4 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry. Its association with Parkinson disease is however unclear. According to a number of studies, variations affecting this gene are not a frequent cause of Parkinson disease, suggesting that GIGYF2 does not play a major role in Parkinson disease etiology (PubMed:19279319, PubMed:19429085, PubMed:19638301, PubMed:19482505, PubMed:20004041, PubMed:19321232, PubMed:20060621).7 Publications
Disease descriptionA complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
See also OMIM:607688
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044440112T → A in PARK11. 1 Publication1
Natural variantiVAR_077935256E → K in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077936273S → C in PARK11; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs141225775Ensembl.1
Natural variantiVAR_044441278I → V in PARK11. 1 PublicationCorresponds to variant dbSNP:rs118203904EnsemblClinVar.1
Natural variantiVAR_044442335S → T in PARK11. 1 PublicationCorresponds to variant dbSNP:rs776898936Ensembl.1
Natural variantiVAR_077937345A → V in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077938349D → E in PARK11; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148277228Ensembl.1
Natural variantiVAR_077939377S → Y in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_044443457N → T in PARK11; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs116074753EnsemblClinVar.1
Natural variantiVAR_077940473P → S in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077941492E → K in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077942519H → Y in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077944580L → F in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077945589R → G in PARK11. 1 Publication1
Natural variantiVAR_044445606D → E in PARK11. 1 PublicationCorresponds to variant dbSNP:rs118203903EnsemblClinVar.1
Natural variantiVAR_077946979Missing in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_0779471070D → H in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_0779491209L → P in PARK11; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs114013774Ensembl.1
Natural variantiVAR_0444491242V → I in PARK11. 1 PublicationCorresponds to variant dbSNP:rs769022021Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi41 – 49YRYGREEML → ARAGREEAA: Abolishes interaction with EIF4E2. 1 Publication9

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

DisGeNET

More...
DisGeNETi
26058

MalaCards human disease database

More...
MalaCardsi
GIGYF2
MIMi607688 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000204120

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
411602 Hereditary late-onset Parkinson disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36647

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2331055

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GIGYF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74710467

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002708372 – 1299GRB10-interacting GYF protein 2Add BLAST1298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei107Omega-N-methylarginineBy similarity1
Modified residuei118Omega-N-methylarginineBy similarity1
Modified residuei120Omega-N-methylarginineBy similarity1
Modified residuei139PhosphoserineCombined sources1
Modified residuei149Omega-N-methylarginineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei382PhosphothreonineCombined sources1
Modified residuei388PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei993PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1284PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6Y7W6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6Y7W6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6Y7W6

PeptideAtlas

More...
PeptideAtlasi
Q6Y7W6

PRoteomics IDEntifications database

More...
PRIDEi
Q6Y7W6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67836
67837 [Q6Y7W6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6Y7W6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6Y7W6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204120 Expressed in 232 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_GIGYF2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6Y7W6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6Y7W6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050899
HPA054612
HPA059918
HPA065064

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598 (PubMed:22751931). Interacts (via the 4EHP-binding motif) with EIF4E2; the interaction is direct (PubMed:22751931). Interacts with ZFP36/TTP (via P-P-P-P-G repeats); the interaction is direct (By similarity). Interacts with GRB10 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117520, 106 interactors

Protein interaction database and analysis system

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IntActi
Q6Y7W6, 23 interactors

Molecular INTeraction database

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MINTi
Q6Y7W6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000387170

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6Y7W6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6Y7W6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6Y7W6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini533 – 581GYFPROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni547 – 563Required for GRB10-bindingBy similarityAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi40 – 504EHP-binding motif1 PublicationAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 111Poly-Gly6
Compositional biasi118 – 272Arg-richAdd BLAST155
Compositional biasi436 – 473Pro-richAdd BLAST38
Compositional biasi607 – 1025Gln-richAdd BLAST419
Compositional biasi738 – 888Glu-richAdd BLAST151
Compositional biasi1198 – 1252Gln-richAdd BLAST55

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GIGYF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1862 Eukaryota
ENOG4111Q0Y LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156108

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000290720

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG082121

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6Y7W6

KEGG Orthology (KO)

More...
KOi
K18730

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6Y7W6

TreeFam database of animal gene trees

More...
TreeFami
TF325513

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00072 GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003169 GYF
IPR035445 GYF-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02213 GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00444 GYF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55277 SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50829 GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6Y7W6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAETQTLNF GPEWLRALSS GGSITSPPLS PALPKYKLAD YRYGREEMLA
60 70 80 90 100
LFLKDNKIPS DLLDKEFLPI LQEEPLPPLA LVPFTEEEQR NFSMSVNSAA
110 120 130 140 150
VLRLTGRGGG GTVVGAPRGR SSSRGRGRGR GECGFYQRSF DEVEGVFGRG
160 170 180 190 200
GGREMHRSQS WEERGDRRFE KPGRKDVGRP NFEEGGPTSV GRKHEFIRSE
210 220 230 240 250
SENWRIFREE QNGEDEDGGW RLAGSRRDGE RWRPHSPDGP RSAGWREHME
260 270 280 290 300
RRRRFEFDFR DRDDERGYRR VRSGSGSIDD DRDSLPEWCL EDAEEEMGTF
310 320 330 340 350
DSSGAFLSLK KVQKEPIPEE QEMDFRPVDE GEECSDSEGS HNEEAKEPDK
360 370 380 390 400
TNKKEGEKTD RVGVEASEET PQTSSSSARP GTPSDHQSQE ASQFERKDEP
410 420 430 440 450
KTEQTEKAEE ETRMENSLPA KVPSRGDEMV ADVQQPLSQI PSDTASPLLI
460 470 480 490 500
LPPPVPNPSP TLRPVETPVV GAPGMGSVST EPDDEEGLKH LEQQAEKMVA
510 520 530 540 550
YLQDSALDDE RLASKLQEHR AKGVSIPLMH EAMQKWYYKD PQGEIQGPFN
560 570 580 590 600
NQEMAEWFQA GYFTMSLLVK RACDESFQPL GDIMKMWGRV PFSPGPAPPP
610 620 630 640 650
HMGELDQERL TRQQELTALY QMQHLQYQQF LIQQQYAQVL AQQQKAALSS
660 670 680 690 700
QQQQQLALLL QQFQTLKMRI SDQNIIPSVT RSVSVPDTGS IWELQPTASQ
710 720 730 740 750
PTVWEGGSVW DLPLDTTTPG PALEQLQQLE KAKAAKLEQE RREAEMRAKR
760 770 780 790 800
EEEERKRQEE LRRQQEEILR RQQEEERKRR EEEELARRKQ EEALRRQREQ
810 820 830 840 850
EIALRRQREE EERQQQEEAL RRLEERRREE EERRKQEELL RKQEEEAAKW
860 870 880 890 900
AREEEEAQRR LEENRLRMEE EAARLRHEEE ERKRKELEVQ RQKELMRQRQ
910 920 930 940 950
QQQEALRRLQ QQQQQQQLAQ MKLPSSSTWG QQSNTTACQS QATLSLAEIQ
960 970 980 990 1000
KLEEERERQL REEQRRQQRE LMKALQQQQQ QQQQKLSGWG NVSKPSGTTK
1010 1020 1030 1040 1050
SLLEIQQEEA RQMQKQQQQQ QQHQQPNRAR NNTHSNLHTS IGNSVWGSIN
1060 1070 1080 1090 1100
TGPPNQWASD LVSSIWSNAD TKNSNMGFWD DAVKEVGPRN STNKNKNNAS
1110 1120 1130 1140 1150
LSKSVGVSNR QNKKVEEEEK LLKLFQGVNK AQDGFTQWCE QMLHALNTAN
1160 1170 1180 1190 1200
NLDVPTFVSF LKEVESPYEV HDYIRAYLGD TSEAKEFAKQ FLERRAKQKA
1210 1220 1230 1240 1250
NQQRQQQQLP QQQQQQPPQQ PPQQPQQQDS VWGMNHSTLH SVFQTNQSNN
1260 1270 1280 1290
QQSNFEAVQS GKKKKKQKMV RADPSLLGFS VNASSERLNM GEIETLDDY
Length:1,299
Mass (Da):150,070
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2282458102F64B71
GO
Isoform 2 (identifier: Q6Y7W6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: V → VGKKNGYYCMYSPVLLLGQPLCQ
     365-365: Missing.

Show »
Length:1,320
Mass (Da):152,399
Checksum:i45DD5F3742C127FF
GO
Isoform 3 (identifier: Q6Y7W6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-243: Missing.
     1205-1211: Missing.

Note: No experimental confirmation available.
Show »
Length:1,286
Mass (Da):148,635
Checksum:iE7FD1ECDDE98DDE1
GO
Isoform 4 (identifier: Q6Y7W6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-243: Missing.

Note: No experimental confirmation available.
Show »
Length:1,293
Mass (Da):149,486
Checksum:iDD5D60E71FFAC884
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I1E4Y6I1E4Y6_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
1,321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESB6E7ESB6_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
836Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHW1C9JHW1_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JH18C9JH18_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRZ2C9JRZ2_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0V6C9J0V6_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7G1C9J7G1_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JW88C9JW88_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCD5F8WCD5_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZD2B8ZZD2_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31617 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91873 differs from that shown. Unlikely isoform.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti565M → T in BX538172 (Ref. 4) Curated1
Sequence conflicti792E → G in CAD98095 (PubMed:17974005).Curated1
Sequence conflicti1153D → G in CAD98095 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04443956N → S Polymorphism; may be associated with PARK11. 3 PublicationsCorresponds to variant dbSNP:rs72554080EnsemblClinVar.1
Natural variantiVAR_044440112T → A in PARK11. 1 Publication1
Natural variantiVAR_077935256E → K in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077936273S → C in PARK11; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs141225775Ensembl.1
Natural variantiVAR_044441278I → V in PARK11. 1 PublicationCorresponds to variant dbSNP:rs118203904EnsemblClinVar.1
Natural variantiVAR_044442335S → T in PARK11. 1 PublicationCorresponds to variant dbSNP:rs776898936Ensembl.1
Natural variantiVAR_077937345A → V in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077938349D → E in PARK11; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148277228Ensembl.1
Natural variantiVAR_077939377S → Y in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_051268423P → L. Corresponds to variant dbSNP:rs34845648Ensembl.1
Natural variantiVAR_044443457N → T in PARK11; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs116074753EnsemblClinVar.1
Natural variantiVAR_044444460P → T2 PublicationsCorresponds to variant dbSNP:rs2289912Ensembl.1
Natural variantiVAR_077940473P → S in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077941492E → K in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077942519H → Y in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077943560A → V1 PublicationCorresponds to variant dbSNP:rs761136505Ensembl.1
Natural variantiVAR_077944580L → F in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_077945589R → G in PARK11. 1 Publication1
Natural variantiVAR_044445606D → E in PARK11. 1 PublicationCorresponds to variant dbSNP:rs118203903EnsemblClinVar.1
Natural variantiVAR_077946979Missing in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_0779471070D → H in PARK11; unknown pathological significance. 1 Publication1
Natural variantiVAR_0779481131A → V1 PublicationCorresponds to variant dbSNP:rs773011114Ensembl.1
Natural variantiVAR_0444461171H → R2 PublicationsCorresponds to variant dbSNP:rs72554081Ensembl.1
Natural variantiVAR_0779491209L → P in PARK11; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs114013774Ensembl.1
Natural variantiVAR_0444471211Missing 4 Publications1
Natural variantiVAR_0444481212Q → QQ1 Publication1
Natural variantiVAR_0444491242V → I in PARK11. 1 PublicationCorresponds to variant dbSNP:rs769022021Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022244177V → VGKKNGYYCMYSPVLLLGQP LCQ in isoform 2. 2 Publications1
Alternative sequenceiVSP_044996238 – 243Missing in isoform 3 and isoform 4. 1 Publication6
Alternative sequenceiVSP_043471365Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_0449971205 – 1211Missing in isoform 3. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY176045 mRNA Translation: AAO46889.1
AB014542 mRNA Translation: BAA31617.2 Different initiation.
BX538172 mRNA No translation available.
AK001739 mRNA Translation: BAA91873.1 Sequence problems.
BX537885 mRNA Translation: CAD97881.1
BX538321 mRNA Translation: CAD98095.1
AC016692 Genomic DNA No translation available.
AC064852 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71016.1
BC008072 mRNA Translation: AAH08072.2
BC136251 mRNA Translation: AAI36252.1
BC146775 mRNA Translation: AAI46776.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33401.1 [Q6Y7W6-1]
CCDS46542.1 [Q6Y7W6-3]
CCDS46543.1 [Q6Y7W6-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00377

NCBI Reference Sequences

More...
RefSeqi
NP_001096616.1, NM_001103146.1 [Q6Y7W6-1]
NP_001096617.1, NM_001103147.1 [Q6Y7W6-3]
NP_001096618.1, NM_001103148.1 [Q6Y7W6-5]
NP_056390.2, NM_015575.3 [Q6Y7W6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.565319

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373563; ENSP00000362664; ENSG00000204120 [Q6Y7W6-1]
ENST00000409196; ENSP00000387070; ENSG00000204120 [Q6Y7W6-5]
ENST00000409451; ENSP00000387170; ENSG00000204120 [Q6Y7W6-3]
ENST00000409547; ENSP00000386537; ENSG00000204120 [Q6Y7W6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26058

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26058

UCSC genome browser

More...
UCSCi
uc002vth.6 human [Q6Y7W6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY176045 mRNA Translation: AAO46889.1
AB014542 mRNA Translation: BAA31617.2 Different initiation.
BX538172 mRNA No translation available.
AK001739 mRNA Translation: BAA91873.1 Sequence problems.
BX537885 mRNA Translation: CAD97881.1
BX538321 mRNA Translation: CAD98095.1
AC016692 Genomic DNA No translation available.
AC064852 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71016.1
BC008072 mRNA Translation: AAH08072.2
BC136251 mRNA Translation: AAI36252.1
BC146775 mRNA Translation: AAI46776.1
CCDSiCCDS33401.1 [Q6Y7W6-1]
CCDS46542.1 [Q6Y7W6-3]
CCDS46543.1 [Q6Y7W6-5]
PIRiT00377
RefSeqiNP_001096616.1, NM_001103146.1 [Q6Y7W6-1]
NP_001096617.1, NM_001103147.1 [Q6Y7W6-3]
NP_001096618.1, NM_001103148.1 [Q6Y7W6-5]
NP_056390.2, NM_015575.3 [Q6Y7W6-1]
UniGeneiHs.565319

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NVLX-ray2.30B/D35-105[»]
5NVMX-ray2.00B/D35-72[»]
ProteinModelPortaliQ6Y7W6
SMRiQ6Y7W6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117520, 106 interactors
IntActiQ6Y7W6, 23 interactors
MINTiQ6Y7W6
STRINGi9606.ENSP00000387170

Chemistry databases

BindingDBiQ6Y7W6
ChEMBLiCHEMBL2331055

PTM databases

iPTMnetiQ6Y7W6
PhosphoSitePlusiQ6Y7W6

Polymorphism and mutation databases

BioMutaiGIGYF2
DMDMi74710467

Proteomic databases

EPDiQ6Y7W6
MaxQBiQ6Y7W6
PaxDbiQ6Y7W6
PeptideAtlasiQ6Y7W6
PRIDEiQ6Y7W6
ProteomicsDBi67836
67837 [Q6Y7W6-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26058
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373563; ENSP00000362664; ENSG00000204120 [Q6Y7W6-1]
ENST00000409196; ENSP00000387070; ENSG00000204120 [Q6Y7W6-5]
ENST00000409451; ENSP00000387170; ENSG00000204120 [Q6Y7W6-3]
ENST00000409547; ENSP00000386537; ENSG00000204120 [Q6Y7W6-1]
GeneIDi26058
KEGGihsa:26058
UCSCiuc002vth.6 human [Q6Y7W6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26058
DisGeNETi26058
EuPathDBiHostDB:ENSG00000204120.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GIGYF2
HGNCiHGNC:11960 GIGYF2
HPAiHPA050899
HPA054612
HPA059918
HPA065064
MalaCardsiGIGYF2
MIMi607688 phenotype
612003 gene
neXtProtiNX_Q6Y7W6
OpenTargetsiENSG00000204120
Orphaneti411602 Hereditary late-onset Parkinson disease
PharmGKBiPA36647

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1862 Eukaryota
ENOG4111Q0Y LUCA
GeneTreeiENSGT00940000156108
HOGENOMiHOG000290720
HOVERGENiHBG082121
InParanoidiQ6Y7W6
KOiK18730
PhylomeDBiQ6Y7W6
TreeFamiTF325513

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GIGYF2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TNRC15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26058

Protein Ontology

More...
PROi
PR:Q6Y7W6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204120 Expressed in 232 organ(s), highest expression level in corpus callosum
CleanExiHS_GIGYF2
ExpressionAtlasiQ6Y7W6 baseline and differential
GenevisibleiQ6Y7W6 HS

Family and domain databases

CDDicd00072 GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169 GYF
IPR035445 GYF-like_dom_sf
PfamiView protein in Pfam
PF02213 GYF, 1 hit
SMARTiView protein in SMART
SM00444 GYF, 1 hit
SUPFAMiSSF55277 SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829 GYF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGYF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6Y7W6
Secondary accession number(s): A6H8W4
, B9EG55, E9PBB0, O75137, Q7Z2Z8, Q7Z3I2, Q96HU4, Q9NV82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: December 5, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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